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Compile Data Set for Download or QSAR

Found 742 hits of ic50 for UniProtKB: Q9UKV0   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 9


(Homo sapiens (Human))		BDBM19410
PNG
(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Show SMILES Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1
Show InChI InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
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n/an/a 0.5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human HDAC9 using pan-HDAC substrate incubated for 3 hrs by fluorescence method

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00830
BindingDB Entry DOI: 10.7270/Q2F76H9K
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM162865
PNG
(US9056843, 156)
Show SMILES C[C@H](CN(C)Cc1ccccc1)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C21H21F3N4O2/c1-14(12-28(2)13-15-6-4-3-5-7-15)25-19(29)17-10-8-16(9-11-17)18-26-20(30-27-18)21(22,23)24/h3-11,14H,12-13H2,1-2H3,(H,25,29)/t14-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2021.114011
BindingDB Entry DOI: 10.7270/Q2WS8Z98
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM50268097
PNG
(6-{[2-(9H-Fluoren-9-yliden)acetyl]amino}-N-hydroxy...)
Show SMILES [#8]-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)\[#6]=[#6]-1\c2ccccc2-c2ccccc-12
Show InChI InChI=1S/C21H22N2O3/c24-20(23-26)12-2-1-7-13-22-21(25)14-19-17-10-5-3-8-15(17)16-9-4-6-11-18(16)19/h3-6,8-11,14,26H,1-2,7,12-13H2,(H,22,25)(H,23,24)
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n/an/a 2.30n/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC9

Eur J Med Chem 44: 1067-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.06.020
BindingDB Entry DOI: 10.7270/Q2BG2NTX
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM50563276
PNG
(CHEMBL4751615)
Show SMILES CC(C)(CNC(=O)c1cccc(c1)-c1noc(n1)C(F)(F)F)c1coc(n1)-c1ccccc1
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n/an/a 2.40n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2021.114011
BindingDB Entry DOI: 10.7270/Q2WS8Z98
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM50268063
PNG
((E)-N-[6-(Hydroxyamino)-6-oxohexyl]-3-(7-quinoliny...)
Show SMILES ONC(=O)CCCCCNC(=O)\C=C\c1ccc2cccnc2c1
Show InChI InChI=1S/C18H21N3O3/c22-17(20-11-3-1-2-6-18(23)21-24)10-8-14-7-9-15-5-4-12-19-16(15)13-14/h4-5,7-10,12-13,24H,1-3,6,11H2,(H,20,22)(H,21,23)/b10-8+
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n/an/a 2.80n/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC9

Eur J Med Chem 44: 1067-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.06.020
BindingDB Entry DOI: 10.7270/Q2BG2NTX
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM50268121
PNG
((E)-3-(4-Chloro-2-fluorophenyl)-N-[6-(hydroxyamino...)
Show SMILES ONC(=O)CCCCCNC(=O)\C=C\c1ccc(Cl)cc1F
Show InChI InChI=1S/C15H18ClFN2O3/c16-12-7-5-11(13(17)10-12)6-8-14(20)18-9-3-1-2-4-15(21)19-22/h5-8,10,22H,1-4,9H2,(H,18,20)(H,19,21)/b8-6+
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n/an/a 3.90n/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC9

Eur J Med Chem 44: 1067-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.06.020
BindingDB Entry DOI: 10.7270/Q2BG2NTX
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM50268042
PNG
((2E,4E)-N-[6-(Hydroxyamino)-6-oxohexyl]-3-methyl-5...)
Show SMILES C\C(\C=C\c1ccccc1)=C/C(=O)NCCCCCC(=O)NO
Show InChI InChI=1S/C18H24N2O3/c1-15(11-12-16-8-4-2-5-9-16)14-18(22)19-13-7-3-6-10-17(21)20-23/h2,4-5,8-9,11-12,14,23H,3,6-7,10,13H2,1H3,(H,19,22)(H,20,21)/b12-11+,15-14+
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n/an/a 4.20n/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC9

Eur J Med Chem 44: 1067-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.06.020
BindingDB Entry DOI: 10.7270/Q2BG2NTX
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM50044636
PNG
(CHEMBL3309297)
Show SMILES CC1(C)CC(=O)Nc2ccc(cc12)C(=O)NC[C@H]1CC[C@@H](CC1)\C=C\C(=O)NO |r,wU:17.18,wD:20.25,(21.24,-20.14,;22.02,-21.48,;22.78,-20.14,;23.36,-22.25,;23.36,-23.79,;24.69,-24.56,;22.02,-24.56,;20.69,-23.79,;19.36,-24.56,;18.02,-23.79,;18.02,-22.25,;19.36,-21.48,;20.69,-22.25,;16.7,-21.48,;16.7,-19.94,;15.36,-22.25,;14.02,-21.48,;12.69,-22.25,;12.69,-23.8,;11.35,-24.56,;10.01,-23.79,;10.02,-22.25,;11.35,-21.48,;8.67,-24.55,;7.34,-23.78,;6.01,-24.54,;6,-26.08,;4.68,-23.76,;3.34,-24.53,)|
Show InChI InChI=1S/C22H29N3O4/c1-22(2)12-20(27)24-18-9-8-16(11-17(18)22)21(28)23-13-15-5-3-14(4-6-15)7-10-19(26)25-29/h7-11,14-15,29H,3-6,12-13H2,1-2H3,(H,23,28)(H,24,27)(H,25,26)/b10-7+/t14-,15-
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n/an/a 5.20n/an/an/an/an/an/a



Nippon Pharmaceutical Chemicals Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human HDAC9 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay

Bioorg Med Chem 22: 3720-31 (2014)


Article DOI: 10.1016/j.bmc.2014.05.001
BindingDB Entry DOI: 10.7270/Q24T6M0V
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM29589
PNG
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Show SMILES Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
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n/an/a 5.70n/an/an/an/an/an/a



Ocean University of China

Curated by ChEMBL


Assay Description
Inhibition of recombinant HDAC9 (unknown origin)

J Med Chem 63: 5501-5525 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00442
BindingDB Entry DOI: 10.7270/Q23X89Z5
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM29589
PNG
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Show SMILES Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
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n/an/a 5.70n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant HDAC9 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01472
BindingDB Entry DOI: 10.7270/Q28W3J6H
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM29589
PNG
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Show SMILES Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
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n/an/a 6n/an/an/an/an/an/a


TBA

Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.

Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM50105327
PNG
(JNJ-26481585 | Quisinostat)
Show SMILES Cn1cc(CNCC2CCN(CC2)c2ncc(cn2)C(=O)NO)c2ccccc12
Show InChI InChI=1S/C21H26N6O2/c1-26-14-17(18-4-2-3-5-19(18)26)11-22-10-15-6-8-27(9-7-15)21-23-12-16(13-24-21)20(28)25-29/h2-5,12-15,22,29H,6-11H2,1H3,(H,25,28)
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n/an/a 6.70n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant full length human HDAC9 expressed in SF9 baculovirus using FAM- labelled acetylated peptide as substrate measured by Electr...

Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112411
BindingDB Entry DOI: 10.7270/Q2JH3QVS
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM50105327
PNG
(JNJ-26481585 | Quisinostat)
Show SMILES Cn1cc(CNCC2CCN(CC2)c2ncc(cn2)C(=O)NO)c2ccccc12
Show InChI InChI=1S/C21H26N6O2/c1-26-14-17(18-4-2-3-5-19(18)26)11-22-10-15-6-8-27(9-7-15)21-23-12-16(13-24-21)20(28)25-29/h2-5,12-15,22,29H,6-11H2,1H3,(H,25,28)
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n/an/a 6.70n/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of recombinant human HDAC9 (604-1066 residues) expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for ...

ACS Med Chem Lett 11: 56-64 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00471
BindingDB Entry DOI: 10.7270/Q26976Z8
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM19428
PNG
((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)
Show SMILES OCCN(CCc1c[nH]c2ccccc12)Cc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C22H25N3O3/c26-14-13-25(12-11-19-15-23-21-4-2-1-3-20(19)21)16-18-7-5-17(6-8-18)9-10-22(27)24-28/h1-10,15,23,26,28H,11-14,16H2,(H,24,27)/b10-9+
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n/an/a 8.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human HDAC9 by fluorimetric assay

J Med Chem 53: 8387-8399 (2010)


Article DOI: 10.1021/jm101092u
BindingDB Entry DOI: 10.7270/Q28G8KZJ
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM162846
PNG
(US9056843, 137)
Show SMILES CCCN(CCC)C[C@@H](C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C19H25F3N4O2/c1-4-10-26(11-5-2)12-13(3)23-17(27)15-8-6-14(7-9-15)16-24-18(28-25-16)19(20,21)22/h6-9,13H,4-5,10-12H2,1-3H3,(H,23,27)/t13-/m1/s1
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n/an/a 10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of HDAC9 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assay

Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00532
BindingDB Entry DOI: 10.7270/Q2474FHW
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM50446481
PNG
(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Show SMILES FC(F)(F)c1nc(no1)-c1cccc(c1)C(=O)NCC1(CCOCC1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C25H21F3N4O3S/c26-25(27,28)22-31-20(32-35-22)17-7-4-8-18(13-17)21(33)29-15-24(9-11-34-12-10-24)23-30-19(14-36-23)16-5-2-1-3-6-16/h1-8,13-14H,9-12,15H2,(H,29,33)
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n/an/a 10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of HDAC9 (unknown origin)

Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113790
BindingDB Entry DOI: 10.7270/Q2611453
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM50581678
PNG
(CHEMBL5072502)
Show SMILES COc1ccc2[nH]cc(CCN(Cc3ccc(cc3)C(=O)NO)C(=O)\C=C\c3ccc(O)c(OC)c3)c2c1
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n/an/a>10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant HDAC9 (unknown origin) using Boc-Lys(trifluoroacetyl)-AMC as substrate pre-incubated for 1 hr followed by substrate additio...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01940
BindingDB Entry DOI: 10.7270/Q2WH2TVR
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272075
PNG
((S)-1-(2,6-Difluorophenyl)-5-(3-fluoro-2- methylph...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1c(F)cccc1F)C(=O)NO |r,wU:8.27,(-1.7,-2.72,;-.37,-3.49,;-.37,-5.03,;-1.7,-5.8,;.96,-5.8,;2.3,-5.03,;2.3,-3.49,;.96,-2.72,;.96,-1.18,;-.28,-2.09,;-1.53,-1.18,;-3.07,-1.18,;-3.54,.28,;-2.3,1.18,;-1.05,.28,;.49,.28,;-2.3,2.72,;-3.63,3.49,;-4.97,2.72,;-3.63,5.03,;-2.3,5.8,;-.96,5.03,;-.96,3.49,;.37,2.72,;2.3,-.41,;2.3,1.13,;3.63,-1.18,;4.97,-.41,)|
Show InChI InChI=1S/C20H16F3N3O2/c1-11-13(4-2-5-14(11)21)20(19(27)25-28)8-12-10-24-26(17(12)9-20)18-15(22)6-3-7-16(18)23/h2-7,10,28H,8-9H2,1H3,(H,25,27)/t20-/m0/s1
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US Patent
n/an/a 12n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10065948 (2018)


BindingDB Entry DOI: 10.7270/Q2154K23
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272075
PNG
((S)-1-(2,6-Difluorophenyl)-5-(3-fluoro-2- methylph...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1c(F)cccc1F)C(=O)NO |r,wU:8.27,(-1.7,-2.72,;-.37,-3.49,;-.37,-5.03,;-1.7,-5.8,;.96,-5.8,;2.3,-5.03,;2.3,-3.49,;.96,-2.72,;.96,-1.18,;-.28,-2.09,;-1.53,-1.18,;-3.07,-1.18,;-3.54,.28,;-2.3,1.18,;-1.05,.28,;.49,.28,;-2.3,2.72,;-3.63,3.49,;-4.97,2.72,;-3.63,5.03,;-2.3,5.8,;-.96,5.03,;-.96,3.49,;.37,2.72,;2.3,-.41,;2.3,1.13,;3.63,-1.18,;4.97,-.41,)|
Show InChI InChI=1S/C20H16F3N3O2/c1-11-13(4-2-5-14(11)21)20(19(27)25-28)8-12-10-24-26(17(12)9-20)18-15(22)6-3-7-16(18)23/h2-7,10,28H,8-9H2,1H3,(H,25,27)/t20-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10457675 (2019)


BindingDB Entry DOI: 10.7270/Q22J6F7J
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM162846
PNG
(US9056843, 137)
Show SMILES CCCN(CCC)C[C@@H](C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C19H25F3N4O2/c1-4-10-26(11-5-2)12-13(3)23-17(27)15-8-6-14(7-9-15)16-24-18(28-25-16)19(20,21)22/h6-9,13H,4-5,10-12H2,1-3H3,(H,23,27)/t13-/m1/s1
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n/an/a 13n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01149
BindingDB Entry DOI: 10.7270/Q2CC14PT
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272071
PNG
((S)-1-(2-Chlorophenyl)-5-(3-fluoro-2-methylphenyl)...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1ccccc1Cl)C(=O)NO |r|
Show InChI InChI=1S/C20H17ClFN3O2/c1-12-14(5-4-7-16(12)22)20(19(26)24-27)9-13-11-23-25(18(13)10-20)17-8-3-2-6-15(17)21/h2-8,11,27H,9-10H2,1H3,(H,24,26)/t20-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10457675 (2019)


BindingDB Entry DOI: 10.7270/Q22J6F7J
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272078
PNG
((S)-1-(2-Chloro-6-fluorophenyl)-5-(3-fluoro-2- met...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1c(F)cccc1Cl)C(=O)NO |r,wD:8.8,(-.17,-3.49,;1.37,-3.49,;2.14,-4.83,;1.37,-6.16,;3.68,-4.83,;4.45,-3.49,;3.68,-2.16,;2.14,-2.16,;1.37,-.83,;.12,-1.73,;-1.13,-.83,;-2.67,-.83,;-3.14,.64,;-1.9,1.54,;-.65,.64,;.89,.64,;-1.9,3.08,;-.56,3.85,;.77,3.08,;-.56,5.39,;-1.9,6.16,;-3.23,5.39,;-3.23,3.85,;-4.56,3.08,;2.77,-.2,;4.02,-1.11,;2.93,1.33,;4.56,2.27,)|
Show InChI InChI=1S/C20H16ClF2N3O2/c1-11-13(4-2-6-15(11)22)20(19(27)25-28)8-12-10-24-26(17(12)9-20)18-14(21)5-3-7-16(18)23/h2-7,10,28H,8-9H2,1H3,(H,25,27)/t20-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10457675 (2019)


BindingDB Entry DOI: 10.7270/Q22J6F7J
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272071
PNG
((S)-1-(2-Chlorophenyl)-5-(3-fluoro-2-methylphenyl)...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1ccccc1Cl)C(=O)NO |r|
Show InChI InChI=1S/C20H17ClFN3O2/c1-12-14(5-4-7-16(12)22)20(19(26)24-27)9-13-11-23-25(18(13)10-20)17-8-3-2-6-15(17)21/h2-8,11,27H,9-10H2,1H3,(H,24,26)/t20-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10065948 (2018)


BindingDB Entry DOI: 10.7270/Q2154K23
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272078
PNG
((S)-1-(2-Chloro-6-fluorophenyl)-5-(3-fluoro-2- met...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1c(F)cccc1Cl)C(=O)NO |r,wD:8.8,(-.17,-3.49,;1.37,-3.49,;2.14,-4.83,;1.37,-6.16,;3.68,-4.83,;4.45,-3.49,;3.68,-2.16,;2.14,-2.16,;1.37,-.83,;.12,-1.73,;-1.13,-.83,;-2.67,-.83,;-3.14,.64,;-1.9,1.54,;-.65,.64,;.89,.64,;-1.9,3.08,;-.56,3.85,;.77,3.08,;-.56,5.39,;-1.9,6.16,;-3.23,5.39,;-3.23,3.85,;-4.56,3.08,;2.77,-.2,;4.02,-1.11,;2.93,1.33,;4.56,2.27,)|
Show InChI InChI=1S/C20H16ClF2N3O2/c1-11-13(4-2-6-15(11)22)20(19(27)25-28)8-12-10-24-26(17(12)9-20)18-14(21)5-3-7-16(18)23/h2-7,10,28H,8-9H2,1H3,(H,25,27)/t20-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10065948 (2018)


BindingDB Entry DOI: 10.7270/Q2154K23
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM50563276
PNG
(CHEMBL4751615)
Show SMILES CC(C)(CNC(=O)c1cccc(c1)-c1noc(n1)C(F)(F)F)c1coc(n1)-c1ccccc1
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n/an/a 16n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human HDAC9 using Ac-LGK(TFA)-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 6...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01967
BindingDB Entry DOI: 10.7270/Q2DV1PMP
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272067
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-l-(2-fluorophenyl)...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1ccccc1F)C(=O)NO |r|
Show InChI InChI=1S/C20H17F2N3O2/c1-12-14(5-4-7-15(12)21)20(19(26)24-27)9-13-11-23-25(18(13)10-20)17-8-3-2-6-16(17)22/h2-8,11,27H,9-10H2,1H3,(H,24,26)/t20-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10065948 (2018)


BindingDB Entry DOI: 10.7270/Q2154K23
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272074
PNG
((S)-1-(3-Chloro-2-fluorophenyl)-5-(3-fluoro-2- met...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1cccc(Cl)c1F)C(=O)NO |r|
Show InChI InChI=1S/C20H16ClF2N3O2/c1-11-13(4-2-6-15(11)22)20(19(27)25-28)8-12-10-24-26(17(12)9-20)16-7-3-5-14(21)18(16)23/h2-7,10,28H,8-9H2,1H3,(H,25,27)/t20-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10065948 (2018)


BindingDB Entry DOI: 10.7270/Q2154K23
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272074
PNG
((S)-1-(3-Chloro-2-fluorophenyl)-5-(3-fluoro-2- met...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1cccc(Cl)c1F)C(=O)NO |r|
Show InChI InChI=1S/C20H16ClF2N3O2/c1-11-13(4-2-6-15(11)22)20(19(27)25-28)8-12-10-24-26(17(12)9-20)16-7-3-5-14(21)18(16)23/h2-7,10,28H,8-9H2,1H3,(H,25,27)/t20-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10457675 (2019)


BindingDB Entry DOI: 10.7270/Q22J6F7J
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272067
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-l-(2-fluorophenyl)...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1ccccc1F)C(=O)NO |r|
Show InChI InChI=1S/C20H17F2N3O2/c1-12-14(5-4-7-15(12)21)20(19(26)24-27)9-13-11-23-25(18(13)10-20)17-8-3-2-6-16(17)22/h2-8,11,27H,9-10H2,1H3,(H,24,26)/t20-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10457675 (2019)


BindingDB Entry DOI: 10.7270/Q22J6F7J
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272079
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-1-(2-fluoro-6- met...)
Show SMILES Cc1cccc(F)c1-n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C |r,wD:13.22,(-4.97,2.72,;-3.63,3.49,;-3.63,5.03,;-2.3,5.8,;-.96,5.03,;-.96,3.49,;.37,2.72,;-2.3,2.72,;-2.3,1.18,;-3.54,.28,;-3.07,-1.18,;-1.53,-1.18,;-.28,-2.09,;.96,-1.18,;.49,.28,;-1.05,.28,;2.3,-.41,;2.3,1.13,;3.63,-1.18,;4.97,-.41,;.96,-2.72,;2.3,-3.49,;2.3,-5.03,;.96,-5.8,;-.37,-5.03,;-1.7,-5.8,;-.37,-3.49,;-1.7,-2.72,)|
Show InChI InChI=1S/C21H19F2N3O2/c1-12-5-3-8-17(23)19(12)26-18-10-21(20(27)25-28,9-14(18)11-24-26)15-6-4-7-16(22)13(15)2/h3-8,11,28H,9-10H2,1-2H3,(H,25,27)/t21-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10457675 (2019)


BindingDB Entry DOI: 10.7270/Q22J6F7J
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272079
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-1-(2-fluoro-6- met...)
Show SMILES Cc1cccc(F)c1-n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C |r,wD:13.22,(-4.97,2.72,;-3.63,3.49,;-3.63,5.03,;-2.3,5.8,;-.96,5.03,;-.96,3.49,;.37,2.72,;-2.3,2.72,;-2.3,1.18,;-3.54,.28,;-3.07,-1.18,;-1.53,-1.18,;-.28,-2.09,;.96,-1.18,;.49,.28,;-1.05,.28,;2.3,-.41,;2.3,1.13,;3.63,-1.18,;4.97,-.41,;.96,-2.72,;2.3,-3.49,;2.3,-5.03,;.96,-5.8,;-.37,-5.03,;-1.7,-5.8,;-.37,-3.49,;-1.7,-2.72,)|
Show InChI InChI=1S/C21H19F2N3O2/c1-12-5-3-8-17(23)19(12)26-18-10-21(20(27)25-28,9-14(18)11-24-26)15-6-4-7-16(22)13(15)2/h3-8,11,28H,9-10H2,1-2H3,(H,25,27)/t21-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10065948 (2018)


BindingDB Entry DOI: 10.7270/Q2154K23
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM50446481
PNG
(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Show SMILES FC(F)(F)c1nc(no1)-c1cccc(c1)C(=O)NCC1(CCOCC1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C25H21F3N4O3S/c26-25(27,28)22-31-20(32-35-22)17-7-4-8-18(13-17)21(33)29-15-24(9-11-34-12-10-24)23-30-19(14-36-23)16-5-2-1-3-6-16/h1-8,13-14H,9-12,15H2,(H,29,33)
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n/an/a 19.4n/an/an/an/an/an/a



Taipei Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human HDAC9 using fluorogenic substrate by fluorescence assay

Eur J Med Chem 125: 1268-1278 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.033
BindingDB Entry DOI: 10.7270/Q2XD145D
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM50563273
PNG
(CHEMBL4748500)
Show SMILES ONC(=O)c1ccc(CN2C(=O)c3ccccc3C2=O)cc1-c1ccccc1
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n/an/a 20n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human HDAC9 using Ac-LGK(TFA)-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 6...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01967
BindingDB Entry DOI: 10.7270/Q2DV1PMP
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM19130
PNG
((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Show SMILES CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C |w:8.7,2.1|
Show InChI InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-12,22H,1-4H3,(H,18,20)
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n/an/a 20n/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC9 using fluorophore-conjugated substrate Boc-L-Lys(Ac)-AMC after 60 mins

J Med Chem 54: 4350-64 (2011)


Article DOI: 10.1021/jm2001025
BindingDB Entry DOI: 10.7270/Q2RX9CG0
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a 20n/an/an/an/an/an/a



Universita` degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of human HDAC9 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay

J Med Chem 54: 2165-82 (2011)


Article DOI: 10.1021/jm101373a
BindingDB Entry DOI: 10.7270/Q2CR5TNZ
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM19130
PNG
((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Show SMILES CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C |w:8.7,2.1|
Show InChI InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-12,22H,1-4H3,(H,18,20)
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n/an/a 20n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of HDAC9 by in vitro deacetylation assay

Nat Chem Biol 6: 25-33 (2009)


Article DOI: 10.1038/nchembio.275
BindingDB Entry DOI: 10.7270/Q2FF3SKD
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272076
PNG
((S)-1-(2,5-Dimethylphenyl)-5-(3-fluoro-2- methylph...)
Show SMILES Cc1ccc(C)c(c1)-n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C |r|
Show InChI InChI=1S/C22H22FN3O2/c1-13-7-8-14(2)19(9-13)26-20-11-22(21(27)25-28,10-16(20)12-24-26)17-5-4-6-18(23)15(17)3/h4-9,12,28H,10-11H2,1-3H3,(H,25,27)/t22-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10065948 (2018)


BindingDB Entry DOI: 10.7270/Q2154K23
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272076
PNG
((S)-1-(2,5-Dimethylphenyl)-5-(3-fluoro-2- methylph...)
Show SMILES Cc1ccc(C)c(c1)-n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C |r|
Show InChI InChI=1S/C22H22FN3O2/c1-13-7-8-14(2)19(9-13)26-20-11-22(21(27)25-28,10-16(20)12-24-26)17-5-4-6-18(23)15(17)3/h4-9,12,28H,10-11H2,1-3H3,(H,25,27)/t22-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10457675 (2019)


BindingDB Entry DOI: 10.7270/Q22J6F7J
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272066
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-l-(o- to...)
Show SMILES Cc1ccccc1-n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C |r|
Show InChI InChI=1S/C21H20FN3O2/c1-13-6-3-4-9-18(13)25-19-11-21(20(26)24-27,10-15(19)12-23-25)16-7-5-8-17(22)14(16)2/h3-9,12,27H,10-11H2,1-2H3,(H,24,26)/t21-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10457675 (2019)


BindingDB Entry DOI: 10.7270/Q22J6F7J
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272066
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-l-(o- to...)
Show SMILES Cc1ccccc1-n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C |r|
Show InChI InChI=1S/C21H20FN3O2/c1-13-6-3-4-9-18(13)25-19-11-21(20(26)24-27,10-15(19)12-23-25)16-7-5-8-17(22)14(16)2/h3-9,12,27H,10-11H2,1-2H3,(H,24,26)/t21-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10065948 (2018)


BindingDB Entry DOI: 10.7270/Q2154K23
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM50446481
PNG
(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Show SMILES FC(F)(F)c1nc(no1)-c1cccc(c1)C(=O)NCC1(CCOCC1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C25H21F3N4O3S/c26-25(27,28)22-31-20(32-35-22)17-7-4-8-18(13-17)21(33)29-15-24(9-11-34-12-10-24)23-30-19(14-36-23)16-5-2-1-3-6-16/h1-8,13-14H,9-12,15H2,(H,29,33)
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n/an/a 23.2n/an/an/an/an/an/a



Sungkyunkwan University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC9 using trifluoroacetyl lysine as substrate

Eur J Med Chem 116: 126-135 (2016)


Article DOI: 10.1016/j.ejmech.2016.03.046
BindingDB Entry DOI: 10.7270/Q2057HTZ
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM50044641
PNG
(CHEMBL3311465)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccc2NC(=O)CCc2c1
Show InChI InChI=1S/C17H23N3O4/c21-15(5-3-1-2-4-6-17(23)20-24)18-13-8-9-14-12(11-13)7-10-16(22)19-14/h8-9,11,24H,1-7,10H2,(H,18,21)(H,19,22)(H,20,23)
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n/an/a 25n/an/an/an/an/an/a



Nippon Pharmaceutical Chemicals Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human HDAC9 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assay

Bioorg Med Chem 22: 3720-31 (2014)


Article DOI: 10.1016/j.bmc.2014.05.001
BindingDB Entry DOI: 10.7270/Q24T6M0V
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272077
PNG
((S)-1-(2,6-Dimethylphenyl)-5-(3-fluoro-2- methylph...)
Show SMILES Cc1cccc(C)c1-n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C |r,wD:13.22,(-4.97,2.72,;-3.63,3.49,;-3.63,5.03,;-2.3,5.8,;-.96,5.03,;-.96,3.49,;.37,2.72,;-2.3,2.72,;-2.3,1.18,;-3.54,.28,;-3.07,-1.18,;-1.53,-1.18,;-.28,-2.09,;.96,-1.18,;.49,.28,;-1.05,.28,;2.3,-.41,;2.3,1.13,;3.63,-1.18,;4.97,-.41,;.96,-2.72,;2.3,-3.49,;2.3,-5.03,;.96,-5.8,;-.37,-5.03,;-1.7,-5.8,;-.37,-3.49,;-1.7,-2.72,)|
Show InChI InChI=1S/C22H22FN3O2/c1-13-6-4-7-14(2)20(13)26-19-11-22(21(27)25-28,10-16(19)12-24-26)17-8-5-9-18(23)15(17)3/h4-9,12,28H,10-11H2,1-3H3,(H,25,27)/t22-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10457675 (2019)


BindingDB Entry DOI: 10.7270/Q22J6F7J
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272158
PNG
((R)-1-Benzyl-4-(3-fluoro-2-methylphenyl)-N-hydroxy...)
Show SMILES Cc1c(F)cccc1[C@@]1(CCc2c1cnn2Cc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C21H20FN3O2/c1-14-16(8-5-9-18(14)22)21(20(26)24-27)11-10-19-17(21)12-23-25(19)13-15-6-3-2-4-7-15/h2-9,12,27H,10-11,13H2,1H3,(H,24,26)/t21-/m1/s1
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n/an/a 27n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10065948 (2018)


BindingDB Entry DOI: 10.7270/Q2154K23
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272077
PNG
((S)-1-(2,6-Dimethylphenyl)-5-(3-fluoro-2- methylph...)
Show SMILES Cc1cccc(C)c1-n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C |r,wD:13.22,(-4.97,2.72,;-3.63,3.49,;-3.63,5.03,;-2.3,5.8,;-.96,5.03,;-.96,3.49,;.37,2.72,;-2.3,2.72,;-2.3,1.18,;-3.54,.28,;-3.07,-1.18,;-1.53,-1.18,;-.28,-2.09,;.96,-1.18,;.49,.28,;-1.05,.28,;2.3,-.41,;2.3,1.13,;3.63,-1.18,;4.97,-.41,;.96,-2.72,;2.3,-3.49,;2.3,-5.03,;.96,-5.8,;-.37,-5.03,;-1.7,-5.8,;-.37,-3.49,;-1.7,-2.72,)|
Show InChI InChI=1S/C22H22FN3O2/c1-13-6-4-7-14(2)20(13)26-19-11-22(21(27)25-28,10-16(19)12-24-26)17-8-5-9-18(23)15(17)3/h4-9,12,28H,10-11H2,1-3H3,(H,25,27)/t22-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10065948 (2018)


BindingDB Entry DOI: 10.7270/Q2154K23
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272158
PNG
((R)-1-Benzyl-4-(3-fluoro-2-methylphenyl)-N-hydroxy...)
Show SMILES Cc1c(F)cccc1[C@@]1(CCc2c1cnn2Cc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C21H20FN3O2/c1-14-16(8-5-9-18(14)22)21(20(26)24-27)11-10-19-17(21)12-23-25(19)13-15-6-3-2-4-7-15/h2-9,12,27H,10-11,13H2,1H3,(H,24,26)/t21-/m1/s1
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n/an/a 27n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10457675 (2019)


BindingDB Entry DOI: 10.7270/Q22J6F7J
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272065
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-1-phenyl...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C20H18FN3O2/c1-13-16(8-5-9-17(13)21)20(19(25)23-26)10-14-12-22-24(18(14)11-20)15-6-3-2-4-7-15/h2-9,12,26H,10-11H2,1H3,(H,23,25)/t20-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10065948 (2018)


BindingDB Entry DOI: 10.7270/Q2154K23
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272088
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-1-(m- to...)
Show SMILES Cc1cccc(c1)-n1ncc2C[C@@](Cc12)(C(=O)NO)c1cccc(F)c1C |r|
Show InChI InChI=1S/C21H20FN3O2/c1-13-5-3-6-16(9-13)25-19-11-21(20(26)24-27,10-15(19)12-23-25)17-7-4-8-18(22)14(17)2/h3-9,12,27H,10-11H2,1-2H3,(H,24,26)/t21-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10457675 (2019)


BindingDB Entry DOI: 10.7270/Q22J6F7J
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM50304782
PNG
(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Show SMILES ONC(=O)c1cnc(nc1)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H19N5O4S/c25-18(22-26)16-12-20-19(21-13-16)23-7-9-24(10-8-23)29(27,28)17-6-5-14-3-1-2-4-15(14)11-17/h1-6,11-13,26H,7-10H2,(H,22,25)
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n/an/a 28n/an/an/an/an/an/a



Ortho-Biotech Oncology Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC9

Bioorg Med Chem Lett 20: 294-8 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.118
BindingDB Entry DOI: 10.7270/Q2DB81ZS
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))		BDBM272065
PNG
((S)-5-(3-Fluoro-2-methylphenyl)-N-hydroxy-1-phenyl...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnn(c2C1)-c1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C20H18FN3O2/c1-13-16(8-5-9-17(13)21)20(19(25)23-26)10-14-12-22-24(18(14)11-20)15-6-3-2-4-7-15/h2-9,12,26H,10-11H2,1H3,(H,23,25)/t20-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...

US Patent US10457675 (2019)


BindingDB Entry DOI: 10.7270/Q22J6F7J
More data for this
Ligand-Target Pair
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