Compile Data Set for Download or QSAR

Found 19 hits of ec50 for UniProtKB: Q16620   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50565738 (CHEMBL4794404) Show SMILES CN1CCN(CC(=O)Nc2nc(C)c(s2)-c2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)CC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	69	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of TEL fused wild type TRKB (unknown origin) transfected in mouse BaF3 cells assessed as reduction in phosphorylation at Y515 residue afte...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112744 BindingDB Entry DOI: 10.7270/Q20V8HJN
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50508282 (CHEMBL4471556) Show SMILES COc1ccc(cc1)-c1cc2cccc(O)c2c(=O)o1 Show InChI InChI=1S/C16H12O4/c1-19-12-7-5-10(6-8-12)14-9-11-3-2-4-13(17)15(11)16(18)20-14/h2-9,17H,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	87	n/a	n/a	n/a	n/a
Indian Institute of Technology Madras Curated by ChEMBL					Assay Description Agonist activity at EGFP-fused TrkB receptor (unknown origin) expressed in HEK293T cells after 6 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 29: 585-590 (2019) Article DOI: 10.1016/j.bmcl.2018.12.057 BindingDB Entry DOI: 10.7270/Q2542RVM
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50073587 (CHEMBL3408947 | US10358436, Example A185 | US20230...) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6C[C@H](C)O[C@H](C)C6)cc5)n[nH]c4c3)c2c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	88	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of TRKB (unknown origin) by cell-based assay				J Med Chem 58: 147-69 (2015) Article DOI: 10.1021/jm5005336 BindingDB Entry DOI: 10.7270/Q2M0475V
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50073587 (CHEMBL3408947 | US10358436, Example A185 | US20230...) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6C[C@H](C)O[C@H](C)C6)cc5)n[nH]c4c3)c2c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	88	n/a	n/a	n/a	n/a
Zhengzhou University Curated by ChEMBL					Assay Description Inhibition of TRKB (unknown origin)				Eur J Med Chem 95: 35-40 (2015) Article DOI: 10.1016/j.ejmech.2015.03.020 BindingDB Entry DOI: 10.7270/Q2NG4SBV
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50505011 (CHEMBL4529332) Show SMILES COCCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccc(C)cc2)c1=O Show InChI InChI=1S/C25H23N3O6/c1-17-8-10-18(11-9-17)27-23(29)26-24(30)28(25(27)31)19-12-13-21(22(16-19)33-15-14-32-2)34-20-6-4-3-5-7-20/h3-13,16H,14-15H2,1-2H3,(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkB (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of BDNF by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50505017 (CHEMBL4462161) Show SMILES COCCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2cccc(C)c2)c1=O Show InChI InChI=1S/C25H23N3O6/c1-17-7-6-8-18(15-17)27-23(29)26-24(30)28(25(27)31)19-11-12-21(22(16-19)33-14-13-32-2)34-20-9-4-3-5-10-20/h3-12,15-16H,13-14H2,1-2H3,(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkB (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of BDNF by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50505010 (CHEMBL4455143) Show SMILES COCCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2cccc(Cl)c2)c1=O Show InChI InChI=1S/C24H20ClN3O6/c1-32-12-13-33-21-15-18(10-11-20(21)34-19-8-3-2-4-9-19)28-23(30)26-22(29)27(24(28)31)17-7-5-6-16(25)14-17/h2-11,14-15H,12-13H2,1H3,(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	230	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkB (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of BDNF by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50505015 (CHEMBL4538772) Show SMILES Brc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C21H14BrN3O4/c22-17-13-15(11-12-18(17)29-16-9-5-2-6-10-16)25-20(27)23-19(26)24(21(25)28)14-7-3-1-4-8-14/h1-13H,(H,23,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkB (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of BDNF by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50505006 (CHEMBL4483402) Show SMILES COc1cc(Oc2ccccc2)ccc1-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O |(72.02,-7.51,;73.36,-8.28,;73.36,-9.82,;72.02,-10.6,;72.03,-12.14,;70.69,-12.91,;69.36,-12.15,;69.36,-10.61,;68.02,-9.84,;66.69,-10.61,;66.7,-12.16,;68.03,-12.92,;73.37,-12.91,;74.7,-12.13,;74.69,-10.6,;76.02,-9.82,;77.36,-10.59,;77.36,-12.13,;78.69,-9.82,;78.69,-8.28,;80.02,-7.52,;77.36,-7.5,;77.36,-5.96,;78.69,-5.19,;78.69,-3.65,;77.36,-2.88,;76.02,-3.66,;76.03,-5.2,;76.02,-8.28,;74.69,-7.52,)| Show InChI InChI=1S/C22H17N3O5/c1-29-19-14-17(30-16-10-6-3-7-11-16)12-13-18(19)25-21(27)23-20(26)24(22(25)28)15-8-4-2-5-9-15/h2-14H,1H3,(H,23,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	270	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkB (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of BDNF by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50505012 (CHEMBL4472787) Show SMILES CC(C)Oc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C24H21N3O5/c1-16(2)31-21-15-18(13-14-20(21)32-19-11-7-4-8-12-19)27-23(29)25-22(28)26(24(27)30)17-9-5-3-6-10-17/h3-16H,1-2H3,(H,25,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	370	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkB (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of BDNF by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50505016 (CHEMBL4527488) Show SMILES CCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C23H19N3O5/c1-2-30-20-15-17(13-14-19(20)31-18-11-7-4-8-12-18)26-22(28)24-21(27)25(23(26)29)16-9-5-3-6-10-16/h3-15H,2H2,1H3,(H,24,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	370	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkB (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of BDNF by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50505007 (CHEMBL4464037) Show SMILES Cc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C22H17N3O4/c1-15-14-17(12-13-19(15)29-18-10-6-3-7-11-18)25-21(27)23-20(26)24(22(25)28)16-8-4-2-5-9-16/h2-14H,1H3,(H,23,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	390	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkB (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of BDNF by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50505018 (CHEMBL4464173) Show SMILES COc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C22H17N3O5/c1-29-19-14-16(12-13-18(19)30-17-10-6-3-7-11-17)25-21(27)23-20(26)24(22(25)28)15-8-4-2-5-9-15/h2-14H,1H3,(H,23,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	450	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkB (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of BDNF by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50505005 (CHEMBL4455810) Show SMILES COCCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccc(Cl)cc2)c1=O Show InChI InChI=1S/C24H20ClN3O6/c1-32-13-14-33-21-15-18(11-12-20(21)34-19-5-3-2-4-6-19)28-23(30)26-22(29)27(24(28)31)17-9-7-16(25)8-10-17/h2-12,15H,13-14H2,1H3,(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	460	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkB (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of BDNF by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50505013 (CHEMBL4574315) Show SMILES Cn1c(=O)[nH]c(=O)n(-c2ccc(Oc3ccccc3)c(OCC3COC3)c2)c1=O Show InChI InChI=1S/C20H19N3O6/c1-22-18(24)21-19(25)23(20(22)26)14-7-8-16(29-15-5-3-2-4-6-15)17(9-14)28-12-13-10-27-11-13/h2-9,13H,10-12H2,1H3,(H,21,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	610	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkB (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of BDNF by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50505014 (CHEMBL4467829) Show SMILES O=c1[nH]c(=O)n(-c2ccc(Oc3ccccc3)c(OC3CCOC3)c2)c(=O)n1-c1ccccc1 Show InChI InChI=1S/C25H21N3O6/c29-23-26-24(30)28(25(31)27(23)17-7-3-1-4-8-17)18-11-12-21(33-19-9-5-2-6-10-19)22(15-18)34-20-13-14-32-16-20/h1-12,15,20H,13-14,16H2,(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkB (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of BDNF by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50505019 (CHEMBL4465865) Show SMILES O=c1[nH]c(=O)n(-c2ccc(Oc3ccccc3)c(OCC3COC3)c2)c(=O)n1-c1ccccc1 Show InChI InChI=1S/C25H21N3O6/c29-23-26-24(30)28(25(31)27(23)18-7-3-1-4-8-18)19-11-12-21(34-20-9-5-2-6-10-20)22(13-19)33-16-17-14-32-15-17/h1-13,17H,14-16H2,(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	790	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkB (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of BDNF by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50505008 (CHEMBL4518577) Show SMILES COc1cccc(c1)-n1c(=O)[nH]c(=O)n(-c2ccc(Oc3ccccc3)cc2)c1=O Show InChI InChI=1S/C22H17N3O5/c1-29-19-9-5-6-16(14-19)25-21(27)23-20(26)24(22(25)28)15-10-12-18(13-11-15)30-17-7-3-2-4-8-17/h2-14H,1H3,(H,23,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	950	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkB (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of BDNF by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50505009 (CHEMBL4542212) Show SMILES O=c1[nH]c(=O)n(-c2ccc(Oc3ccccc3)cc2)c(=O)n1-c1ccccc1 Show InChI InChI=1S/C21H15N3O4/c25-19-22-20(26)24(21(27)23(19)15-7-3-1-4-8-15)16-11-13-18(14-12-16)28-17-9-5-2-6-10-17/h1-14H,(H,22,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkB (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of BDNF by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair