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Compile Data Set for Download or QSAR

Found 19 hits of ec50 data for polymerid = 6107   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50105689
PNG
((E)-3-[4-(3,4-Dimethoxy-benzenesulfonylamino)-phen...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)Nc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C17H18N2O6S/c1-24-15-9-8-14(11-16(15)25-2)26(22,23)19-13-6-3-12(4-7-13)5-10-17(20)18-21/h3-11,19,21H,1-2H3,(H,18,20)/b10-5+
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n/an/an/an/a 1.00E+3n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50123967
PNG
(3-[4-(Biphenyl-4-ylsulfamoyl)-phenyl]-N-hydroxy-ac...)
Show SMILES ONC(=O)\C=C\c1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H18N2O4S/c24-21(22-25)15-8-16-6-13-20(14-7-16)28(26,27)23-19-11-9-18(10-12-19)17-4-2-1-3-5-17/h1-15,23,25H,(H,22,24)/b15-8+
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n/an/an/an/a 1.00E+3n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50123958
PNG
(3-[4-(3,4-Dimethoxy-phenylsulfamoyl)-phenyl]-N-hyd...)
Show SMILES COc1ccc(NS(=O)(=O)c2ccc(\C=C\C(=O)NO)cc2)cc1OC
Show InChI InChI=1S/C17H18N2O6S/c1-24-15-9-6-13(11-16(15)25-2)19-26(22,23)14-7-3-12(4-8-14)5-10-17(20)18-21/h3-11,19,21H,1-2H3,(H,18,20)/b10-5+
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n/an/an/an/a 1.00E+3n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM19130
PNG
((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Show SMILES CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C |w:8.7,2.1|
Show InChI InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-12,22H,1-4H3,(H,18,20)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50123975
PNG
(3-[4-(biphenyl-4-sulfonylamino)-phenyl]-N-hydroxy-...)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C21H18N2O4S/c24-21(22-25)15-8-16-6-11-19(12-7-16)23-28(26,27)20-13-9-18(10-14-20)17-4-2-1-3-5-17/h1-15,23,25H,(H,22,24)/b15-8+
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n/an/an/an/a 1.00E+3n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50123974
PNG
(CHEMBL149534 | N-Hydroxy-3-(4-p-tolylsulfamoyl-phe...)
Show SMILES Cc1ccc(NS(=O)(=O)c2ccc(\C=C\C(=O)NO)cc2)cc1
Show InChI InChI=1S/C16H16N2O4S/c1-12-2-7-14(8-3-12)18-23(21,22)15-9-4-13(5-10-15)6-11-16(19)17-20/h2-11,18,20H,1H3,(H,17,19)/b11-6+
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n/an/an/an/a 1.00E+3n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM19130
PNG
((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Show SMILES CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C |w:8.7,2.1|
Show InChI InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-12,22H,1-4H3,(H,18,20)
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n/an/an/an/a 4.00E+3n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50105678
PNG
((E)-N-Hydroxy-3-[4-(4-methoxy-benzenesulfonylamino...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C16H16N2O5S/c1-23-14-7-9-15(10-8-14)24(21,22)18-13-5-2-12(3-6-13)4-11-16(19)17-20/h2-11,18,20H,1H3,(H,17,19)/b11-4+
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n/an/an/an/a 5.00E+3n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50105684
PNG
(3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-propio...)
Show SMILES ONC(=O)CCc1ccc(NS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C15H16N2O4S/c18-15(16-19)11-8-12-6-9-13(10-7-12)17-22(20,21)14-4-2-1-3-5-14/h1-7,9-10,17,19H,8,11H2,(H,16,18)
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n/an/an/an/a 5.00E+3n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50105682
PNG
(4-Benzenesulfonylamino-N-hydroxy-benzamide | CHEMB...)
Show SMILES ONC(=O)c1ccc(NS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C13H12N2O4S/c16-13(14-17)10-6-8-11(9-7-10)15-20(18,19)12-4-2-1-3-5-12/h1-9,15,17H,(H,14,16)
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n/an/an/an/a 5.00E+3n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50105691
PNG
((E)-3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-ac...)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C15H14N2O4S/c18-15(16-19)11-8-12-6-9-13(10-7-12)17-22(20,21)14-4-2-1-3-5-14/h1-11,17,19H,(H,16,18)/b11-8+
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n/an/an/an/a 5.00E+3n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50105677
PNG
((E)-N-Hydroxy-3-[4-(toluene-4-sulfonylamino)-pheny...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C16H16N2O4S/c1-12-2-9-15(10-3-12)23(21,22)18-14-7-4-13(5-8-14)6-11-16(19)17-20/h2-11,18,20H,1H3,(H,17,19)/b11-6+
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n/an/an/an/a 1.00E+4n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50105690
PNG
(2-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-acetam...)
Show SMILES ONC(=O)Cc1ccc(NS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O4S/c17-14(15-18)10-11-6-8-12(9-7-11)16-21(19,20)13-4-2-1-3-5-13/h1-9,16,18H,10H2,(H,15,17)
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n/an/an/an/a>2.50E+4n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50105694
PNG
(4-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-butyra...)
Show SMILES ONC(=O)CCCc1ccc(NS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C16H18N2O4S/c19-16(17-20)8-4-5-13-9-11-14(12-10-13)18-23(21,22)15-6-2-1-3-7-15/h1-3,6-7,9-12,18,20H,4-5,8H2,(H,17,19)
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n/an/an/an/a>2.50E+4n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50105685
PNG
((E)-3-[4-(Benzenesulfonyl-methyl-amino)-phenyl]-N-...)
Show SMILES CN(c1ccc(\C=C\C(=O)NO)cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H16N2O4S/c1-18(23(21,22)15-5-3-2-4-6-15)14-10-7-13(8-11-14)9-12-16(19)17-20/h2-12,20H,1H3,(H,17,19)/b12-9+
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n/an/an/an/a>2.50E+4n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50105680
PNG
(3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-meth...)
Show SMILES CC(Cc1ccc(NS(=O)(=O)c2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C16H18N2O4S/c1-12(16(19)17-20)11-13-7-9-14(10-8-13)18-23(21,22)15-5-3-2-4-6-15/h2-10,12,18,20H,11H2,1H3,(H,17,19)
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n/an/an/an/a>2.50E+4n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50123973
PNG
(3-{4-[3-(3,4-Dimethoxy-phenyl)-ureido]-phenyl}-N-h...)
Show SMILES COc1ccc(NC(=O)Nc2ccc(\C=C\C(=O)NO)cc2)cc1OC
Show InChI InChI=1S/C18H19N3O5/c1-25-15-9-8-14(11-16(15)26-2)20-18(23)19-13-6-3-12(4-7-13)5-10-17(22)21-24/h3-11,24H,1-2H3,(H,21,22)(H2,19,20,23)/b10-5+
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n/an/an/an/a>2.50E+4n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50105695
PNG
((E)-3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-...)
Show SMILES C\C(=C/c1ccc(NS(=O)(=O)c2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C16H16N2O4S/c1-12(16(19)17-20)11-13-7-9-14(10-8-13)18-23(21,22)15-5-3-2-4-6-15/h2-11,18,20H,1H3,(H,17,19)/b12-11+
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n/an/an/an/a>2.50E+4n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50105676
PNG
(2-(4-Benzenesulfonylamino-benzyl)-N-hydroxy-3-meth...)
Show SMILES CC(C)C(Cc1ccc(NS(=O)(=O)c2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H22N2O4S/c1-13(2)17(18(21)19-22)12-14-8-10-15(11-9-14)20-25(23,24)16-6-4-3-5-7-16/h3-11,13,17,20,22H,12H2,1-2H3,(H,19,21)
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n/an/an/an/a>2.50E+4n/an/an/an/a



Aton Pharma, Inc

Curated by ChEMBL


Assay Description
Inhibition of acetylation of histone-4 in human T-24 cancer cells


J Med Chem 46: 5097-116 (2003)


Article DOI: 10.1021/jm0303094
More data for this
Ligand-Target Pair