Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148155 (US8962612, 26) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB US Patent | 0.680 | -13.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148163 (US8962612, 66) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.75 | -12.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50098551 ((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.780 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to 5HT5A receptor (unknown origin) | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01093 BindingDB Entry DOI: 10.7270/Q2833WTS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148169 (US8962612, 80) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.850 | -12.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148165 (US8962612, 74) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.880 | -12.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148171 (US8962612, 86) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.950 | -12.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM78940 (METHIOTHEPIN | MLS000859918 | Methiothepin mesylat...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine 5A receptor was evaluated using [3H]-5-CT as radioligand | J Med Chem 46: 2795-812 (2003) Article DOI: 10.1021/jm030030n BindingDB Entry DOI: 10.7270/Q2M0465F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50175465 (7-methyl-3-[2-(4-quinolin-4-yl-piperazin-1-yl)-eth...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott GmbH & Co. KG Curated by ChEMBL | Assay Description Inhibitory activity against 5HT5A receptor | Bioorg Med Chem Lett 15: 5567-73 (2005) Article DOI: 10.1016/j.bmcl.2005.04.077 BindingDB Entry DOI: 10.7270/Q2CR5SX4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM78940 (METHIOTHEPIN | MLS000859918 | Methiothepin mesylat...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine 5A receptor | J Med Chem 46: 2795-812 (2003) Article DOI: 10.1021/jm030030n BindingDB Entry DOI: 10.7270/Q2M0465F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148156 (US8962612, 28) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.10 | -12.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148154 (US8962612, 23) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.10 | -12.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM135790 (US8853242, 162) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.20 | -12.2 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Astellas Pharma Inc. US Patent | Assay Description A solution of the compound to be tested and 100 μM 5-CT (5-carboxamidetriptamine) in DMSO was added to a 96-well plate at 2 μl/well, suspen... | US Patent US8853242 (2014) BindingDB Entry DOI: 10.7270/Q2NP2346 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM135785 (US8853242, 152) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.30 | -12.1 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Astellas Pharma Inc. US Patent | Assay Description A solution of the compound to be tested and 100 μM 5-CT (5-carboxamidetriptamine) in DMSO was added to a 96-well plate at 2 μl/well, suspen... | US Patent US8853242 (2014) BindingDB Entry DOI: 10.7270/Q2NP2346 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148167 (US8962612, 78) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.30 | -12.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM135780 (US8853242, 60) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.30 | -12.1 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Astellas Pharma Inc. US Patent | Assay Description A solution of the compound to be tested and 100 μM 5-CT (5-carboxamidetriptamine) in DMSO was added to a 96-well plate at 2 μl/well, suspen... | US Patent US8853242 (2014) BindingDB Entry DOI: 10.7270/Q2NP2346 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM135783 (US8853242, 148) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.40 | -12.1 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Astellas Pharma Inc. US Patent | Assay Description A solution of the compound to be tested and 100 μM 5-CT (5-carboxamidetriptamine) in DMSO was added to a 96-well plate at 2 μl/well, suspen... | US Patent US8853242 (2014) BindingDB Entry DOI: 10.7270/Q2NP2346 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50585913 (CHEMBL5093295) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]-5-CT from human 5-HT5A receptor at 32 uM incubated for 2 hr by radioligand binding assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02031 BindingDB Entry DOI: 10.7270/Q2G73JM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM135782 (US8853242, 147) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.60 | -12.0 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Astellas Pharma Inc. US Patent | Assay Description A solution of the compound to be tested and 100 μM 5-CT (5-carboxamidetriptamine) in DMSO was added to a 96-well plate at 2 μl/well, suspen... | US Patent US8853242 (2014) BindingDB Entry DOI: 10.7270/Q2NP2346 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50371998 (CHEMBL404372) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Binding affinity to human 5HT5A receptor | Bioorg Med Chem Lett 18: 262-6 (2008) Article DOI: 10.1016/j.bmcl.2007.10.078 BindingDB Entry DOI: 10.7270/Q2FJ2HNN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148164 (US8962612, 69) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.60 | -12.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM135795 (US8853242, 192) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.80 | -11.9 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Astellas Pharma Inc. US Patent | Assay Description A solution of the compound to be tested and 100 μM 5-CT (5-carboxamidetriptamine) in DMSO was added to a 96-well plate at 2 μl/well, suspen... | US Patent US8853242 (2014) BindingDB Entry DOI: 10.7270/Q2NP2346 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50371981 (CHEMBL256694) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Binding affinity to human 5HT5A receptor | Bioorg Med Chem Lett 18: 262-6 (2008) Article DOI: 10.1016/j.bmcl.2007.10.078 BindingDB Entry DOI: 10.7270/Q2FJ2HNN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM135792 (US8853242, 170) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.90 | -11.9 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Astellas Pharma Inc. US Patent | Assay Description A solution of the compound to be tested and 100 μM 5-CT (5-carboxamidetriptamine) in DMSO was added to a 96-well plate at 2 μl/well, suspen... | US Patent US8853242 (2014) BindingDB Entry DOI: 10.7270/Q2NP2346 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148162 (US8962612, 62) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.90 | -12.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50371464 (CHEMBL273170) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human recombinant 5HT5A receptor expressed in HEK293-EBNA cells | Bioorg Med Chem Lett 18: 256-61 (2008) Article DOI: 10.1016/j.bmcl.2007.10.080 BindingDB Entry DOI: 10.7270/Q2KD1ZQD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM135796 (US8853242, 211) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 2.30 | -11.8 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Astellas Pharma Inc. US Patent | Assay Description A solution of the compound to be tested and 100 μM 5-CT (5-carboxamidetriptamine) in DMSO was added to a 96-well plate at 2 μl/well, suspen... | US Patent US8853242 (2014) BindingDB Entry DOI: 10.7270/Q2NP2346 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50585914 (CHEMBL5079273) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]-5-CT from human 5-HT5A receptor at 1 uM incubated for 2 hr by radioligand binding assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02031 BindingDB Entry DOI: 10.7270/Q2G73JM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148161 (US8962612, 61) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 2.5 | -12.2 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148157 (US8962612, 44) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 2.70 | -12.2 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148166 (US8962612, 76) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 2.70 | -12.2 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50130266 (8-Piperazin-1-yl-naphthalen-2-ol | CHEMBL24462) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity for rodent 5-hydroxytryptamine 5A receptor | J Med Chem 46: 2795-812 (2003) Article DOI: 10.1021/jm030030n BindingDB Entry DOI: 10.7270/Q2M0465F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50585912 (CHEMBL5075486) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]-5-CT from human 5-HT5A receptor at 32 uM incubated for 2 hr by radioligand binding assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02031 BindingDB Entry DOI: 10.7270/Q2G73JM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM135788 (US8853242, 160) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 3.30 | -11.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Astellas Pharma Inc. US Patent | Assay Description A solution of the compound to be tested and 100 μM 5-CT (5-carboxamidetriptamine) in DMSO was added to a 96-well plate at 2 μl/well, suspen... | US Patent US8853242 (2014) BindingDB Entry DOI: 10.7270/Q2NP2346 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM135789 (US8853242, 161) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 3.40 | -11.5 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Astellas Pharma Inc. US Patent | Assay Description A solution of the compound to be tested and 100 μM 5-CT (5-carboxamidetriptamine) in DMSO was added to a 96-well plate at 2 μl/well, suspen... | US Patent US8853242 (2014) BindingDB Entry DOI: 10.7270/Q2NP2346 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148153 (US8962612, 8) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 3.60 | -12.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM135781 (US8853242, 114) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 3.70 | -11.5 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Astellas Pharma Inc. US Patent | Assay Description A solution of the compound to be tested and 100 μM 5-CT (5-carboxamidetriptamine) in DMSO was added to a 96-well plate at 2 μl/well, suspen... | US Patent US8853242 (2014) BindingDB Entry DOI: 10.7270/Q2NP2346 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148168 (US8962612, 79) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 3.70 | -12.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148160 (US8962612, 60) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 3.90 | -11.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50585909 (CHEMBL5089996) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]-5-CT from human 5-HT5A receptor at 32 uM incubated for 2 hr by radioligand binding assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02031 BindingDB Entry DOI: 10.7270/Q2G73JM6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM135784 (US8853242, 151) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 4.10 | -11.4 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Astellas Pharma Inc. US Patent | Assay Description A solution of the compound to be tested and 100 μM 5-CT (5-carboxamidetriptamine) in DMSO was added to a 96-well plate at 2 μl/well, suspen... | US Patent US8853242 (2014) BindingDB Entry DOI: 10.7270/Q2NP2346 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148170 (US8962612, 81) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 4.20 | -11.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM148152 (US8962612, 4) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 4.30 | -11.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Astellas Pharma Inc. US Patent | Assay Description A test compound and 150 uM of a DMSO solution of 5-carboxamide tryptamine (5-CT) were added to a 96-well plate at 2 ul/well and suspended in the incu... | US Patent US8962612 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM135794 (US8853242, 187) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 4.60 | -11.4 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Astellas Pharma Inc. US Patent | Assay Description A solution of the compound to be tested and 100 μM 5-CT (5-carboxamidetriptamine) in DMSO was added to a 96-well plate at 2 μl/well, suspen... | US Patent US8853242 (2014) BindingDB Entry DOI: 10.7270/Q2NP2346 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50371460 (CHEMBL401745) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human recombinant 5HT5A receptor expressed in HEK293-EBNA cells | Bioorg Med Chem Lett 18: 256-61 (2008) Article DOI: 10.1016/j.bmcl.2007.10.080 BindingDB Entry DOI: 10.7270/Q2KD1ZQD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM135791 (US8853242, 164) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 4.70 | -11.4 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Astellas Pharma Inc. US Patent | Assay Description A solution of the compound to be tested and 100 μM 5-CT (5-carboxamidetriptamine) in DMSO was added to a 96-well plate at 2 μl/well, suspen... | US Patent US8853242 (2014) BindingDB Entry DOI: 10.7270/Q2NP2346 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50474933 (CHEMBL361256) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity towards human 5-hydroxytryptamine receptor 5A expressed in CHO cells using the radioligand [3H]LSD | Bioorg Med Chem Lett 15: 4014-8 (2005) Article DOI: 10.1016/j.bmcl.2005.06.024 BindingDB Entry DOI: 10.7270/Q25141Z0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50147217 (CHEMBL3763779) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yonsei University Curated by ChEMBL | Assay Description Binding affinity to recombinant 5-HT5 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay | Eur J Med Chem 110: 302-10 (2016) Article DOI: 10.1016/j.ejmech.2016.01.043 BindingDB Entry DOI: 10.7270/Q2SJ1NH7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50371466 (CHEMBL270177) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human recombinant 5HT5A receptor expressed in HEK293-EBNA cells | Bioorg Med Chem Lett 18: 256-61 (2008) Article DOI: 10.1016/j.bmcl.2007.10.080 BindingDB Entry DOI: 10.7270/Q2KD1ZQD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM135786 (US8853242, 157) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | 5.30 | -11.3 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Astellas Pharma Inc. US Patent | Assay Description A solution of the compound to be tested and 100 μM 5-CT (5-carboxamidetriptamine) in DMSO was added to a 96-well plate at 2 μl/well, suspen... | US Patent US8853242 (2014) BindingDB Entry DOI: 10.7270/Q2NP2346 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50371974 (CHEMBL256047) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Binding affinity to human 5HT5A receptor | Bioorg Med Chem Lett 18: 262-6 (2008) Article DOI: 10.1016/j.bmcl.2007.10.078 BindingDB Entry DOI: 10.7270/Q2FJ2HNN | |||||||||||
More data for this Ligand-Target Pair |
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