BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 118 hits of ec50 for UniProtKB: Q9QZN9   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50303551
PNG
(3-(2-(3-(2,2,3,3-Tetramethylcyclopropanecarbonyl)-...)
Show SMILES CC1(C)C(C(=O)c2cn(CCN3CCOC3=O)c3ccccc23)C1(C)C
Show InChI InChI=1S/C21H26N2O3/c1-20(2)18(21(20,3)4)17(24)15-13-23(16-8-6-5-7-14(15)16)10-9-22-11-12-26-19(22)25/h5-8,13,18H,9-12H2,1-4H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 0.0700n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at rat CB2 receptor assessed as inhibition of forskolin-induced cAMP production by cell based assay

J Med Chem 53: 295-315 (2010)


Article DOI: 10.1021/jm901214q
BindingDB Entry DOI: 10.7270/Q2KD1Z00
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50272234
PNG
(3-(3-(2-Cyano-4-fluorophenyl)-1,2,4-oxadiazol-5-yl...)
Show SMILES CCn1c2ccccc2c2cc(NC(=O)CCc3nc(no3)-c3ccc(F)cc3C#N)ccc12
Show InChI InChI=1S/C26H20FN5O2/c1-2-32-22-6-4-3-5-20(22)21-14-18(8-10-23(21)32)29-24(33)11-12-25-30-26(31-34-25)19-9-7-17(27)13-16(19)15-28/h3-10,13-14H,2,11-12H2,1H3,(H,29,33)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 0.130n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level

J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM21284
PNG
(1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopr...)
Show SMILES CC1(C)C(C(=O)c2cn(CC3CCOCC3)c3ccccc23)C1(C)C
Show InChI InChI=1S/C22H29NO2/c1-21(2)20(22(21,3)4)19(24)17-14-23(13-15-9-11-25-12-10-15)18-8-6-5-7-16(17)18/h5-8,14-15,20H,9-13H2,1-4H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 0.170n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at rat CB2 receptor assessed as inhibition of forskolin-induced cAMP production by cell based assay

J Med Chem 53: 295-315 (2010)


Article DOI: 10.1021/jm901214q
BindingDB Entry DOI: 10.7270/Q2KD1Z00
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50272233
PNG
(CHEMBL501472 | N-(9-Ethyl-9H-carbazol-3-yl)-3-(3-(...)
Show SMILES CCn1c2ccccc2c2cc(NC(=O)CCc3nc(no3)-c3ccc(F)cc3C)ccc12
Show InChI InChI=1S/C26H23FN4O2/c1-3-31-22-7-5-4-6-20(22)21-15-18(9-11-23(21)31)28-24(32)12-13-25-29-26(30-33-25)19-10-8-17(27)14-16(19)2/h4-11,14-15H,3,12-13H2,1-2H3,(H,28,32)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 0.270n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level

J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50072775
PNG
(2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohe...)
Show SMILES CCCCCCC(C)(C)c1ccc([C@@H]2C[C@H](O)CC[C@H]2CCCO)c(O)c1 |r|
Show InChI InChI=1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3/t18-,20-,22-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 0.340n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level

J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50272274
PNG
(CHEMBL500655 | N-(9-Ethyl-9H-carbazol-3-yl)-3-(3-(...)
Show SMILES CCn1c2ccccc2c2cc(NC(=O)CCc3nc(no3)C3CCOCC3)ccc12
Show InChI InChI=1S/C24H26N4O3/c1-2-28-20-6-4-3-5-18(20)19-15-17(7-8-21(19)28)25-22(29)9-10-23-26-24(27-31-23)16-11-13-30-14-12-16/h3-8,15-16H,2,9-14H2,1H3,(H,25,29)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.380n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level

J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50272346
PNG
(CHEMBL499060 | N-(5-tert-Butylisoxazol-3-yl)-3-(3-...)
Show SMILES CC(C)(C)c1cc(NC(=O)CCc2nc(no2)-c2ccc(F)cc2Cl)no1
Show InChI InChI=1S/C18H18ClFN4O3/c1-18(2,3)13-9-14(23-26-13)21-15(25)6-7-16-22-17(24-27-16)11-5-4-10(20)8-12(11)19/h4-5,8-9H,6-7H2,1-3H3,(H,21,23,25)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 0.400n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level

J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50272276
PNG
(CHEMBL499050 | N-(6-Chloro-1,8-naphthyridin-3-yl)-...)
Show SMILES Fc1ccc(-c2noc(CCC(=O)Nc3cnc4ncc(Cl)cc4c3)n2)c(Cl)c1
Show InChI InChI=1S/C19H12Cl2FN5O2/c20-11-5-10-6-13(9-24-18(10)23-8-11)25-16(28)3-4-17-26-19(27-29-17)14-2-1-12(22)7-15(14)21/h1-2,5-9H,3-4H2,(H,25,28)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 0.400n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level

J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50272232
PNG
(3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-y...)
Show SMILES CCn1c2ccccc2c2cc(NC(=O)CCc3nc(no3)-c3ccc(F)cc3Cl)ccc12
Show InChI InChI=1S/C25H20ClFN4O2/c1-2-31-21-6-4-3-5-17(21)19-14-16(8-10-22(19)31)28-23(32)11-12-24-29-25(30-33-24)18-9-7-15(27)13-20(18)26/h3-10,13-14H,2,11-12H2,1H3,(H,28,32)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 0.400n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level

J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50272311
PNG
(3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-y...)
Show SMILES Fc1ccc(-c2noc(CCC(=O)Nc3nnc(s3)N3CCCCC3)n2)c(Cl)c1
Show InChI InChI=1S/C18H18ClFN6O2S/c19-13-10-11(20)4-5-12(13)16-22-15(28-25-16)7-6-14(27)21-17-23-24-18(29-17)26-8-2-1-3-9-26/h4-5,10H,1-3,6-9H2,(H,21,23,27)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.10n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level

J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM227552
PNG
(US9339486, CP55,940)
Show SMILES CCCCCCC(C)(C)c1ccc(C2CC(O)CCC2CCCO)c(O)c1
Show InChI InChI=1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem
US Patent
n/an/an/an/a 1.13n/an/an/an/a



The Cleveland Clinic Foundation

US Patent


Assay Description
The compound of Example 3 was tested for agonist activity at the rat CB1 (rCB1) and rCB2 receptors, at eight concentrations, in duplicate: 10, 3, 1, ...

US Patent US9339486 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43W9
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50040989
PNG
(CHEMBL3354955)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CCCC1 |r|
Show InChI InChI=1S/C20H21F2N3O2/c21-12-3-4-16(15(22)9-12)25-18-13-7-11(13)8-14(18)17(24-25)19(27)23-20(10-26)5-1-2-6-20/h3-4,9,11,13,26H,1-2,5-8,10H2,(H,23,27)/t11-,13-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method

Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
BindingDB Entry DOI: 10.7270/Q21J9CDS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50272345
PNG
(CHEMBL499059 | N-(2-tert-Butylpyrimidin-5-yl)-3-(3...)
Show SMILES CC(C)(C)c1ncc(NC(=O)CCc2nc(no2)-c2ccc(F)cc2Cl)cn1
Show InChI InChI=1S/C19H19ClFN5O2/c1-19(2,3)18-22-9-12(10-23-18)24-15(27)6-7-16-25-17(26-28-16)13-5-4-11(21)8-14(13)20/h4-5,8-10H,6-7H2,1-3H3,(H,24,27)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.30n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level

J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50272394
PNG
(6-Chloro-N-(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Show SMILES Fc1ccc(-c2noc(CCCNc3cnc4ccc(Cl)cc4c3)n2)c(Cl)c1
Show InChI InChI=1S/C20H15Cl2FN4O/c21-13-3-6-18-12(8-13)9-15(11-25-18)24-7-1-2-19-26-20(27-28-19)16-5-4-14(23)10-17(16)22/h3-6,8-11,24H,1-2,7H2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.30n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level

J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50272395
PNG
(CHEMBL499066 | N-(3-(3-(2-Chloro-4-fluorophenyl)-1...)
Show SMILES Fc1ccc(-c2noc(CCCNc3ccc4ncc(OC(F)(F)F)cc4c3)n2)c(Cl)c1
Show InChI InChI=1S/C21H15ClF4N4O2/c22-17-10-13(23)3-5-16(17)20-29-19(32-30-20)2-1-7-27-14-4-6-18-12(8-14)9-15(11-28-18)31-21(24,25)26/h3-6,8-11,27H,1-2,7H2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.30n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level

J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50272235
PNG
(3-(3-(3-Cyanopyridin-4-yl)-1,2,4-oxadiazol-5-yl)-N...)
Show SMILES CCn1c2ccccc2c2cc(NC(=O)CCc3nc(no3)-c3ccncc3C#N)ccc12
Show InChI InChI=1S/C25H20N6O2/c1-2-31-21-6-4-3-5-19(21)20-13-17(7-8-22(20)31)28-23(32)9-10-24-29-25(30-33-24)18-11-12-27-15-16(18)14-26/h3-8,11-13,15H,2,9-10H2,1H3,(H,28,32)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.30n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level

J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50286064
PNG
(CHEMBL4174510)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1c[n+]([O-])ccn1)C(=O)N[C@H](CF)C(C)(C)C |r|
Show InChI InChI=1S/C18H22FN5O2/c1-18(2,3)13(8-19)21-17(25)15-12-7-10-6-11(10)16(12)24(22-15)14-9-23(26)5-4-20-14/h4-5,9-11,13H,6-8H2,1-3H3,(H,21,25)/t10-,11-,13+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.5n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at recombinant rat CB2 receptor expressed in HEK293 cells assessed as increase in beta arrestin recruitment measured after 2 to 3 hr...

ACS Med Chem Lett 8: 1309-1313 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00396
BindingDB Entry DOI: 10.7270/Q25D8VCM
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50040995
PNG
(CHEMBL3354948)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)c1cccnc1 |r|
Show InChI InChI=1S/C22H20F2N4O/c1-22(2,13-4-3-7-25-11-13)26-21(29)19-16-9-12-8-15(12)20(16)28(27-19)18-6-5-14(23)10-17(18)24/h3-7,10-12,15H,8-9H2,1-2H3,(H,26,29)/t12-,15-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.5n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method

Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
BindingDB Entry DOI: 10.7270/Q21J9CDS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM21281
PNG
((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Show SMILES Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23 |r|
Show InChI InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3/t20-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 1.5n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at rat CB2 receptor assessed as inhibition of forskolin-induced cAMP production by cell based assay

J Med Chem 53: 295-315 (2010)


Article DOI: 10.1021/jm901214q
BindingDB Entry DOI: 10.7270/Q2KD1Z00
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50286058
PNG
(CHEMBL4161506)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1c[n+]([O-])ccn1)C(=O)NC1(CCC1)C(F)(F)F |r|
Show InChI InChI=1S/C17H16F3N5O2/c18-17(19,20)16(2-1-3-16)22-15(26)13-11-7-9-6-10(9)14(11)25(23-13)12-8-24(27)5-4-21-12/h4-5,8-10H,1-3,6-7H2,(H,22,26)/t9-,10-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.60n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at recombinant rat CB2 receptor expressed in HEK293 cells assessed as increase in beta arrestin recruitment measured after 2 to 3 hr...

ACS Med Chem Lett 8: 1309-1313 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00396
BindingDB Entry DOI: 10.7270/Q25D8VCM
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM21311
PNG
(4-(2-{3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]...)
Show SMILES CC1(C)C(C(=O)c2cn(CCN3CCOCC3)c3ccccc23)C1(C)C
Show InChI InChI=1S/C22H30N2O2/c1-21(2)20(22(21,3)4)19(25)17-15-24(18-8-6-5-7-16(17)18)10-9-23-11-13-26-14-12-23/h5-8,15,20H,9-14H2,1-4H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.60n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at rat CB2 receptor assessed as inhibition of forskolin-induced cAMP production by cell based assay

J Med Chem 53: 295-315 (2010)


Article DOI: 10.1021/jm901214q
BindingDB Entry DOI: 10.7270/Q2KD1Z00
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50302304
PNG
(1,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyrid...)
Show SMILES CC1CCCCC1(C)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C20H31N3O2/c1-15-13-21-18(12-17(15)14-23-8-10-25-11-9-23)22-19(24)20(3)7-5-4-6-16(20)2/h12-13,16H,4-11,14H2,1-3H3,(H,21,22,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 2.80n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at CB2 receptor in rat cerebellar membrane assessed as WIN 55212-2-stimulated [35S]GTPgammaS binding after 6 hrs by scintillation sp...

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50040985
PNG
(CHEMBL3354960)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CN1CCOCC1 |r|
Show InChI InChI=1S/C22H26F2N4O2/c1-22(2,12-27-5-7-30-8-6-27)25-21(29)19-16-10-13-9-15(13)20(16)28(26-19)18-4-3-14(23)11-17(18)24/h3-4,11,13,15H,5-10,12H2,1-2H3,(H,25,29)/t13-,15-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 2.90n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method

Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
BindingDB Entry DOI: 10.7270/Q21J9CDS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50272344
PNG
(3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-y...)
Show SMILES Fc1ccc(-c2noc(CCC(=O)Nc3cnc(OCC(F)(F)F)c(c3)C#N)n2)c(Cl)c1
Show InChI InChI=1S/C19H12ClF4N5O3/c20-14-6-11(21)1-2-13(14)17-28-16(32-29-17)4-3-15(30)27-12-5-10(7-25)18(26-8-12)31-9-19(22,23)24/h1-2,5-6,8H,3-4,9H2,(H,27,30)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 3.10n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level

J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50272175
PNG
(CHEMBL499628 | N-(9-ethyl-9H-carbazol-3-yl)-3-(3-(...)
Show SMILES CCn1c2ccccc2c2cc(NC(=O)CCc3nc(no3)-c3ccc(F)cc3)ccc12
Show InChI InChI=1S/C25H21FN4O2/c1-2-30-21-6-4-3-5-19(21)20-15-18(11-12-22(20)30)27-23(31)13-14-24-28-25(29-32-24)16-7-9-17(26)10-8-16/h3-12,15H,2,13-14H2,1H3,(H,27,31)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 3.20n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level

J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50302299
PNG
(2,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyrid...)
Show SMILES CCCC(C)(C)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C18H29N3O2/c1-5-6-18(3,4)17(22)20-16-11-15(14(2)12-19-16)13-21-7-9-23-10-8-21/h11-12H,5-10,13H2,1-4H3,(H,19,20,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 4.10n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at CB2 receptor in rat cerebellar membrane assessed as WIN 55212-2-stimulated [35S]GTPgammaS binding after 6 hrs by scintillation sp...

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50303530
PNG
((1-(4-Hydroxybutyl)-1H-indol-3-yl)(2,2,3,3-tetrame...)
Show SMILES CC1(C)C(C(=O)c2cn(CCCCO)c3ccccc23)C1(C)C
Show InChI InChI=1S/C20H27NO2/c1-19(2)18(20(19,3)4)17(23)15-13-21(11-7-8-12-22)16-10-6-5-9-14(15)16/h5-6,9-10,13,18,22H,7-8,11-12H2,1-4H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 4.40n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at rat CB2 receptor assessed as inhibition of forskolin-induced cAMP production by cell based assay

J Med Chem 53: 295-315 (2010)


Article DOI: 10.1021/jm901214q
BindingDB Entry DOI: 10.7270/Q2KD1Z00
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50040988
PNG
(CHEMBL3354957)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)N[C@@H](CO)c1ccccc1 |r|
Show InChI InChI=1S/C22H19F2N3O2/c23-14-6-7-19(17(24)10-14)27-21-15-8-13(15)9-16(21)20(26-27)22(29)25-18(11-28)12-4-2-1-3-5-12/h1-7,10,13,15,18,28H,8-9,11H2,(H,25,29)/t13-,15-,18+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 4.40n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method

Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
BindingDB Entry DOI: 10.7270/Q21J9CDS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50040993
PNG
(CHEMBL3354950)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)C |r|
Show InChI InChI=1S/C18H19F2N3O/c1-18(2,3)21-17(24)15-12-7-9-6-11(9)16(12)23(22-15)14-5-4-10(19)8-13(14)20/h4-5,8-9,11H,6-7H2,1-3H3,(H,21,24)/t9-,11-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 4.80n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method

Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
BindingDB Entry DOI: 10.7270/Q21J9CDS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50272428
PNG
(6-Chloro-3-(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Show SMILES Fc1ccc(-c2noc(CCCOc3cnc4ccc(Cl)cc4c3)n2)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2FN3O2/c21-13-3-6-18-12(8-13)9-15(11-24-18)27-7-1-2-19-25-20(26-28-19)16-5-4-14(23)10-17(16)22/h3-6,8-11H,1-2,7H2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 5.10n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level

J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50040997
PNG
(CHEMBL3354946)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CC1)c1ccccc1 |r|
Show InChI InChI=1S/C23H19F2N3O/c24-15-6-7-19(18(25)12-15)28-21-16-10-13(16)11-17(21)20(27-28)22(29)26-23(8-9-23)14-4-2-1-3-5-14/h1-7,12-13,16H,8-11H2,(H,26,29)/t13-,16-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 5.70n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method

Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
BindingDB Entry DOI: 10.7270/Q21J9CDS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50040994
PNG
(CHEMBL3354949)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)c1ccccn1 |r|
Show InChI InChI=1S/C22H20F2N4O/c1-22(2,18-5-3-4-8-25-18)26-21(29)19-15-10-12-9-14(12)20(15)28(27-19)17-7-6-13(23)11-16(17)24/h3-8,11-12,14H,9-10H2,1-2H3,(H,26,29)/t12-,14-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 6.20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method

Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
BindingDB Entry DOI: 10.7270/Q21J9CDS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50286056
PNG
(CHEMBL4172104)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1c[n+]([O-])ccn1)C(=O)NC(C)(C)C(F)(F)F |r|
Show InChI InChI=1S/C16H16F3N5O2/c1-15(2,16(17,18)19)21-14(25)12-10-6-8-5-9(8)13(10)24(22-12)11-7-23(26)4-3-20-11/h3-4,7-9H,5-6H2,1-2H3,(H,21,25)/t8-,9-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 6.30n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at recombinant rat CB2 receptor expressed in HEK293 cells assessed as increase in beta arrestin recruitment measured after 2 to 3 hr...

ACS Med Chem Lett 8: 1309-1313 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00396
BindingDB Entry DOI: 10.7270/Q25D8VCM
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50286061
PNG
(CHEMBL4166597)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1c[n+]([O-])ccn1)C(=O)N[C@H](CF)C(C)C |r|
Show InChI InChI=1S/C17H20FN5O2/c1-9(2)13(7-18)20-17(24)15-12-6-10-5-11(10)16(12)23(21-15)14-8-22(25)4-3-19-14/h3-4,8-11,13H,5-7H2,1-2H3,(H,20,24)/t10-,11-,13+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 6.40n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at recombinant rat CB2 receptor expressed in HEK293 cells assessed as increase in beta arrestin recruitment measured after 2 to 3 hr...

ACS Med Chem Lett 8: 1309-1313 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00396
BindingDB Entry DOI: 10.7270/Q25D8VCM
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50040990
PNG
(CHEMBL3354954)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC1(CO)CCC1 |r|
Show InChI InChI=1S/C19H19F2N3O2/c20-11-2-3-15(14(21)8-11)24-17-12-6-10(12)7-13(17)16(23-24)18(26)22-19(9-25)4-1-5-19/h2-3,8,10,12,25H,1,4-7,9H2,(H,22,26)/t10-,12-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 6.70n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method

Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
BindingDB Entry DOI: 10.7270/Q21J9CDS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50286060
PNG
(CHEMBL4161266)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1c[n+]([O-])ccn1)C(=O)NC1(CO)CCCC1 |r|
Show InChI InChI=1S/C18H21N5O3/c24-10-18(3-1-2-4-18)20-17(25)15-13-8-11-7-12(11)16(13)23(21-15)14-9-22(26)6-5-19-14/h5-6,9,11-12,24H,1-4,7-8,10H2,(H,20,25)/t11-,12-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 6.80n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at recombinant rat CB2 receptor expressed in HEK293 cells assessed as increase in beta arrestin recruitment measured after 2 to 3 hr...

ACS Med Chem Lett 8: 1309-1313 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00396
BindingDB Entry DOI: 10.7270/Q25D8VCM
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50272277
PNG
(3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-y...)
Show SMILES Fc1ccc(-c2noc(CCC(=O)Nc3nc4ccc(OC(F)(F)F)cc4s3)n2)c(Cl)c1
Show InChI InChI=1S/C19H11ClF4N4O3S/c20-12-7-9(21)1-3-11(12)17-27-16(31-28-17)6-5-15(29)26-18-25-13-4-2-10(8-14(13)32-18)30-19(22,23)24/h1-4,7-8H,5-6H2,(H,25,26,29)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 6.90n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level

J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50285941
PNG
(APD-371 | Olorinab)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1c[n+]([O-])ccn1)C(=O)N[C@H](CO)C(C)(C)C |r|
Show InChI InChI=1S/C18H23N5O3/c1-18(2,3)13(9-24)20-17(25)15-12-7-10-6-11(10)16(12)23(21-15)14-8-22(26)5-4-19-14/h4-5,8,10-11,13,24H,6-7,9H2,1-3H3,(H,20,25)/t10-,11-,13+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
PDB
UniChem

Similars
Article
PubMed
n/an/an/an/a 7.60n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at recombinant rat CB2 receptor expressed in HEK293 cells assessed as increase in beta arrestin recruitment measured after 2 to 3 hr...

ACS Med Chem Lett 8: 1309-1313 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00396
BindingDB Entry DOI: 10.7270/Q25D8VCM
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50040974
PNG
(CHEMBL3354971)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1cc(F)ccc1F)C(=O)NC(C)(C)CO |r|
Show InChI InChI=1S/C18H19F2N3O2/c1-18(2,8-24)21-17(25)15-12-6-9-5-11(9)16(12)23(22-15)14-7-10(19)3-4-13(14)20/h3-4,7,9,11,24H,5-6,8H2,1-2H3,(H,21,25)/t9-,11-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 7.90n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method

Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
BindingDB Entry DOI: 10.7270/Q21J9CDS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50302303
PNG
(1-ethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-...)
Show SMILES CCC1(CCCCC1)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C20H31N3O2/c1-3-20(7-5-4-6-8-20)19(24)22-18-13-17(16(2)14-21-18)15-23-9-11-25-12-10-23/h13-14H,3-12,15H2,1-2H3,(H,21,22,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 8.80n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at CB2 receptor in rat cerebellar membrane assessed as WIN 55212-2-stimulated [35S]GTPgammaS binding after 6 hrs by scintillation sp...

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50302295
PNG
(CHEMBL570792 | N-(5-ethyl-4-(morpholinomethyl)pyri...)
Show SMILES CCc1cnc(NC(=O)C(C)(C)CC)cc1CN1CCOCC1
Show InChI InChI=1S/C18H29N3O2/c1-5-14-12-19-16(20-17(22)18(3,4)6-2)11-15(14)13-21-7-9-23-10-8-21/h11-12H,5-10,13H2,1-4H3,(H,19,20,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 9.60n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at CB2 receptor in rat cerebellar membrane assessed as WIN 55212-2-stimulated [35S]GTPgammaS binding after 6 hrs by scintillation sp...

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50040986
PNG
(CHEMBL3354959)
Show SMILES [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NCC1CCOCC1 |r|
Show InChI InChI=1S/C20H21F2N3O2/c21-13-1-2-17(16(22)9-13)25-19-14-7-12(14)8-15(19)18(24-25)20(26)23-10-11-3-5-27-6-4-11/h1-2,9,11-12,14H,3-8,10H2,(H,23,26)/t12-,14-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method

Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
BindingDB Entry DOI: 10.7270/Q21J9CDS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50042912
PNG
(CHEMBL3354553)
Show SMILES CC(C)(C)c1cc(NC(=O)[C@@H]2CCCCN2C(=O)N2CCS(=O)(=O)CC2)no1 |r|
Show InChI InChI=1S/C18H28N4O5S/c1-18(2,3)14-12-15(20-27-14)19-16(23)13-6-4-5-7-22(13)17(24)21-8-10-28(25,26)11-9-21/h12-13H,4-11H2,1-3H3,(H,19,20,23)/t13-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 10n/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat CB2 receptor assessed as inhibition of forskolin-induced cAMP accumulation

Bioorg Med Chem Lett 25: 587-92 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.031
BindingDB Entry DOI: 10.7270/Q2QZ2CM5
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50304916
PNG
(CHEMBL593625 | N-(3,4-dimethyl-5-(morpholinosulfon...)
Show SMILES Cc1cc(NC(=O)C(C)(C(F)(F)F)C(F)(F)F)cc(c1C)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C17H20F6N2O4S/c1-10-8-12(24-14(26)15(3,16(18,19)20)17(21,22)23)9-13(11(10)2)30(27,28)25-4-6-29-7-5-25/h8-9H,4-7H2,1-3H3,(H,24,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 11n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at rat brain CB2 receptor by GTPgammaS binding assay

Bioorg Med Chem Lett 20: 387-91 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.062
BindingDB Entry DOI: 10.7270/Q27P8ZGK
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50272275
PNG
(3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-y...)
Show SMILES Fc1ccc(-c2noc(CCC(=O)Nc3cnc4ccc(Cl)cc4c3)n2)c(Cl)c1
Show InChI InChI=1S/C20H13Cl2FN4O2/c21-12-1-4-17-11(7-12)8-14(10-24-17)25-18(28)5-6-19-26-20(27-29-19)15-3-2-13(23)9-16(15)22/h1-4,7-10H,5-6H2,(H,25,28)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 11n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level

J Med Chem 51: 5019-34 (2008)


Article DOI: 10.1021/jm800463f
BindingDB Entry DOI: 10.7270/Q2W096VS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50277339
PNG
(2,2,3,3-tetramethyl-N-(4-methyl-3-(morpholinosulfo...)
Show SMILES Cc1ccc(NC(=O)C2C(C)(C)C2(C)C)cc1S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C19H28N2O4S/c1-13-6-7-14(20-17(22)16-18(2,3)19(16,4)5)12-15(13)26(23,24)21-8-10-25-11-9-21/h6-7,12,16H,8-11H2,1-5H3,(H,20,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 11n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at rat brain CB2 receptor by GTPgammaS binding assay

Bioorg Med Chem Lett 20: 387-91 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.062
BindingDB Entry DOI: 10.7270/Q27P8ZGK
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50040983
PNG
(CHEMBL3354962)
Show SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)C |r|
Show InChI InChI=1S/C18H19F2N3O/c1-18(2,3)21-17(24)15-12-7-9-6-11(9)16(12)23(22-15)14-5-4-10(19)8-13(14)20/h4-5,8-9,11H,6-7H2,1-3H3,(H,21,24)/t9-,11-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 12n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method

Bioorg Med Chem Lett 25: 322-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.040
BindingDB Entry DOI: 10.7270/Q21J9CDS
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50304925
PNG
(CHEMBL602128 | N-(3,4-dimethyl-5-(thiazolidin-3-yl...)
Show SMILES CCC(C)(C)C(=O)Nc1cc(C)c(C)c(c1)S(=O)(=O)N1CCSC1
Show InChI InChI=1S/C17H26N2O3S2/c1-6-17(4,5)16(20)18-14-9-12(2)13(3)15(10-14)24(21,22)19-7-8-23-11-19/h9-10H,6-8,11H2,1-5H3,(H,18,20)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 12n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at rat brain CB2 receptor by GTPgammaS binding assay

Bioorg Med Chem Lett 20: 387-91 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.062
BindingDB Entry DOI: 10.7270/Q27P8ZGK
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50304926
PNG
(CHEMBL602105 | N-(3,4-dimethyl-5-(piperidin-1-ylsu...)
Show SMILES CCC(C)(C)C(=O)Nc1cc(C)c(C)c(c1)S(=O)(=O)N1CCCCC1
Show InChI InChI=1S/C19H30N2O3S/c1-6-19(4,5)18(22)20-16-12-14(2)15(3)17(13-16)25(23,24)21-10-8-7-9-11-21/h12-13H,6-11H2,1-5H3,(H,20,22)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 13n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at rat brain CB2 receptor by GTPgammaS binding assay

Bioorg Med Chem Lett 20: 387-91 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.062
BindingDB Entry DOI: 10.7270/Q27P8ZGK
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50302302
PNG
(1-ethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-...)
Show SMILES CCC1(CCCC1)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C19H29N3O2/c1-3-19(6-4-5-7-19)18(23)21-17-12-16(15(2)13-20-17)14-22-8-10-24-11-9-22/h12-13H,3-11,14H2,1-2H3,(H,20,21,23)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 13n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at CB2 receptor in rat cerebellar membrane assessed as WIN 55212-2-stimulated [35S]GTPgammaS binding after 6 hrs by scintillation sp...

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 118 total )  |  Next  |  Last  >>
Jump to: