Found 708 hits of ic50 for UniProtKB: P43115 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315482
(CHEMBL1093897 | N-(3-chlorophenylsulfonyl)-3-(3,3-...)Show SMILES FC1(F)C(=O)N(Cc2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1cccc(Cl)c1 Show InChI InChI=1S/C28H19ClF2N2O4S/c29-22-8-4-9-23(16-22)38(36,37)32-25(34)14-13-20-7-3-10-24-26(20)33(27(35)28(24,30)31)17-18-11-12-19-5-1-2-6-21(19)15-18/h1-16H,17H2,(H,32,34)/b14-13+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315493
(3-(1-(2,4-dichlorobenzyl)-2-oxoindolin-7-yl)-N-(2,...)Show SMILES Fc1cc(F)c(cc1F)S(=O)(=O)NC(=O)\C=C\c1cccc2CC(=O)N(Cc3ccc(Cl)cc3Cl)c12 Show InChI InChI=1S/C24H15Cl2F3N2O4S/c25-16-6-4-15(17(26)9-16)12-31-23(33)8-14-3-1-2-13(24(14)31)5-7-22(32)30-36(34,35)21-11-19(28)18(27)10-20(21)29/h1-7,9-11H,8,12H2,(H,30,32)/b7-5+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254766
(2-(3-(2,4-dichlorophenylthio)-1H-indol-4-yloxy)-N-...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc(Cl)cc3Cl)c12 Show InChI InChI=1S/C20H12Cl4N2O4S3/c21-10-4-5-15(11(22)6-10)31-16-8-25-13-2-1-3-14(19(13)16)30-9-17(27)26-33(28,29)18-7-12(23)20(24)32-18/h1-8,25H,9H2,(H,26,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007 BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315480
(3-(3,3-difluoro-1-(naphthalen-2-ylmethyl)-2-oxoind...)Show SMILES Fc1ccc(cc1F)S(=O)(=O)NC(=O)\C=C\c1cccc2c1N(Cc1ccc3ccccc3c1)C(=O)C2(F)F Show InChI InChI=1S/C28H18F4N2O4S/c29-23-12-11-21(15-24(23)30)39(37,38)33-25(35)13-10-19-6-3-7-22-26(19)34(27(36)28(22,31)32)16-17-8-9-18-4-1-2-5-20(18)14-17/h1-15H,16H2,(H,33,35)/b13-10+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315476
(3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindoli...)Show SMILES Fc1ccc(cc1)S(=O)(=O)NC(=O)\C=C\c1cccc2c1N(Cc1ccc(Cl)cc1Cl)C(=O)C2(F)F Show InChI InChI=1S/C24H15Cl2F3N2O4S/c25-16-6-4-15(20(26)12-16)13-31-22-14(2-1-3-19(22)24(28,29)23(31)33)5-11-21(32)30-36(34,35)18-9-7-17(27)8-10-18/h1-12H,13H2,(H,30,32)/b11-5+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315474
(CHEMBL1089095 | N-(3-chlorophenylsulfonyl)-3-(1-(2...)Show SMILES FC1(F)C(=O)N(Cc2ccc(Cl)cc2Cl)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1cccc(Cl)c1 Show InChI InChI=1S/C24H15Cl3F2N2O4S/c25-16-4-2-5-18(11-16)36(34,35)30-21(32)10-8-14-3-1-6-19-22(14)31(23(33)24(19,28)29)13-15-7-9-17(26)12-20(15)27/h1-12H,13H2,(H,30,32)/b10-8+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315473
(3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindoli...)Show SMILES FC1(F)C(=O)N(Cc2ccc(Cl)cc2Cl)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C24H14Cl4F2N2O4S/c25-15-6-4-14(19(27)10-15)12-32-22-13(2-1-3-17(22)24(29,30)23(32)34)5-9-21(33)31-37(35,36)16-7-8-18(26)20(28)11-16/h1-11H,12H2,(H,31,33)/b9-5+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315472
(3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindoli...)Show SMILES Fc1ccc(cc1F)S(=O)(=O)NC(=O)\C=C\c1cccc2c1N(Cc1ccc(Cl)cc1Cl)C(=O)C2(F)F Show InChI InChI=1S/C24H14Cl2F4N2O4S/c25-15-6-4-14(18(26)10-15)12-32-22-13(2-1-3-17(22)24(29,30)23(32)34)5-9-21(33)31-37(35,36)16-7-8-19(27)20(28)11-16/h1-11H,12H2,(H,31,33)/b9-5+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315471
(3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindoli...)Show SMILES Fc1cc(F)c(cc1F)S(=O)(=O)NC(=O)\C=C\c1cccc2c1N(Cc1ccc(Cl)cc1Cl)C(=O)C2(F)F Show InChI InChI=1S/C24H13Cl2F5N2O4S/c25-14-6-4-13(16(26)8-14)11-33-22-12(2-1-3-15(22)24(30,31)23(33)35)5-7-21(34)32-38(36,37)20-10-18(28)17(27)9-19(20)29/h1-10H,11H2,(H,32,34)/b7-5+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315479
(3-(3,3-difluoro-1-(naphthalen-2-ylmethyl)-2-oxoind...)Show SMILES Fc1cc(F)c(cc1F)S(=O)(=O)NC(=O)\C=C\c1cccc2c1N(Cc1ccc3ccccc3c1)C(=O)C2(F)F Show InChI InChI=1S/C28H17F5N2O4S/c29-21-13-23(31)24(14-22(21)30)40(38,39)34-25(36)11-10-18-6-3-7-20-26(18)35(27(37)28(20,32)33)15-16-8-9-17-4-1-2-5-19(17)12-16/h1-14H,15H2,(H,34,36)/b11-10+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315481
(CHEMBL1090222 | N-(3,4-dichlorophenylsulfonyl)-3-(...)Show SMILES FC1(F)C(=O)N(Cc2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C28H18Cl2F2N2O4S/c29-23-12-11-21(15-24(23)30)39(37,38)33-25(35)13-10-19-6-3-7-22-26(19)34(27(36)28(22,31)32)16-17-8-9-18-4-1-2-5-20(18)14-17/h1-15H,16H2,(H,33,35)/b13-10+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254687
(CHEMBL464032 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C24H16Cl2N2O4S3/c25-17-11-22(34-24(17)26)35(30,31)28-21(29)13-32-19-7-3-6-18-23(19)20(12-27-18)33-16-9-8-14-4-1-2-5-15(14)10-16/h1-12,27H,13H2,(H,28,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007 BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254841
(2-(3-(3,4-dichlorophenylthio)-1H-indol-4-yloxy)-N-...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc(Cl)c(Cl)c3)c12 Show InChI InChI=1S/C20H12Cl4N2O4S3/c21-11-5-4-10(6-12(11)22)31-16-8-25-14-2-1-3-15(19(14)16)30-9-17(27)26-33(28,29)18-7-13(23)20(24)32-18/h1-8,25H,9H2,(H,26,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description Antagonist activity at human EP3 receptor assessed as cAMP production by cell-based assay |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007 BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315498
(3-(1-(naphthalen-2-ylmethyl)-2-oxoindolin-7-yl)-N-...)Show SMILES Fc1cc(F)c(cc1F)S(=O)(=O)NC(=O)\C=C\c1cccc2CC(=O)N(Cc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C28H19F3N2O4S/c29-22-14-24(31)25(15-23(22)30)38(36,37)32-26(34)11-10-19-6-3-7-21-13-27(35)33(28(19)21)16-17-8-9-18-4-1-2-5-20(18)12-17/h1-12,14-15H,13,16H2,(H,32,34)/b11-10+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315503
(CHEMBL1092871 | N-(3,4-dichlorophenylsulfonyl)-3-(...)Show SMILES Fc1ccc(CN2C(=O)Cc3cccc(\C=C\C(=O)NS(=O)(=O)c4ccc(Cl)c(Cl)c4)c23)cc1F Show InChI InChI=1S/C24H16Cl2F2N2O4S/c25-18-7-6-17(12-19(18)26)35(33,34)29-22(31)9-5-15-2-1-3-16-11-23(32)30(24(15)16)13-14-4-8-20(27)21(28)10-14/h1-10,12H,11,13H2,(H,29,31)/b9-5+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315528
(3-(3-methyl-1-(naphthalen-2-ylmethyl)-2-oxoindolin...)Show SMILES CC1C(=O)N(Cc2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1cc(F)c(F)cc1F Show InChI InChI=1S/C29H21F3N2O4S/c1-17-22-8-4-7-20(11-12-27(35)33-39(37,38)26-15-24(31)23(30)14-25(26)32)28(22)34(29(17)36)16-18-9-10-19-5-2-3-6-21(19)13-18/h2-15,17H,16H2,1H3,(H,33,35)/b12-11+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315499
(CHEMBL1088822 | N-(3,4-difluorophenylsulfonyl)-3-(...)Show SMILES Fc1ccc(cc1F)S(=O)(=O)NC(=O)\C=C\c1cccc2CC(=O)N(Cc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C28H20F2N2O4S/c29-24-12-11-23(16-25(24)30)37(35,36)31-26(33)13-10-20-6-3-7-22-15-27(34)32(28(20)22)17-18-8-9-19-4-1-2-5-21(19)14-18/h1-14,16H,15,17H2,(H,31,33)/b13-10+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315529
(CHEMBL1089454 | N-(3-chlorophenylsulfonyl)-3-(3-me...)Show SMILES CC1C(=O)N(Cc2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1cccc(Cl)c1 Show InChI InChI=1S/C29H23ClN2O4S/c1-19-26-11-4-8-22(14-15-27(33)31-37(35,36)25-10-5-9-24(30)17-25)28(26)32(29(19)34)18-20-12-13-21-6-2-3-7-23(21)16-20/h2-17,19H,18H2,1H3,(H,31,33)/b15-14+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315521
(3-(1-(2,4-dichlorobenzyl)-3-methyl-2-oxoindolin-7-...)Show SMILES CC1C(=O)N(Cc2ccc(Cl)cc2Cl)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C25H18Cl2F2N2O4S/c1-14-19-4-2-3-15(24(19)31(25(14)33)13-16-5-7-17(26)11-20(16)27)6-10-23(32)30-36(34,35)18-8-9-21(28)22(29)12-18/h2-12,14H,13H2,1H3,(H,30,32)/b10-6+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315506
(CHEMBL1091146 | N-(4,5-dichlorothiophen-2-ylsulfon...)Show SMILES Fc1ccc(CN2C(=O)Cc3cccc(\C=C\C(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)cc1F Show InChI InChI=1S/C22H14Cl2F2N2O4S2/c23-15-10-20(33-22(15)24)34(31,32)27-18(29)7-5-13-2-1-3-14-9-19(30)28(21(13)14)11-12-4-6-16(25)17(26)8-12/h1-8,10H,9,11H2,(H,27,29)/b7-5+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315504
(CHEMBL1088848 | N-(3-chlorophenylsulfonyl)-3-(1-(3...)Show SMILES Fc1ccc(CN2C(=O)Cc3cccc(\C=C\C(=O)NS(=O)(=O)c4cccc(Cl)c4)c23)cc1F Show InChI InChI=1S/C24H17ClF2N2O4S/c25-18-5-2-6-19(13-18)34(32,33)28-22(30)10-8-16-3-1-4-17-12-23(31)29(24(16)17)14-15-7-9-20(26)21(27)11-15/h1-11,13H,12,14H2,(H,28,30)/b10-8+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315523
(CHEMBL1089161 | N-(3-chlorophenylsulfonyl)-3-(1-(2...)Show SMILES CC1C(=O)N(Cc2ccc(Cl)cc2Cl)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1cccc(Cl)c1 Show InChI InChI=1S/C25H19Cl3N2O4S/c1-15-21-7-2-4-16(9-11-23(31)29-35(33,34)20-6-3-5-18(26)12-20)24(21)30(25(15)32)14-17-8-10-19(27)13-22(17)28/h2-13,15H,14H2,1H3,(H,29,31)/b11-9+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254883
(CHEMBL479434 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES COc1ccc(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)cc1 Show InChI InChI=1S/C21H16Cl2N2O5S3/c1-29-12-5-7-13(8-6-12)31-17-10-24-15-3-2-4-16(20(15)17)30-11-18(26)25-33(27,28)19-9-14(22)21(23)32-19/h2-10,24H,11H2,1H3,(H,25,26) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007 BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315500
(CHEMBL1088823 | N-(3,4-dichlorophenylsulfonyl)-3-(...)Show SMILES Clc1ccc(cc1Cl)S(=O)(=O)NC(=O)\C=C\c1cccc2CC(=O)N(Cc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C28H20Cl2N2O4S/c29-24-12-11-23(16-25(24)30)37(35,36)31-26(33)13-10-20-6-3-7-22-15-27(34)32(28(20)22)17-18-8-9-19-4-1-2-5-21(19)14-18/h1-14,16H,15,17H2,(H,31,33)/b13-10+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315492
(CHEMBL1092230 | N-(3-chlorophenylsulfonyl)-3-(1-(2...)Show SMILES Clc1ccc(CN2C(=O)Cc3cccc(\C=C\C(=O)NS(=O)(=O)c4cccc(Cl)c4)c23)c(Cl)c1 Show InChI InChI=1S/C24H17Cl3N2O4S/c25-18-5-2-6-20(12-18)34(32,33)28-22(30)10-8-15-3-1-4-16-11-23(31)29(24(15)16)14-17-7-9-19(26)13-21(17)27/h1-10,12-13H,11,14H2,(H,28,30)/b10-8+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315524
(3-(1-(2,4-dichlorobenzyl)-3-methyl-2-oxoindolin-7-...)Show SMILES CC1C(=O)N(Cc2ccc(Cl)cc2Cl)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1cc(F)c(F)cc1F Show InChI InChI=1S/C25H17Cl2F3N2O4S/c1-13-17-4-2-3-14(24(17)32(25(13)34)12-15-5-7-16(26)9-18(15)27)6-8-23(33)31-37(35,36)22-11-20(29)19(28)10-21(22)30/h2-11,13H,12H2,1H3,(H,31,33)/b8-6+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315527
(CHEMBL1090459 | N-(3,4-difluorophenylsulfonyl)-3-(...)Show SMILES CC1C(=O)N(Cc2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C29H22F2N2O4S/c1-18-24-8-4-7-21(11-14-27(34)32-38(36,37)23-12-13-25(30)26(31)16-23)28(24)33(29(18)35)17-19-9-10-20-5-2-3-6-22(20)15-19/h2-16,18H,17H2,1H3,(H,32,34)/b14-11+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315501
(CHEMBL1088846 | N-(3-chlorophenylsulfonyl)-3-(1-(n...)Show SMILES Clc1cccc(c1)S(=O)(=O)NC(=O)\C=C\c1cccc2CC(=O)N(Cc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C28H21ClN2O4S/c29-24-9-4-10-25(17-24)36(34,35)30-26(32)14-13-21-7-3-8-23-16-27(33)31(28(21)23)18-19-11-12-20-5-1-2-6-22(20)15-19/h1-15,17H,16,18H2,(H,30,32)/b14-13+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315469
(3-(3-hydroxy-1-(naphthalen-2-ylmethyl)-2-oxoindoli...)Show SMILES OC1C(=O)N(Cc2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1cc(F)c(F)cc1F Show InChI InChI=1S/C28H19F3N2O5S/c29-21-13-23(31)24(14-22(21)30)39(37,38)32-25(34)11-10-18-6-3-7-20-26(18)33(28(36)27(20)35)15-16-8-9-17-4-1-2-5-19(17)12-16/h1-14,27,35H,15H2,(H,32,34)/b11-10+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315518
(3-(1-(naphthalen-2-ylmethyl)-2,3-dioxoindolin-7-yl...)Show SMILES Fc1cc(F)c(cc1F)S(=O)(=O)NC(=O)\C=C\c1cccc2C(=O)C(=O)N(Cc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C28H17F3N2O5S/c29-21-13-23(31)24(14-22(21)30)39(37,38)32-25(34)11-10-18-6-3-7-20-26(18)33(28(36)27(20)35)15-16-8-9-17-4-1-2-5-19(17)12-16/h1-14H,15H2,(H,32,34)/b11-10+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315530
(CHEMBL1089455 | N-(3,4-dichlorophenylsulfonyl)-3-(...)Show SMILES CC1C(=O)N(Cc2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C29H22Cl2N2O4S/c1-18-24-8-4-7-21(11-14-27(34)32-38(36,37)23-12-13-25(30)26(31)16-23)28(24)33(29(18)35)17-19-9-10-20-5-2-3-6-22(20)15-19/h2-16,18H,17H2,1H3,(H,32,34)/b14-11+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315505
(3-(1-(3,4-difluorobenzyl)-2-oxoindolin-7-yl)-N-(2,...)Show SMILES Fc1ccc(CN2C(=O)Cc3cccc(\C=C\C(=O)NS(=O)(=O)c4cc(F)c(F)cc4F)c23)cc1F Show InChI InChI=1S/C24H15F5N2O4S/c25-16-6-4-13(8-17(16)26)12-31-23(33)9-15-3-1-2-14(24(15)31)5-7-22(32)30-36(34,35)21-11-19(28)18(27)10-20(21)29/h1-8,10-11H,9,12H2,(H,30,32)/b7-5+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315494
(3-(1-(2,4-dichlorobenzyl)-2-oxoindolin-7-yl)-N-(3,...)Show SMILES Fc1ccc(cc1F)S(=O)(=O)NC(=O)\C=C\c1cccc2CC(=O)N(Cc3ccc(Cl)cc3Cl)c12 Show InChI InChI=1S/C24H16Cl2F2N2O4S/c25-17-6-4-16(19(26)11-17)13-30-23(32)10-15-3-1-2-14(24(15)30)5-9-22(31)29-35(33,34)18-7-8-20(27)21(28)12-18/h1-9,11-12H,10,13H2,(H,29,31)/b9-5+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254520
(CHEMBL466184 | N-(3,4-difluorophenylsulfonyl)-2-(3...)Show SMILES Fc1ccc(cc1F)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C26H18F2N2O4S2/c27-20-11-10-19(13-21(20)28)36(32,33)30-25(31)15-34-23-7-3-6-22-26(23)24(14-29-22)35-18-9-8-16-4-1-2-5-17(16)12-18/h1-14,29H,15H2,(H,30,31) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007 BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254728
(CHEMBL465947 | N-(4-methoxyphenylsulfonyl)-2-(3-(n...)Show SMILES COc1ccc(cc1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C27H22N2O5S2/c1-33-20-10-13-22(14-11-20)36(31,32)29-26(30)17-34-24-8-4-7-23-27(24)25(16-28-23)35-21-12-9-18-5-2-3-6-19(18)15-21/h2-16,28H,17H2,1H3,(H,29,30) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007 BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315531
(CHEMBL1093124 | N-(3,4-dichlorophenylsulfonyl)-3-(...)Show SMILES CC1C(=O)N(Cc2ccc(F)c(F)c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C25H18Cl2F2N2O4S/c1-14-18-4-2-3-16(24(18)31(25(14)33)13-15-5-9-21(28)22(29)11-15)6-10-23(32)30-36(34,35)17-7-8-19(26)20(27)12-17/h2-12,14H,13H2,1H3,(H,30,32)/b10-6+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315467
(CHEMBL1093791 | N-(4-fluorophenylsulfonyl)-3-(3-hy...)Show SMILES OC1C(=O)N(Cc2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1ccc(F)cc1 Show InChI InChI=1S/C28H21FN2O5S/c29-22-11-13-23(14-12-22)37(35,36)30-25(32)15-10-20-6-3-7-24-26(20)31(28(34)27(24)33)17-18-8-9-19-4-1-2-5-21(19)16-18/h1-16,27,33H,17H2,(H,30,32)/b15-10+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315502
(3-(1-(3,4-difluorobenzyl)-2-oxoindolin-7-yl)-N-(3,...)Show SMILES Fc1ccc(CN2C(=O)Cc3cccc(\C=C\C(=O)NS(=O)(=O)c4ccc(F)c(F)c4)c23)cc1F Show InChI InChI=1S/C24H16F4N2O4S/c25-18-7-4-14(10-20(18)27)13-30-23(32)11-16-3-1-2-15(24(16)30)5-9-22(31)29-35(33,34)17-6-8-19(26)21(28)12-17/h1-10,12H,11,13H2,(H,29,31)/b9-5+ | PDB
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Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315522
(3-(1-(2,4-dichlorobenzyl)-3-methyl-2-oxoindolin-7-...)Show SMILES CC1C(=O)N(Cc2ccc(Cl)cc2Cl)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C25H18Cl4N2O4S/c1-14-19-4-2-3-15(24(19)31(25(14)33)13-16-5-7-17(26)11-21(16)28)6-10-23(32)30-36(34,35)18-8-9-20(27)22(29)12-18/h2-12,14H,13H2,1H3,(H,30,32)/b10-6+ | PDB
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Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM35847
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 | PDB
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Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 0.940 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description Binding affinity to EP3 receptor |
J Med Chem 53: 4332-53 (2010)
Article DOI: 10.1021/jm9018756 BindingDB Entry DOI: 10.7270/Q21R6QPF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50311623
(CHEMBL1081186 | N-(5-(1-(2,4-dichlorobenzyl)-5-flu...)Show SMILES Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(cc(F)cc12)-c1cc(NS(=O)(=O)c2ccc(F)c(F)c2)no1 Show InChI InChI=1S/C25H16Cl2F3N3O3S/c1-13-11-33(12-14-2-3-15(26)6-20(14)27)25-18(13)7-16(28)8-19(25)23-10-24(31-36-23)32-37(34,35)17-4-5-21(29)22(30)9-17/h2-11H,12H2,1H3,(H,31,32) | PDB
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| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 6797-800 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.084 BindingDB Entry DOI: 10.7270/Q2833S51 |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50315517
(CHEMBL1093133 | N-(3,4-dichlorophenylsulfonyl)-3-(...)Show SMILES Clc1ccc(cc1Cl)S(=O)(=O)NC(=O)\C=C\c1cccc2C(=O)C(=O)N(Cc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C28H18Cl2N2O5S/c29-23-12-11-21(15-24(23)30)38(36,37)31-25(33)13-10-19-6-3-7-22-26(19)32(28(35)27(22)34)16-17-8-9-18-4-1-2-5-20(18)14-17/h1-15H,16H2,(H,31,33)/b13-10+ | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in buffer |
Bioorg Med Chem Lett 20: 2658-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.028 BindingDB Entry DOI: 10.7270/Q2668DCG |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254647
(2-(3-(3,4-dichlorophenylsulfonyl)-1H-indol-4-yloxy...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H12Cl4N2O6S3/c21-11-5-4-10(6-12(11)22)34(28,29)16-8-25-14-2-1-3-15(19(14)16)32-9-17(27)26-35(30,31)18-7-13(23)20(24)33-18/h1-8,25H,9H2,(H,26,27) | PDB
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Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description Antagonist activity at human EP3 receptor assessed as cAMP production by cell-based assay |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007 BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50311624
(3,4-difluoro-N-(5-(5-fluoro-3-methyl-1-(naphthalen...)Show SMILES Cc1cn(Cc2ccc3ccccc3c2)c2c(cc(F)cc12)-c1cc(NS(=O)(=O)c2ccc(F)c(F)c2)no1 Show InChI InChI=1S/C29H20F3N3O3S/c1-17-15-35(16-18-6-7-19-4-2-3-5-20(19)10-18)29-23(17)11-21(30)12-24(29)27-14-28(33-38-27)34-39(36,37)22-8-9-25(31)26(32)13-22/h2-15H,16H2,1H3,(H,33,34) | PDB
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Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 6797-800 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.084 BindingDB Entry DOI: 10.7270/Q2833S51 |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50580032
(CHEMBL5078847)Show SMILES F\C(CNC(=O)NS(=O)(=O)c1cc(Cl)c(Cl)s1)=C1\CCCc2cnn(Cc3ccc(Cl)cc3Cl)c12 | PDB
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| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Antagonist activity at human EP3 receptor expressed in CHO-K1 cells assessed as reduction in sulprostone induced inhibition of forskolin stimulated c... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00594 BindingDB Entry DOI: 10.7270/Q2HT2T6X |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50303711
(3,4-Difluoro-N-{(E)-3-[5-fluoro-1-(3-methoxybenzyl...)Show SMILES COc1cccc(Cn2cc(C)c3cc(F)cc(\C=C\C(=O)NS(=O)(=O)c4ccc(F)c(F)c4)c23)c1 Show InChI InChI=1S/C26H21F3N2O4S/c1-16-14-31(15-17-4-3-5-20(10-17)35-2)26-18(11-19(27)12-22(16)26)6-9-25(32)30-36(33,34)21-7-8-23(28)24(29)13-21/h3-14H,15H2,1-2H3,(H,30,32)/b9-6+ | PDB
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Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation counting |
J Med Chem 53: 18-36 (2010)
Article DOI: 10.1021/jm9005912 BindingDB Entry DOI: 10.7270/Q2XP752H |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50311615
(4,5-dichloro-N-(5-(5-fluoro-3-methyl-1-(naphthalen...)Show SMILES Cc1cn(Cc2ccc3ccccc3c2)c2c(cc(F)cc12)-c1cc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)no1 Show InChI InChI=1S/C27H18Cl2FN3O3S2/c1-15-13-33(14-16-6-7-17-4-2-3-5-18(17)8-16)26-20(15)9-19(30)10-21(26)23-12-24(31-36-23)32-38(34,35)25-11-22(28)27(29)37-25/h2-13H,14H2,1H3,(H,31,32) | PDB
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Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 6797-800 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.084 BindingDB Entry DOI: 10.7270/Q2833S51 |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50311621
(3,4-dichloro-N-(5-(1-(2,4-dichlorobenzyl)-5-fluoro...)Show SMILES Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(cc(F)cc12)-c1cc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)no1 Show InChI InChI=1S/C25H16Cl4FN3O3S/c1-13-11-33(12-14-2-3-15(26)6-21(14)28)25-18(13)7-16(30)8-19(25)23-10-24(31-36-23)32-37(34,35)17-4-5-20(27)22(29)9-17/h2-11H,12H2,1H3,(H,31,32) | PDB
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| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 6797-800 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.084 BindingDB Entry DOI: 10.7270/Q2833S51 |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254841
(2-(3-(3,4-dichlorophenylthio)-1H-indol-4-yloxy)-N-...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc(Cl)c(Cl)c3)c12 Show InChI InChI=1S/C20H12Cl4N2O4S3/c21-11-5-4-10(6-12(11)22)31-16-8-25-14-2-1-3-15(19(14)16)30-9-17(27)26-33(28,29)18-7-13(23)20(24)32-18/h1-8,25H,9H2,(H,26,27) | PDB
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Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007 BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50303675
(2-(1-(2,4-dichlorobenzyl)-1H-benzo[d]imidazol-7-yl...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12 Show InChI InChI=1S/C20H13Cl4N3O4S2/c21-12-5-4-11(13(22)6-12)8-27-10-25-15-2-1-3-16(19(15)27)31-9-17(28)26-33(29,30)18-7-14(23)20(24)32-18/h1-7,10H,8-9H2,(H,26,28) | PDB
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| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]PGE2 from human EP3 receptor after 60 mins repeated washing by liquid scintillation counting |
J Med Chem 53: 18-36 (2010)
Article DOI: 10.1021/jm9005912 BindingDB Entry DOI: 10.7270/Q2XP752H |
More data for this Ligand-Target Pair | |