Compile Data Set for Download or QSAR

Found 1829 hits of ic50 data for polymerid = 6277   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50259656 (CHEMBL4089402) Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)N1CCc2ccccc2C1)B(O)O |r| Show InChI InChI=1S/C24H32BN3O4/c1-17(2)14-22(25(31)32)27-23(29)21(15-18-8-4-3-5-9-18)26-24(30)28-13-12-19-10-6-7-11-20(19)16-28/h3-11,17,21-22,31-32H,12-16H2,1-2H3,(H,26,30)(H,27,29)/t21-,22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.000200	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Dissociation constant against galectin-3 using competitive fluorescence polarization				Eur J Med Chem 125: 925-939 (2017) Article DOI: 10.1016/j.ejmech.2016.10.023 BindingDB Entry DOI: 10.7270/Q2348NTK
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50259645 (CHEMBL4070336) Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)NCc1cccc(c1)-c1ccccc1)B(O)O |r| Show InChI InChI=1S/C28H34BN3O4/c1-20(2)16-26(29(35)36)32-27(33)25(18-21-10-5-3-6-11-21)31-28(34)30-19-22-12-9-15-24(17-22)23-13-7-4-8-14-23/h3-15,17,20,25-26,35-36H,16,18-19H2,1-2H3,(H,32,33)(H2,30,31,34)/t25-,26-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVYaminoluciferin as substrate after 2 hrs by fluorescence ...				Eur J Med Chem 125: 925-939 (2017) Article DOI: 10.1016/j.ejmech.2016.10.023 BindingDB Entry DOI: 10.7270/Q2348NTK
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50069989 ((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...) Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O |r| Show InChI InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Nagahama Institute of Bio-Science and Technology Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-MCA as substrate measured for 1 hr by fluorescence assay				Eur J Med Chem 146: 636-650 (2018) Article DOI: 10.1016/j.ejmech.2018.01.045 BindingDB Entry DOI: 10.7270/Q2DF6TV7
					More data for this Ligand-Target Pair				3D Structure (crystal)
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50234966 (CHEMBL4061262) Show SMILES CC(C)(C)CNC(=O)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1cnccn1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl |r| Show InChI InChI=1S/C37H47ClN8O5/c1-37(2,3)24-42-32(47)21-30(44-36(51)46-19-15-26(16-20-46)33(48)45-31-23-39-17-18-40-31)35(50)43-29(14-13-25-9-5-4-6-10-25)34(49)41-22-27-11-7-8-12-28(27)38/h4-12,17-18,23,26,29-30H,13-16,19-22,24H2,1-3H3,(H,41,49)(H,42,47)(H,43,50)(H,44,51)(H,40,45,48)/t29-,30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Xixi Hospital Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome pretreated for 15 mins followed by Suc-Leu-Leu-Val-Tyr-AMC substrate addition by flu...				Eur J Med Chem 126: 1056-1070 (2017) Article DOI: 10.1016/j.ejmech.2016.12.034 BindingDB Entry DOI: 10.7270/Q2MK6G4X
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50526811 (Kzr-616) Show SMILES COc1ccc(cc1)[C@@H](O)[C@H](NC(=O)[C@H](C)NC(=O)CN1CCOCC1)C(=O)N[C@@H](CC1=CCCC1)C(=O)[C@@]1(C)CO1 |t:33| Show InChI InChI=1S/C30H42N4O8/c1-19(31-24(35)17-34-12-14-41-15-13-34)28(38)33-25(26(36)21-8-10-22(40-3)11-9-21)29(39)32-23(16-20-6-4-5-7-20)27(37)30(2)18-42-30/h6,8-11,19,23,25-26,36H,4-5,7,12-18H2,1-3H3,(H,31,35)(H,32,39)(H,33,38)/t19-,23-,25-,26+,30+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.688	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Xixi Hospital Curated by ChEMBL					Assay Description Inhibition of 20S proteasome beta 5c (unknown origin) after 1 hr by fluorescence based assay				Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111646 BindingDB Entry DOI: 10.7270/Q2154MHB
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50234983 (CHEMBL4104744) Show SMILES CC(C)(C)CNC(=O)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1cccnc1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl |r| Show InChI InChI=1S/C38H48ClN7O5/c1-38(2,3)25-42-33(47)22-32(45-37(51)46-20-17-27(18-21-46)34(48)43-29-13-9-19-40-24-29)36(50)44-31(16-15-26-10-5-4-6-11-26)35(49)41-23-28-12-7-8-14-30(28)39/h4-14,19,24,27,31-32H,15-18,20-23,25H2,1-3H3,(H,41,49)(H,42,47)(H,43,48)(H,44,50)(H,45,51)/t31-,32-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Xixi Hospital Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome pretreated for 15 mins followed by Suc-Leu-Leu-Val-Tyr-AMC substrate addition by flu...				Eur J Med Chem 126: 1056-1070 (2017) Article DOI: 10.1016/j.ejmech.2016.12.034 BindingDB Entry DOI: 10.7270/Q2MK6G4X
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50593006 (CHEMBL5206237) Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)c1cc(Cl)ccc1Cl)C(C)C)B(O)O |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.708	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00523 BindingDB Entry DOI: 10.7270/Q2K35ZNX
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50163687 (CHEMBL3793848) Show SMILES [H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(OC1C2)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cccc2CCCCc12 |r| Show InChI InChI=1S/C35H47BN2O4/c1-22(2)18-31(36-41-30-21-25-20-29(34(25,3)4)35(30,5)42-36)38-33(40)28(19-23-12-7-6-8-13-23)37-32(39)27-17-11-15-24-14-9-10-16-26(24)27/h6-8,11-13,15,17,22,25,28-31H,9-10,14,16,18-21H2,1-5H3,(H,37,39)(H,38,40)/t25-,28-,29-,30?,31-,35-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Forestry University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...				Bioorg Med Chem 24: 2576-88 (2016) Article DOI: 10.1016/j.bmc.2016.04.025 BindingDB Entry DOI: 10.7270/Q2P84DSC
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50163687 (CHEMBL3793848) Show SMILES [H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(OC1C2)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cccc2CCCCc12 |r| Show InChI InChI=1S/C35H47BN2O4/c1-22(2)18-31(36-41-30-21-25-20-29(34(25,3)4)35(30,5)42-36)38-33(40)28(19-23-12-7-6-8-13-23)37-32(39)27-17-11-15-24-14-9-10-16-26(24)27/h6-8,11-13,15,17,22,25,28-31H,9-10,14,16,18-21H2,1-5H3,(H,37,39)(H,38,40)/t25-,28-,29-,30?,31-,35-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Forestry University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...				Bioorg Med Chem 24: 2576-88 (2016) Article DOI: 10.1016/j.bmc.2016.04.025 BindingDB Entry DOI: 10.7270/Q2P84DSC
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50549204 (CHEMBL4747480) Show SMILES CC(C)(C)NC(=O)CC[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1cccnc1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by subs...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115867 BindingDB Entry DOI: 10.7270/Q2XP78J1
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50234982 (CHEMBL4102324) Show SMILES CC(C)(C)CNC(=O)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1nccs1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl |r| Show InChI InChI=1S/C36H46ClN7O5S/c1-36(2,3)23-40-30(45)21-29(42-35(49)44-18-15-25(16-19-44)31(46)43-34-38-17-20-50-34)33(48)41-28(14-13-24-9-5-4-6-10-24)32(47)39-22-26-11-7-8-12-27(26)37/h4-12,17,20,25,28-29H,13-16,18-19,21-23H2,1-3H3,(H,39,47)(H,40,45)(H,41,48)(H,42,49)(H,38,43,46)/t28-,29-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Xixi Hospital Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome pretreated for 15 mins followed by Suc-Leu-Leu-Val-Tyr-AMC substrate addition by flu...				Eur J Med Chem 126: 1056-1070 (2017) Article DOI: 10.1016/j.ejmech.2016.12.034 BindingDB Entry DOI: 10.7270/Q2MK6G4X
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50549205 (CHEMBL4794118) Show SMILES CC(C)(C)NC(=O)CC[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1cnccn1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by subs...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115867 BindingDB Entry DOI: 10.7270/Q2XP78J1
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50593011 (CHEMBL5208208) Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1cc(Cl)ccc1Cl)B(O)O |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00523 BindingDB Entry DOI: 10.7270/Q2K35ZNX
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50234962 (CHEMBL4078056) Show SMILES CC(C)(C)CNC(=O)C[C@H](NC(=O)N1CCC(CC1)C(=O)NCc1nccs1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl |r| Show InChI InChI=1S/C37H48ClN7O5S/c1-37(2,3)24-42-31(46)21-30(44-36(50)45-18-15-26(16-19-45)33(47)41-23-32-39-17-20-51-32)35(49)43-29(14-13-25-9-5-4-6-10-25)34(48)40-22-27-11-7-8-12-28(27)38/h4-12,17,20,26,29-30H,13-16,18-19,21-24H2,1-3H3,(H,40,48)(H,41,47)(H,42,46)(H,43,49)(H,44,50)/t29-,30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Xixi Hospital Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome pretreated for 15 mins followed by Suc-Leu-Leu-Val-Tyr-AMC substrate addition by flu...				Eur J Med Chem 126: 1056-1070 (2017) Article DOI: 10.1016/j.ejmech.2016.12.034 BindingDB Entry DOI: 10.7270/Q2MK6G4X
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50234978 (CHEMBL4064404) Show SMILES CC(C)(C)CNC(=O)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1ccccn1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl |r| Show InChI InChI=1S/C38H48ClN7O5/c1-38(2,3)25-42-33(47)23-31(44-37(51)46-21-18-27(19-22-46)34(48)45-32-15-9-10-20-40-32)36(50)43-30(17-16-26-11-5-4-6-12-26)35(49)41-24-28-13-7-8-14-29(28)39/h4-15,20,27,30-31H,16-19,21-25H2,1-3H3,(H,41,49)(H,42,47)(H,43,50)(H,44,51)(H,40,45,48)/t30-,31-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Xixi Hospital Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome pretreated for 15 mins followed by Suc-Leu-Leu-Val-Tyr-AMC substrate addition by flu...				Eur J Med Chem 126: 1056-1070 (2017) Article DOI: 10.1016/j.ejmech.2016.12.034 BindingDB Entry DOI: 10.7270/Q2MK6G4X
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50160869 (CHEMBL3786398) Show SMILES CC(C)C[C@@H](NC(=O)CC(NC(=O)[C@H]1CCCc2ccccc12)c1cccc(F)c1)B(O)O |r| Show InChI InChI=1S/C25H32BFN2O4/c1-16(2)13-23(26(32)33)29-24(30)15-22(18-9-5-10-19(27)14-18)28-25(31)21-12-6-8-17-7-3-4-11-20(17)21/h3-5,7,9-11,14,16,21-23,32-33H,6,8,12-13,15H2,1-2H3,(H,28,31)(H,29,30)/t21-,22?,23+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human erythrocyte-derived 20S proteasome preincubated for 10 mins using Suc-LLVY-AMC as substrate after 6...				Bioorg Med Chem Lett 26: 1958-62 (2016) Article DOI: 10.1016/j.bmcl.2016.03.007 BindingDB Entry DOI: 10.7270/Q2GT5Q2Q
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50307481 ((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...) Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C36H42N6O5/c1-24(2)19-28(32(43)36(3)23-47-36)38-33(44)29(20-25-13-7-4-8-14-25)39-34(45)30(21-26-15-9-5-10-16-26)40-35(46)31(41-42-37)22-27-17-11-6-12-18-27/h4-18,24,28-31H,19-23H2,1-3H3,(H,38,44)(H,39,45)(H,40,46)/t28-,29-,30-,31-,36+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Chemistry and Netherlands Proteomics Centre Curated by ChEMBL					Assay Description Inhibition of 26S proteasome beta 5 using LLVY as substrate				J Med Chem 53: 2319-23 (2010) Article DOI: 10.1021/jm9015685 BindingDB Entry DOI: 10.7270/Q2WS8TCH
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50234984 (CHEMBL3218837) Show SMILES CC(C)(C)CNC(=O)C[C@H](NC(=O)C(=O)c1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCc1ccccc1Cl |r| Show InChI InChI=1S/C34H37ClN6O5/c1-34(2,3)20-39-29(42)17-28(41-33(46)30(43)24-19-37-26-11-7-5-9-23(24)26)32(45)40-27(16-21-12-14-36-15-13-21)31(44)38-18-22-8-4-6-10-25(22)35/h4-15,19,27-28,37H,16-18,20H2,1-3H3,(H,38,44)(H,39,42)(H,40,45)(H,41,46)/t27-,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Xixi Hospital Curated by ChEMBL					Assay Description Inhibition of 20s immunoproteasome chymotrypsin-like activity in human peripheral blood monocyte using Ac-ANW-AMC as substrate in presence of proteas...				Eur J Med Chem 126: 1056-1070 (2017) Article DOI: 10.1016/j.ejmech.2016.12.034 BindingDB Entry DOI: 10.7270/Q2MK6G4X
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50234967 (CHEMBL4072652) Show SMILES CC(C)(C)CNC(=O)C[C@H](NC(=O)N1CCC(CC1)NC(=O)c1cnccn1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl |r| Show InChI InChI=1S/C37H47ClN8O5/c1-37(2,3)24-42-32(47)21-30(45-36(51)46-19-15-27(16-20-46)43-35(50)31-23-39-17-18-40-31)34(49)44-29(14-13-25-9-5-4-6-10-25)33(48)41-22-26-11-7-8-12-28(26)38/h4-12,17-18,23,27,29-30H,13-16,19-22,24H2,1-3H3,(H,41,48)(H,42,47)(H,43,50)(H,44,49)(H,45,51)/t29-,30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Xixi Hospital Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome pretreated for 15 mins followed by Suc-Leu-Leu-Val-Tyr-AMC substrate addition by flu...				Eur J Med Chem 126: 1056-1070 (2017) Article DOI: 10.1016/j.ejmech.2016.12.034 BindingDB Entry DOI: 10.7270/Q2MK6G4X
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50186686 (CHEMBL204992 | benzenesulfonyl-Glu(OtBu)-Ser-LeuVS...) Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NS(=O)(=O)c1ccccc1)\C=C\S(C)(=O)=O Show InChI InChI=1S/C26H41N3O9S2/c1-18(2)16-19(14-15-39(6,34)35)27-25(33)22(17-30)28-24(32)21(12-13-23(31)38-26(3,4)5)29-40(36,37)20-10-8-7-9-11-20/h7-11,14-15,18-19,21-22,29-30H,12-13,16-17H2,1-6H3,(H,27,33)(H,28,32)/b15-14+/t19-,21+,22+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Celera Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like proteasome activity of human 20S proteasome				J Med Chem 49: 2953-68 (2006) Article DOI: 10.1021/jm058289o BindingDB Entry DOI: 10.7270/Q2FF3S0S
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50593023 (CHEMBL5183504) Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cccc(F)c1F)B(O)O |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00523 BindingDB Entry DOI: 10.7270/Q2K35ZNX
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50163559 (CHEMBL3794168) Show SMILES [H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(OC1C2)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCc2ccccc12 |r| Show InChI InChI=1S/C35H47BN2O4/c1-22(2)18-31(36-41-30-21-25-20-29(34(25,3)4)35(30,5)42-36)38-33(40)28(19-23-12-7-6-8-13-23)37-32(39)27-17-11-15-24-14-9-10-16-26(24)27/h6-10,12-14,16,22,25,27-31H,11,15,17-21H2,1-5H3,(H,37,39)(H,38,40)/t25-,27-,28-,29-,30?,31-,35-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Forestry University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...				Bioorg Med Chem 24: 2576-88 (2016) Article DOI: 10.1016/j.bmc.2016.04.025 BindingDB Entry DOI: 10.7270/Q2P84DSC
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50163559 (CHEMBL3794168) Show SMILES [H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(OC1C2)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCc2ccccc12 |r| Show InChI InChI=1S/C35H47BN2O4/c1-22(2)18-31(36-41-30-21-25-20-29(34(25,3)4)35(30,5)42-36)38-33(40)28(19-23-12-7-6-8-13-23)37-32(39)27-17-11-15-24-14-9-10-16-26(24)27/h6-10,12-14,16,22,25,27-31H,11,15,17-21H2,1-5H3,(H,37,39)(H,38,40)/t25-,27-,28-,29-,30?,31-,35-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.12	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Forestry University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...				Bioorg Med Chem 24: 2576-88 (2016) Article DOI: 10.1016/j.bmc.2016.04.025 BindingDB Entry DOI: 10.7270/Q2P84DSC
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50163685 (CHEMBL3793581) Show SMILES [H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(OC1C2)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)c1cccc2CCCCc12 |r| Show InChI InChI=1S/C32H49BN2O4/c1-19(2)15-25(34-29(36)24-14-10-12-21-11-8-9-13-23(21)24)30(37)35-28(16-20(3)4)33-38-27-18-22-17-26(31(22,5)6)32(27,7)39-33/h10,12,14,19-20,22,25-28H,8-9,11,13,15-18H2,1-7H3,(H,34,36)(H,35,37)/t22-,25-,26-,27?,28-,32-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.15	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Forestry University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...				Bioorg Med Chem 24: 2576-88 (2016) Article DOI: 10.1016/j.bmc.2016.04.025 BindingDB Entry DOI: 10.7270/Q2P84DSC
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50163698 (CHEMBL3794310) Show SMILES [H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(OC1C2)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cccc2CCCCc12 |r| Show InChI InChI=1S/C39H49BN2O4/c1-24(2)19-35(40-45-34-23-29-22-33(38(29,3)4)39(34,5)46-40)42-37(44)32(21-25-17-18-26-11-6-7-13-28(26)20-25)41-36(43)31-16-10-14-27-12-8-9-15-30(27)31/h6-7,10-11,13-14,16-18,20,24,29,32-35H,8-9,12,15,19,21-23H2,1-5H3,(H,41,43)(H,42,44)/t29-,32-,33-,34?,35-,39-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.16	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Forestry University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...				Bioorg Med Chem 24: 2576-88 (2016) Article DOI: 10.1016/j.bmc.2016.04.025 BindingDB Entry DOI: 10.7270/Q2P84DSC
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50163673 (CHEMBL3793238) Show SMILES [H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(OC1C2)[C@H](Cc1ccc(C)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)C1CCc2ccccc2C1 |r| Show InChI InChI=1S/C39H47BN2O4/c1-25-14-16-27(17-15-25)21-35(40-45-34-24-31-23-33(38(31,2)3)39(34,4)46-40)42-37(44)32(20-26-10-6-5-7-11-26)41-36(43)30-19-18-28-12-8-9-13-29(28)22-30/h5-17,30-35H,18-24H2,1-4H3,(H,41,43)(H,42,44)/t30?,31-,32-,33-,34?,35-,39-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.16	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Forestry University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...				Bioorg Med Chem 24: 2576-88 (2016) Article DOI: 10.1016/j.bmc.2016.04.025 BindingDB Entry DOI: 10.7270/Q2P84DSC
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50069985 ((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...) Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O |r| Show InChI InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Adelaide Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of 26S proteasome beta 5 subunit (unknown origin) by fluorescence assay				Bioorg Med Chem 27: 436-441 (2019) Article DOI: 10.1016/j.bmc.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27P1
					More data for this Ligand-Target Pair				3D Structure (crystal)
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50069985 ((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...) Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O |r| Show InChI InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human platelet Thromboxane synthetase				J Med Chem 20: 430-9 (1977) Article DOI: 10.1021/jm00213a022 BindingDB Entry DOI: 10.7270/Q2ZC85WV
					More data for this Ligand-Target Pair				3D Structure (crystal)
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50160867 (CHEMBL499361) Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCc2ccccc12)B(O)O |r| Show InChI InChI=1S/C25H33BN2O4/c1-17(2)15-23(26(31)32)28-25(30)22(16-18-9-4-3-5-10-18)27-24(29)21-14-8-12-19-11-6-7-13-20(19)21/h3-7,9-11,13,17,21-23,31-32H,8,12,14-16H2,1-2H3,(H,27,29)(H,28,30)/t21-,22-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Forestry University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...				Bioorg Med Chem 24: 2576-88 (2016) Article DOI: 10.1016/j.bmc.2016.04.025 BindingDB Entry DOI: 10.7270/Q2P84DSC
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50234981 (CHEMBL4078693) Show SMILES CC(C)(C)CNC(=O)C[C@H](NC(=O)N1CCC(CC1)NC(=O)c1ccc(F)cc1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl |r| Show InChI InChI=1S/C39H48ClFN6O5/c1-39(2,3)25-43-34(48)23-33(46-38(52)47-21-19-30(20-22-47)44-35(49)27-14-16-29(41)17-15-27)37(51)45-32(18-13-26-9-5-4-6-10-26)36(50)42-24-28-11-7-8-12-31(28)40/h4-12,14-17,30,32-33H,13,18-25H2,1-3H3,(H,42,50)(H,43,48)(H,44,49)(H,45,51)(H,46,52)/t32-,33-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Xixi Hospital Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome pretreated for 15 mins followed by Suc-Leu-Leu-Val-Tyr-AMC substrate addition by flu...				Eur J Med Chem 126: 1056-1070 (2017) Article DOI: 10.1016/j.ejmech.2016.12.034 BindingDB Entry DOI: 10.7270/Q2MK6G4X
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50593017 (CHEMBL5196305) Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cccc(Cl)c1Cl)B(O)O |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00523 BindingDB Entry DOI: 10.7270/Q2K35ZNX
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50163673 (CHEMBL3793238) Show SMILES [H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(OC1C2)[C@H](Cc1ccc(C)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)C1CCc2ccccc2C1 |r| Show InChI InChI=1S/C39H47BN2O4/c1-25-14-16-27(17-15-25)21-35(40-45-34-24-31-23-33(38(31,2)3)39(34,4)46-40)42-37(44)32(20-26-10-6-5-7-11-26)41-36(43)30-19-18-28-12-8-9-13-29(28)22-30/h5-17,30-35H,18-24H2,1-4H3,(H,41,43)(H,42,44)/t30?,31-,32-,33-,34?,35-,39-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Forestry University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...				Bioorg Med Chem 24: 2576-88 (2016) Article DOI: 10.1016/j.bmc.2016.04.025 BindingDB Entry DOI: 10.7270/Q2P84DSC
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50234984 (CHEMBL3218837) Show SMILES CC(C)(C)CNC(=O)C[C@H](NC(=O)C(=O)c1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCc1ccccc1Cl |r| Show InChI InChI=1S/C34H37ClN6O5/c1-34(2,3)20-39-29(42)17-28(41-33(46)30(43)24-19-37-26-11-7-5-9-23(24)26)32(45)40-27(16-21-12-14-36-15-13-21)31(44)38-18-22-8-4-6-10-25(22)35/h4-15,19,27-28,37H,16-18,20H2,1-3H3,(H,38,44)(H,39,42)(H,40,45)(H,41,46)/t27-,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Xixi Hospital Curated by ChEMBL					Assay Description Inhibition of 20s immunoproteasome chymotrypsin-like activity in human peripheral blood monocyte using Ac-ANW-AMC as substrate in presence of proteas...				Eur J Med Chem 126: 1056-1070 (2017) Article DOI: 10.1016/j.ejmech.2016.12.034 BindingDB Entry DOI: 10.7270/Q2MK6G4X
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50160867 (CHEMBL499361) Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCc2ccccc12)B(O)O |r| Show InChI InChI=1S/C25H33BN2O4/c1-17(2)15-23(26(31)32)28-25(30)22(16-18-9-4-3-5-10-18)27-24(29)21-14-8-12-19-11-6-7-13-20(19)21/h3-7,9-11,13,17,21-23,31-32H,8,12,14-16H2,1-2H3,(H,27,29)(H,28,30)/t21-,22-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human erythrocyte-derived 20S proteasome preincubated for 10 mins using Suc-LLVY-AMC as substrate after 6...				Bioorg Med Chem Lett 26: 1958-62 (2016) Article DOI: 10.1016/j.bmcl.2016.03.007 BindingDB Entry DOI: 10.7270/Q2GT5Q2Q
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50160867 (CHEMBL499361) Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCc2ccccc12)B(O)O |r| Show InChI InChI=1S/C25H33BN2O4/c1-17(2)15-23(26(31)32)28-25(30)22(16-18-9-4-3-5-10-18)27-24(29)21-14-8-12-19-11-6-7-13-20(19)21/h3-7,9-11,13,17,21-23,31-32H,8,12,14-16H2,1-2H3,(H,27,29)(H,28,30)/t21-,22-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Forestry University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...				Bioorg Med Chem 24: 2576-88 (2016) Article DOI: 10.1016/j.bmc.2016.04.025 BindingDB Entry DOI: 10.7270/Q2P84DSC
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50234984 (CHEMBL3218837) Show SMILES CC(C)(C)CNC(=O)C[C@H](NC(=O)C(=O)c1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCc1ccccc1Cl |r| Show InChI InChI=1S/C34H37ClN6O5/c1-34(2,3)20-39-29(42)17-28(41-33(46)30(43)24-19-37-26-11-7-5-9-23(24)26)32(45)40-27(16-21-12-14-36-15-13-21)31(44)38-18-22-8-4-6-10-25(22)35/h4-15,19,27-28,37H,16-18,20H2,1-3H3,(H,38,44)(H,39,42)(H,40,45)(H,41,46)/t27-,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of constitutive 20S proteasome beta 5 subunit in human erythrocytes using Ac-WLA-AMC as substrate in presence of PA28alpha by fluorimetry ...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115867 BindingDB Entry DOI: 10.7270/Q2XP78J1
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50163685 (CHEMBL3793581) Show SMILES [H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(OC1C2)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)c1cccc2CCCCc12 |r| Show InChI InChI=1S/C32H49BN2O4/c1-19(2)15-25(34-29(36)24-14-10-12-21-11-8-9-13-23(21)24)30(37)35-28(16-20(3)4)33-38-27-18-22-17-26(31(22,5)6)32(27,7)39-33/h10,12,14,19-20,22,25-28H,8-9,11,13,15-18H2,1-7H3,(H,34,36)(H,35,37)/t22-,25-,26-,27?,28-,32-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Forestry University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...				Bioorg Med Chem 24: 2576-88 (2016) Article DOI: 10.1016/j.bmc.2016.04.025 BindingDB Entry DOI: 10.7270/Q2P84DSC
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50163698 (CHEMBL3794310) Show SMILES [H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(OC1C2)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cccc2CCCCc12 |r| Show InChI InChI=1S/C39H49BN2O4/c1-24(2)19-35(40-45-34-23-29-22-33(38(29,3)4)39(34,5)46-40)42-37(44)32(21-25-17-18-26-11-6-7-13-28(26)20-25)41-36(43)31-16-10-14-27-12-8-9-15-30(27)31/h6-7,10-11,13-14,16-18,20,24,29,32-35H,8-9,12,15,19,21-23H2,1-5H3,(H,41,43)(H,42,44)/t29-,32-,33-,34?,35-,39-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Forestry University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...				Bioorg Med Chem 24: 2576-88 (2016) Article DOI: 10.1016/j.bmc.2016.04.025 BindingDB Entry DOI: 10.7270/Q2P84DSC
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50163565 (CHEMBL3794136) Show SMILES [H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(OC1C2)[C@H](Cc1ccc(F)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCc2ccccc12 |r| Show InChI InChI=1S/C38H44BFN2O4/c1-37(2)27-22-32(37)38(3)33(23-27)45-39(46-38)34(21-25-16-18-28(40)19-17-25)42-36(44)31(20-24-10-5-4-6-11-24)41-35(43)30-15-9-13-26-12-7-8-14-29(26)30/h4-8,10-12,14,16-19,27,30-34H,9,13,15,20-23H2,1-3H3,(H,41,43)(H,42,44)/t27-,30-,31-,32-,33?,34-,38-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.26	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Forestry University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...				Bioorg Med Chem 24: 2576-88 (2016) Article DOI: 10.1016/j.bmc.2016.04.025 BindingDB Entry DOI: 10.7270/Q2P84DSC
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50163689 (CHEMBL3794207) Show SMILES [H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(OC1C2)[C@H](CC(C)C)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)c1cccc2CCCCc12 |r| Show InChI InChI=1S/C39H49BN2O4/c1-24(2)20-35(40-45-34-23-28-22-33(38(28,3)4)39(34,5)46-40)42-37(44)32(21-27-16-10-14-25-12-6-8-17-29(25)27)41-36(43)31-19-11-15-26-13-7-9-18-30(26)31/h6,8,10-12,14-17,19,24,28,32-35H,7,9,13,18,20-23H2,1-5H3,(H,41,43)(H,42,44)/t28-,32-,33-,34?,35-,39-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Forestry University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...				Bioorg Med Chem 24: 2576-88 (2016) Article DOI: 10.1016/j.bmc.2016.04.025 BindingDB Entry DOI: 10.7270/Q2P84DSC
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50163565 (CHEMBL3794136) Show SMILES [H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(OC1C2)[C@H](Cc1ccc(F)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCc2ccccc12 |r| Show InChI InChI=1S/C38H44BFN2O4/c1-37(2)27-22-32(37)38(3)33(23-27)45-39(46-38)34(21-25-16-18-28(40)19-17-25)42-36(44)31(20-24-10-5-4-6-11-24)41-35(43)30-15-9-13-26-12-7-8-14-29(26)30/h4-8,10-12,14,16-19,27,30-34H,9,13,15,20-23H2,1-3H3,(H,41,43)(H,42,44)/t27-,30-,31-,32-,33?,34-,38-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Forestry University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...				Bioorg Med Chem 24: 2576-88 (2016) Article DOI: 10.1016/j.bmc.2016.04.025 BindingDB Entry DOI: 10.7270/Q2P84DSC
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50163689 (CHEMBL3794207) Show SMILES [H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(OC1C2)[C@H](CC(C)C)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)c1cccc2CCCCc12 |r| Show InChI InChI=1S/C39H49BN2O4/c1-24(2)20-35(40-45-34-23-28-22-33(38(28,3)4)39(34,5)46-40)42-37(44)32(21-27-16-10-14-25-12-6-8-17-29(25)27)41-36(43)31-19-11-15-26-13-7-9-18-30(26)31/h6,8,10-12,14-17,19,24,28,32-35H,7,9,13,18,20-23H2,1-5H3,(H,41,43)(H,42,44)/t28-,32-,33-,34?,35-,39-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.34	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Forestry University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...				Bioorg Med Chem 24: 2576-88 (2016) Article DOI: 10.1016/j.bmc.2016.04.025 BindingDB Entry DOI: 10.7270/Q2P84DSC
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50200507 (CHEMBL3890793) Show SMILES Clc1ccccc1CNC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)N1CCC(CC1)C(=O)Nc1cccnc1 |r| Show InChI InChI=1S/C39H43ClN6O4/c40-33-16-8-7-14-31(33)26-42-37(48)34(19-17-28-10-3-1-4-11-28)44-38(49)35(20-18-29-12-5-2-6-13-29)45-39(50)46-24-21-30(22-25-46)36(47)43-32-15-9-23-41-27-32/h1-16,23,27,30,34-35H,17-22,24-26H2,(H,42,48)(H,43,47)(H,44,49)(H,45,50)/t34-,35-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Xixi Hospital Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome preincubated for 15 mins followed by addition of Suc-Leu-Leu-Val-Tyr-AMC as substrat...				Bioorg Med Chem 24: 6206-6214 (2016) Article DOI: 10.1016/j.bmc.2016.10.002 BindingDB Entry DOI: 10.7270/Q2K64M2T
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50550643 (CHEMBL4749207) Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccc(O)cc1)B(O)O |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 20S constitutive proteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presen...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01161 BindingDB Entry DOI: 10.7270/Q2K077W3
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50549212 (CHEMBL4749316) Show SMILES CC(C)(C)CNC(=O)CC[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1cccnc1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by subs...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115867 BindingDB Entry DOI: 10.7270/Q2XP78J1
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50163668 (CHEMBL3793242) Show SMILES [H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(OC1C2)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)C1CCc2ccccc2C1 |r| Show InChI InChI=1S/C35H47BN2O4/c1-22(2)17-31(36-41-30-21-27-20-29(34(27,3)4)35(30,5)42-36)38-33(40)28(18-23-11-7-6-8-12-23)37-32(39)26-16-15-24-13-9-10-14-25(24)19-26/h6-14,22,26-31H,15-21H2,1-5H3,(H,37,39)(H,38,40)/t26?,27-,28-,29-,30?,31-,35-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.46	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Forestry University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...				Bioorg Med Chem 24: 2576-88 (2016) Article DOI: 10.1016/j.bmc.2016.04.025 BindingDB Entry DOI: 10.7270/Q2P84DSC
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50186721 (CHEMBL382203 | Cbz-Ile-NeopentylAsn-Ala-LeuVSMe) Show SMILES CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)NCC(C)(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C=CS(C)(=O)=O |w:43.44| Show InChI InChI=1S/C34H55N5O8S/c1-10-23(4)29(39-33(44)47-20-25-14-12-11-13-15-25)32(43)38-27(19-28(40)35-21-34(6,7)8)31(42)36-24(5)30(41)37-26(18-22(2)3)16-17-48(9,45)46/h11-17,22-24,26-27,29H,10,18-21H2,1-9H3,(H,35,40)(H,36,42)(H,37,41)(H,38,43)(H,39,44)/t23-,24-,26+,27-,29-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Celera Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like proteasome activity of human 20S proteasome				J Med Chem 49: 2953-68 (2006) Article DOI: 10.1021/jm058289o BindingDB Entry DOI: 10.7270/Q2FF3S0S
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50234989 (CHEMBL4094582) Show SMILES CC(C)(C)CNC(=O)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1ccc(F)cc1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl |r| Show InChI InChI=1S/C39H48ClFN6O5/c1-39(2,3)25-43-34(48)23-33(46-38(52)47-21-19-27(20-22-47)35(49)44-30-16-14-29(41)15-17-30)37(51)45-32(18-13-26-9-5-4-6-10-26)36(50)42-24-28-11-7-8-12-31(28)40/h4-12,14-17,27,32-33H,13,18-25H2,1-3H3,(H,42,50)(H,43,48)(H,44,49)(H,45,51)(H,46,52)/t32-,33-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Xixi Hospital Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome pretreated for 15 mins followed by Suc-Leu-Leu-Val-Tyr-AMC substrate addition by flu...				Eur J Med Chem 126: 1056-1070 (2017) Article DOI: 10.1016/j.ejmech.2016.12.034 BindingDB Entry DOI: 10.7270/Q2MK6G4X
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50531806 (CHEMBL4460323) Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1nccs1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C34H48N6O6S/c1-21(2)17-25(28(41)34(5)20-46-34)36-31(44)27(19-23-9-7-6-8-10-23)37-30(43)26(18-22(3)4)38-33(45)40-14-11-24(12-15-40)29(42)39-32-35-13-16-47-32/h6-10,13,16,21-22,24-27H,11-12,14-15,17-20H2,1-5H3,(H,36,44)(H,37,43)(H,38,45)(H,35,39,42)/t25-,26-,27-,34+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Institute of Innovative Medicine Curated by ChEMBL					Assay Description Inhibition of human 20s constitutive proteasome beta5 chymotrypsin-like activity using Suc-LLVY-AMC as substrate preincubated for 15 mins followed by...				Eur J Med Chem 164: 602-614 (2019) Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Homo sapiens (Human))	BDBM50329819 ((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)b...) Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)c1cccc(n1)-c1ccccc1)[C@@H](C)O)B(O)O Show InChI InChI=1S/C21H28BN3O5/c1-13(2)12-18(22(29)30)24-21(28)19(14(3)26)25-20(27)17-11-7-10-16(23-17)15-8-5-4-6-9-15/h4-11,13-14,18-19,26,29-30H,12H2,1-3H3,(H,24,28)(H,25,27)/t14-,18+,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria				J Med Chem 20: 430-9 (1977) Article DOI: 10.1021/jm00213a022 BindingDB Entry DOI: 10.7270/Q2ZC85WV
					More data for this Ligand-Target Pair

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