Found 44 hits of ic50 for UniProtKB: Q13324 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM581978
(DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2 (hUcn...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(N)=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| WIPO WO2023285347
| n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Receptor SPA binding assays were performed in white 96-well plates in a total volume of 200 mI per well. Freeze dried analogues were dissolved in 80%... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q23B63Z2 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026978
(CHEMBL2368116)Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@H]([C@H](C)CC)C(N)=O Show InChI InChI=1S/C181H305N49O54/c1-27-31-47-105(201-149(256)106(48-35-39-68-182)202-153(260)110(52-43-72-195-178(190)191)206-166(273)123(78-94(13)14)225-176(283)180(25,85-95(15)16)229-172(279)125(80-104-87-194-89-197-104)221-167(274)124(79-103-45-33-32-34-46-103)220-171(278)130(88-231)224-165(272)122(77-93(11)12)219-170(277)128(83-140(248)249)200-102(24)232)160(267)226-143(98(20)29-3)175(282)214-118(60-67-139(246)247)161(268)227-144(99(21)30-4)174(281)213-117(59-66-138(244)245)159(266)205-107(49-36-40-69-183)150(257)208-112(54-61-131(186)233)155(262)212-115(57-64-136(240)241)157(264)204-108(50-37-41-70-184)151(258)210-114(56-63-135(238)239)156(263)203-109(51-38-42-71-185)152(259)211-116(58-65-137(242)243)158(265)209-113(55-62-134(236)237)148(255)199-100(22)146(253)198-101(23)147(254)215-126(81-132(187)234)169(276)222-127(82-133(188)235)168(275)207-111(53-44-73-196-179(192)193)154(261)216-119(74-90(5)6)162(269)217-120(75-91(7)8)163(270)218-121(76-92(9)10)164(271)223-129(84-141(250)251)173(280)230-181(26,86-96(17)18)177(284)228-142(145(189)252)97(19)28-2/h32-34,45-46,87,89-101,105-130,142-144,231H,27-31,35-44,47-86,88,182-185H2,1-26H3,(H2,186,233)(H2,187,234)(H2,188,235)(H2,189,252)(H,194,197)(H,198,253)(H,199,255)(H,200,232)(H,201,256)(H,202,260)(H,203,263)(H,204,264)(H,205,266)(H,206,273)(H,207,275)(H,208,257)(H,209,265)(H,210,258)(H,211,259)(H,212,262)(H,213,281)(H,214,282)(H,215,254)(H,216,261)(H,217,269)(H,218,270)(H,219,277)(H,220,278)(H,221,274)(H,222,276)(H,223,271)(H,224,272)(H,225,283)(H,226,267)(H,227,268)(H,228,284)(H,229,279)(H,230,280)(H,236,237)(H,238,239)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H4,190,191,195)(H4,192,193,196)/t97-,98+,99+,100+,101+,105+,106+,107+,108+,109+,110+,111+,112+,113+,114+,115+,116+,117+,118+,119+,120+,121+,122+,123+,124-,125+,126+,127+,128+,129+,130+,142-,143+,144+,180+,181+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026954
(CHEMBL2370929)Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C184H310N50O55/c1-26-30-48-108(206-152(261)109(49-34-39-72-185)207-156(265)114(54-44-77-199-181(193)194)212-170(279)127(82-96(11)12)229-179(288)183(24,88-97(13)14)233-175(284)129(84-107-90-197-92-201-107)225-171(280)128(83-106-46-32-31-33-47-106)224-174(283)133(91-235)228-169(278)126(81-95(9)10)223-173(282)131(86-143(253)254)204-105(23)237)165(274)230-146(100(18)28-3)178(287)220-123(63-71-142(251)252)166(275)231-147(101(19)29-4)177(286)219-122(62-70-141(249)250)163(272)211-110(50-35-40-73-186)153(262)214-117(57-65-135(190)239)159(268)218-120(60-68-139(245)246)161(270)210-111(51-36-41-74-187)154(263)216-119(59-67-138(243)244)160(269)209-112(52-37-42-75-188)155(264)217-121(61-69-140(247)248)162(271)215-118(58-66-137(241)242)151(260)203-102(20)149(258)202-103(21)150(259)205-116(56-64-134(189)238)164(273)226-130(85-136(191)240)172(281)213-115(55-45-78-200-182(195)196)157(266)208-113(53-38-43-76-198-104(22)236)158(267)221-124(79-93(5)6)167(276)222-125(80-94(7)8)168(277)227-132(87-144(255)256)176(285)234-184(25,89-98(15)16)180(289)232-145(148(192)257)99(17)27-2/h31-33,46-47,90,92-103,108-133,145-147,235H,26-30,34-45,48-89,91,185-188H2,1-25H3,(H2,189,238)(H2,190,239)(H2,191,240)(H2,192,257)(H,197,201)(H,198,236)(H,202,258)(H,203,260)(H,204,237)(H,205,259)(H,206,261)(H,207,265)(H,208,266)(H,209,269)(H,210,270)(H,211,272)(H,212,279)(H,213,281)(H,214,262)(H,215,271)(H,216,263)(H,217,264)(H,218,268)(H,219,286)(H,220,287)(H,221,267)(H,222,276)(H,223,282)(H,224,283)(H,225,280)(H,226,273)(H,227,277)(H,228,278)(H,229,288)(H,230,274)(H,231,275)(H,232,289)(H,233,284)(H,234,285)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,193,194,199)(H4,195,196,200)/t99-,100-,101-,102-,103-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128+,129-,130-,131-,132-,133-,145-,146-,147-,183-,184-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026959
(CHEMBL2370916)Show SMILES [#6]-[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6](-[#8])=O)-[#6@@H](-[#6])-[#6]-[#6])-[#6@@H](-[#6])-[#6]-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6@@H](-[#6])-[#6]-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6@@H](-[#6])-[#6]-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@H]-1-[#6]-[#6]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#7])=O)-[#7]-[#6]-1=O)-[#6](=O)-[#7](-[#6])-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6@@H](-[#6])-[#6]-[#6])-[#6](-[#7])=O Show InChI InChI=1S/C211H362N58O66/c1-29-35-50-117(232-174(300)118(51-36-41-78-212)233-178(304)122(56-46-83-228-210(223)224)237-188(314)133(87-102(7)8)250-191(317)136(90-105(13)14)249-185(311)129(66-75-159(286)287)244-189(315)134(88-103(9)10)254-199(325)144(100-270)259-194(320)139(93-108(19)20)253-197(323)142(96-162(292)293)258-205(331)167(112(24)33-5)264-200(326)145(101-271)260-206(332)168(113(25)34-6)265-201(327)146-58-48-86-269(146)209(335)147-59-49-85-268(147)155(279)99-230-172(298)116(216)60-72-156(280)281)186(312)262-165(110(22)31-3)204(330)246-131(68-77-161(290)291)187(313)263-166(111(23)32-4)203(329)245-130(67-76-160(288)289)184(310)236-119(52-37-42-79-213)175(301)240-125(62-70-150(218)274)180(306)243-128(65-74-158(284)285)183(309)235-121(54-39-44-81-215)177(303)242-127(64-73-157(282)283)182(308)234-120(53-38-43-80-214)176(302)241-126-63-71-154(278)227-82-45-40-55-132(247-171(297)114(26)231-173(299)124(239-181(126)307)61-69-149(217)273)208(334)267(28)148(98-153(221)277)202(328)257-141(95-152(220)276)196(322)255-140(94-151(219)275)195(321)238-123(57-47-84-229-211(225)226)179(305)248-135(89-104(11)12)190(316)251-137(91-106(15)16)192(318)252-138(92-107(17)18)193(319)256-143(97-163(294)295)198(324)266-169(115(27)272)207(333)261-164(170(222)296)109(21)30-2/h102-148,164-169,270-272H,29-101,212-216H2,1-28H3,(H2,217,273)(H2,218,274)(H2,219,275)(H2,220,276)(H2,221,277)(H2,222,296)(H,227,278)(H,230,298)(H,231,299)(H,232,300)(H,233,304)(H,234,308)(H,235,309)(H,236,310)(H,237,314)(H,238,321)(H,239,307)(H,240,301)(H,241,302)(H,242,303)(H,243,306)(H,244,315)(H,245,329)(H,246,330)(H,247,297)(H,248,305)(H,249,311)(H,250,317)(H,251,316)(H,252,318)(H,253,323)(H,254,325)(H,255,322)(H,256,319)(H,257,328)(H,258,331)(H,259,320)(H,260,332)(H,261,333)(H,262,312)(H,263,313)(H,264,326)(H,265,327)(H,266,324)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,290,291)(H,292,293)(H,294,295)(H4,223,224,228)(H4,225,226,229)/t109-,110-,111-,112-,113-,114+,115+,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,164-,165-,166-,167-,168-,169-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.570 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM581979
(IVLSLDVPIGLLQILLEQARARAAREQATTNARILARV-NH2(hUcn2) ...)Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(N)=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| WIPO WO2023285347
| n/a | n/a | 0.580 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Receptor SPA binding assays were performed in white 96-well plates in a total volume of 200 mI per well. Freeze dried analogues were dissolved in 80%... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q23B63Z2 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026983
(CHEMBL2370926)Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C185H310N48O56/c1-27-31-48-108(204-153(260)109(49-35-40-71-186)205-157(264)114(54-45-76-199-183(195)196)210-171(278)127(81-97(13)14)228-181(288)184(25,88-98(15)16)232-177(284)129(83-107-90-197-92-200-107)223-172(279)128(82-106-46-33-32-34-47-106)222-176(283)134(91-234)227-170(277)126(80-96(11)12)221-175(282)132(86-145(253)254)202-105(24)236)165(272)229-148(101(20)29-3)180(287)217-122(62-70-144(251)252)166(273)230-149(102(21)30-4)179(286)216-121(61-69-143(249)250)163(270)208-110(50-36-41-72-187)154(261)211-116(56-64-136(191)238)159(266)215-119(59-67-141(245)246)161(268)207-111(51-37-42-73-188)155(262)213-118(58-66-140(243)244)160(267)206-112(52-38-43-74-189)156(263)214-120(60-68-142(247)248)162(269)212-117(57-65-139(241)242)152(259)201-103(22)151(258)203-115(55-63-135(190)237)164(271)224-131(85-138(193)240)174(281)225-130(84-137(192)239)173(280)209-113(53-39-44-75-198-104(23)235)158(265)218-123(77-93(5)6)167(274)219-124(78-94(7)8)168(275)220-125(79-95(9)10)169(276)226-133(87-146(255)256)178(285)233-185(26,89-99(17)18)182(289)231-147(150(194)257)100(19)28-2/h32-34,46-47,90,92-103,108-134,147-149,234H,27-31,35-45,48-89,91,186-189H2,1-26H3,(H2,190,237)(H2,191,238)(H2,192,239)(H2,193,240)(H2,194,257)(H,197,200)(H,198,235)(H,201,259)(H,202,236)(H,203,258)(H,204,260)(H,205,264)(H,206,267)(H,207,268)(H,208,270)(H,209,280)(H,210,278)(H,211,261)(H,212,269)(H,213,262)(H,214,263)(H,215,266)(H,216,286)(H,217,287)(H,218,265)(H,219,274)(H,220,275)(H,221,282)(H,222,283)(H,223,279)(H,224,271)(H,225,281)(H,226,276)(H,227,277)(H,228,288)(H,229,272)(H,230,273)(H,231,289)(H,232,284)(H,233,285)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,195,196,199)/t100-,101-,102-,103-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128+,129-,130-,131-,132-,133-,134-,147-,148-,149-,184-,185-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026976
(CHEMBL2370933)Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C182H305N49O54/c1-25-29-47-106(203-150(257)107(48-33-38-71-183)204-154(261)112(53-43-76-196-179(190)191)209-168(275)125(81-95(11)12)226-177(284)181(23,87-96(13)14)230-173(280)127(83-105-89-194-91-198-105)222-169(276)126(82-104-45-31-30-32-46-104)221-172(279)131(90-232)225-167(274)124(80-94(9)10)220-171(278)129(85-141(249)250)201-103(22)233)163(270)227-144(99(18)27-3)176(283)217-121(62-70-140(247)248)164(271)228-145(100(19)28-4)175(282)216-120(61-69-139(245)246)161(268)208-108(49-34-39-72-184)151(258)211-114(55-63-132(187)234)157(264)215-118(59-67-137(241)242)159(266)207-109(50-35-40-73-185)152(259)213-117(58-66-136(239)240)158(265)206-110(51-36-41-74-186)153(260)214-119(60-68-138(243)244)160(267)212-116(57-65-135(237)238)149(256)200-101(20)147(254)199-102(21)148(255)202-115-56-64-134(236)195-75-42-37-52-111(205-155(262)113(54-44-77-197-180(192)193)210-170(277)128(84-133(188)235)223-162(115)269)156(263)218-122(78-92(5)6)165(272)219-123(79-93(7)8)166(273)224-130(86-142(251)252)174(281)231-182(24,88-97(15)16)178(285)229-143(146(189)253)98(17)26-2/h30-32,45-46,89,91-102,106-131,143-145,232H,25-29,33-44,47-88,90,183-186H2,1-24H3,(H2,187,234)(H2,188,235)(H2,189,253)(H,194,198)(H,195,236)(H,199,254)(H,200,256)(H,201,233)(H,202,255)(H,203,257)(H,204,261)(H,205,262)(H,206,265)(H,207,266)(H,208,268)(H,209,275)(H,210,277)(H,211,258)(H,212,267)(H,213,259)(H,214,260)(H,215,264)(H,216,282)(H,217,283)(H,218,263)(H,219,272)(H,220,278)(H,221,279)(H,222,276)(H,223,269)(H,224,273)(H,225,274)(H,226,284)(H,227,270)(H,228,271)(H,229,285)(H,230,280)(H,231,281)(H,237,238)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H4,190,191,196)(H4,192,193,197)/t98-,99-,100-,101-,102-,106-,107-,108-,109-,110-,111+,112-,113+,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126+,127-,128-,129-,130?,131-,143-,144-,145-,181+,182-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.610 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50370170
(CHEMBL1794009)Show SMILES CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@H](C)CC)C(=O)N[C@@H]([C@H](C)CC)C(N)=O Show InChI InChI=1S/C161H269N49O42/c1-23-27-41-96(189-145(239)107(52-59-123(217)218)199-152(246)114(71-84(13)14)207-157(251)126(85(15)16)208-147(241)108(53-60-124(219)220)197-140(234)102(47-38-66-179-161(172)173)193-151(245)112(69-82(9)10)204-153(247)113(70-83(11)12)205-155(249)116(74-94-77-175-79-181-94)201-134(228)95(163)72-92-39-30-29-31-40-92)135(229)182-88(19)130(224)186-100(45-36-64-177-159(168)169)136(230)183-89(20)131(225)188-106(51-58-122(215)216)144(238)195-104(49-56-119(165)212)146(240)202-110(67-80(5)6)149(243)185-90(21)132(226)187-103(48-55-118(164)211)143(237)196-105-50-57-121(214)176-63-35-33-44-99(192-154(248)115(73-93-76-174-78-180-93)200-133(227)91(22)184-137(105)231)142(236)206-117(75-120(166)213)156(250)194-101(46-37-65-178-160(170)171)139(233)190-98(43-32-34-62-162)141(235)203-111(68-81(7)8)150(244)191-97(42-28-24-2)138(232)198-109(54-61-125(221)222)148(242)210-128(87(18)26-4)158(252)209-127(129(167)223)86(17)25-3/h29-31,39-40,76-91,95-117,126-128H,23-28,32-38,41-75,162-163H2,1-22H3,(H2,164,211)(H2,165,212)(H2,166,213)(H2,167,223)(H,174,180)(H,175,181)(H,176,214)(H,182,229)(H,183,230)(H,184,231)(H,185,243)(H,186,224)(H,187,226)(H,188,225)(H,189,239)(H,190,233)(H,191,244)(H,192,248)(H,193,245)(H,194,250)(H,195,238)(H,196,237)(H,197,234)(H,198,232)(H,199,246)(H,200,227)(H,201,228)(H,202,240)(H,203,235)(H,204,247)(H,205,249)(H,206,236)(H,207,251)(H,208,241)(H,209,252)(H,210,242)(H,215,216)(H,217,218)(H,219,220)(H,221,222)(H4,168,169,177)(H4,170,171,178)(H4,172,173,179)/t86-,87-,88+,89+,90+,91+,95+,96+,97+,98+,99-,100+,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112+,113+,114+,115-,116+,117+,126+,127+,128+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026956
(CHEMBL2370938)Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C185H314N50O53/c1-28-32-50-110(207-153(260)112(51-36-41-72-186)208-157(264)116(56-46-77-200-182(194)195)212-171(278)129(83-98(13)14)230-180(287)184(26,89-99(15)16)234-176(283)131(85-109-91-198-93-202-109)226-172(279)130(84-108-48-34-33-35-49-108)225-175(282)135(92-236)229-170(277)128(82-97(11)12)224-174(281)133(87-144(252)253)205-107(25)238)165(272)231-147(102(20)30-3)179(286)220-124(64-71-143(250)251)166(273)232-148(103(21)31-4)178(285)219-123(63-70-142(248)249)164(271)211-113(52-37-42-73-187)154(261)215-119(59-66-137(191)240)160(267)218-121(61-68-140(244)245)162(269)210-114(53-38-43-74-188)155(262)216-120(60-67-139(242)243)161(268)209-115(54-39-44-75-189)156(263)217-122(62-69-141(246)247)163(270)214-118(58-65-136(190)239)152(259)204-104(22)150(257)203-105(23)151(258)206-111(55-40-45-76-199-106(24)237)158(265)227-132(86-138(192)241)173(280)213-117(57-47-78-201-183(196)197)159(266)221-125(79-94(5)6)167(274)222-126(80-95(7)8)168(275)223-127(81-96(9)10)169(276)228-134(88-145(254)255)177(284)235-185(27,90-100(17)18)181(288)233-146(149(193)256)101(19)29-2/h33-35,48-49,91,93-105,110-135,146-148,236H,28-32,36-47,50-90,92,186-189H2,1-27H3,(H2,190,239)(H2,191,240)(H2,192,241)(H2,193,256)(H,198,202)(H,199,237)(H,203,257)(H,204,259)(H,205,238)(H,206,258)(H,207,260)(H,208,264)(H,209,268)(H,210,269)(H,211,271)(H,212,278)(H,213,280)(H,214,270)(H,215,261)(H,216,262)(H,217,263)(H,218,267)(H,219,285)(H,220,286)(H,221,266)(H,222,274)(H,223,275)(H,224,281)(H,225,282)(H,226,279)(H,227,265)(H,228,276)(H,229,277)(H,230,287)(H,231,272)(H,232,273)(H,233,288)(H,234,283)(H,235,284)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H4,194,195,200)(H4,196,197,201)/t101-,102-,103-,104-,105-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130+,131-,132-,133-,134-,135-,146-,147-,148-,184-,185-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.720 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026982
(CHEMBL2370927)Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C183H307N47O56/c1-26-30-47-106(201-151(257)107(48-34-39-70-184)202-155(261)112(53-44-75-196-181(193)194)207-169(275)125(80-96(13)14)225-179(285)182(24,87-97(15)16)229-175(281)127(82-105-89-195-91-197-105)220-170(276)126(81-104-45-32-31-33-46-104)219-174(280)132(90-231)224-168(274)124(79-95(11)12)218-173(279)130(85-143(250)251)199-103(23)232)163(269)226-146(100(20)28-3)178(284)214-120(61-69-142(248)249)164(270)227-147(101(21)29-4)177(283)213-119(60-68-141(246)247)161(267)205-108(49-35-40-71-185)152(258)208-113(54-62-133(189)233)157(263)212-117(58-66-139(242)243)159(265)204-109(50-36-41-72-186)153(259)210-116(57-65-138(240)241)158(264)203-110(51-37-42-73-187)154(260)211-118(59-67-140(244)245)160(266)209-114(55-63-136(236)237)150(256)198-102(22)149(255)200-115(56-64-137(238)239)162(268)221-129(84-135(191)235)172(278)222-128(83-134(190)234)171(277)206-111(52-38-43-74-188)156(262)215-121(76-92(5)6)165(271)216-122(77-93(7)8)166(272)217-123(78-94(9)10)167(273)223-131(86-144(252)253)176(282)230-183(25,88-98(17)18)180(286)228-145(148(192)254)99(19)27-2/h31-33,45-46,89,91-102,106-132,145-147,231H,26-30,34-44,47-88,90,184-188H2,1-25H3,(H2,189,233)(H2,190,234)(H2,191,235)(H2,192,254)(H,195,197)(H,198,256)(H,199,232)(H,200,255)(H,201,257)(H,202,261)(H,203,264)(H,204,265)(H,205,267)(H,206,277)(H,207,275)(H,208,258)(H,209,266)(H,210,259)(H,211,260)(H,212,263)(H,213,283)(H,214,284)(H,215,262)(H,216,271)(H,217,272)(H,218,279)(H,219,280)(H,220,276)(H,221,268)(H,222,278)(H,223,273)(H,224,274)(H,225,285)(H,226,269)(H,227,270)(H,228,286)(H,229,281)(H,230,282)(H,236,237)(H,238,239)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H4,193,194,196)/t99-,100-,101-,102-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126+,127-,128-,129-,130-,131-,132-,145-,146-,147-,182-,183-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026961
(CHEMBL2370915)Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C170H284N44O49/c1-24-28-45-100(188-141(237)101(46-32-37-68-171)189-145(241)106(51-42-73-183-168(179)180)194-158(254)118(77-90(11)12)209-166(262)169(22,83-91(13)14)213-162(258)120(79-99-85-181-86-184-99)205-159(255)119(186-97(21)215)78-98-43-30-29-31-44-98)153(249)210-136(94(18)26-3)165(261)201-114(59-67-133(230)231)154(250)211-137(95(19)27-4)164(260)200-113(58-66-132(228)229)151(247)192-102(47-33-38-69-172)142(238)195-107(52-60-124(175)216)147(243)199-111(56-64-130(224)225)149(245)191-103(48-34-39-70-173)143(239)197-110(55-63-129(222)223)148(244)190-104(49-35-40-71-174)144(240)198-112(57-65-131(226)227)150(246)196-109(54-62-128(220)221)140(236)185-96(20)139(235)187-108-53-61-127(219)182-72-41-36-50-105(193-160(256)121(80-125(176)217)207-161(257)122(81-126(177)218)206-152(108)248)146(242)202-115(74-87(5)6)155(251)203-116(75-88(7)8)156(252)204-117(76-89(9)10)157(253)208-123(82-134(232)233)163(259)214-170(23,84-92(15)16)167(263)212-135(138(178)234)93(17)25-2/h29-31,43-44,85-96,100-123,135-137H,24-28,32-42,45-84,171-174H2,1-23H3,(H2,175,216)(H2,176,217)(H2,177,218)(H2,178,234)(H,181,184)(H,182,219)(H,185,236)(H,186,215)(H,187,235)(H,188,237)(H,189,241)(H,190,244)(H,191,245)(H,192,247)(H,193,256)(H,194,254)(H,195,238)(H,196,246)(H,197,239)(H,198,240)(H,199,243)(H,200,260)(H,201,261)(H,202,242)(H,203,251)(H,204,252)(H,205,255)(H,206,248)(H,207,257)(H,208,253)(H,209,262)(H,210,249)(H,211,250)(H,212,263)(H,213,258)(H,214,259)(H,220,221)(H,222,223)(H,224,225)(H,226,227)(H,228,229)(H,230,231)(H,232,233)(H4,179,180,183)/t93-,94-,95-,96-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119+,120-,121-,122+,123-,135-,136-,137-,169-,170-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026981
(CHEMBL2370939)Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1CCC(=O)NNC(=O)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C186H312N52O55/c1-27-31-47-107(206-153(264)108(48-35-39-70-187)207-157(268)112(52-43-74-200-183(195)196)211-171(282)126(80-96(13)14)231-181(292)185(25,87-97(15)16)235-177(288)128(82-106-89-199-91-202-106)227-172(283)127(81-105-45-33-32-34-46-105)226-176(287)133(90-239)230-170(281)125(79-95(11)12)225-175(286)131(85-144(256)257)205-104(24)240)165(276)232-147(100(20)29-3)180(291)220-121(61-69-143(254)255)166(277)233-148(101(21)30-4)179(290)219-120(60-68-142(252)253)164(275)210-109(49-36-40-71-188)154(265)213-114(54-62-134(191)241)160(271)218-118(58-66-140(248)249)162(273)209-110(50-37-41-72-189)155(266)216-117(57-65-139(246)247)161(272)208-111(51-38-42-73-190)156(267)217-119(59-67-141(250)251)163(274)214-115(55-63-135(192)242)159(270)215-116-56-64-137(244)237-238-138(245)84-130(221-151(262)103(23)203-150(261)102(22)204-152(116)263)174(285)228-129(83-136(193)243)173(284)212-113(53-44-75-201-184(197)198)158(269)222-122(76-92(5)6)167(278)223-123(77-93(7)8)168(279)224-124(78-94(9)10)169(280)229-132(86-145(258)259)178(289)236-186(26,88-98(17)18)182(293)234-146(149(194)260)99(19)28-2/h32-34,45-46,89,91-103,107-133,146-148,239H,27-31,35-44,47-88,90,187-190H2,1-26H3,(H2,191,241)(H2,192,242)(H2,193,243)(H2,194,260)(H,199,202)(H,203,261)(H,204,263)(H,205,240)(H,206,264)(H,207,268)(H,208,272)(H,209,273)(H,210,275)(H,211,282)(H,212,284)(H,213,265)(H,214,274)(H,215,270)(H,216,266)(H,217,267)(H,218,271)(H,219,290)(H,220,291)(H,221,262)(H,222,269)(H,223,278)(H,224,279)(H,225,286)(H,226,287)(H,227,283)(H,228,285)(H,229,280)(H,230,281)(H,231,292)(H,232,276)(H,233,277)(H,234,293)(H,235,288)(H,236,289)(H,237,244)(H,238,245)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H4,195,196,200)(H4,197,198,201)/t99-,100-,101-,102+,103-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116+,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,146-,147-,148-,185-,186-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026980
(CHEMBL2370940)Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C183H305N47O55/c1-26-30-47-106(201-151(256)107(48-34-39-70-184)202-155(260)112(53-44-75-196-181(192)193)207-169(274)125(80-96(13)14)225-179(284)182(24,87-97(15)16)229-175(280)127(82-105-89-194-91-197-105)220-170(275)126(81-104-45-32-31-33-46-104)219-174(279)132(90-231)224-168(273)124(79-95(11)12)218-173(278)130(85-143(249)250)199-103(23)232)163(268)226-146(100(20)28-3)178(283)214-120(61-69-142(247)248)164(269)227-147(101(21)29-4)177(282)213-119(60-68-141(245)246)161(266)205-108(49-35-40-71-185)152(257)208-113(54-62-133(188)233)157(262)212-117(58-66-139(241)242)159(264)204-109(50-36-41-72-186)153(258)210-116(57-65-138(239)240)158(263)203-110(51-37-42-73-187)154(259)211-118(59-67-140(243)244)160(265)209-115(56-64-137(237)238)150(255)198-102(22)149(254)200-114-55-63-136(236)195-74-43-38-52-111(206-171(276)128(83-134(189)234)222-172(277)129(84-135(190)235)221-162(114)267)156(261)215-121(76-92(5)6)165(270)216-122(77-93(7)8)166(271)217-123(78-94(9)10)167(272)223-131(86-144(251)252)176(281)230-183(25,88-98(17)18)180(285)228-145(148(191)253)99(19)27-2/h31-33,45-46,89,91-102,106-132,145-147,231H,26-30,34-44,47-88,90,184-187H2,1-25H3,(H2,188,233)(H2,189,234)(H2,190,235)(H2,191,253)(H,194,197)(H,195,236)(H,198,255)(H,199,232)(H,200,254)(H,201,256)(H,202,260)(H,203,263)(H,204,264)(H,205,266)(H,206,276)(H,207,274)(H,208,257)(H,209,265)(H,210,258)(H,211,259)(H,212,262)(H,213,282)(H,214,283)(H,215,261)(H,216,270)(H,217,271)(H,218,278)(H,219,279)(H,220,275)(H,221,267)(H,222,277)(H,223,272)(H,224,273)(H,225,284)(H,226,268)(H,227,269)(H,228,285)(H,229,280)(H,230,281)(H,237,238)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H4,192,193,196)/t99-,100-,101-,102-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126+,127-,128-,129+,130-,131-,132-,145-,146-,147-,182-,183-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026946
(CHEMBL2370917)Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C183H307N51O53/c1-26-30-46-105(204-150(258)107(47-34-38-69-184)206-153(261)110(51-42-73-199-180(193)194)209-168(276)124(79-95(13)14)229-178(286)182(24,86-96(15)16)233-174(282)126(81-104-88-197-90-201-104)225-169(277)125(80-103-44-32-31-33-45-103)224-173(281)131(89-235)228-167(275)123(78-94(11)12)223-172(280)129(84-142(251)252)203-102(23)236)162(270)230-145(99(20)28-3)177(285)218-119(60-68-141(249)250)163(271)231-146(100(21)29-4)176(284)217-118(59-67-140(247)248)161(269)208-108(48-35-39-70-185)151(259)211-113(54-62-133(188)238)157(265)216-116(57-65-138(243)244)159(267)207-109(49-36-40-71-186)152(260)215-117(58-66-139(245)246)160(268)214-115-56-64-137(242)198-72-41-37-50-106(205-155(263)112(53-61-132(187)237)212-156(264)114(213-158(115)266)55-63-134(189)239)149(257)202-101(22)148(256)219-127(82-135(190)240)171(279)226-128(83-136(191)241)170(278)210-111(52-43-74-200-181(195)196)154(262)220-120(75-91(5)6)164(272)221-121(76-92(7)8)165(273)222-122(77-93(9)10)166(274)227-130(85-143(253)254)175(283)234-183(25,87-97(17)18)179(287)232-144(147(192)255)98(19)27-2/h31-33,44-45,88,90-101,105-131,144-146,235H,26-30,34-43,46-87,89,184-186H2,1-25H3,(H2,187,237)(H2,188,238)(H2,189,239)(H2,190,240)(H2,191,241)(H2,192,255)(H,197,201)(H,198,242)(H,202,257)(H,203,236)(H,204,258)(H,205,263)(H,206,261)(H,207,267)(H,208,269)(H,209,276)(H,210,278)(H,211,259)(H,212,264)(H,213,266)(H,214,268)(H,215,260)(H,216,265)(H,217,284)(H,218,285)(H,219,256)(H,220,262)(H,221,272)(H,222,273)(H,223,280)(H,224,281)(H,225,277)(H,226,279)(H,227,274)(H,228,275)(H,229,286)(H,230,270)(H,231,271)(H,232,287)(H,233,282)(H,234,283)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H4,193,194,199)(H4,195,196,200)/t98-,99-,100-,101-,105-,106+,107-,108-,109-,110-,111-,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125+,126-,127-,128-,129-,130-,131-,144-,145-,146-,182-,183-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50158983
(CHEMBL439883 | E G P P I S I D L S L E L L R K M I...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O Show InChI InChI=1S/C202H345N55O64S/c1-29-103(20)156(250-178(298)125(62-71-153(276)277)236-195(315)157(104(21)30-2)251-179(299)126(72-81-322-28)234-169(289)114(49-37-41-76-206)222-170(290)115(50-42-77-216-201(212)213)226-180(300)127(82-96(6)7)240-183(303)130(85-99(12)13)239-177(297)123(60-69-151(272)273)233-181(301)128(83-97(8)9)244-191(311)138(94-258)248-186(306)133(88-102(18)19)243-189(309)136(91-154(278)279)247-196(316)158(105(22)31-3)252-192(312)139(95-259)249-197(317)159(106(23)32-4)253-193(313)140-52-44-80-257(140)199(319)141-53-45-79-256(141)148(267)93-218-164(284)117-57-66-147(266)221-117)194(314)235-124(61-70-152(274)275)176(296)225-112(47-35-39-74-204)167(287)230-120(56-65-144(209)263)173(293)232-122(59-68-150(270)271)175(295)224-113(48-36-40-75-205)168(288)231-121(58-67-149(268)269)174(294)223-111(46-34-38-73-203)166(286)229-119(55-64-143(208)262)172(292)228-118(54-63-142(207)261)165(285)220-108(25)162(282)219-109(26)163(283)237-134(89-145(210)264)188(308)245-135(90-146(211)265)187(307)227-116(51-43-78-217-202(214)215)171(291)238-129(84-98(10)11)182(302)241-131(86-100(14)15)184(304)242-132(87-101(16)17)185(305)246-137(92-155(280)281)190(310)255-161(110(27)260)198(318)254-160(200(320)321)107(24)33-5/h96-141,156-161,258-260H,29-95,203-206H2,1-28H3,(H2,207,261)(H2,208,262)(H2,209,263)(H2,210,264)(H2,211,265)(H,218,284)(H,219,282)(H,220,285)(H,221,266)(H,222,290)(H,223,294)(H,224,295)(H,225,296)(H,226,300)(H,227,307)(H,228,292)(H,229,286)(H,230,287)(H,231,288)(H,232,293)(H,233,301)(H,234,289)(H,235,314)(H,236,315)(H,237,283)(H,238,291)(H,239,297)(H,240,303)(H,241,302)(H,242,304)(H,243,309)(H,244,311)(H,245,308)(H,246,305)(H,247,316)(H,248,306)(H,249,317)(H,250,298)(H,251,299)(H,252,312)(H,253,313)(H,254,318)(H,255,310)(H,268,269)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,212,213,216)(H4,214,215,217)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-,161-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026965
(CHEMBL2370914)Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C170H286N44O50/c1-24-28-45-100(188-141(238)101(46-32-37-68-171)189-145(242)106(51-42-73-183-168(180)181)194-158(255)118(77-90(11)12)209-166(263)169(22,83-91(13)14)213-162(259)120(79-99-85-182-86-184-99)205-159(256)119(186-97(21)215)78-98-43-30-29-31-44-98)153(250)210-136(94(18)26-3)165(262)201-114(59-67-133(231)232)154(251)211-137(95(19)27-4)164(261)200-113(58-66-132(229)230)151(248)192-102(47-33-38-69-172)142(239)195-107(52-60-124(176)216)147(244)199-111(56-64-130(225)226)149(246)191-103(48-34-39-70-173)143(240)197-110(55-63-129(223)224)148(245)190-104(49-35-40-71-174)144(241)198-112(57-65-131(227)228)150(247)196-108(53-61-127(219)220)140(237)185-96(20)139(236)187-109(54-62-128(221)222)152(249)206-122(81-126(178)218)161(258)207-121(80-125(177)217)160(257)193-105(50-36-41-72-175)146(243)202-115(74-87(5)6)155(252)203-116(75-88(7)8)156(253)204-117(76-89(9)10)157(254)208-123(82-134(233)234)163(260)214-170(23,84-92(15)16)167(264)212-135(138(179)235)93(17)25-2/h29-31,43-44,85-96,100-123,135-137H,24-28,32-42,45-84,171-175H2,1-23H3,(H2,176,216)(H2,177,217)(H2,178,218)(H2,179,235)(H,182,184)(H,185,237)(H,186,215)(H,187,236)(H,188,238)(H,189,242)(H,190,245)(H,191,246)(H,192,248)(H,193,257)(H,194,255)(H,195,239)(H,196,247)(H,197,240)(H,198,241)(H,199,244)(H,200,261)(H,201,262)(H,202,243)(H,203,252)(H,204,253)(H,205,256)(H,206,249)(H,207,258)(H,208,254)(H,209,263)(H,210,250)(H,211,251)(H,212,264)(H,213,259)(H,214,260)(H,219,220)(H,221,222)(H,223,224)(H,225,226)(H,227,228)(H,229,230)(H,231,232)(H,233,234)(H4,180,181,183)/t93-,94-,95-,96-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119+,120-,121-,122-,123-,135-,136-,137-,169-,170-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026984
(CHEMBL2369694)Show SMILES CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](C)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C159H266N48O42/c1-23-27-41-95(186-142(235)105(51-57-121(214)215)195-149(242)112(69-83(13)14)203-155(248)124(84(15)16)205-144(237)106(52-58-122(216)217)193-139(232)101(47-38-64-176-159(169)170)189-148(241)110(67-81(9)10)200-150(243)111(68-82(11)12)201-151(244)114(72-93-75-172-78-178-93)197-132(225)94(161)70-91-39-30-29-31-40-91)133(226)179-87(19)128(221)184-99(45-36-62-174-157(165)166)134(227)180-88(20)130(223)185-104(50-56-120(212)213)141(234)192-103-49-55-119(211)173-61-35-33-44-97(183-129(222)89(21)182-146(239)108(65-79(5)6)198-143(103)236)137(230)191-102(48-54-117(162)209)135(228)181-90(22)131(224)196-113(71-92-74-171-77-177-92)152(245)204-116(76-208)154(247)202-115(73-118(163)210)153(246)190-100(46-37-63-175-158(167)168)138(231)187-98(43-32-34-60-160)140(233)199-109(66-80(7)8)147(240)188-96(42-28-24-2)136(229)194-107(53-59-123(218)219)145(238)207-126(86(18)26-4)156(249)206-125(127(164)220)85(17)25-3/h29-31,39-40,74-75,77-90,94-116,124-126,208H,23-28,32-38,41-73,76,160-161H2,1-22H3,(H2,162,209)(H2,163,210)(H2,164,220)(H,171,177)(H,172,178)(H,173,211)(H,179,226)(H,180,227)(H,181,228)(H,182,239)(H,183,222)(H,184,221)(H,185,223)(H,186,235)(H,187,231)(H,188,240)(H,189,241)(H,190,246)(H,191,230)(H,192,234)(H,193,232)(H,194,229)(H,195,242)(H,196,224)(H,197,225)(H,198,236)(H,199,233)(H,200,243)(H,201,244)(H,202,247)(H,203,248)(H,204,245)(H,205,237)(H,206,249)(H,207,238)(H,212,213)(H,214,215)(H,216,217)(H,218,219)(H4,165,166,174)(H4,167,168,175)(H4,169,170,176)/t85-,86-,87-,88-,89+,90-,94+,95-,96-,97+,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,124-,125-,126-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026950
(CHEMBL2369741)Show SMILES CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](C)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C158H267N47O43/c1-23-27-41-93(185-142(235)104(52-59-120(213)214)194-149(242)111(71-82(13)14)201-154(247)123(83(15)16)203-144(237)105(53-60-121(215)216)192-137(230)99(47-38-66-175-158(169)170)188-148(241)109(69-80(9)10)198-150(243)110(70-81(11)12)199-151(244)112(73-91-75-171-77-176-91)195-131(224)92(160)72-90-39-30-29-31-40-90)132(225)177-86(19)128(221)182-97(45-36-64-173-156(165)166)133(226)178-88(21)129(222)184-103(51-58-119(211)212)141(234)191-101(49-56-116(162)208)143(236)196-107(67-78(5)6)146(239)180-89(22)130(223)183-102-50-57-118(210)172-63-35-33-44-95(181-127(220)87(20)179-134(227)100(190-140(102)233)48-55-115(161)207)139(232)202-114(76-206)153(246)200-113(74-117(163)209)152(245)189-98(46-37-65-174-157(167)168)136(229)186-96(43-32-34-62-159)138(231)197-108(68-79(7)8)147(240)187-94(42-28-24-2)135(228)193-106(54-61-122(217)218)145(238)205-125(85(18)26-4)155(248)204-124(126(164)219)84(17)25-3/h29-31,39-40,75,77-89,92-114,123-125,206H,23-28,32-38,41-74,76,159-160H2,1-22H3,(H2,161,207)(H2,162,208)(H2,163,209)(H2,164,219)(H,171,176)(H,172,210)(H,177,225)(H,178,226)(H,179,227)(H,180,239)(H,181,220)(H,182,221)(H,183,223)(H,184,222)(H,185,235)(H,186,229)(H,187,240)(H,188,241)(H,189,245)(H,190,233)(H,191,234)(H,192,230)(H,193,228)(H,194,242)(H,195,224)(H,196,236)(H,197,231)(H,198,243)(H,199,244)(H,200,246)(H,201,247)(H,202,232)(H,203,237)(H,204,248)(H,205,238)(H,211,212)(H,213,214)(H,215,216)(H,217,218)(H4,165,166,173)(H4,167,168,174)(H4,169,170,175)/t84-,85-,86-,87+,88-,89-,92+,93-,94-,95+,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-,124-,125-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026977
(CHEMBL2370931)Show SMILES CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NC1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C163H272N50O44/c1-21-25-39-95(189-146(243)107(51-59-125(222)223)201-153(250)114(71-85(13)14)209-159(256)128(86(15)16)211-148(245)108(52-60-126(224)225)198-139(236)101(45-36-66-182-163(175)176)193-151(248)112(69-83(9)10)205-154(251)113(70-84(11)12)206-155(252)115(73-92-76-177-79-183-92)202-134(231)94(165)72-91-37-28-27-29-38-91)135(232)185-89(19)132(229)187-99(43-34-64-180-161(171)172)136(233)186-90(20)133(230)188-106(50-58-124(220)221)145(242)197-104(48-56-121(168)217)147(244)204-111(68-82(7)8)152(249)200-105-49-57-123(219)179-63-33-31-42-98(191-142(239)102(46-54-119(166)215)195-143(240)103(196-144(105)241)47-55-120(167)216)141(238)207-116(74-93-77-178-80-184-93)156(253)210-118(78-214)158(255)208-117(75-122(169)218)157(254)194-100(44-35-65-181-162(173)174)138(235)190-97(41-30-32-62-164)140(237)203-110(67-81(5)6)150(247)192-96(40-26-22-2)137(234)199-109(53-61-127(226)227)149(246)213-130(88(18)24-4)160(257)212-129(131(170)228)87(17)23-3/h27-29,37-38,76-77,79-90,94-118,128-130,214H,21-26,30-36,39-75,78,164-165H2,1-20H3,(H2,166,215)(H2,167,216)(H2,168,217)(H2,169,218)(H2,170,228)(H,177,183)(H,178,184)(H,179,219)(H,185,232)(H,186,233)(H,187,229)(H,188,230)(H,189,243)(H,190,235)(H,191,239)(H,192,247)(H,193,248)(H,194,254)(H,195,240)(H,196,241)(H,197,242)(H,198,236)(H,199,234)(H,200,249)(H,201,250)(H,202,231)(H,203,237)(H,204,244)(H,205,251)(H,206,252)(H,207,238)(H,208,255)(H,209,256)(H,210,253)(H,211,245)(H,212,257)(H,213,246)(H,220,221)(H,222,223)(H,224,225)(H,226,227)(H4,171,172,180)(H4,173,174,181)(H4,175,176,182)/t87-,88-,89-,90-,94+,95-,96-,97-,98-,99-,100-,101-,102-,103+,104-,105?,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,128-,129-,130-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50119607
(CHEMBL440057 | E G P P I S I D L S L E L L R K M I...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(O)=O Show InChI InChI=1S/C208H343N59O64S2/c1-30-106(20)161(263-198(323)147-49-41-75-266(147)204(329)148-50-42-76-267(148)203(328)132(59-68-158(286)287)246-179(304)126(55-64-154(278)279)235-169(294)117(210)93-268)200(325)260-146(95-270)197(322)253-137(83-102(12)13)189(314)256-144(90-159(288)289)194(319)252-139(85-104(16)17)195(320)265-164(113(27)271)202(327)258-140(86-114-43-34-33-35-44-114)190(315)254-142(88-116-92-222-97-227-116)191(316)251-136(82-101(10)11)188(313)250-135(81-100(8)9)185(310)237-121(48-40-74-225-208(219)220)174(299)241-128(57-66-156(282)283)182(307)261-160(105(18)19)199(324)257-138(84-103(14)15)187(312)243-127(56-65-155(280)281)178(303)244-130(69-77-332-28)172(297)230-109(23)165(290)232-119(46-38-72-223-206(215)216)170(295)228-110(24)166(291)234-125(54-63-153(276)277)177(302)240-124(53-62-151(213)274)180(305)248-133(79-98(4)5)184(309)231-111(25)167(292)233-123(52-61-150(212)273)176(301)239-122(51-60-149(211)272)171(296)229-112(26)168(293)247-141(87-115-91-221-96-226-115)192(317)259-145(94-269)196(321)255-143(89-152(214)275)193(318)238-120(47-39-73-224-207(217)218)173(298)236-118(45-36-37-71-209)175(300)249-134(80-99(6)7)186(311)245-131(70-78-333-29)181(306)242-129(58-67-157(284)285)183(308)262-162(107(21)31-2)201(326)264-163(205(330)331)108(22)32-3/h33-35,43-44,91-92,96-113,117-148,160-164,268-271H,30-32,36-42,45-90,93-95,209-210H2,1-29H3,(H2,211,272)(H2,212,273)(H2,213,274)(H2,214,275)(H,221,226)(H,222,227)(H,228,295)(H,229,296)(H,230,297)(H,231,309)(H,232,290)(H,233,292)(H,234,291)(H,235,294)(H,236,298)(H,237,310)(H,238,318)(H,239,301)(H,240,302)(H,241,299)(H,242,306)(H,243,312)(H,244,303)(H,245,311)(H,246,304)(H,247,293)(H,248,305)(H,249,300)(H,250,313)(H,251,316)(H,252,319)(H,253,322)(H,254,315)(H,255,321)(H,256,314)(H,257,324)(H,258,327)(H,259,317)(H,260,325)(H,261,307)(H,262,308)(H,263,323)(H,264,326)(H,265,320)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,330,331)(H4,215,216,223)(H4,217,218,224)(H4,219,220,225)/t106-,107-,108-,109-,110-,111-,112-,113+,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,160-,161-,162-,163-,164-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026949
(CHEMBL2370930)Show SMILES CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C178H302N56O46/c1-22-26-44-105(208-161(266)119(58-66-137(242)243)222-168(273)126(80-94(13)14)230-174(279)140(95(15)16)232-163(268)120(59-67-138(244)245)220-156(261)113(52-41-75-200-178(193)194)214-167(272)124(78-92(9)10)227-169(274)125(79-93(11)12)228-170(275)128(83-103-86-196-89-202-103)224-147(252)104(182)81-101-42-29-28-30-43-101)148(253)203-98(19)144(249)206-111(50-39-73-198-176(189)190)149(254)204-99(20)145(250)207-118-57-65-136(241)197-72-38-34-49-110(213-166(271)123(77-91(7)8)226-162(267)117(219-160(118)265)56-64-134(186)239)154(259)217-115(54-62-132(184)237)158(263)211-107(46-31-35-69-179)152(257)209-108(47-32-36-70-180)153(258)218-116(55-63-133(185)238)159(264)216-114(53-61-131(183)236)150(255)205-100(21)146(251)223-127(82-102-85-195-88-201-102)171(276)231-130(87-235)173(278)229-129(84-135(187)240)172(277)215-112(51-40-74-199-177(191)192)155(260)210-109(48-33-37-71-181)157(262)225-122(76-90(5)6)165(270)212-106(45-27-23-2)151(256)221-121(60-68-139(246)247)164(269)234-142(97(18)25-4)175(280)233-141(143(188)248)96(17)24-3/h28-30,42-43,85-86,88-100,104-130,140-142,235H,22-27,31-41,44-84,87,179-182H2,1-21H3,(H2,183,236)(H2,184,237)(H2,185,238)(H2,186,239)(H2,187,240)(H2,188,248)(H,195,201)(H,196,202)(H,197,241)(H,203,253)(H,204,254)(H,205,255)(H,206,249)(H,207,250)(H,208,266)(H,209,257)(H,210,260)(H,211,263)(H,212,270)(H,213,271)(H,214,272)(H,215,277)(H,216,264)(H,217,259)(H,218,258)(H,219,265)(H,220,261)(H,221,256)(H,222,273)(H,223,251)(H,224,252)(H,225,262)(H,226,267)(H,227,274)(H,228,275)(H,229,278)(H,230,279)(H,231,276)(H,232,268)(H,233,280)(H,234,269)(H,242,243)(H,244,245)(H,246,247)(H4,189,190,198)(H4,191,192,199)(H4,193,194,200)/t96-,97-,98-,99-,100-,104+,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123+,124-,125-,126-,127-,128-,129-,130-,140-,141-,142-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50370167
(CHEMBL1794010)Show SMILES CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@H](C)CC)C(=O)N[C@@H]([C@H](C)CC)C(N)=O Show InChI InChI=1S/C157H263N45O44/c1-23-27-40-92(182-141(232)103(51-59-120(211)212)191-149(240)110(70-81(13)14)198-154(245)123(82(15)16)200-144(235)104(52-60-121(213)214)189-137(228)97(45-37-65-172-157(167)168)186-148(239)108(68-79(9)10)195-150(241)109(69-80(11)12)196-151(242)111(72-90-74-169-76-173-90)192-131(222)91(159)71-89-38-30-29-31-39-89)132(223)174-85(19)127(218)178-96(44-36-64-171-156(165)166)133(224)175-86(20)129(220)181-102(50-58-119(209)210)140(231)188-100(48-56-116(162)206)142(233)193-106(66-77(5)6)146(237)177-88(22)130(221)179-99(47-55-115(161)205)139(230)187-98(46-54-114(160)204)134(225)176-87(21)128(219)180-101-49-57-118(208)170-63-35-33-43-95(185-152(243)112(73-117(163)207)197-153(244)113(75-203)199-143(101)234)136(227)183-94(42-32-34-62-158)138(229)194-107(67-78(7)8)147(238)184-93(41-28-24-2)135(226)190-105(53-61-122(215)216)145(236)202-125(84(18)26-4)155(246)201-124(126(164)217)83(17)25-3/h29-31,38-39,74,76-88,91-113,123-125,203H,23-28,32-37,40-73,75,158-159H2,1-22H3,(H2,160,204)(H2,161,205)(H2,162,206)(H2,163,207)(H2,164,217)(H,169,173)(H,170,208)(H,174,223)(H,175,224)(H,176,225)(H,177,237)(H,178,218)(H,179,221)(H,180,219)(H,181,220)(H,182,232)(H,183,227)(H,184,238)(H,185,243)(H,186,239)(H,187,230)(H,188,231)(H,189,228)(H,190,226)(H,191,240)(H,192,222)(H,193,233)(H,194,229)(H,195,241)(H,196,242)(H,197,244)(H,198,245)(H,199,234)(H,200,235)(H,201,246)(H,202,236)(H,209,210)(H,211,212)(H,213,214)(H,215,216)(H4,165,166,171)(H4,167,168,172)/t83-,84-,85+,86+,87+,88+,91+,92+,93+,94+,95-,96+,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112-,113+,123+,124+,125+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026988
(CHEMBL2370920)Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C180H299N47O55/c1-25-29-46-104(198-149(254)105(47-33-38-69-181)199-153(258)110(52-43-74-193-178(189)190)204-166(271)122(78-93(11)12)222-176(281)179(23,85-94(13)14)226-172(277)124(80-103-87-191-89-194-103)218-167(272)123(79-102-44-31-30-32-45-102)217-171(276)129(88-228)221-165(270)121(77-92(9)10)216-170(275)127(83-140(246)247)197-101(22)229)161(266)223-143(97(18)27-3)175(280)212-118(60-68-139(244)245)162(267)224-144(98(19)28-4)174(279)211-117(59-67-138(242)243)159(264)202-106(48-34-39-70-182)150(255)205-111(53-61-130(185)230)155(260)209-115(57-65-136(238)239)157(262)201-107(49-35-40-71-183)151(256)207-114(56-64-135(236)237)156(261)200-108(50-36-41-72-184)152(257)208-116(58-66-137(240)241)158(263)206-113(55-63-134(234)235)148(253)196-99(20)146(251)195-100(21)147(252)213-125(81-131(186)231)169(274)219-126(82-132(187)232)168(273)210-112-54-62-133(233)192-73-42-37-51-109(203-163(268)119(75-90(5)6)215-164(269)120(76-91(7)8)214-160(112)265)154(259)220-128(84-141(248)249)173(278)227-180(24,86-95(15)16)177(282)225-142(145(188)250)96(17)26-2/h30-32,44-45,87,89-100,104-129,142-144,228H,25-29,33-43,46-86,88,181-184H2,1-24H3,(H2,185,230)(H2,186,231)(H2,187,232)(H2,188,250)(H,191,194)(H,192,233)(H,195,251)(H,196,253)(H,197,229)(H,198,254)(H,199,258)(H,200,261)(H,201,262)(H,202,264)(H,203,268)(H,204,271)(H,205,255)(H,206,263)(H,207,256)(H,208,257)(H,209,260)(H,210,273)(H,211,279)(H,212,280)(H,213,252)(H,214,265)(H,215,269)(H,216,275)(H,217,276)(H,218,272)(H,219,274)(H,220,259)(H,221,270)(H,222,281)(H,223,266)(H,224,267)(H,225,282)(H,226,277)(H,227,278)(H,234,235)(H,236,237)(H,238,239)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H4,189,190,193)/t96-,97-,98-,99-,100-,104-,105-,106-,107-,108-,109+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119+,120-,121-,122-,123+,124-,125-,126-,127-,128-,129-,142-,143-,144-,179-,180-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50370166
(CHEMBL1794007)Show SMILES CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC1=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@H](C)CC)C(=O)N[C@@H]([C@H](C)CC)C(N)=O Show InChI InChI=1S/C160H266N50O44/c1-20-24-38-93(187-144(241)105(50-58-122(219)220)199-150(247)111(69-82(11)12)206-156(253)125(83(13)14)208-146(243)106(51-59-123(221)222)197-139(236)99(44-35-65-179-160(172)173)191-149(246)109(67-80(7)8)203-151(248)110(68-81(9)10)204-152(249)113(72-91-75-175-78-181-91)201-132(229)92(162)70-89-36-27-26-28-37-89)133(230)182-86(17)129(226)185-97(42-33-63-177-158(168)169)137(234)195-103-48-56-120(216)176-62-32-30-41-95(188-142(239)102(47-55-118(165)214)194-145(242)104(196-143(103)240)49-57-121(217)218)134(231)183-87(18)130(227)186-101(46-54-117(164)213)141(238)193-100(45-53-116(163)212)135(232)184-88(19)131(228)200-112(71-90-74-174-77-180-90)153(250)207-115(76-211)155(252)205-114(73-119(166)215)154(251)192-98(43-34-64-178-159(170)171)138(235)189-96(40-29-31-61-161)140(237)202-108(66-79(5)6)148(245)190-94(39-25-21-2)136(233)198-107(52-60-124(223)224)147(244)210-127(85(16)23-4)157(254)209-126(128(167)225)84(15)22-3/h26-28,36-37,74-75,77-88,92-115,125-127,211H,20-25,29-35,38-73,76,161-162H2,1-19H3,(H2,163,212)(H2,164,213)(H2,165,214)(H2,166,215)(H2,167,225)(H,174,180)(H,175,181)(H,176,216)(H,182,230)(H,183,231)(H,184,232)(H,185,226)(H,186,227)(H,187,241)(H,188,239)(H,189,235)(H,190,245)(H,191,246)(H,192,251)(H,193,238)(H,194,242)(H,195,234)(H,196,240)(H,197,236)(H,198,233)(H,199,247)(H,200,228)(H,201,229)(H,202,237)(H,203,248)(H,204,249)(H,205,252)(H,206,253)(H,207,250)(H,208,243)(H,209,254)(H,210,244)(H,217,218)(H,219,220)(H,221,222)(H,223,224)(H4,168,169,177)(H4,170,171,178)(H4,172,173,179)/t84-,85-,86+,87+,88+,92-,93+,94+,95-,96+,97+,98+,99+,100+,101+,102-,103+,104+,105+,106+,107+,108+,109+,110+,111+,112+,113+,114+,115+,125+,126+,127+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026985
(CHEMBL2369693)Show SMILES CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C160H265N49O45/c1-20-24-38-93(186-143(240)105(50-58-122(219)220)198-150(247)111(69-82(11)12)205-156(253)125(83(13)14)207-146(243)106(51-59-123(221)222)196-139(236)99(44-35-65-178-160(171)172)190-149(246)109(67-80(7)8)202-151(248)110(68-81(9)10)203-152(249)113(72-91-75-174-78-180-91)200-132(229)92(162)70-89-36-27-26-28-37-89)133(230)181-86(17)129(226)184-97(42-33-63-176-158(167)168)137(234)194-103(48-56-120(215)216)145(242)195-104(49-57-121(217)218)144(241)192-101(46-54-117(164)212)142(239)193-102-47-55-119(214)175-62-32-30-41-95(187-141(238)100(45-53-116(163)211)185-130(227)87(18)183-135(102)232)134(231)182-88(19)131(228)199-112(71-90-74-173-77-179-90)153(250)206-115(76-210)155(252)204-114(73-118(165)213)154(251)191-98(43-34-64-177-159(169)170)138(235)188-96(40-29-31-61-161)140(237)201-108(66-79(5)6)148(245)189-94(39-25-21-2)136(233)197-107(52-60-124(223)224)147(244)209-127(85(16)23-4)157(254)208-126(128(166)225)84(15)22-3/h26-28,36-37,74-75,77-88,92-115,125-127,210H,20-25,29-35,38-73,76,161-162H2,1-19H3,(H2,163,211)(H2,164,212)(H2,165,213)(H2,166,225)(H,173,179)(H,174,180)(H,175,214)(H,181,230)(H,182,231)(H,183,232)(H,184,226)(H,185,227)(H,186,240)(H,187,238)(H,188,235)(H,189,245)(H,190,246)(H,191,251)(H,192,241)(H,193,239)(H,194,234)(H,195,242)(H,196,236)(H,197,233)(H,198,247)(H,199,228)(H,200,229)(H,201,237)(H,202,248)(H,203,249)(H,204,252)(H,205,253)(H,206,250)(H,207,243)(H,208,254)(H,209,244)(H,215,216)(H,217,218)(H,219,220)(H,221,222)(H,223,224)(H4,167,168,176)(H4,169,170,177)(H4,171,172,178)/t84-,85-,86-,87-,88-,92+,93-,94-,95+,96-,97-,98-,99-,100+,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,125-,126-,127-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50370163
(CHEMBL1794006)Show SMILES CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@H](C)CC)C(=O)N[C@@H]([C@H](C)CC)C(N)=O Show InChI InChI=1S/C161H271N49O43/c1-23-27-41-96(189-145(240)107(52-59-123(218)219)199-152(247)114(71-84(13)14)207-157(252)126(85(15)16)208-147(242)108(53-60-124(220)221)197-140(235)102(47-38-66-179-161(173)174)193-151(246)112(69-82(9)10)204-153(248)113(70-83(11)12)205-155(250)116(74-94-77-176-79-181-94)201-134(229)95(164)72-92-39-30-29-31-40-92)135(230)182-88(19)130(225)186-100(45-36-64-177-159(169)170)136(231)183-89(20)131(226)188-106(51-58-122(216)217)144(239)195-104(49-56-119(166)212)146(241)202-110(67-80(5)6)149(244)185-90(21)132(227)187-103(48-55-118(165)211)143(238)196-105(50-57-121(214)215)137(232)184-91(22)133(228)200-115(73-93-76-175-78-180-93)154(249)192-99(44-33-35-63-163)142(237)206-117(75-120(167)213)156(251)194-101(46-37-65-178-160(171)172)139(234)190-98(43-32-34-62-162)141(236)203-111(68-81(7)8)150(245)191-97(42-28-24-2)138(233)198-109(54-61-125(222)223)148(243)210-128(87(18)26-4)158(253)209-127(129(168)224)86(17)25-3/h29-31,39-40,76-91,95-117,126-128H,23-28,32-38,41-75,162-164H2,1-22H3,(H2,165,211)(H2,166,212)(H2,167,213)(H2,168,224)(H,175,180)(H,176,181)(H,182,230)(H,183,231)(H,184,232)(H,185,244)(H,186,225)(H,187,227)(H,188,226)(H,189,240)(H,190,234)(H,191,245)(H,192,249)(H,193,246)(H,194,251)(H,195,239)(H,196,238)(H,197,235)(H,198,233)(H,199,247)(H,200,228)(H,201,229)(H,202,241)(H,203,236)(H,204,248)(H,205,250)(H,206,237)(H,207,252)(H,208,242)(H,209,253)(H,210,243)(H,214,215)(H,216,217)(H,218,219)(H,220,221)(H,222,223)(H4,169,170,177)(H4,171,172,178)(H4,173,174,179)/t86-,87-,88+,89+,90+,91+,95-,96+,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112+,113+,114+,115+,116+,117+,126+,127+,128+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026986
(CHEMBL2370924)Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](C)NC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C185H312N50O53/c1-26-30-48-108(205-152(259)109(49-34-39-72-186)206-157(264)114(54-44-77-200-182(194)195)212-171(278)128(83-98(13)14)230-180(287)184(24,89-99(15)16)234-176(283)130(85-107-91-198-93-202-107)227-172(279)129(84-106-46-32-31-33-47-106)226-175(282)134(92-236)229-170(277)127(82-97(11)12)225-174(281)132(87-144(252)253)204-105(23)237)165(272)231-147(102(20)28-3)179(286)220-123(63-71-143(250)251)166(273)232-148(103(21)29-4)178(285)219-122(62-70-142(248)249)164(271)209-110(50-35-40-73-187)154(261)213-116(56-64-135(190)238)160(267)218-120(60-68-140(244)245)162(269)208-111(51-36-41-74-188)155(262)216-119(59-67-139(242)243)161(268)207-112(52-37-42-75-189)156(263)217-121(61-69-141(246)247)163(270)214-117(57-65-136(191)239)159(266)215-118-58-66-138(241)199-76-43-38-53-113(211-173(280)131(86-137(192)240)221-150(257)104(22)203-151(118)258)153(260)210-115(55-45-78-201-183(196)197)158(265)222-124(79-94(5)6)167(274)223-125(80-95(7)8)168(275)224-126(81-96(9)10)169(276)228-133(88-145(254)255)177(284)235-185(25,90-100(17)18)181(288)233-146(149(193)256)101(19)27-2/h31-33,46-47,91,93-104,108-134,146-148,236H,26-30,34-45,48-90,92,186-189H2,1-25H3,(H2,190,238)(H2,191,239)(H2,192,240)(H2,193,256)(H,198,202)(H,199,241)(H,203,258)(H,204,237)(H,205,259)(H,206,264)(H,207,268)(H,208,269)(H,209,271)(H,210,260)(H,211,280)(H,212,278)(H,213,261)(H,214,270)(H,215,266)(H,216,262)(H,217,263)(H,218,267)(H,219,285)(H,220,286)(H,221,257)(H,222,265)(H,223,274)(H,224,275)(H,225,281)(H,226,282)(H,227,279)(H,228,276)(H,229,277)(H,230,287)(H,231,272)(H,232,273)(H,233,288)(H,234,283)(H,235,284)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H4,194,195,200)(H4,196,197,201)/t101-,102-,103-,104+,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129+,130-,131-,132-,133-,134-,146-,147-,148-,184-,185+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026987
(CHEMBL2370921)Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C182H305N49O54/c1-25-29-47-106(202-150(257)107(48-33-38-71-183)203-154(261)112(53-43-76-196-179(190)191)209-168(275)125(81-95(11)12)226-177(284)181(23,87-96(13)14)230-173(280)127(83-105-89-194-91-198-105)223-169(276)126(82-104-45-31-30-32-46-104)222-172(279)131(90-232)225-167(274)124(80-94(9)10)221-171(278)129(85-141(249)250)201-103(22)233)163(270)227-144(99(18)27-3)176(283)217-121(62-70-140(247)248)164(271)228-145(100(19)28-4)175(282)216-120(61-69-139(245)246)162(269)206-108(49-34-39-72-184)151(258)210-114(55-63-132(187)234)157(264)214-118(59-67-137(241)242)160(267)205-109(50-35-40-73-185)152(259)212-117(58-66-136(239)240)159(266)204-110(51-36-41-74-186)153(260)213-119(60-68-138(243)244)161(268)211-116(57-65-135(237)238)149(256)200-101(20)147(254)199-102(21)148(255)218-128(84-133(188)235)170(277)215-115-56-64-134(236)195-75-42-37-52-111(208-165(272)122(78-92(5)6)219-156(263)113(207-158(115)265)54-44-77-197-180(192)193)155(262)220-123(79-93(7)8)166(273)224-130(86-142(251)252)174(281)231-182(24,88-97(15)16)178(285)229-143(146(189)253)98(17)26-2/h30-32,45-46,89,91-102,106-131,143-145,232H,25-29,33-44,47-88,90,183-186H2,1-24H3,(H2,187,234)(H2,188,235)(H2,189,253)(H,194,198)(H,195,236)(H,199,254)(H,200,256)(H,201,233)(H,202,257)(H,203,261)(H,204,266)(H,205,267)(H,206,269)(H,207,265)(H,208,272)(H,209,275)(H,210,258)(H,211,268)(H,212,259)(H,213,260)(H,214,264)(H,215,277)(H,216,282)(H,217,283)(H,218,255)(H,219,263)(H,220,262)(H,221,278)(H,222,279)(H,223,276)(H,224,273)(H,225,274)(H,226,284)(H,227,270)(H,228,271)(H,229,285)(H,230,280)(H,231,281)(H,237,238)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H4,190,191,196)(H4,192,193,197)/t98-,99-,100-,101-,102-,106-,107-,108-,109-,110-,111+,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122+,123-,124-,125-,126+,127-,128-,129-,130-,131-,143-,144-,145-,181-,182-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026979
(CHEMBL2370941)Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C187H315N49O56/c1-27-31-49-110(206-154(263)111(50-35-40-73-188)207-159(268)116(55-45-78-201-184(195)196)213-173(282)130(84-99(13)14)231-182(291)186(25,90-100(15)16)235-178(287)132(86-109-92-199-94-203-109)228-174(283)131(85-108-47-33-32-34-48-108)227-177(286)136(93-237)230-172(281)129(83-98(11)12)226-176(285)134(88-146(256)257)205-107(24)239)167(276)232-149(103(20)29-3)181(290)221-125(64-72-145(254)255)168(277)233-150(104(21)30-4)180(289)220-124(63-71-144(252)253)166(275)210-112(51-36-41-74-189)156(265)214-118(57-65-137(192)240)161(270)218-121(60-68-141(246)247)163(272)209-113(52-37-42-75-190)157(266)216-120(59-67-140(244)245)162(271)208-114(53-38-43-76-191)158(267)217-122(61-69-142(248)249)165(274)219-123(62-70-143(250)251)164(273)215-119(58-66-139(242)243)153(262)204-105(22)152(261)222-133(87-138(193)241)175(284)212-115(54-39-44-77-200-106(23)238)155(264)211-117(56-46-79-202-185(197)198)160(269)223-126(80-95(5)6)169(278)224-127(81-96(7)8)170(279)225-128(82-97(9)10)171(280)229-135(89-147(258)259)179(288)236-187(26,91-101(17)18)183(292)234-148(151(194)260)102(19)28-2/h32-34,47-48,92,94-105,110-136,148-150,237H,27-31,35-46,49-91,93,188-191H2,1-26H3,(H2,192,240)(H2,193,241)(H2,194,260)(H,199,203)(H,200,238)(H,204,262)(H,205,239)(H,206,263)(H,207,268)(H,208,271)(H,209,272)(H,210,275)(H,211,264)(H,212,284)(H,213,282)(H,214,265)(H,215,273)(H,216,266)(H,217,267)(H,218,270)(H,219,274)(H,220,289)(H,221,290)(H,222,261)(H,223,269)(H,224,278)(H,225,279)(H,226,285)(H,227,286)(H,228,283)(H,229,280)(H,230,281)(H,231,291)(H,232,276)(H,233,277)(H,234,292)(H,235,287)(H,236,288)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H4,195,196,201)(H4,197,198,202)/t102-,103-,104-,105-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131+,132-,133-,134-,135-,136-,148-,149-,150-,186-,187-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50026955
(CHEMBL2369740)Show SMILES CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(=O)[C@@H](CCC(N)=O)C(=O)N[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O Show InChI InChI=1S/C163H271N49O44/c1-22-26-40-97(191-145(241)108(52-60-124(220)221)200-154(250)115(72-85(13)14)207-159(255)127(86(15)16)209-148(244)109(53-61-125(222)223)198-142(238)103(46-37-67-181-163(174)175)195-153(249)113(70-83(9)10)204-155(251)114(71-84(11)12)205-156(252)116(74-93-76-176-79-182-93)201-136(232)96(165)73-92-38-29-28-30-39-92)137(233)184-89(19)131(227)187-101(44-35-65-179-161(170)171)138(234)185-90(20)132(228)189-107(51-59-123(218)219)144(240)197-104(48-56-120(167)215)146(242)202-111(68-81(5)6)151(247)186-91(21)133(229)188-105(49-57-121(168)216)150(246)212-135(231)95(47-55-119(166)214)134(230)190-106-50-58-122(217)178-64-34-32-43-100(196-158(254)118(78-213)208-157(253)117(206-147(106)243)75-94-77-177-80-183-94)140(236)193-102(45-36-66-180-162(172)173)141(237)192-99(42-31-33-63-164)143(239)203-112(69-82(7)8)152(248)194-98(41-27-23-2)139(235)199-110(54-62-126(224)225)149(245)211-129(88(18)25-4)160(256)210-128(130(169)226)87(17)24-3/h28-30,38-39,76-77,79-91,95-118,127-129,213H,22-27,31-37,40-75,78,164-165H2,1-21H3,(H2,166,214)(H2,167,215)(H2,168,216)(H2,169,226)(H,176,182)(H,177,183)(H,178,217)(H,184,233)(H,185,234)(H,186,247)(H,187,227)(H,188,229)(H,189,228)(H,190,230)(H,191,241)(H,192,237)(H,193,236)(H,194,248)(H,195,249)(H,196,254)(H,197,240)(H,198,238)(H,199,235)(H,200,250)(H,201,232)(H,202,242)(H,203,239)(H,204,251)(H,205,252)(H,206,243)(H,207,255)(H,208,253)(H,209,244)(H,210,256)(H,211,245)(H,218,219)(H,220,221)(H,222,223)(H,224,225)(H4,170,171,179)(H4,172,173,180)(H4,174,175,181)(H,212,231,246)/t87-,88-,89-,90-,91-,95-,96+,97-,98-,99-,100-,101-,102-,103-,104-,105-,106+,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117+,118-,127-,128-,129-/m0/s1 | PDB
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Salk Institute
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu... |
J Med Chem 45: 4737-47 (2002)
BindingDB Entry DOI: 10.7270/Q2WQ04JR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM131860
(US8835444, 1.8)Show SMILES COc1ccc(-c2c(C)[nH]nc2NC[C@H]2CC[C@@H](CC2)NC(=O)c2cc(ccc2Cl)C(F)(F)F)c(Cl)c1 |r,wU:14.14,wD:17.21,(5.96,-4.65,;7.29,-3.88,;7.29,-2.34,;5.96,-1.57,;5.96,-.03,;7.29,.74,;7.29,2.28,;8.54,3.19,;9.87,2.42,;8.06,4.65,;6.52,4.65,;6.05,3.19,;4.71,2.42,;3.38,3.19,;2.04,2.42,;2.04,.88,;.71,.11,;-.62,.88,;-.62,2.42,;.71,3.19,;-1.96,.11,;-3.29,.88,;-3.29,2.42,;-4.62,.11,;-5.96,.88,;-7.29,.11,;-7.29,-1.43,;-5.96,-2.2,;-4.62,-1.43,;-3.29,-2.2,;-8.62,.88,;-9.96,.11,;-8.62,2.42,;-7.29,1.65,;8.62,-.03,;9.96,.74,;8.62,-1.57,)| | PDB
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Novartis AG
US Patent
| Assay Description
Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89... |
US Patent US8835444 (2014)
BindingDB Entry DOI: 10.7270/Q28K77ST |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM131882
(US8835444, 5.27)Show SMILES CCc1cc(C)n(C[C@H]2CC[C@@H](CC2)NC(=O)c2cc(ccc2Cl)C(F)(F)F)n1 |r,wU:8.7,wD:11.14,(9.91,1.86,;8.58,2.63,;7.25,1.86,;6.77,.39,;5.23,.39,;4.46,-.94,;4.76,1.86,;3.42,2.63,;2.09,1.86,;2.09,.32,;.75,-.45,;-.58,.32,;-.58,1.86,;.75,2.63,;-1.91,-.45,;-3.25,.32,;-3.25,1.86,;-4.58,-.45,;-5.91,.32,;-7.25,-.45,;-7.25,-1.99,;-5.91,-2.76,;-4.58,-1.99,;-3.25,-2.76,;-8.58,.32,;-8.58,1.86,;-9.91,-.45,;-9.91,1.09,;6,2.76,)| Show InChI InChI=1S/C21H25ClF3N3O/c1-3-16-10-13(2)28(27-16)12-14-4-7-17(8-5-14)26-20(29)18-11-15(21(23,24)25)6-9-19(18)22/h6,9-11,14,17H,3-5,7-8,12H2,1-2H3,(H,26,29)/t14-,17- | PDB
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Novartis AG
US Patent
| Assay Description
Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89... |
US Patent US8835444 (2014)
BindingDB Entry DOI: 10.7270/Q28K77ST |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM131869
(US8835444, 3.6)Show SMILES Cc1cc(nn1C[C@H]1CC[C@@H](CC1)NC(=O)c1cc(Cl)cnc1C)-c1cccnc1 |r,wU:7.7,wD:10.14,(2,-.38,;3.33,.38,;4.67,-.39,;6,.38,;6,1.93,;3.33,1.93,;2,2.69,;.67,1.93,;.67,.38,;-.67,-.38,;-2,.38,;-2,1.93,;-.67,2.69,;-3.33,-.38,;-4.67,.38,;-4.67,1.93,;-6,-.38,;-7.34,.38,;-8.67,-.38,;-10,.38,;-8.67,-1.93,;-7.34,-2.69,;-6,-1.93,;-4.67,-2.69,;7.34,-.38,;7.34,-1.93,;8.67,-2.69,;10,-1.93,;10,-.38,;8.67,.38,)| Show InChI InChI=1S/C23H26ClN5O/c1-15-10-22(18-4-3-9-25-12-18)28-29(15)14-17-5-7-20(8-6-17)27-23(30)21-11-19(24)13-26-16(21)2/h3-4,9-13,17,20H,5-8,14H2,1-2H3,(H,27,30)/t17-,20- | PDB
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Novartis AG
US Patent
| Assay Description
Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89... |
US Patent US8835444 (2014)
BindingDB Entry DOI: 10.7270/Q28K77ST |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM131868
(US8835444, 3.3)Show SMILES Cc1cc(nn1C[C@H]1CC[C@H](CC1)NC(=O)c1cc(Cl)cnc1C)-c1ccc(F)cc1 |r,wU:10.14,7.7,(1.07,-.38,;2.4,.38,;3.87,-.09,;4.77,1.15,;3.87,2.4,;2.4,1.93,;1.07,2.69,;-.26,1.93,;-.26,.38,;-1.6,-.38,;-2.93,.38,;-2.93,1.93,;-1.6,2.69,;-4.26,-.38,;-5.6,.38,;-5.6,1.93,;-6.93,-.38,;-8.27,.38,;-9.6,-.38,;-10.93,.38,;-9.6,-1.93,;-8.27,-2.69,;-6.93,-1.93,;-5.6,-2.69,;6.31,1.15,;7.08,-.18,;8.62,-.18,;9.39,1.15,;10.93,1.15,;8.62,2.49,;7.08,2.49,)| Show InChI InChI=1S/C24H26ClFN4O/c1-15-11-23(18-5-7-20(26)8-6-18)29-30(15)14-17-3-9-21(10-4-17)28-24(31)22-12-19(25)13-27-16(22)2/h5-8,11-13,17,21H,3-4,9-10,14H2,1-2H3,(H,28,31)/t17-,21+ | PDB
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Novartis AG
US Patent
| Assay Description
Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89... |
US Patent US8835444 (2014)
BindingDB Entry DOI: 10.7270/Q28K77ST |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM131880
(US8835444, 5.21)Show SMILES OCc1nn(C[C@H]2CC[C@@H](CC2)NC(=O)c2cc(ccc2Cl)C(F)(F)F)cc1Cl |r,wU:6.5,wD:9.12,(7.44,-2.27,;8.21,-.94,;7.44,.39,;5.9,.39,;5.42,1.86,;4.09,2.63,;2.76,1.86,;2.76,.32,;1.42,-.45,;.09,.32,;.09,1.86,;1.42,2.63,;-1.25,-.45,;-2.58,.32,;-2.58,1.86,;-3.91,-.45,;-5.25,.32,;-6.58,-.45,;-6.58,-1.99,;-5.25,-2.76,;-3.91,-1.99,;-2.58,-2.76,;-7.91,.32,;-7.91,1.86,;-9.25,-.45,;-9.25,1.09,;6.67,2.76,;7.91,1.86,;9.25,2.63,)| Show InChI InChI=1S/C19H20Cl2F3N3O2/c20-15-6-3-12(19(22,23)24)7-14(15)18(29)25-13-4-1-11(2-5-13)8-27-9-16(21)17(10-28)26-27/h3,6-7,9,11,13,28H,1-2,4-5,8,10H2,(H,25,29)/t11-,13- | PDB
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Novartis AG
US Patent
| Assay Description
Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89... |
US Patent US8835444 (2014)
BindingDB Entry DOI: 10.7270/Q28K77ST |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM131858
(US8835444, 1.1)Show SMILES CCc1[nH]nc(NC[C@H]2CC[C@@H](CC2)NC(=O)c2cc(Cl)cnc2C)c1C |r,wU:11.14,wD:8.7,(9.52,.08,;9.13,1.56,;7.64,1.96,;7.16,3.43,;5.62,3.43,;5.15,1.96,;3.81,1.19,;2.48,1.96,;1.15,1.19,;-.19,1.96,;-1.52,1.19,;-1.52,-.35,;-.19,-1.12,;1.15,-.35,;-2.86,-1.12,;-4.19,-.35,;-4.19,1.19,;-5.52,-1.12,;-6.86,-.35,;-8.19,-1.12,;-9.52,-.35,;-8.19,-2.66,;-6.86,-3.43,;-5.52,-2.66,;-4.19,-3.43,;6.39,1.06,;6.39,-.48,)| | PDB
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Novartis AG
US Patent
| Assay Description
Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89... |
US Patent US8835444 (2014)
BindingDB Entry DOI: 10.7270/Q28K77ST |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM131863
(US8835444, 2.4)Show SMILES Cc1cc(nn1C[C@H]1CC[C@H](CC1)NC(=O)c1cc(Cl)cnc1C)-c1ccccc1 |r,wU:10.14,7.7,(1.84,-.38,;3.17,.38,;4.64,-.09,;5.54,1.15,;4.64,2.4,;3.17,1.93,;1.84,2.69,;.51,1.93,;.51,.38,;-.83,-.38,;-2.16,.38,;-2.16,1.93,;-.83,2.69,;-3.49,-.38,;-4.83,.38,;-4.83,1.93,;-6.16,-.38,;-7.5,.38,;-8.83,-.38,;-10.16,.38,;-8.83,-1.93,;-7.5,-2.69,;-6.16,-1.93,;-4.83,-2.69,;7.08,1.15,;7.85,-.18,;9.39,-.18,;10.16,1.15,;9.39,2.49,;7.85,2.49,)| Show InChI InChI=1S/C24H27ClN4O/c1-16-12-23(19-6-4-3-5-7-19)28-29(16)15-18-8-10-21(11-9-18)27-24(30)22-13-20(25)14-26-17(22)2/h3-7,12-14,18,21H,8-11,15H2,1-2H3,(H,27,30)/t18-,21+ | PDB
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Novartis AG
US Patent
| Assay Description
Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89... |
US Patent US8835444 (2014)
BindingDB Entry DOI: 10.7270/Q28K77ST |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50460168
(CHEMBL4225709)Show SMILES COc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc([C@@H](OC(F)F)C(F)(F)F)c32)c(C)n1 |r| Show InChI InChI=1S/C20H19ClF5N5O2/c1-9-14(10(2)28-18(27-9)32-3)30-7-4-8-31-15-11(16(20(24,25)26)33-17(22)23)5-6-12(21)13(15)29-19(30)31/h5-6,16-17H,4,7-8H2,1-3H3/t16-/m1/s1 | PDB
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Takeda Pharmaceutical Company Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human CRF2beta receptor expressed in CHO cells assessed as inhibition of human CRF-stimulated cAMP accumulation after 4 hrs by... |
Bioorg Med Chem 26: 2229-2250 (2018)
Article DOI: 10.1016/j.bmc.2018.01.020
BindingDB Entry DOI: 10.7270/Q2474DG1 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50460168
(CHEMBL4225709)Show SMILES COc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc([C@@H](OC(F)F)C(F)(F)F)c32)c(C)n1 |r| Show InChI InChI=1S/C20H19ClF5N5O2/c1-9-14(10(2)28-18(27-9)32-3)30-7-4-8-31-15-11(16(20(24,25)26)33-17(22)23)5-6-12(21)13(15)29-19(30)31/h5-6,16-17H,4,7-8H2,1-3H3/t16-/m1/s1 | PDB
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Takeda Pharmaceutical Company Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human CRF2alpha receptor expressed in CHO cells assessed as inhibition of human CRF-stimulated cAMP accumulation after 4 hrs b... |
Bioorg Med Chem 26: 2229-2250 (2018)
Article DOI: 10.1016/j.bmc.2018.01.020
BindingDB Entry DOI: 10.7270/Q2474DG1 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50398565
(CHEMBL2179195)Show SMILES CCCCN(C1CCOCC1)c1c(OC)nn2c(csc12)-c1c(OC)cc(COCC)cc1OC |(2.51,-41.6,;3.29,-42.93,;4.83,-42.92,;5.59,-41.58,;7.13,-41.58,;7.85,-40.22,;9.39,-40.17,;10.11,-38.82,;9.3,-37.51,;7.76,-37.56,;7.03,-38.92,;7.67,-43.03,;6.79,-44.29,;5.26,-44.32,;4.52,-45.67,;7.72,-45.51,;9.18,-45.01,;10.66,-45.45,;11.53,-44.19,;10.6,-42.96,;9.15,-43.47,;11.4,-46.8,;10.62,-48.12,;9.08,-48.09,;8.28,-49.41,;11.36,-49.46,;12.9,-49.49,;13.65,-50.84,;15.19,-50.87,;15.93,-52.21,;17.47,-52.24,;13.69,-48.17,;12.94,-46.82,;13.74,-45.5,;12.99,-44.16,)| Show InChI InChI=1S/C26H37N3O5S/c1-6-8-11-28(19-9-12-34-13-10-19)24-25(32-5)27-29-20(17-35-26(24)29)23-21(30-3)14-18(16-33-7-2)15-22(23)31-4/h14-15,17,19H,6-13,16H2,1-5H3 | PDB
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Eisai Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human CRF2 receptor assessed as inhibition of CRF-induced intracellular cAMP accumulation |
J Med Chem 55: 8450-63 (2012)
Article DOI: 10.1021/jm300864p
BindingDB Entry DOI: 10.7270/Q2KD202P |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50152049
(3-(2,4-Dichloro-phenyl)-7-dicyclopropylmethyl-8-et...)Show SMILES CCc1nc2N(CN(C)C(=O)c2n1C(C1CC1)C1CC1)c1ccc(Cl)cc1Cl Show InChI InChI=1S/C21H24Cl2N4O/c1-3-17-24-20-19(27(17)18(12-4-5-12)13-6-7-13)21(28)25(2)11-26(20)16-9-8-14(22)10-15(16)23/h8-10,12-13,18H,3-7,11H2,1-2H3 | PDB
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Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of [125I]- sauvagine binding to corticotropin releasing factor receptor 2 of porcine choroid plexus |
J Med Chem 47: 4741-54 (2004)
Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50135329
(CHEMBL128100 | {5-[(Cyclopropylmethyl-propyl-amino...)Show SMILES CCCN(CC1CC1)Cc1sc(Nc2c(Cl)cc(Cl)cc2Cl)nc1C(F)(F)F Show InChI InChI=1S/C18H19Cl3F3N3S/c1-2-5-27(8-10-3-4-10)9-14-16(18(22,23)24)26-17(28-14)25-15-12(20)6-11(19)7-13(15)21/h6-7,10H,2-5,8-9H2,1H3,(H,25,26) | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against Corticotropin releasing factor receptor 2 |
Bioorg Med Chem Lett 13: 3997-4000 (2003)
BindingDB Entry DOI: 10.7270/Q2MW2GJW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50152038
(3-(2,4-Dichloro-phenyl)-8-ethyl-1-methyl-7-(1-prop...)Show SMILES CCCC(CCC)n1c(CC)nc2N(CN(C)C(=O)c12)c1ccc(Cl)cc1Cl Show InChI InChI=1S/C21H28Cl2N4O/c1-5-8-15(9-6-2)27-18(7-3)24-20-19(27)21(28)25(4)13-26(20)17-11-10-14(22)12-16(17)23/h10-12,15H,5-9,13H2,1-4H3 | PDB
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Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of [125I]- sauvagine binding to corticotropin releasing factor receptor 2 of porcine choroid plexus |
J Med Chem 47: 4741-54 (2004)
Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 2
(Homo sapiens (Human)) | BDBM50318666
((1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-2,3,4,9-te...)Show SMILES C[C@H]1Cc2c([nH]c3cc(Cl)c(F)cc23)[C@@]2(N1)C(=O)Nc1ccc(Cl)cc21 |r| Show InChI InChI=1S/C19H14Cl2FN3O/c1-8-4-11-10-6-14(22)13(21)7-16(10)23-17(11)19(25-8)12-5-9(20)2-3-15(12)24-18(19)26/h2-3,5-8,23,25H,4H2,1H3,(H,24,26)/t8-,19+/m0/s1 | PDB
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Swiss Tropical and Public Health Institute
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant CRF2alpha receptor |
Science 329: 1175-80 (2010)
Article DOI: 10.1126/science.1193225
BindingDB Entry DOI: 10.7270/Q2SB45ZB |
More data for this
Ligand-Target Pair | |
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