Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM165905 (US9067922, 247) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited US Patent | Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... | US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM165898 (US9067922, 239) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited US Patent | Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... | US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM50239134 (CHEMBL4087516) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou... | Bioorg Med Chem Lett 27: 1919-1922 (2017) Article DOI: 10.1016/j.bmcl.2017.03.041 BindingDB Entry DOI: 10.7270/Q2NK3H6D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM165900 (US9067922, 241) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited US Patent | Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... | US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM165745 (US9067922, 235 | US9067922, 79) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited US Patent | Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... | US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM290450 (2{[4-(4-Cyanonaphthalen)isoquinolin-6-yl]thio}-2-m...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent | Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... | US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM165896 (US9067922, 237) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 8 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited US Patent | Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... | US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM290480 (US10100016, Compound 45B) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent | Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... | US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM152051 (US8987473, 137) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd. US Patent | Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result... | US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM152041 (US8987473, 122) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd. US Patent | Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result... | US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM50239146 (CHEMBL4088988) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou... | Bioorg Med Chem Lett 27: 1919-1922 (2017) Article DOI: 10.1016/j.bmcl.2017.03.041 BindingDB Entry DOI: 10.7270/Q2NK3H6D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM290470 (US10100016, Compound 43A) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent | Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... | US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM290481 (3-[4-(4-Cyanonaphthalen-1-yl)isoquinolin-6-yl]-2,2...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent | Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... | US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM165893 (US9067922, 232) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited US Patent | Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... | US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM318948 (2-Methyl-2-[[7-(4-nitrophenyl)benzo[d]isothiazol-6...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Chemiphar Co., Ltd.; J-Pharma Co., Ltd.; DeThree Res. Lab. Inc. US Patent | Assay Description URAT1 stably expressed HEK293 cells (HEK-URAT1) or HEK293 cells transfected with empty vector (HEK-mock) were cultured in DMEM culture medium supplem... | US Patent US10173990 (2019) BindingDB Entry DOI: 10.7270/Q2RR21BP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM290489 (3-[4-(4-Cyanophenyl)thieno[2,3-c]pyridin-2-yl]-2,2...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent | Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... | US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM165745 (US9067922, 235 | US9067922, 79) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited US Patent | Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... | US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM165667 (US9067922, 1) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited US Patent | Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... | US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM152048 (US8987473, 134) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd. US Patent | Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result... | US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM377700 (US10266496, Example 27) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Curacyte Chemistry GmbH | Assay Description a. Construction of a Cell Line Stably Expressing hURAT1hURAT1 plasmid was transfected into HEK293T cell, and a cell line stably expressing hURAT1 was... | J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2ST7S5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM290479 (3-[4-(4-Cyanonaphthalen-1-yl)isoquinolin-6-yl]-2-m...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent | Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... | US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM377703 (US10266496, Example 30) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Curacyte Chemistry GmbH | Assay Description a. Construction of a Cell Line Stably Expressing hURAT1hURAT1 plasmid was transfected into HEK293T cell, and a cell line stably expressing hURAT1 was... | J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2ST7S5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM152079 (US8987473, 183) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd. US Patent | Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result... | US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM290448 (2{[4-(4-Cyanophenyl)isoquinolin-6-yl]thio-2-methyl...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent | Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... | US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM152017 (US8987473, 82) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd. US Patent | Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result... | US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM165769 (US9067922, 104) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited US Patent | Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... | US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM152047 (US8987473, 133) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd. US Patent | Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result... | US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM152080 (US8987473, 185) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd. US Patent | Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result... | US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM290487 (3-[4-(4-Cyanonaphthalen-1-yl)thieno[2,3-c]pyridin-...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent | Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... | US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM290488 (2-{[4-(2-Chloro-4-cyanophenyl)isoquinolin-6-yl]thi...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent | Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... | US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM152026 (US8987473, 97) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd. US Patent | Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result... | US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM152016 (US8987473, 80) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd. US Patent | Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result... | US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM290490 (1-{[4-(4-cyanonaphthalen-1-yl)isoquinolin-6-yl]thi...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent | Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... | US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM290467 (2{[4-(5-Cyanonaphthalen-1-yl)isoquinolin-6-yl]thio...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent | Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... | US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM290515 (3-[4-(4-Cyanophenyl)isoquinolin-6-yl]-2,2-dimethyl...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent | Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... | US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM165744 (US9067922, 78) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 19 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited US Patent | Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... | US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM377690 (US10266496, Example 2) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Curacyte Chemistry GmbH | Assay Description a. Construction of a Cell Line Stably Expressing hURAT1hURAT1 plasmid was transfected into HEK293T cell, and a cell line stably expressing hURAT1 was... | J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2ST7S5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM50134635 (CHEMBL3746329 | US9637484, 3) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD. US Patent | Assay Description In vitro URAT1 assay can be used to identify compounds having potential activity for decreasing serum uric acid. In a suitable test, the vectors that... | US Patent US9637484 (2017) BindingDB Entry DOI: 10.7270/Q2S75JD2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM318954 (2-[[7-(4-Cyanophenyl)benzo[d]isothiazol-6-yl]thio]...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Chemiphar Co., Ltd.; J-Pharma Co., Ltd.; DeThree Res. Lab. Inc. US Patent | Assay Description URAT1 stably expressed HEK293 cells (HEK-URAT1) or HEK293 cells transfected with empty vector (HEK-mock) were cultured in DMEM culture medium supplem... | US Patent US10173990 (2019) BindingDB Entry DOI: 10.7270/Q2RR21BP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM60431 (US9067922, 249) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited US Patent | Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... | US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM318946 (1-[[7-(4-Cyanophenyl)benzo[d]isothiazol-6-yl]thio]...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 21.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Chemiphar Co., Ltd.; J-Pharma Co., Ltd.; DeThree Res. Lab. Inc. US Patent | Assay Description URAT1 stably expressed HEK293 cells (HEK-URAT1) or HEK293 cells transfected with empty vector (HEK-mock) were cultured in DMEM culture medium supplem... | US Patent US10173990 (2019) BindingDB Entry DOI: 10.7270/Q2RR21BP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM152011 (US8987473, 64) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd. US Patent | Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result... | US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM290431 (CAS No.:1352792-74-5 | RDEA3170 | US10100016, Veri...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
West China Hospital of Sichuan University Curated by ChEMBL | Assay Description Inhibition of human URAT1 | Eur J Med Chem 166: 186-196 (2019) Article DOI: 10.1016/j.ejmech.2019.01.043 BindingDB Entry DOI: 10.7270/Q20C50BS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM152049 (US8987473, 135) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd. US Patent | Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result... | US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM152023 (US8987473, 89) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd. US Patent | Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result... | US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM290468 (3-[4-(4-Cyanonaphthalen-1-yl)thieno[2,3-c]pyridin-...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent | Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... | US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM290477 (3-[4-(4-Cyanonaphthalen-1-yl)isoquinolin-6-yl]buty...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. US Patent | Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... | US Patent US10100016 (2018) BindingDB Entry DOI: 10.7270/Q2TH8PQZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM152054 (US8987473, 140) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd. US Patent | Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result... | US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM152015 (US8987473, 78) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd. US Patent | Assay Description It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The result... | US Patent US8987473 (2015) BindingDB Entry DOI: 10.7270/Q23F4NCB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM165780 (US9067922, 115) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 24 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited US Patent | Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... | US Patent US9067922 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31F0 | |||||||||||
More data for this Ligand-Target Pair |
Displayed 1 to 50 (of 886 total ) | Next | Last >> |