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Compile Data Set for Download or QSAR

Found 416 hits of ic50 data for polymerid = 6472   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160301
PNG
(US9040691, 29)
Show SMILES COc1cc(cc(F)c1CO)-c1cc([C@H]2CC[C@H](O)CC2)n2ncnc(N)c12 |r,wU:14.14,wD:17.18,(-4.5,3.38,;-3.41,4.47,;-1.92,4.08,;-1.52,2.59,;-.03,2.19,;1.06,3.28,;.66,4.77,;1.75,5.85,;-.83,5.16,;-1.23,6.65,;-.14,7.74,;.36,.7,;-.54,-.54,;.36,-1.79,;-.03,-3.28,;1.06,-4.37,;.66,-5.85,;-.83,-6.25,;-1.23,-7.74,;-1.92,-5.16,;-1.52,-3.68,;1.83,-1.31,;3.16,-2.08,;4.5,-1.31,;4.5,.23,;3.16,1,;3.16,2.54,;1.83,.23,)|
Show InChI InChI=1S/C20H23FN4O3/c1-28-18-7-12(6-16(21)15(18)9-26)14-8-17(11-2-4-13(27)5-3-11)25-19(14)20(22)23-10-24-25/h6-8,10-11,13,26-27H,2-5,9H2,1H3,(H2,22,23,24)/t11-,13-
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n/an/a 1n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160276
PNG
(US9040691, 4)
Show SMILES Nc1ncnn2c(CCCCO)cc(-c3ccc(CO)cc3)c12
Show InChI InChI=1S/C17H20N4O2/c18-17-16-15(13-6-4-12(10-23)5-7-13)9-14(3-1-2-8-22)21(16)20-11-19-17/h4-7,9,11,22-23H,1-3,8,10H2,(H2,18,19,20)
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n/an/a 1n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160312
PNG
(US9040691, 40 | US9040691, 41 | US9040691, 42)
Show SMILES COc1cc(ccc1CO)-c1cc(C(O)C2CC2)n2ncnc(N)c12
Show InChI InChI=1S/C18H20N4O3/c1-25-15-6-11(4-5-12(15)8-23)13-7-14(17(24)10-2-3-10)22-16(13)18(19)20-9-21-22/h4-7,9-10,17,23-24H,2-3,8H2,1H3,(H2,19,20,21)
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n/an/a 1.20n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160277
PNG
(US9040691, 5)
Show SMILES Nc1ncnn2c(cc(-c3cc(F)c(CO)c(F)c3)c12)C(O)C1CC1
Show InChI InChI=1S/C17H16F2N4O2/c18-12-3-9(4-13(19)11(12)6-24)10-5-14(16(25)8-1-2-8)23-15(10)17(20)21-7-22-23/h3-5,7-8,16,24-25H,1-2,6H2,(H2,20,21,22)
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n/an/a 1.30n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM130909
PNG
(US10683289, Example Staurosporine | US10927120, Co...)
Show SMILES CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)
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n/an/a 1.36n/an/an/an/a7.5n/a



Chembridge Corporation

US Patent


Assay Description
Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...

US Patent US8822500 (2014)


BindingDB Entry DOI: 10.7270/Q2319TKV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM102619
PNG
(K02288a | US10688093, Compound 382_0087_0284 | US1...)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc(cnc1N)-c1cccc(O)c1
Show InChI InChI=1S/C20H20N2O4/c1-24-17-9-13(10-18(25-2)19(17)26-3)16-8-14(11-22-20(16)21)12-5-4-6-15(23)7-12/h4-11,23H,1-3H3,(H2,21,22)
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n/an/a 1.80n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128452
BindingDB Entry DOI: 10.7270/Q2JS9VGJ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160283
PNG
(US9040691, 11)
Show SMILES Nc1ncnn2c(cc(-c3cc(F)c(CO)c(F)c3)c12)[C@@H]1CCCNC1 |r|
Show InChI InChI=1S/C18H19F2N5O/c19-14-4-11(5-15(20)13(14)8-26)12-6-16(10-2-1-3-22-7-10)25-17(12)18(21)23-9-24-25/h4-6,9-10,22,26H,1-3,7-8H2,(H2,21,23,24)/t10-/m1/s1
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n/an/a 1.90n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160315
PNG
(US9040691, 43)
Show SMILES CC(C)c1cc(-c2cc(F)c(CO)c(F)c2)c2c(N)ncnn12
Show InChI InChI=1S/C16H16F2N4O/c1-8(2)14-5-10(15-16(19)20-7-21-22(14)15)9-3-12(17)11(6-23)13(18)4-9/h3-5,7-8,23H,6H2,1-2H3,(H2,19,20,21)
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n/an/a 1.90n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160302
PNG
(US9040691, 30)
Show SMILES COc1cc(cc(F)c1CO)-c1cc(C2CCCNC2)n2ncnc(N)c12
Show InChI InChI=1S/C19H22FN5O2/c1-27-17-6-12(5-15(20)14(17)9-26)13-7-16(11-3-2-4-22-8-11)25-18(13)19(21)23-10-24-25/h5-7,10-11,22,26H,2-4,8-9H2,1H3,(H2,21,23,24)
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n/an/a 2n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160289
PNG
(US9040691, 17)
Show SMILES Nc1nc(cs1)-c1cc(-c2ccc(CO)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C16H14N6OS/c17-15-14-11(10-3-1-9(6-23)2-4-10)5-13(22(14)20-8-19-15)12-7-24-16(18)21-12/h1-5,7-8,23H,6H2,(H2,18,21)(H2,17,19,20)
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n/an/a 2n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160273
PNG
(US9040691, 1)
Show SMILES CCCc1cc(-c2ccc(CO)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C16H18N4O/c1-2-3-13-8-14(12-6-4-11(9-21)5-7-12)15-16(17)18-10-19-20(13)15/h4-8,10,21H,2-3,9H2,1H3,(H2,17,18,19)
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n/an/a 2n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160279
PNG
(US9040691, 7)
Show SMILES Nc1ncnn2c(cc(-c3cc(F)c(CO)c(F)c3)c12)[C@H]1CC[C@H](O)CC1 |r,wU:20.22,wD:23.26,(2.62,2.54,;2.62,1,;3.95,.23,;3.95,-1.31,;2.62,-2.08,;1.28,-1.31,;-.18,-1.79,;-1.09,-.54,;-.18,.7,;-.58,2.19,;-2.07,2.59,;-2.46,4.08,;-3.95,4.47,;-1.38,5.16,;-1.77,6.65,;-.69,7.74,;.11,4.77,;1.2,5.85,;.51,3.28,;1.28,.23,;-.58,-3.28,;.51,-4.37,;.11,-5.85,;-1.38,-6.25,;-1.77,-7.74,;-2.46,-5.16,;-2.07,-3.68,)|
Show InChI InChI=1S/C19H20F2N4O2/c20-15-5-11(6-16(21)14(15)8-26)13-7-17(10-1-3-12(27)4-2-10)25-18(13)19(22)23-9-24-25/h5-7,9-10,12,26-27H,1-4,8H2,(H2,22,23,24)/t10-,12-
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n/an/a 2n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160288
PNG
(US9040691, 16)
Show SMILES CCc1nc(cs1)-c1cc(-c2cc(F)c(CO)c(F)c2)c2c(N)ncnn12
Show InChI InChI=1S/C18H15F2N5OS/c1-2-16-24-14(7-27-16)15-5-10(17-18(21)22-8-23-25(15)17)9-3-12(19)11(6-26)13(20)4-9/h3-5,7-8,26H,2,6H2,1H3,(H2,21,22,23)
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n/an/a 2.60n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160274
PNG
(US9040691, 2)
Show SMILES CCCc1cc(-c2cc(F)c(CO)c(F)c2)c2c(N)ncnn12
Show InChI InChI=1S/C16H16F2N4O/c1-2-3-10-6-11(15-16(19)20-8-21-22(10)15)9-4-13(17)12(7-23)14(18)5-9/h4-6,8,23H,2-3,7H2,1H3,(H2,19,20,21)
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n/an/a 2.80n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160283
PNG
(US9040691, 11)
Show SMILES Nc1ncnn2c(cc(-c3cc(F)c(CO)c(F)c3)c12)[C@@H]1CCCNC1 |r|
Show InChI InChI=1S/C18H19F2N5O/c19-14-4-11(5-15(20)13(14)8-26)12-6-16(10-2-1-3-22-7-10)25-17(12)18(21)23-9-24-25/h4-6,9-10,22,26H,1-3,7-8H2,(H2,21,23,24)/t10-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
ALKl (Invitrogen, Carlsbad, CA, USA) kinase activity was measured at ProQinase GmbH ( Freiburg. Germany) in a radiometric assay using gamma-33P-ATP a...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160309
PNG
(US9040691, 37)
Show SMILES CCc1cc(cc(F)c1CO)-c1cc(C2CCNC2)n2ncnc(N)c12
Show InChI InChI=1S/C19H22FN5O/c1-2-11-5-13(6-16(20)15(11)9-26)14-7-17(12-3-4-22-8-12)25-18(14)19(21)23-10-24-25/h5-7,10,12,22,26H,2-4,8-9H2,1H3,(H2,21,23,24)
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n/an/a<3n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
ALKl (Invitrogen, Carlsbad, CA, USA) kinase activity was measured at ProQinase GmbH ( Freiburg. Germany) in a radiometric assay using gamma-33P-ATP a...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160312
PNG
(US9040691, 40 | US9040691, 41 | US9040691, 42)
Show SMILES COc1cc(ccc1CO)-c1cc(C(O)C2CC2)n2ncnc(N)c12
Show InChI InChI=1S/C18H20N4O3/c1-25-15-6-11(4-5-12(15)8-23)13-7-14(17(24)10-2-3-10)22-16(13)18(19)20-9-21-22/h4-7,9-10,17,23-24H,2-3,8H2,1H3,(H2,19,20,21)
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n/an/a 3.20n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160312
PNG
(US9040691, 40 | US9040691, 41 | US9040691, 42)
Show SMILES COc1cc(ccc1CO)-c1cc(C(O)C2CC2)n2ncnc(N)c12
Show InChI InChI=1S/C18H20N4O3/c1-25-15-6-11(4-5-12(15)8-23)13-7-14(17(24)10-2-3-10)22-16(13)18(19)20-9-21-22/h4-7,9-10,17,23-24H,2-3,8H2,1H3,(H2,19,20,21)
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n/an/a 3.5n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160316
PNG
(US9040691, 44)
Show SMILES CC(O)c1cc(-c2cc(F)c(CO)c(F)c2)c2c(N)ncnn12
Show InChI InChI=1S/C15H14F2N4O2/c1-7(23)13-4-9(14-15(18)19-6-20-21(13)14)8-2-11(16)10(5-22)12(17)3-8/h2-4,6-7,22-23H,5H2,1H3,(H2,18,19,20)
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n/an/a 3.80n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160275
PNG
(US9040691, 3)
Show SMILES Nc1ncnn2c(CCCO)cc(-c3ccc(CO)cc3)c12
Show InChI InChI=1S/C16H18N4O2/c17-16-15-14(12-5-3-11(9-22)4-6-12)8-13(2-1-7-21)20(15)19-10-18-16/h3-6,8,10,21-22H,1-2,7,9H2,(H2,17,18,19)
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n/an/a 4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM111123
PNG
(US10017516, Compound 2 | US9682983, 2)
Show SMILES C[C@H]1CNC[C@@H](C)N1c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 |r|
Show InChI InChI=1S/C27H26N6/c1-18-13-28-14-19(2)33(18)22-9-7-20(8-10-22)21-15-30-27-25(16-31-32(27)17-21)23-11-12-29-26-6-4-3-5-24(23)26/h3-12,15-19,28H,13-14H2,1-2H3/t18-,19+
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n/an/a 4n/an/an/an/an/an/a



The Brigham and Women's Hospital, Inc.

US Patent


Assay Description
Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ...

US Patent US10017516 (2018)


BindingDB Entry DOI: 10.7270/Q20P12CN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM143311
PNG
(US10017516, Compound 11 | US9682983, 11)
Show SMILES C[C@H]1CNC[C@@H](C)N1c1ccc(cc1)-c1cnc2c(cnn2c1)-c1cc(C)nc2ccccc12 |r|
Show InChI InChI=1S/C28H28N6/c1-18-12-25(24-6-4-5-7-27(24)32-18)26-16-31-33-17-22(15-30-28(26)33)21-8-10-23(11-9-21)34-19(2)13-29-14-20(34)3/h4-12,15-17,19-20,29H,13-14H2,1-3H3/t19-,20+
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n/an/a 4n/an/an/an/an/an/a



The Brigham and Women's Hospital, Inc.

US Patent


Assay Description
Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ...

US Patent US10017516 (2018)


BindingDB Entry DOI: 10.7270/Q20P12CN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM161920
PNG
(US10017516, Compound 53 | US9682983, 52 | US968298...)
Show SMILES C[C@H]1CNC[C@@H](C)N1c1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12 |r|
Show InChI InChI=1S/C27H26N6/c1-18-13-28-14-19(2)33(18)22-10-8-20(9-11-22)21-15-30-27-25(16-31-32(27)17-21)23-5-3-7-26-24(23)6-4-12-29-26/h3-12,15-19,28H,13-14H2,1-2H3/t18-,19+
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n/an/a 4n/an/an/an/a7.5n/a



The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health

US Patent


Assay Description
Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2...

US Patent US9682983 (2017)


BindingDB Entry DOI: 10.7270/Q28S4N3R
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM143311
PNG
(US10017516, Compound 11 | US9682983, 11)
Show SMILES C[C@H]1CNC[C@@H](C)N1c1ccc(cc1)-c1cnc2c(cnn2c1)-c1cc(C)nc2ccccc12 |r|
Show InChI InChI=1S/C28H28N6/c1-18-12-25(24-6-4-5-7-27(24)32-18)26-16-31-33-17-22(15-30-28(26)33)21-8-10-23(11-9-21)34-19(2)13-29-14-20(34)3/h4-12,15-17,19-20,29H,13-14H2,1-3H3/t19-,20+
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n/an/a 4n/an/an/an/a7.5n/a



The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health

US Patent


Assay Description
Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2...

US Patent US9682983 (2017)


BindingDB Entry DOI: 10.7270/Q28S4N3R
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160310
PNG
(US9040691, 38)
Show SMILES CCc1cc(cc(F)c1CO)-c1cc(C2CCCNC2)n2ncnc(N)c12
Show InChI InChI=1S/C20H24FN5O/c1-2-12-6-14(7-17(21)16(12)10-27)15-8-18(13-4-3-5-23-9-13)26-19(15)20(22)24-11-25-26/h6-8,11,13,23,27H,2-5,9-10H2,1H3,(H2,22,24,25)
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n/an/a 4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
ALKl (Invitrogen, Carlsbad, CA, USA) kinase activity was measured at ProQinase GmbH ( Freiburg. Germany) in a radiometric assay using gamma-33P-ATP a...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160303
PNG
(US9040691, 31)
Show SMILES Cc1cc(cc(F)c1CO)-c1cc(C2CCCNC2)n2ncnc(N)c12
Show InChI InChI=1S/C19H22FN5O/c1-11-5-13(6-16(20)15(11)9-26)14-7-17(12-3-2-4-22-8-12)25-18(14)19(21)23-10-24-25/h5-7,10,12,22,26H,2-4,8-9H2,1H3,(H2,21,23,24)
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n/an/a 4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160304
PNG
(US9040691, 32)
Show SMILES Cc1cc(cc(F)c1CO)-c1cc(C2CCNC2)n2ncnc(N)c12
Show InChI InChI=1S/C18H20FN5O/c1-10-4-12(5-15(19)14(10)8-25)13-6-16(11-2-3-21-7-11)24-17(13)18(20)22-9-23-24/h4-6,9,11,21,25H,2-3,7-8H2,1H3,(H2,20,22,23)
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n/an/a 4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160285
PNG
(US9040691, 13)
Show SMILES Cc1nc(cs1)-c1cc(-c2ccc(CO)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C17H15N5OS/c1-10-21-14(8-24-10)15-6-13(12-4-2-11(7-23)3-5-12)16-17(18)19-9-20-22(15)16/h2-6,8-9,23H,7H2,1H3,(H2,18,19,20)
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n/an/a 4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160306
PNG
(US9040691, 34)
Show SMILES NCc1nc(cs1)-c1cc(-c2cc(F)c(CO)c(F)c2)c2c(N)ncnn12
Show InChI InChI=1S/C17H14F2N6OS/c18-11-1-8(2-12(19)10(11)5-26)9-3-14(13-6-27-15(4-20)24-13)25-16(9)17(21)22-7-23-25/h1-3,6-7,26H,4-5,20H2,(H2,21,22,23)
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n/an/a 4.10n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160280
PNG
(US9040691, 35 | US9040691, 36 | US9040691, 8)
Show SMILES Nc1ncnn2c(cc(-c3cc(F)c(CO)c(F)c3)c12)C1CCNC1
Show InChI InChI=1S/C17H17F2N5O/c18-13-3-10(4-14(19)12(13)7-25)11-5-15(9-1-2-21-6-9)24-16(11)17(20)22-8-23-24/h3-5,8-9,21,25H,1-2,6-7H2,(H2,20,22,23)
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n/an/a 4.40n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM130912
PNG
(US8822500, [1])
Show SMILES C[C@@H](Cc1c(F)c(F)cc(F)c1F)Nc1cc[nH]c(=O)c1-c1nc2cc3C(=O)N(CCN(C)C)Cc3cc2[nH]1 |r|
Show InChI InChI=1S/C27H27F4N6O2/c1-13(8-16-23(30)17(28)11-18(29)24(16)31)33-19-4-5-32-26(38)22(19)25-34-20-9-14-12-37(7-6-36(2)3)27(39)15(14)10-21(20)35-25/h4-5,9-11,13,34-35H,6-8,12H2,1-3H3,(H2,32,33,38)/t13-/m0/s1
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n/an/a 4.70n/an/an/an/a7.5n/a



Chembridge Corporation

US Patent


Assay Description
Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...

US Patent US8822500 (2014)


BindingDB Entry DOI: 10.7270/Q2319TKV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM50560477
PNG
(CHEMBL4742906)
Show SMILES Cc1cc(-c2cnc3cc(ccn23)-c2ccc(cc2)C2CNCCN2)c2ccccc2n1
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n/an/a<5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human ALK1 using casein as substrate by [gamma-33P]-ATP assay

Citation and Details

Article DOI: 10.1016/j.bmcl.2020.127418
BindingDB Entry DOI: 10.7270/Q2WW7NDJ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160286
PNG
(US9040691, 14)
Show SMILES Cc1nc(cs1)-c1cc(-c2cc(F)c(CO)c(F)c2)c2c(N)ncnn12
Show InChI InChI=1S/C17H13F2N5OS/c1-8-23-14(6-26-8)15-4-10(16-17(20)21-7-22-24(15)16)9-2-12(18)11(5-25)13(19)3-9/h2-4,6-7,25H,5H2,1H3,(H2,20,21,22)
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n/an/a 5.30n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160281
PNG
(US9040691, 9)
Show SMILES Nc1ncnn2c(cc(-c3cc(F)c(CO)c(F)c3)c12)C1(O)CCCNC1
Show InChI InChI=1S/C18H19F2N5O2/c19-13-4-10(5-14(20)12(13)7-26)11-6-15(18(27)2-1-3-22-8-18)25-16(11)17(21)23-9-24-25/h4-6,9,22,26-27H,1-3,7-8H2,(H2,21,23,24)
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n/an/a 5.70n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160311
PNG
(US9040691, 39)
Show SMILES CCc1cc(cc(F)c1CO)-c1cc(C(O)C2CC2)n2ncnc(N)c12
Show InChI InChI=1S/C19H21FN4O2/c1-2-10-5-12(6-15(20)14(10)8-25)13-7-16(18(26)11-3-4-11)24-17(13)19(21)22-9-23-24/h5-7,9,11,18,25-26H,2-4,8H2,1H3,(H2,21,22,23)
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n/an/a 5.70n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
ALKl (Invitrogen, Carlsbad, CA, USA) kinase activity was measured at ProQinase GmbH ( Freiburg. Germany) in a radiometric assay using gamma-33P-ATP a...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM111123
PNG
(US10017516, Compound 2 | US9682983, 2)
Show SMILES C[C@H]1CNC[C@@H](C)N1c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 |r|
Show InChI InChI=1S/C27H26N6/c1-18-13-28-14-19(2)33(18)22-9-7-20(8-10-22)21-15-30-27-25(16-31-32(27)17-21)23-11-12-29-26-6-4-3-5-24(23)26/h3-12,15-19,28H,13-14H2,1-2H3/t18-,19+
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n/an/a 5.80n/an/an/an/a7.5n/a



The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health

US Patent


Assay Description
Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2...

US Patent US9682983 (2017)


BindingDB Entry DOI: 10.7270/Q28S4N3R
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM111123
PNG
(US10017516, Compound 2 | US9682983, 2)
Show SMILES C[C@H]1CNC[C@@H](C)N1c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 |r|
Show InChI InChI=1S/C27H26N6/c1-18-13-28-14-19(2)33(18)22-9-7-20(8-10-22)21-15-30-27-25(16-31-32(27)17-21)23-11-12-29-26-6-4-3-5-24(23)26/h3-12,15-19,28H,13-14H2,1-2H3/t18-,19+
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n/an/a 5.80n/an/an/an/an/an/a



The Brigham and Women's Hospital, Inc.

US Patent


Assay Description
Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ...

US Patent US10017516 (2018)


BindingDB Entry DOI: 10.7270/Q20P12CN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160284
PNG
(US9040691, 12)
Show SMILES Nc1ncnn2c(cc(-c3cc(F)c(CO)c(F)c3)c12)[C@H]1CCCNC1 |r|
Show InChI InChI=1S/C18H19F2N5O/c19-14-4-11(5-15(20)13(14)8-26)12-6-16(10-2-1-3-22-7-10)25-17(12)18(21)23-9-24-25/h4-6,9-10,22,26H,1-3,7-8H2,(H2,21,23,24)/t10-/m0/s1
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n/an/a 5.90n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM518186
PNG
(US11111247, Example 17)
Show SMILES COC(=O)N1C[C@H](C)N([C@H](C)C1)c1ncc2[nH]nc(-c3ccc(nc3)N3CCN[C@H](C)C3)c2n1 |r|
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n/an/a 5.90n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acsmedchemlett.2c00206
BindingDB Entry DOI: 10.7270/Q2R78K72
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160279
PNG
(US9040691, 7)
Show SMILES Nc1ncnn2c(cc(-c3cc(F)c(CO)c(F)c3)c12)[C@H]1CC[C@H](O)CC1 |r,wU:20.22,wD:23.26,(2.62,2.54,;2.62,1,;3.95,.23,;3.95,-1.31,;2.62,-2.08,;1.28,-1.31,;-.18,-1.79,;-1.09,-.54,;-.18,.7,;-.58,2.19,;-2.07,2.59,;-2.46,4.08,;-3.95,4.47,;-1.38,5.16,;-1.77,6.65,;-.69,7.74,;.11,4.77,;1.2,5.85,;.51,3.28,;1.28,.23,;-.58,-3.28,;.51,-4.37,;.11,-5.85,;-1.38,-6.25,;-1.77,-7.74,;-2.46,-5.16,;-2.07,-3.68,)|
Show InChI InChI=1S/C19H20F2N4O2/c20-15-5-11(6-16(21)14(15)8-26)13-7-17(10-1-3-12(27)4-2-10)25-18(13)19(22)23-9-24-25/h5-7,9-10,12,26-27H,1-4,8H2,(H2,22,23,24)/t10-,12-
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US Patent
n/an/a 6.70n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
ALKl (Invitrogen, Carlsbad, CA, USA) kinase activity was measured at ProQinase GmbH ( Freiburg. Germany) in a radiometric assay using gamma-33P-ATP a...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160280
PNG
(US9040691, 35 | US9040691, 36 | US9040691, 8)
Show SMILES Nc1ncnn2c(cc(-c3cc(F)c(CO)c(F)c3)c12)C1CCNC1
Show InChI InChI=1S/C17H17F2N5O/c18-13-3-10(4-14(19)12(13)7-25)11-5-15(9-1-2-21-6-9)24-16(11)17(20)22-8-23-24/h3-5,8-9,21,25H,1-2,6-7H2,(H2,20,22,23)
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n/an/a 6.90n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
ALKl (Invitrogen, Carlsbad, CA, USA) kinase activity was measured at ProQinase GmbH ( Freiburg. Germany) in a radiometric assay using gamma-33P-ATP a...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM160282
PNG
(US9040691, 10)
Show SMILES Nc1ncnn2c(cc(-c3ccc(CO)cc3)c12)C1CCNCC1
Show InChI InChI=1S/C18H21N5O/c19-18-17-15(13-3-1-12(10-24)2-4-13)9-16(23(17)22-11-21-18)14-5-7-20-8-6-14/h1-4,9,11,14,20,24H,5-8,10H2,(H2,19,21,22)
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n/an/a 8n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...

US Patent US9040691 (2015)


BindingDB Entry DOI: 10.7270/Q25H7F1T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM130919
PNG
(US8822500, [18])
Show SMILES CC(Cc1cc(F)ccc1F)Nc1cc[nH]c(=O)c1-c1nc2cc3CN(CCN(C)C)C(=O)c3cc2[nH]1
Show InChI InChI=1S/C27H28F2N6O2/c1-15(10-16-11-18(28)4-5-20(16)29)31-21-6-7-30-26(36)24(21)25-32-22-12-17-14-35(9-8-34(2)3)27(37)19(17)13-23(22)33-25/h4-7,11-13,15H,8-10,14H2,1-3H3,(H,32,33)(H2,30,31,36)
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n/an/a 9.16n/an/an/an/a7.5n/a



Chembridge Corporation

US Patent


Assay Description
Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...

US Patent US8822500 (2014)


BindingDB Entry DOI: 10.7270/Q2319TKV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM130910
PNG
(US8822500, [4])
Show SMILES C[C@@H](Cc1c(F)c(F)cc(F)c1F)Nc1cc[nH]c(=O)c1-c1nc2cc3C(=O)N(Cc3cc2[nH]1)C1CCN(C)CC1 |r|
Show InChI InChI=1S/C29H29F4N6O2/c1-14(9-18-25(32)19(30)12-20(31)26(18)33)35-21-3-6-34-28(40)24(21)27-36-22-10-15-13-39(16-4-7-38(2)8-5-16)29(41)17(15)11-23(22)37-27/h3,6,10-12,14,16,36-37H,4-5,7-9,13H2,1-2H3,(H2,34,35,40)/t14-/m0/s1
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n/an/a 9.81n/an/an/an/a7.5n/a



Chembridge Corporation

US Patent


Assay Description
Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...

US Patent US8822500 (2014)


BindingDB Entry DOI: 10.7270/Q2319TKV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM518194
PNG
(US11111247, Example 24)
Show SMILES COC(=O)N1C[C@H](C)N([C@H](C)C1)c1ncc2[nH]nc(-c3ccc(nc3)N3CCN(C)CC3)c2n1 |r|
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n/an/a 10n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acsmedchemlett.2c00206
BindingDB Entry DOI: 10.7270/Q2R78K72
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM518173
PNG
(US11111247, Example 9)
Show SMILES C[C@@H]1CN(CCN1)c1ccc(cn1)-c1n[nH]c2cnc(nc12)N1[C@@H](C)CN(C[C@H]1C)C(=O)N1CCCC1 |r|
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n/an/a 10n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acsmedchemlett.2c00206
BindingDB Entry DOI: 10.7270/Q2R78K72
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM108945
PNG
(US10017516, Compound 48 | US9682983, 48)
Show SMILES C1CC(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12
Show InChI InChI=1S/C26H23N5/c1-2-4-25-23(3-1)22(11-14-28-25)24-16-30-31-17-21(15-29-26(24)31)19-7-5-18(6-8-19)20-9-12-27-13-10-20/h1-8,11,14-17,20,27H,9-10,12-13H2
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n/an/a 11n/an/an/an/an/an/a



The Brigham and Women's Hospital, Inc.

US Patent


Assay Description
Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ...

US Patent US10017516 (2018)


BindingDB Entry DOI: 10.7270/Q20P12CN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM50596220
PNG
(CHEMBL5205781)
Show SMILES Nc1ncc(-c2cnn(c2)C2CCCNC2)c2CCN(C3CCCCC3)C(=O)c12
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n/an/a 11n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128452
BindingDB Entry DOI: 10.7270/Q2JS9VGJ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM50262079
PNG
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12
Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2
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n/an/a 11n/an/an/an/an/an/a



Korea University

Curated by ChEMBL


Assay Description
Inhibition of human ALK1 using casein as substrate in presence of 10 uM ATP by radiometric kinase assay

J Med Chem 60: 1495-1508 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01679
BindingDB Entry DOI: 10.7270/Q2TQ63S4
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))		BDBM108945
PNG
(US10017516, Compound 48 | US9682983, 48)
Show SMILES C1CC(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12
Show InChI InChI=1S/C26H23N5/c1-2-4-25-23(3-1)22(11-14-28-25)24-16-30-31-17-21(15-29-26(24)31)19-7-5-18(6-8-19)20-9-12-27-13-10-20/h1-8,11,14-17,20,27H,9-10,12-13H2
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n/an/a 11n/an/an/an/a7.5n/a



The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health

US Patent


Assay Description
Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2...

US Patent US9682983 (2017)


BindingDB Entry DOI: 10.7270/Q28S4N3R
More data for this
Ligand-Target Pair
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