Compile Data Set for Download or QSAR

Found 27 hits of ec50 for UniProtKB: P43140   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50230393 (CHEMBL553231) Show SMILES Cl.CC(C1=NCCN1)c1cccc2ccccc12 |t:2| Show InChI InChI=1S/C15H16N2.ClH/c1-11(15-16-9-10-17-15)13-8-4-6-12-5-2-3-7-14(12)13;/h2-8,11H,9-10H2,1H3,(H,16,17);1H	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.000540	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aorta				J Med Chem 35: 750-5 (1992) BindingDB Entry DOI: 10.7270/Q27H1MTJ
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50230392 (CHEMBL554581) Show SMILES Cl.CC(c1ncc[nH]1)c1cccc2ccccc12 Show InChI InChI=1S/C15H14N2.ClH/c1-11(15-16-9-10-17-15)13-8-4-6-12-5-2-3-7-14(12)13;/h2-11H,1H3,(H,16,17);1H	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.00770	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aorta				J Med Chem 35: 750-5 (1992) BindingDB Entry DOI: 10.7270/Q27H1MTJ
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50470944 (CHEMBL336161) Show SMILES [H][C@]1(CCCc2c(NS(C)(=O)=O)c(O)ccc12)C1=NCCN1 |t:19| Show InChI InChI=1S/C14H19N3O3S/c1-21(19,20)17-13-10-3-2-4-11(14-15-7-8-16-14)9(10)5-6-12(13)18/h5-6,11,17-18H,2-4,7-8H2,1H3,(H,15,16)/t11-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.20	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens				J Med Chem 39: 4116-9 (1996) Article DOI: 10.1021/jm960354u BindingDB Entry DOI: 10.7270/Q2FN18WJ
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50118703 (CHEMBL109783 | N-[5-(4,5-Dihydro-1H-imidazol-2-yl)...) Show SMILES CS(=O)(=O)Nc1c(O)ccc2C(CCCc12)C1=NCCN1 |t:18| Show InChI InChI=1S/C14H19N3O3S/c1-21(19,20)17-13-10-3-2-4-11(14-15-7-8-16-14)9(10)5-6-12(13)18/h5-6,11,17-18H,2-4,7-8H2,1H3,(H,15,16)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	n/a	n/a	5.80	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens				J Med Chem 39: 4116-9 (1996) Article DOI: 10.1021/jm960354u BindingDB Entry DOI: 10.7270/Q2FN18WJ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50001922 (2-Naphthalen-1-ylmethyl-4,5-dihydro-1H-imidazole; ...) Show SMILES C(C1=NCCN1)c1cccc2ccccc12 |t:1| Show InChI InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aorta				J Med Chem 35: 750-5 (1992) BindingDB Entry DOI: 10.7270/Q27H1MTJ
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50027031 ((2-Chloro-phenyl)-(4,5-dihydro-1H-imidazol-2-ylmet...) Show SMILES Clc1ccccc1NCC1=NCCN1 |t:10| Show InChI InChI=1S/C10H12ClN3/c11-8-3-1-2-4-9(8)14-7-10-12-5-6-13-10/h1-4,14H,5-7H2,(H,12,13)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity against alpha-1 adrenergic receptor from rat vas deferens				J Med Chem 26: 1769-72 (1984) BindingDB Entry DOI: 10.7270/Q2668DRD
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50027035 (3-[(4,5-Dihydro-1H-imidazol-2-ylmethyl)-amino]-phe...) Show SMILES Oc1cccc(NCC2=NCCN2)c1 |t:8| Show InChI InChI=1S/C10H13N3O/c14-9-3-1-2-8(6-9)13-7-10-11-4-5-12-10/h1-3,6,13-14H,4-5,7H2,(H,11,12)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	n/a	n/a	61	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand				J Med Chem 26: 1769-72 (1984) BindingDB Entry DOI: 10.7270/Q2668DRD
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50036910 (4-(1-Naphthalen-1-yl-ethyl)-1H-imidazole | CHEMBL3...) Show SMILES CC(c1cnc[nH]1)c1cccc2ccccc12 Show InChI InChI=1S/C15H14N2/c1-11(15-9-16-10-17-15)13-8-4-6-12-5-2-3-7-14(12)13/h2-11H,1H3,(H,16,17)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	153	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description 50% Molar effective concentration for agonistic activity against Alpha-1 adrenergic receptor in rat aorta				J Med Chem 39: 3001-13 (1996) Article DOI: 10.1021/jm9506074 BindingDB Entry DOI: 10.7270/Q2BV7KBH
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50230389 (CHEMBL541105) Show SMILES Cl.CC(c1c[nH]cn1)c1cccc2ccccc12 Show InChI InChI=1S/C15H14N2.ClH/c1-11(15-9-16-10-17-15)13-8-4-6-12-5-2-3-7-14(12)13;/h2-11H,1H3,(H,16,17);1H	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aorta				J Med Chem 35: 750-5 (1992) BindingDB Entry DOI: 10.7270/Q27H1MTJ
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50230388 (CHEMBL537830) Show SMILES Cl.C(c1ncc[nH]1)c1cccc2ccccc12 Show InChI InChI=1S/C14H12N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-9H,10H2,(H,15,16)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aorta				J Med Chem 35: 750-5 (1992) BindingDB Entry DOI: 10.7270/Q27H1MTJ
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50036913 ((+-)-4-(alpha,2,3-trimethylbenzyl)imidazole | 4-[1...) Show SMILES CC(c1cnc[nH]1)c1cccc(C)c1C Show InChI InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	281	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description 50% Molar effective concentration afainst Alpha-1 adrenergic receptor in rat aorta				J Med Chem 39: 3001-13 (1996) Article DOI: 10.1021/jm9506074 BindingDB Entry DOI: 10.7270/Q2BV7KBH
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM30712 (6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimet...) Show SMILES Cc1cc(c(O)c(C)c1CC1=NCCN1)C(C)(C)C |t:11| Show InChI InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	288	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens				J Med Chem 39: 4116-9 (1996) Article DOI: 10.1021/jm960354u BindingDB Entry DOI: 10.7270/Q2FN18WJ
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50027036 ((4,5-Dihydro-1H-imidazol-2-ylmethyl)-methyl-p-toly...) Show SMILES CN(CC1=NCCN1)c1ccc(C)cc1 |t:3| Show InChI InChI=1S/C12H17N3/c1-10-3-5-11(6-4-10)15(2)9-12-13-7-8-14-12/h3-6H,7-9H2,1-2H3,(H,13,14)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligand				J Med Chem 26: 1769-72 (1984) BindingDB Entry DOI: 10.7270/Q2668DRD
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50230390 (CHEBI:48556 | MEDETOMIDINE HYDROCHLORIDE | MPV-785...) Show SMILES Cl.CC(c1c[nH]cn1)c1cccc(C)c1C Show InChI InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	310	n/a	n/a	n/a	n/a
Ohio State University Curated by ChEMBL					Assay Description Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aorta				J Med Chem 35: 750-5 (1992) BindingDB Entry DOI: 10.7270/Q27H1MTJ
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50027032 ((4,5-Dihydro-1H-imidazol-2-ylmethyl)-p-tolyl-amine...) Show SMILES Cc1ccc(NCC2=NCCN2)cc1 |t:7| Show InChI InChI=1S/C11H15N3/c1-9-2-4-10(5-3-9)14-8-11-12-6-7-13-11/h2-5,14H,6-8H2,1H3,(H,12,13)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	340	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity against alpha-1 adrenergic receptor from rat vas deferens				J Med Chem 26: 1769-72 (1984) BindingDB Entry DOI: 10.7270/Q2668DRD
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50131411 (4-(4-Chloro-benzyl)-2-methyl-2H-phthalazin-1-one |...) Show SMILES Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O Show InChI InChI=1S/C16H13ClN2O/c1-19-16(20)14-5-3-2-4-13(14)15(18-19)10-11-6-8-12(17)9-7-11/h2-9H,10H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	810	n/a	n/a	n/a	n/a
Universidad de Salamanca Curated by ChEMBL					Assay Description Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction				Bioorg Med Chem Lett 16: 2786-90 (2006) Article DOI: 10.1016/j.bmcl.2006.02.003 BindingDB Entry DOI: 10.7270/Q22R3R8N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM31046 (3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...) Show SMILES Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1 |t:10| Show InChI InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity against alpha-1 adrenergic receptor from rat vas deferens				J Med Chem 26: 1769-72 (1984) BindingDB Entry DOI: 10.7270/Q2668DRD
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50029051 ((-)-arterenol | (-)-noradrenaline | (-)-norepineph...) Show SMILES NC[C@H](O)c1ccc(O)c(O)c1 |r| Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.18E+3	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens				J Med Chem 39: 4116-9 (1996) Article DOI: 10.1021/jm960354u BindingDB Entry DOI: 10.7270/Q2FN18WJ
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50131423 (4-Benzyl-2-methyl-2H-phthalazin-1-one | 4-benzyl-2...) Show SMILES Cn1nc(Cc2ccccc2)c2ccccc2c1=O Show InChI InChI=1S/C16H14N2O/c1-18-16(19)14-10-6-5-9-13(14)15(17-18)11-12-7-3-2-4-8-12/h2-10H,11H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a
Universidad de Salamanca Curated by ChEMBL					Assay Description Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction				Bioorg Med Chem Lett 16: 2786-90 (2006) Article DOI: 10.1016/j.bmcl.2006.02.003 BindingDB Entry DOI: 10.7270/Q22R3R8N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50027037 ((4,5-Dihydro-1H-imidazol-2-ylmethyl)-ethyl-p-tolyl...) Show SMILES CCN(CC1=NCCN1)c1ccc(C)cc1 |t:4| Show InChI InChI=1S/C13H19N3/c1-3-16(10-13-14-8-9-15-13)12-6-4-11(2)5-7-12/h4-7H,3,8-10H2,1-2H3,(H,14,15)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity against alpha-1 adrenergic receptor from rat vas deferens				J Med Chem 26: 1769-72 (1984) BindingDB Entry DOI: 10.7270/Q2668DRD
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50067212 (CHEBI:8093 | Cyclomydril | Duo-Medihaler | Phenyle...) Show SMILES CNC[C@H](O)c1cccc(O)c1 |r| Show InChI InChI=1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.66E+3	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens				J Med Chem 39: 4116-9 (1996) Article DOI: 10.1021/jm960354u BindingDB Entry DOI: 10.7270/Q2FN18WJ
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50131414 (4-(benzo[d][1,3]dioxol-5-ylmethyl)phthalazin-1(2H)...) Show SMILES O=c1[nH]nc(Cc2ccc3OCOc3c2)c2ccccc12 Show InChI InChI=1S/C16H12N2O3/c19-16-12-4-2-1-3-11(12)13(17-18-16)7-10-5-6-14-15(8-10)21-9-20-14/h1-6,8H,7,9H2,(H,18,19)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
Universidad de Salamanca Curated by ChEMBL					Assay Description Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction				Bioorg Med Chem Lett 16: 2786-90 (2006) Article DOI: 10.1016/j.bmcl.2006.02.003 BindingDB Entry DOI: 10.7270/Q22R3R8N
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM56339 (4-(4-chlorobenzyl)-1(2H)-phthalazinone | 4-(4-chlo...) Show SMILES Clc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1 Show InChI InChI=1S/C15H11ClN2O/c16-11-7-5-10(6-8-11)9-14-12-3-1-2-4-13(12)15(19)18-17-14/h1-8H,9H2,(H,18,19)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a
Universidad de Salamanca Curated by ChEMBL					Assay Description Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction				Bioorg Med Chem Lett 16: 2786-90 (2006) Article DOI: 10.1016/j.bmcl.2006.02.003 BindingDB Entry DOI: 10.7270/Q22R3R8N
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50183665 (4-(4-chlorobenzyl)-2-allylphthalazin-1(2H)-one | C...) Show SMILES Clc1ccc(Cc2nn(CC=C)c(=O)c3ccccc23)cc1 Show InChI InChI=1S/C18H15ClN2O/c1-2-11-21-18(22)16-6-4-3-5-15(16)17(20-21)12-13-7-9-14(19)10-8-13/h2-10H,1,11-12H2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a
Universidad de Salamanca Curated by ChEMBL					Assay Description Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction				Bioorg Med Chem Lett 16: 2786-90 (2006) Article DOI: 10.1016/j.bmcl.2006.02.003 BindingDB Entry DOI: 10.7270/Q22R3R8N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50027034 ((4,5-Dihydro-1H-imidazol-2-ylmethyl)-phenyl-p-toly...) Show SMILES Cc1ccc(cc1)N(CC1=NCCN1)c1ccccc1 |t:10| Show InChI InChI=1S/C17H19N3/c1-14-7-9-16(10-8-14)20(13-17-18-11-12-19-17)15-5-3-2-4-6-15/h2-10H,11-13H2,1H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity against alpha-1 adrenergic receptor from rat vas deferens				J Med Chem 26: 1769-72 (1984) BindingDB Entry DOI: 10.7270/Q2668DRD
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50027033 (CHEMBL541208 | Cyclohexyl-(4,5-dihydro-1H-imidazol...) Show SMILES Cc1ccc(cc1)N(CC1=NCCN1)C1CCCCC1 |t:10| Show InChI InChI=1S/C17H25N3/c1-14-7-9-16(10-8-14)20(13-17-18-11-12-19-17)15-5-3-2-4-6-15/h7-10,15H,2-6,11-13H2,1H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity against alpha-1 adrenergic receptor from rat vas deferens				J Med Chem 26: 1769-72 (1984) BindingDB Entry DOI: 10.7270/Q2668DRD
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50470943 (CHEMBL133451) Show SMILES [H][C@@]1(CCCc2c(NS(C)(=O)=O)c(O)ccc12)C1=NCCN1 |t:19| Show InChI InChI=1S/C14H19N3O3S/c1-21(19,20)17-13-10-3-2-4-11(14-15-7-8-16-14)9(10)5-6-12(13)18/h5-6,11,17-18H,2-4,7-8H2,1H3,(H,15,16)/t11-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	3.09E+4	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens				J Med Chem 39: 4116-9 (1996) Article DOI: 10.1021/jm960354u BindingDB Entry DOI: 10.7270/Q2FN18WJ
					More data for this Ligand-Target Pair				3D Structure (crystal)