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Compile Data Set for Download or QSAR

Found 474 hits of ic50 for UniProtKB: P31391   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM81767
PNG
(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O |r|
Show InChI InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1
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n/an/a 0.0800n/an/an/an/an/an/a



University of California at San Diego

Curated by ChEMBL


Assay Description
Tested for inhibition of radioligand binding to cloned somatostatin receptor hSSTR4


J Med Chem 40: 2241-51 (1997)


Article DOI: 10.1021/jm960850i
BindingDB Entry DOI: 10.7270/Q2125TBX
More data for this
Ligand-Target Pair
Somatostatin receptor


(Homo sapiens (Human))
BDBM50212467
PNG
(SANDOSTATINM | Sandostatinm)
Show SMILES [H][C@@]1(NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccccc2)SSC[C@@H](NC1=O)C(=O)N[C@H](CO)[C@@H](C)O)[C@@H](C)O
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n/an/a 0.460n/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2X350M0
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50159419
PNG
(CHEMBL262379 | Des-AA1,2,5-[D-Trp8,Tyr11]SRIF)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C67H90N14O16S2/c1-37(83)55-65(94)77-51(31-41-23-25-43(85)26-24-41)63(92)81-56(38(2)84)66(95)78-53(34-82)64(93)79-54(67(96)97)36-99-98-35-45(70)57(86)72-47(21-11-13-27-68)58(87)74-49(29-39-15-5-3-6-16-39)60(89)75-50(30-40-17-7-4-8-18-40)61(90)76-52(32-42-33-71-46-20-10-9-19-44(42)46)62(91)73-48(59(88)80-55)22-12-14-28-69/h3-10,15-20,23-26,33,37-38,45,47-56,71,82-85H,11-14,21-22,27-32,34-36,68-70H2,1-2H3,(H,72,86)(H,73,91)(H,74,87)(H,75,89)(H,76,90)(H,77,94)(H,78,95)(H,79,93)(H,80,88)(H,81,92)(H,96,97)/t37-,38-,45-,47-,48+,49-,50+,51+,52+,53+,54+,55-,56-/m1/s1
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n/an/a 0.5n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of [Leu8,D-Trp22,125I-Tyr25]SRIF-28 binding to human somatostatin receptor type 4


J Med Chem 48: 507-14 (2005)


Article DOI: 10.1021/jm049520l
BindingDB Entry DOI: 10.7270/Q2QR4WNH
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136800
PNG
((4R,7S,10R,13S,16S,19S,22R,25S)-25-Amino-13-(4-ami...)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(O)=O
Show InChI InChI=1S/C54H66N10O11S2/c1-31(65)46-53(73)62-43(26-34-19-21-36(66)22-20-34)51(71)63-45(54(74)75)30-77-76-29-38(56)47(67)59-41(24-32-12-4-2-5-13-32)49(69)60-42(25-33-14-6-3-7-15-33)50(70)61-44(27-35-28-57-39-17-9-8-16-37(35)39)52(72)58-40(48(68)64-46)18-10-11-23-55/h2-9,12-17,19-22,28,31,38,40-46,57,65-66H,10-11,18,23-27,29-30,55-56H2,1H3,(H,58,72)(H,59,67)(H,60,69)(H,61,70)(H,62,73)(H,63,71)(H,64,68)(H,74,75)/t31-,38-,40+,41-,42+,43+,44+,45+,46-/m1/s1
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n/an/a 0.510n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136774
PNG
(6-amino-18-(4-aminobutyl)-9,24-dibenzyl-12-(4-hydr...)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)[C@@H](C)c1ccc2ccccc2c1
Show InChI InChI=1S/C57H69N9O11S2/c1-33(39-23-22-38-17-9-10-18-40(38)30-39)48-55(74)60-43(19-11-12-26-58)51(70)66-49(34(2)67)56(75)63-45(28-36-15-7-4-8-16-36)53(72)64-47(57(76)77)32-79-78-31-42(59)50(69)61-44(27-35-13-5-3-6-14-35)52(71)62-46(54(73)65-48)29-37-20-24-41(68)25-21-37/h3-10,13-18,20-25,30,33-34,42-49,67-68H,11-12,19,26-29,31-32,58-59H2,1-2H3,(H,60,74)(H,61,69)(H,62,71)(H,63,75)(H,64,72)(H,65,73)(H,66,70)(H,76,77)/t33-,34+,42+,43-,44+,45-,46-,47-,48+,49+/m0/s1
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n/an/a 0.530n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity at human Somatostatin receptor type 4 by [125I][Leu8,D-Trp22,Tyr25]SRIF-28 displacement.


J Med Chem 46: 5587-96 (2003)


Article DOI: 10.1021/jm0302445
BindingDB Entry DOI: 10.7270/Q2FX7B50
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136826
PNG
((14S,16R,25R)-25-Amino-13-(4-amino-butyl)-7,22-dib...)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)C(NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)[C@@H](C)c1ccc2ccccc2c1
Show InChI InChI=1S/C57H69N9O11S2/c1-33(39-23-22-38-17-9-10-18-40(38)30-39)48-55(74)60-43(19-11-12-26-58)51(70)66-49(34(2)67)56(75)63-45(28-36-15-7-4-8-16-36)53(72)64-47(57(76)77)32-79-78-31-42(59)50(69)61-44(27-35-13-5-3-6-14-35)52(71)62-46(54(73)65-48)29-37-20-24-41(68)25-21-37/h3-10,13-18,20-25,30,33-34,42-49,67-68H,11-12,19,26-29,31-32,58-59H2,1-2H3,(H,60,74)(H,61,69)(H,62,71)(H,63,75)(H,64,72)(H,65,73)(H,66,70)(H,76,77)/t33-,34+,42-,43-,44+,45-,46-,47-,48?,49+/m0/s1
KEGG

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n/an/a 0.550n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human Somatostatin receptor type 4 using 125I-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand


J Med Chem 46: 5606-18 (2003)


Article DOI: 10.1021/jm030246p
BindingDB Entry DOI: 10.7270/Q2GT5MMN
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50159451
PNG
(CHEMBL216992 | Des-AA1,2,5,12,13-[D-Trp8]SRIF)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C60H78N12O11S2/c1-36(73)51-59(81)70-48(31-39-21-9-4-10-22-39)57(79)71-50(60(82)83)35-85-84-34-42(63)52(74)65-44(25-13-15-27-61)53(75)67-46(29-37-17-5-2-6-18-37)55(77)68-47(30-38-19-7-3-8-20-38)56(78)69-49(32-40-33-64-43-24-12-11-23-41(40)43)58(80)66-45(54(76)72-51)26-14-16-28-62/h2-12,17-24,33,36,42,44-51,64,73H,13-16,25-32,34-35,61-63H2,1H3,(H,65,74)(H,66,80)(H,67,75)(H,68,77)(H,69,78)(H,70,81)(H,71,79)(H,72,76)(H,82,83)/t36-,42-,44-,45+,46-,47+,48+,49+,50+,51-/m1/s1
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n/an/a 0.600n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of 125I-[Leu8,D-Trp22,Tyr25]SRIF-28 binding to human somatostatin receptor type 4


J Med Chem 48: 515-22 (2005)


Article DOI: 10.1021/jm049519m
BindingDB Entry DOI: 10.7270/Q2QV3N9S
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136812
PNG
((S)-25-Amino-13-(4-amino-butyl)-7,19,22-tribenzyl-...)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C54H66N10O10S2/c1-32(65)46-53(72)62-43(27-35-19-9-4-10-20-35)51(70)63-45(54(73)74)31-76-75-30-38(56)47(66)59-41(25-33-15-5-2-6-16-33)49(68)60-42(26-34-17-7-3-8-18-34)50(69)61-44(28-36-29-57-39-22-12-11-21-37(36)39)52(71)58-40(48(67)64-46)23-13-14-24-55/h2-12,15-22,29,32,38,40-46,57,65H,13-14,23-28,30-31,55-56H2,1H3,(H,58,71)(H,59,66)(H,60,68)(H,61,69)(H,62,72)(H,63,70)(H,64,67)(H,73,74)/t32-,38-,40+,41-,42+,43+,44-,45+,46-/m1/s1
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n/an/a 0.700n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human Somatostatin receptor type 4 using 125I-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand


J Med Chem 46: 5606-18 (2003)


Article DOI: 10.1021/jm030246p
BindingDB Entry DOI: 10.7270/Q2GT5MMN
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136812
PNG
((S)-25-Amino-13-(4-amino-butyl)-7,19,22-tribenzyl-...)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C54H66N10O10S2/c1-32(65)46-53(72)62-43(27-35-19-9-4-10-20-35)51(70)63-45(54(73)74)31-76-75-30-38(56)47(66)59-41(25-33-15-5-2-6-16-33)49(68)60-42(26-34-17-7-3-8-18-34)50(69)61-44(28-36-29-57-39-22-12-11-21-37(36)39)52(71)58-40(48(67)64-46)23-13-14-24-55/h2-12,15-22,29,32,38,40-46,57,65H,13-14,23-28,30-31,55-56H2,1H3,(H,58,71)(H,59,66)(H,60,68)(H,61,69)(H,62,72)(H,63,70)(H,64,67)(H,73,74)/t32-,38-,40+,41-,42+,43+,44-,45+,46-/m1/s1
KEGG

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n/an/a 0.700n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50261393
PNG
((4R,7S,10S,13S,16R,19S,22S,25S)-25-Acetylamino-13-...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(C)=O |r|
Show InChI InChI=1S/C56H68N10O11S2/c1-33(67)48-55(75)64-44(28-37-20-10-5-11-21-37)52(72)65-47(56(76)77)32-79-78-31-46(59-34(2)68)54(74)62-43(27-36-18-8-4-9-19-36)50(70)61-42(26-35-16-6-3-7-17-35)51(71)63-45(29-38-30-58-40-23-13-12-22-39(38)40)53(73)60-41(49(69)66-48)24-14-15-25-57/h3-13,16-23,30,33,41-48,58,67H,14-15,24-29,31-32,57H2,1-2H3,(H,59,68)(H,60,73)(H,61,70)(H,62,74)(H,63,71)(H,64,75)(H,65,72)(H,66,69)(H,76,77)/t33-,41+,42+,43+,44+,45-,46-,47+,48+/m1/s1
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n/an/a 0.700n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF-28 from human cloned sst4 receptor expressed in CCL39 cells


J Med Chem 51: 2668-75 (2008)


Article DOI: 10.1021/jm701444y
BindingDB Entry DOI: 10.7270/Q2CF9R1G
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136765
PNG
((S)-25-Amino-13-(4-amino-butyl)-7,19,22-tribenzyl-...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C54H66N10O10S2/c1-32(65)46-53(72)62-43(27-35-19-9-4-10-20-35)51(70)63-45(54(73)74)31-76-75-30-38(56)47(66)59-41(25-33-15-5-2-6-16-33)49(68)60-42(26-34-17-7-3-8-18-34)50(69)61-44(28-36-29-57-39-22-12-11-21-37(36)39)52(71)58-40(48(67)64-46)23-13-14-24-55/h2-12,15-22,29,32,38,40-46,57,65H,13-14,23-28,30-31,55-56H2,1H3,(H,58,71)(H,59,66)(H,60,68)(H,61,69)(H,62,72)(H,63,70)(H,64,67)(H,73,74)/t32-,38-,40-,41-,42-,43-,44+,45-,46+/m1/s1
KEGG

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n/an/a 0.700n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human Somatostatin receptor type 4 using 125I-[Leu,DTrp,Tyr]SRIF-28 as radioligand


J Med Chem 46: 5579-86 (2003)


Article DOI: 10.1021/jm030243c
BindingDB Entry DOI: 10.7270/Q2KP82W9
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50352482
PNG
(CHEMBL1824055)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O |r|
Show InChI InChI=1S/C54H66N10O10S2/c1-32(65)46-53(72)62-43(27-35-19-9-4-10-20-35)51(70)63-45(54(73)74)31-76-75-30-38(56)47(66)59-41(25-33-15-5-2-6-16-33)49(68)60-42(26-34-17-7-3-8-18-34)50(69)61-44(28-36-29-57-39-22-12-11-21-37(36)39)52(71)58-40(48(67)64-46)23-13-14-24-55/h2-12,15-22,29,32,38,40-46,57,65H,13-14,23-28,30-31,55-56H2,1H3,(H,58,71)(H,59,66)(H,60,68)(H,61,69)(H,62,72)(H,63,70)(H,64,67)(H,73,74)/t32-,38+,40+,41+,42+,43+,44+,45+,46+/m1/s1
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n/an/a 0.700n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Displacement of 125I-[LTT]-SRIF-28 from human sst4 receptor in CCL39 cells after 2 hrs by autoradiography


J Med Chem 54: 5981-7 (2011)


Article DOI: 10.1021/jm200307v
BindingDB Entry DOI: 10.7270/Q2BV7H1N
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136789
PNG
((S)-25-Amino-13-(4-amino-butyl)-7,22-dibenzyl-10-(...)
Show SMILES C[C@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C48H62N10O10S2/c1-27-41(60)54-38(23-31-24-51-34-18-10-9-17-32(31)34)46(65)53-35(19-11-12-20-49)43(62)58-40(28(2)59)47(66)56-37(22-30-15-7-4-8-16-30)45(64)57-39(48(67)68)26-70-69-25-33(50)42(61)55-36(44(63)52-27)21-29-13-5-3-6-14-29/h3-10,13-18,24,27-28,33,35-40,51,59H,11-12,19-23,25-26,49-50H2,1-2H3,(H,52,63)(H,53,65)(H,54,60)(H,55,61)(H,56,66)(H,57,64)(H,58,62)(H,67,68)/t27-,28-,33+,35-,36+,37-,38-,39-,40-/m0/s1
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n/an/a 0.840n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136830
PNG
((S)-25-Amino-13-(4-amino-butyl)-7,22-dibenzyl-10-(...)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C48H62N10O10S2/c1-27-41(60)54-38(23-31-24-51-34-18-10-9-17-32(31)34)46(65)53-35(19-11-12-20-49)43(62)58-40(28(2)59)47(66)56-37(22-30-15-7-4-8-16-30)45(64)57-39(48(67)68)26-70-69-25-33(50)42(61)55-36(44(63)52-27)21-29-13-5-3-6-14-29/h3-10,13-18,24,27-28,33,35-40,51,59H,11-12,19-23,25-26,49-50H2,1-2H3,(H,52,63)(H,53,65)(H,54,60)(H,55,61)(H,56,66)(H,57,64)(H,58,62)(H,67,68)/t27-,28+,33+,35-,36+,37-,38+,39-,40+/m0/s1
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n/an/a 0.840n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human Somatostatin receptor type 4 using 125I-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand


J Med Chem 46: 5606-18 (2003)


Article DOI: 10.1021/jm030246p
BindingDB Entry DOI: 10.7270/Q2GT5MMN
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136791
PNG
((S)-25-Amino-19-(4-amino-benzyl)-13-(4-amino-butyl...)
Show SMILES C[C@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(N)cc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C54H67N11O10S2/c1-31(66)46-53(73)63-43(25-33-14-6-3-7-15-33)51(71)64-45(54(74)75)30-77-76-29-38(57)47(67)60-41(24-32-12-4-2-5-13-32)49(69)61-42(26-34-19-21-36(56)22-20-34)50(70)62-44(27-35-28-58-39-17-9-8-16-37(35)39)52(72)59-40(48(68)65-46)18-10-11-23-55/h2-9,12-17,19-22,28,31,38,40-46,58,66H,10-11,18,23-27,29-30,55-57H2,1H3,(H,59,72)(H,60,67)(H,61,69)(H,62,70)(H,63,73)(H,64,71)(H,65,68)(H,74,75)/t31-,38+,40-,41+,42-,43-,44-,45-,46-/m0/s1
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n/an/a 0.880n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50261408
PNG
((4R,7S,10S,13S,16R,19S,22S,25R)-25-Acetylamino-13-...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CCSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(C)=O |r|
Show InChI InChI=1S/C57H70N10O11S2/c1-34(68)49-56(76)65-46(30-38-20-10-5-11-21-38)54(74)66-48(57(77)78)33-80-79-27-25-43(60-35(2)69)50(70)62-44(28-36-16-6-3-7-17-36)52(72)63-45(29-37-18-8-4-9-19-37)53(73)64-47(31-39-32-59-41-23-13-12-22-40(39)41)55(75)61-42(51(71)67-49)24-14-15-26-58/h3-13,16-23,32,34,42-49,59,68H,14-15,24-31,33,58H2,1-2H3,(H,60,69)(H,61,75)(H,62,70)(H,63,72)(H,64,73)(H,65,76)(H,66,74)(H,67,71)(H,77,78)/t34-,42+,43-,44+,45+,46+,47-,48+,49+/m1/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF-28 from human cloned sst4 receptor expressed in CCL39 cells


J Med Chem 51: 2668-75 (2008)


Article DOI: 10.1021/jm701444y
BindingDB Entry DOI: 10.7270/Q2CF9R1G
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136822
PNG
(CHEMBL406374 | Somatostatin analogue)
Show SMILES C[C@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@H](N)Cc1ccc(O)cc1)[C@@H](C)c1c[nH]c2ccccc12
Show InChI InChI=1S/C64H77N11O12S2/c1-37(45-34-67-47-23-13-12-22-44(45)47)54-62(84)68-48(24-14-15-29-65)57(79)75-55(38(2)76)63(85)71-50(32-40-18-8-4-9-19-40)59(81)73-53(64(86)87)36-89-88-35-52(72-56(78)46(66)30-42-25-27-43(77)28-26-42)61(83)70-49(31-39-16-6-3-7-17-39)58(80)69-51(60(82)74-54)33-41-20-10-5-11-21-41/h3-13,16-23,25-28,34,37-38,46,48-55,67,76-77H,14-15,24,29-33,35-36,65-66H2,1-2H3,(H,68,84)(H,69,80)(H,70,83)(H,71,85)(H,72,78)(H,73,81)(H,74,82)(H,75,79)(H,86,87)/t37-,38-,46+,48-,49+,50-,51-,52+,53-,54+,55-/m0/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136811
PNG
((S)-25-Amino-13-(4-amino-butyl)-7,22-dibenzyl-10-(...)
Show SMILES C[C@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C48H62N10O10S2/c1-27-41(60)54-38(23-31-24-51-34-18-10-9-17-32(31)34)46(65)53-35(19-11-12-20-49)43(62)58-40(28(2)59)47(66)56-37(22-30-15-7-4-8-16-30)45(64)57-39(48(67)68)26-70-69-25-33(50)42(61)55-36(44(63)52-27)21-29-13-5-3-6-14-29/h3-10,13-18,24,27-28,33,35-40,51,59H,11-12,19-23,25-26,49-50H2,1-2H3,(H,52,63)(H,53,65)(H,54,60)(H,55,61)(H,56,66)(H,57,64)(H,58,62)(H,67,68)/t27-,28-,33+,35-,36+,37-,38+,39-,40-/m0/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136832
PNG
((S)-25-Amino-13-(4-amino-butyl)-7,22-dibenzyl-10-(...)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C48H62N10O10S2/c1-27-41(60)54-38(23-31-24-51-34-18-10-9-17-32(31)34)46(65)53-35(19-11-12-20-49)43(62)58-40(28(2)59)47(66)56-37(22-30-15-7-4-8-16-30)45(64)57-39(48(67)68)26-70-69-25-33(50)42(61)55-36(44(63)52-27)21-29-13-5-3-6-14-29/h3-10,13-18,24,27-28,33,35-40,51,59H,11-12,19-23,25-26,49-50H2,1-2H3,(H,52,63)(H,53,65)(H,54,60)(H,55,61)(H,56,66)(H,57,64)(H,58,62)(H,67,68)/t27-,28+,33+,35-,36+,37-,38-,39-,40+/m0/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human Somatostatin receptor type 4 using 125I-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand


J Med Chem 46: 5606-18 (2003)


Article DOI: 10.1021/jm030246p
BindingDB Entry DOI: 10.7270/Q2GT5MMN
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50254255
PNG
((5S)-6-oxo-5-[(4R)-3-oxo-4-[(phenylacetyl)amino]-3...)
Show SMILES C[C@H](NC(=O)[C@H](CCCCN)N1Cc2[nH]c3ccccc3c2C[C@@H](NC(=O)Cc2ccccc2)C1=O)c1ccccc1 |r|
Show InChI InChI=1S/C34H39N5O3/c1-23(25-14-6-3-7-15-25)36-33(41)31(18-10-11-19-35)39-22-30-27(26-16-8-9-17-28(26)37-30)21-29(34(39)42)38-32(40)20-24-12-4-2-5-13-24/h2-9,12-17,23,29,31,37H,10-11,18-22,35H2,1H3,(H,36,41)(H,38,40)/t23-,29+,31-/m0/s1
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Vrije Universiteit Brussel

Curated by ChEMBL


Assay Description
Displacement of [125I]-[Leu8, DTrp22, Tyr25]-somatostatin-28 from human recombinant sst4 receptor expressed in chinese hamster CCL39 cells


J Med Chem 52: 95-104 (2009)


Article DOI: 10.1021/jm801205x
BindingDB Entry DOI: 10.7270/Q27W6D3B
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50261389
PNG
((4R,7S,10S,13S,16R,19S,22S,25R)-25-Amino-13-(4-ami...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O |r|
Show InChI InChI=1S/C54H66N10O10S2/c1-32(65)46-53(72)62-43(27-35-19-9-4-10-20-35)51(70)63-45(54(73)74)31-76-75-30-38(56)47(66)59-41(25-33-15-5-2-6-16-33)49(68)60-42(26-34-17-7-3-8-18-34)50(69)61-44(28-36-29-57-39-22-12-11-21-37(36)39)52(71)58-40(48(67)64-46)23-13-14-24-55/h2-12,15-22,29,32,38,40-46,57,65H,13-14,23-28,30-31,55-56H2,1H3,(H,58,71)(H,59,66)(H,60,68)(H,61,69)(H,62,72)(H,63,70)(H,64,67)(H,73,74)/t32-,38-,40+,41+,42+,43+,44-,45+,46+/m1/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF-28 from human cloned sst4 receptor expressed in CCL39 cells


J Med Chem 51: 2668-75 (2008)


Article DOI: 10.1021/jm701444y
BindingDB Entry DOI: 10.7270/Q2CF9R1G
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136790
PNG
((4R,7S,10R,13S,16S,19S,22R,25S)-13-(4-Amino-butyl)...)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(O)=O)NC(N)=O
Show InChI InChI=1S/C55H67N11O12S2/c1-31(67)46-53(75)63-42(26-34-19-21-36(68)22-20-34)50(72)64-45(54(76)77)30-80-79-29-44(65-55(57)78)52(74)61-41(25-33-14-6-3-7-15-33)48(70)60-40(24-32-12-4-2-5-13-32)49(71)62-43(27-35-28-58-38-17-9-8-16-37(35)38)51(73)59-39(47(69)66-46)18-10-11-23-56/h2-9,12-17,19-22,28,31,39-46,58,67-68H,10-11,18,23-27,29-30,56H2,1H3,(H,59,73)(H,60,70)(H,61,74)(H,62,71)(H,63,75)(H,64,72)(H,66,69)(H,76,77)(H3,57,65,78)/t31-,39+,40+,41-,42+,43+,44-,45+,46-/m1/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50159450
PNG
(CHEMBL386784 | Des-AA1,2,4,5,13-[D-Trp8]-SRIF)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC1=O)C(O)=O)[C@@H](C)O
Show InChI InChI=1S/C58H73N11O12S2/c1-33(70)48-56(78)66-45(28-37-20-10-5-11-21-37)55(77)69-49(34(2)71)57(79)67-47(58(80)81)32-83-82-31-40(60)50(72)63-43(26-35-16-6-3-7-17-35)52(74)64-44(27-36-18-8-4-9-19-36)53(75)65-46(29-38-30-61-41-23-13-12-22-39(38)41)54(76)62-42(51(73)68-48)24-14-15-25-59/h3-13,16-23,30,33-34,40,42-49,61,70-71H,14-15,24-29,31-32,59-60H2,1-2H3,(H,62,76)(H,63,72)(H,64,74)(H,65,75)(H,66,78)(H,67,79)(H,68,73)(H,69,77)(H,80,81)/t33-,34-,40-,42+,43-,44+,45+,46+,47+,48-,49-/m1/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of 125I-[Leu8,D-Trp22,Tyr25]SRIF-28 binding to human somatostatin receptor type 4


J Med Chem 48: 515-22 (2005)


Article DOI: 10.1021/jm049519m
BindingDB Entry DOI: 10.7270/Q2QV3N9S
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136807
PNG
(CHEMBL405735 | Somatostatin analogue)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(N)cc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(O)=O
Show InChI InChI=1S/C54H67N11O11S2/c1-30(66)46-53(74)63-43(25-33-16-20-36(67)21-17-33)51(72)64-45(54(75)76)29-78-77-28-38(57)47(68)60-41(23-31-9-3-2-4-10-31)49(70)61-42(24-32-14-18-35(56)19-15-32)50(71)62-44(26-34-27-58-39-12-6-5-11-37(34)39)52(73)59-40(48(69)65-46)13-7-8-22-55/h2-6,9-12,14-21,27,30,38,40-46,58,66-67H,7-8,13,22-26,28-29,55-57H2,1H3,(H,59,73)(H,60,68)(H,61,70)(H,62,71)(H,63,74)(H,64,72)(H,65,69)(H,75,76)/t30-,38-,40+,41-,42+,43+,44-,45+,46-/m1/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136813
PNG
((4R,7S,10S,13S,16R,19S,22R,25S)-19-(4-Amino-benzyl...)
Show SMILES C[C@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(N)cc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(N)=O
Show InChI InChI=1S/C55H68N12O11S2/c1-31(68)46-53(75)64-42(25-33-14-6-3-7-15-33)50(72)65-45(54(76)77)30-80-79-29-44(66-55(58)78)52(74)62-40(24-32-12-4-2-5-13-32)48(70)61-41(26-34-19-21-36(57)22-20-34)49(71)63-43(27-35-28-59-38-17-9-8-16-37(35)38)51(73)60-39(47(69)67-46)18-10-11-23-56/h2-9,12-17,19-22,28,31,39-46,59,68H,10-11,18,23-27,29-30,56-57H2,1H3,(H,60,73)(H,61,70)(H,62,74)(H,63,71)(H,64,75)(H,65,72)(H,67,69)(H,76,77)(H3,58,66,78)/t31-,39-,40+,41-,42-,43+,44+,45-,46-/m0/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136810
PNG
(CHEMBL406815 | Somatostatin analogue)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C57H71N11O12S2/c1-32-49(71)63-45(28-37-29-60-41-18-10-9-17-39(37)41)54(76)62-42(19-11-12-24-58)51(73)68-48(33(2)69)56(78)65-44(27-35-15-7-4-8-16-35)53(75)67-47(57(79)80)31-82-81-30-46(66-50(72)40(59)25-36-20-22-38(70)23-21-36)55(77)64-43(52(74)61-32)26-34-13-5-3-6-14-34/h3-10,13-18,20-23,29,32-33,40,42-48,60,69-70H,11-12,19,24-28,30-31,58-59H2,1-2H3,(H,61,74)(H,62,76)(H,63,71)(H,64,77)(H,65,78)(H,66,72)(H,67,75)(H,68,73)(H,79,80)/t32-,33+,40+,42-,43+,44-,45+,46+,47-,48+/m0/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136804
PNG
(CHEMBL439077 | Somatostatin analogue)
Show SMILES C[C@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(N)cc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C63H76N12O12S2/c1-36(76)54-62(85)72-50(30-38-14-6-3-7-15-38)59(82)74-53(63(86)87)35-89-88-34-52(73-55(78)45(66)28-39-21-25-43(77)26-22-39)61(84)70-48(29-37-12-4-2-5-13-37)57(80)69-49(31-40-19-23-42(65)24-20-40)58(81)71-51(32-41-33-67-46-17-9-8-16-44(41)46)60(83)68-47(56(79)75-54)18-10-11-27-64/h2-9,12-17,19-26,33,36,45,47-54,67,76-77H,10-11,18,27-32,34-35,64-66H2,1H3,(H,68,83)(H,69,80)(H,70,84)(H,71,81)(H,72,85)(H,73,78)(H,74,82)(H,75,79)(H,86,87)/t36-,45+,47-,48+,49-,50-,51-,52+,53-,54-/m0/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136817
PNG
(CHEMBL410599 | Somatostatin analogue)
Show SMILES C[C@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(N)cc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(N)=O
Show InChI InChI=1S/C64H77N13O13S2/c1-36(78)54-62(87)73-49(29-38-14-6-3-7-15-38)58(83)75-53(63(88)89)35-92-91-34-52(74-59(84)50(76-64(67)90)31-40-21-25-43(79)26-22-40)61(86)71-47(28-37-12-4-2-5-13-37)56(81)70-48(30-39-19-23-42(66)24-20-39)57(82)72-51(32-41-33-68-45-17-9-8-16-44(41)45)60(85)69-46(55(80)77-54)18-10-11-27-65/h2-9,12-17,19-26,33,36,46-54,68,78-79H,10-11,18,27-32,34-35,65-66H2,1H3,(H,69,85)(H,70,81)(H,71,86)(H,72,82)(H,73,87)(H,74,84)(H,75,83)(H,77,80)(H,88,89)(H3,67,76,90)/t36-,46-,47+,48-,49-,50+,51+,52+,53-,54-/m0/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50159457
PNG
(CHEMBL263587 | Des-AA1,2,4,12,13-[D-Trp8]SRIF)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C58H72N12O12S2/c1-33(71)49-57(80)68-44(27-36-19-9-4-10-20-36)54(77)69-47(58(81)82)32-84-83-31-39(60)50(73)64-46(29-48(61)72)56(79)66-42(25-34-15-5-2-6-16-34)52(75)65-43(26-35-17-7-3-8-18-35)53(76)67-45(28-37-30-62-40-22-12-11-21-38(37)40)55(78)63-41(51(74)70-49)23-13-14-24-59/h2-12,15-22,30,33,39,41-47,49,62,71H,13-14,23-29,31-32,59-60H2,1H3,(H2,61,72)(H,63,78)(H,64,73)(H,65,75)(H,66,79)(H,67,76)(H,68,80)(H,69,77)(H,70,74)(H,81,82)/t33-,39-,41+,42-,43+,44+,45+,46+,47+,49-/m1/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of 125I-[Leu8,D-Trp22,Tyr25]SRIF-28 binding to human somatostatin receptor type 4


J Med Chem 48: 515-22 (2005)


Article DOI: 10.1021/jm049519m
BindingDB Entry DOI: 10.7270/Q2QV3N9S
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136795
PNG
((S)-25-Amino-19-(4-amino-benzyl)-13-(4-amino-butyl...)
Show SMILES C[C@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(N)cc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C54H67N11O10S2/c1-31(66)46-53(73)63-43(25-33-14-6-3-7-15-33)51(71)64-45(54(74)75)30-77-76-29-38(57)47(67)60-41(24-32-12-4-2-5-13-32)49(69)61-42(26-34-19-21-36(56)22-20-34)50(70)62-44(27-35-28-58-39-17-9-8-16-37(35)39)52(72)59-40(48(68)65-46)18-10-11-23-55/h2-9,12-17,19-22,28,31,38,40-46,58,66H,10-11,18,23-27,29-30,55-57H2,1H3,(H,59,72)(H,60,67)(H,61,69)(H,62,70)(H,63,73)(H,64,71)(H,65,68)(H,74,75)/t31-,38+,40-,41+,42-,43-,44+,45-,46-/m0/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136784
PNG
(6-amino-18-(4-aminobutyl)-9,24-dibenzyl-12-(4-hydr...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)C(Cc2cccc3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C56H67N9O11S2/c1-33(66)48-55(74)63-45(28-35-15-6-3-7-16-35)53(72)64-47(56(75)76)32-78-77-31-41(58)49(68)60-43(27-34-13-4-2-5-14-34)51(70)61-44(29-36-22-24-39(67)25-23-36)52(71)62-46(30-38-19-12-18-37-17-8-9-20-40(37)38)54(73)59-42(50(69)65-48)21-10-11-26-57/h2-9,12-20,22-25,33,41-48,66-67H,10-11,21,26-32,57-58H2,1H3,(H,59,73)(H,60,68)(H,61,70)(H,62,71)(H,63,74)(H,64,72)(H,65,69)(H,75,76)/t33-,41+,42+,43-,44+,45+,46?,47-,48+/m1/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity at human Somatostatin receptor type 4 by [125I][Leu8,D-Trp22,Tyr25]SRIF-28 displacement.


J Med Chem 46: 5587-96 (2003)


Article DOI: 10.1021/jm0302445
BindingDB Entry DOI: 10.7270/Q2FX7B50
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136820
PNG
((4R,7S,10R,13S,16R,19S,22R,25S)-25-Amino-13-(4-ami...)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(O)=O
Show InChI InChI=1S/C54H66N10O11S2/c1-31(65)46-53(73)62-43(26-34-19-21-36(66)22-20-34)51(71)63-45(54(74)75)30-77-76-29-38(56)47(67)59-41(24-32-12-4-2-5-13-32)49(69)60-42(25-33-14-6-3-7-15-33)50(70)61-44(27-35-28-57-39-17-9-8-16-37(35)39)52(72)58-40(48(68)64-46)18-10-11-23-55/h2-9,12-17,19-22,28,31,38,40-46,57,65-66H,10-11,18,23-27,29-30,55-56H2,1H3,(H,58,72)(H,59,67)(H,60,69)(H,61,70)(H,62,73)(H,63,71)(H,64,68)(H,74,75)/t31-,38-,40+,41-,42+,43+,44-,45+,46-/m1/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50100746
PNG
(CHEMBL265912 | Des-AA1,2,4,5,12,13-[DTrp8]-SRIF)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C54H66N10O10S2/c1-32(65)46-53(72)62-43(27-35-19-9-4-10-20-35)51(70)63-45(54(73)74)31-76-75-30-38(56)47(66)59-41(25-33-15-5-2-6-16-33)49(68)60-42(26-34-17-7-3-8-18-34)50(69)61-44(28-36-29-57-39-22-12-11-21-37(36)39)52(71)58-40(48(67)64-46)23-13-14-24-55/h2-12,15-22,29,32,38,40-46,57,65H,13-14,23-28,30-31,55-56H2,1H3,(H,58,71)(H,59,66)(H,60,68)(H,61,69)(H,62,72)(H,63,70)(H,64,67)(H,73,74)/t32-,38-,40+,41+,42+,43+,44-,45+,46-/m1/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) recept...


J Med Chem 44: 2238-46 (2001)


BindingDB Entry DOI: 10.7270/Q21R6PSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50254244
PNG
((5S)-5-[(4R)-4-(benzoylamino)-3-oxo-3,4,5,10-tetra...)
Show SMILES NCCCC[C@H](N1Cc2[nH]c3ccccc3c2C[C@@H](NC(=O)c2ccccc2)C1=O)C(=O)NCc1ccccc1 |r|
Show InChI InChI=1S/C32H35N5O3/c33-18-10-9-17-29(31(39)34-20-22-11-3-1-4-12-22)37-21-28-25(24-15-7-8-16-26(24)35-28)19-27(32(37)40)36-30(38)23-13-5-2-6-14-23/h1-8,11-16,27,29,35H,9-10,17-21,33H2,(H,34,39)(H,36,38)/t27-,29+/m1/s1
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Vrije Universiteit Brussel

Curated by ChEMBL


Assay Description
Displacement of [125I]-[Leu8, DTrp22, Tyr25]-somatostatin-28 from human recombinant sst4 receptor expressed in chinese hamster CCL39 cells


J Med Chem 52: 95-104 (2009)


Article DOI: 10.1021/jm801205x
BindingDB Entry DOI: 10.7270/Q27W6D3B
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136803
PNG
((S)-25-Amino-13-(4-amino-butyl)-7,22-dibenzyl-19-(...)
Show SMILES C[C@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C54H66N10O11S2/c1-31(65)46-53(73)62-43(25-33-14-6-3-7-15-33)51(71)63-45(54(74)75)30-77-76-29-38(56)47(67)59-41(24-32-12-4-2-5-13-32)49(69)60-42(26-34-19-21-36(66)22-20-34)50(70)61-44(27-35-28-57-39-17-9-8-16-37(35)39)52(72)58-40(48(68)64-46)18-10-11-23-55/h2-9,12-17,19-22,28,31,38,40-46,57,65-66H,10-11,18,23-27,29-30,55-56H2,1H3,(H,58,72)(H,59,67)(H,60,69)(H,61,70)(H,62,73)(H,63,71)(H,64,68)(H,74,75)/t31-,38+,40-,41+,42-,43-,44-,45-,46-/m0/s1
KEGG

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n/an/a 1.30n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50261392
PNG
((4R,7S,10S,13S,16R,19S,22S,25R)-25-Acetylamino-13-...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(C)=O |r|
Show InChI InChI=1S/C56H68N10O11S2/c1-33(67)48-55(75)64-44(28-37-20-10-5-11-21-37)52(72)65-47(56(76)77)32-79-78-31-46(59-34(2)68)54(74)62-43(27-36-18-8-4-9-19-36)50(70)61-42(26-35-16-6-3-7-17-35)51(71)63-45(29-38-30-58-40-23-13-12-22-39(38)40)53(73)60-41(49(69)66-48)24-14-15-25-57/h3-13,16-23,30,33,41-48,58,67H,14-15,24-29,31-32,57H2,1-2H3,(H,59,68)(H,60,73)(H,61,70)(H,62,74)(H,63,71)(H,64,75)(H,65,72)(H,66,69)(H,76,77)/t33-,41+,42+,43+,44+,45-,46+,47+,48+/m1/s1
KEGG

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n/an/a 1.30n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF-28 from human cloned sst4 receptor expressed in CCL39 cells


J Med Chem 51: 2668-75 (2008)


Article DOI: 10.1021/jm701444y
BindingDB Entry DOI: 10.7270/Q2CF9R1G
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50261409
PNG
((4R,7S,10S,13S,16R,19S,22S,25S)-25-Acetylamino-13-...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(C)=O |r|
Show InChI InChI=1S/C57H70N10O11S2/c1-34(68)49-56(76)65-46(30-38-20-10-5-11-21-38)54(74)66-48(57(77)78)33-80-79-27-25-43(60-35(2)69)50(70)62-44(28-36-16-6-3-7-17-36)52(72)63-45(29-37-18-8-4-9-19-37)53(73)64-47(31-39-32-59-41-23-13-12-22-40(39)41)55(75)61-42(51(71)67-49)24-14-15-26-58/h3-13,16-23,32,34,42-49,59,68H,14-15,24-31,33,58H2,1-2H3,(H,60,69)(H,61,75)(H,62,70)(H,63,72)(H,64,73)(H,65,76)(H,66,74)(H,67,71)(H,77,78)/t34-,42+,43+,44+,45+,46+,47-,48+,49+/m1/s1
KEGG

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n/an/a 1.40n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF-28 from human cloned sst4 receptor expressed in CCL39 cells


J Med Chem 51: 2668-75 (2008)


Article DOI: 10.1021/jm701444y
BindingDB Entry DOI: 10.7270/Q2CF9R1G
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50159444
PNG
(CHEMBL410047 | Des-AA1,2,4,13-[D-Trp8]SRIF)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](N)CSSC[C@H](NC1=O)C(O)=O)[C@@H](C)O
Show InChI InChI=1S/C62H79N13O14S2/c1-34(76)51-60(86)72-46(28-38-20-10-5-11-21-38)59(85)75-52(35(2)77)61(87)73-49(62(88)89)33-91-90-32-41(64)53(79)68-48(30-50(65)78)58(84)70-44(26-36-16-6-3-7-17-36)55(81)69-45(27-37-18-8-4-9-19-37)56(82)71-47(29-39-31-66-42-23-13-12-22-40(39)42)57(83)67-43(54(80)74-51)24-14-15-25-63/h3-13,16-23,31,34-35,41,43-49,51-52,66,76-77H,14-15,24-30,32-33,63-64H2,1-2H3,(H2,65,78)(H,67,83)(H,68,79)(H,69,81)(H,70,84)(H,71,82)(H,72,86)(H,73,87)(H,74,80)(H,75,85)(H,88,89)/t34-,35-,41-,43+,44-,45+,46+,47+,48+,49+,51-,52-/m1/s1
KEGG

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n/an/a 1.40n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of 125I-[Leu8,D-Trp22,Tyr25]SRIF-28 binding to human somatostatin receptor type 4


J Med Chem 48: 515-22 (2005)


Article DOI: 10.1021/jm049519m
BindingDB Entry DOI: 10.7270/Q2QV3N9S
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136778
PNG
(6-amino-18-(4-aminobutyl)-9,24-dibenzyl-12-(4-hydr...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)C(Cc2cccc3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C56H67N9O11S2/c1-33(66)48-55(74)63-45(28-35-15-6-3-7-16-35)53(72)64-47(56(75)76)32-78-77-31-41(58)49(68)60-43(27-34-13-4-2-5-14-34)51(70)61-44(29-36-22-24-39(67)25-23-36)52(71)62-46(30-38-19-12-18-37-17-8-9-20-40(37)38)54(73)59-42(50(69)65-48)21-10-11-26-57/h2-9,12-20,22-25,33,41-48,66-67H,10-11,21,26-32,57-58H2,1H3,(H,59,73)(H,60,68)(H,61,70)(H,62,71)(H,63,74)(H,64,72)(H,65,69)(H,75,76)/t33-,41-,42+,43-,44+,45+,46?,47-,48+/m1/s1
KEGG

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n/an/a 1.40n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity at human Somatostatin receptor type 4 by [125I][Leu8,D-Trp22,Tyr25]SRIF-28 displacement.


J Med Chem 46: 5587-96 (2003)


Article DOI: 10.1021/jm0302445
BindingDB Entry DOI: 10.7270/Q2FX7B50
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50261400
PNG
((3R,6S,9S,12S,15R,18S,21S,24S)-24-Acetylamino-12-(...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CSS[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(C)=O |r|
Show InChI InChI=1S/C55H66N10O11S2/c1-32(66)46-53(74)63-43(28-36-20-10-5-11-21-36)51(72)65-54(55(75)76)78-77-31-45(58-33(2)67)52(73)61-42(27-35-18-8-4-9-19-35)48(69)60-41(26-34-16-6-3-7-17-34)49(70)62-44(29-37-30-57-39-23-13-12-22-38(37)39)50(71)59-40(47(68)64-46)24-14-15-25-56/h3-13,16-23,30,32,40-46,54,57,66H,14-15,24-29,31,56H2,1-2H3,(H,58,67)(H,59,71)(H,60,69)(H,61,73)(H,62,70)(H,63,74)(H,64,68)(H,65,72)(H,75,76)/t32-,40+,41+,42+,43+,44-,45-,46+,54-/m1/s1
KEGG

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n/an/a 1.5n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF-28 from human cloned sst4 receptor expressed in CCL39 cells


J Med Chem 51: 2668-75 (2008)


Article DOI: 10.1021/jm701444y
BindingDB Entry DOI: 10.7270/Q2CF9R1G
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136788
PNG
((4R,7S,10S,13S,16S,19S,22R,25S)-19-(4-Amino-benzyl...)
Show SMILES C[C@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(N)cc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(N)=O
Show InChI InChI=1S/C55H68N12O11S2/c1-31(68)46-53(75)64-42(25-33-14-6-3-7-15-33)50(72)65-45(54(76)77)30-80-79-29-44(66-55(58)78)52(74)62-40(24-32-12-4-2-5-13-32)48(70)61-41(26-34-19-21-36(57)22-20-34)49(71)63-43(27-35-28-59-38-17-9-8-16-37(35)38)51(73)60-39(47(69)67-46)18-10-11-23-56/h2-9,12-17,19-22,28,31,39-46,59,68H,10-11,18,23-27,29-30,56-57H2,1H3,(H,60,73)(H,61,70)(H,62,74)(H,63,71)(H,64,75)(H,65,72)(H,67,69)(H,76,77)(H3,58,66,78)/t31-,39-,40+,41-,42-,43-,44+,45-,46-/m0/s1
KEGG

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Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50159392
PNG
((4R,7R,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37...)
Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C137H207N41O39S3/c1-69(154-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)156-114(195)88(46-54-218-7)158-110(191)71(3)155-129(210)100-42-28-53-178(100)134(215)95(61-104(144)186)171-126(207)96(65-180)172-124(205)93(59-102(142)184)165-111(192)70(2)153-112(193)80(141)64-179)109(190)152-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(58-78-62-151-81-36-18-17-35-79(78)81)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(60-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,62,69-74,80,82-101,107-108,151,179-183H,19-28,37-61,63-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,152,190)(H,153,193)(H,154,194)(H,155,210)(H,156,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)/t69-,70-,71-,72-,73+,74+,80-,82-,83+,84-,85-,86-,87-,88-,89+,90-,91-,92+,93-,94-,95-,96-,97-,98+,99-,100-,101-,107+,108+/m0/s1
KEGG

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n/an/a 1.60n/an/an/an/an/an/a



University of Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I](Leu8,D-Trp22,Tyr25)-SRIF28 from human sst4 receptor


J Med Chem 51: 512-20 (2008)


Article DOI: 10.1021/jm070886i
BindingDB Entry DOI: 10.7270/Q26974D8
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136798
PNG
(CHEMBL410372 | Somatostatin analogue)
Show SMILES C[C@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C63H75N11O12S2/c1-37(75)54-62(84)71-50(32-40-19-9-4-10-20-40)59(81)73-53(63(85)86)36-88-87-35-52(72-55(77)45(65)29-41-24-26-43(76)27-25-41)61(83)69-49(31-39-17-7-3-8-18-39)57(79)68-48(30-38-15-5-2-6-16-38)58(80)70-51(33-42-34-66-46-22-12-11-21-44(42)46)60(82)67-47(56(78)74-54)23-13-14-28-64/h2-12,15-22,24-27,34,37,45,47-54,66,75-76H,13-14,23,28-33,35-36,64-65H2,1H3,(H,67,82)(H,68,79)(H,69,83)(H,70,80)(H,71,84)(H,72,77)(H,73,81)(H,74,78)(H,85,86)/t37-,45+,47-,48-,49+,50-,51+,52+,53-,54-/m0/s1
KEGG

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n/an/a 1.60n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50159392
PNG
((4R,7R,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37...)
Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C137H207N41O39S3/c1-69(154-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)156-114(195)88(46-54-218-7)158-110(191)71(3)155-129(210)100-42-28-53-178(100)134(215)95(61-104(144)186)171-126(207)96(65-180)172-124(205)93(59-102(142)184)165-111(192)70(2)153-112(193)80(141)64-179)109(190)152-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(58-78-62-151-81-36-18-17-35-79(78)81)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(60-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,62,69-74,80,82-101,107-108,151,179-183H,19-28,37-61,63-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,152,190)(H,153,193)(H,154,194)(H,155,210)(H,156,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)/t69-,70-,71-,72-,73+,74+,80-,82-,83+,84-,85-,86-,87-,88-,89+,90-,91-,92+,93-,94-,95-,96-,97-,98+,99-,100-,101-,107+,108+/m0/s1
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n/an/a 1.60n/an/an/an/an/an/a



University of Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]-[LTT] SIRF-28 from human SST4 receptor expressed in human CCL39 cells by autoradiography


J Med Chem 53: 6188-97 (2010)


Article DOI: 10.1021/jm1005868
BindingDB Entry DOI: 10.7270/Q2NC625N
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50261406
PNG
((3R,6S,9S,12S,15R,18S,21S,24R)-24-Acetylamino-12-(...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(C)=O)SS[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O |r|
Show InChI InChI=1S/C54H64N10O11S2/c1-31(65)44-50(72)61-42(28-35-20-10-5-11-21-35)49(71)64-53(54(74)75)77-76-52(57-32(2)66)51(73)62-41(27-34-18-8-4-9-19-34)47(69)59-40(26-33-16-6-3-7-17-33)46(68)60-43(29-36-30-56-38-23-13-12-22-37(36)38)48(70)58-39(45(67)63-44)24-14-15-25-55/h3-13,16-23,30-31,39-44,52-53,56,65H,14-15,24-29,55H2,1-2H3,(H,57,66)(H,58,70)(H,59,69)(H,60,68)(H,61,72)(H,62,73)(H,63,67)(H,64,71)(H,74,75)/t31-,39+,40+,41+,42+,43-,44+,52-,53-/m1/s1
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n/an/a 1.60n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF-28 from human cloned sst4 receptor expressed in CCL39 cells


J Med Chem 51: 2668-75 (2008)


Article DOI: 10.1021/jm701444y
BindingDB Entry DOI: 10.7270/Q2CF9R1G
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50159422
PNG
(CHEMBL408338 | Des-AA5-[D-Trp8]SRIF)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O
Show InChI InChI=1S/C72H98N16O17S2/c1-40(75)61(93)77-36-58(92)78-56-38-106-107-39-57(72(104)105)86-68(100)55(37-89)85-71(103)60(42(3)91)88-67(99)53(33-45-23-11-6-12-24-45)84-70(102)59(41(2)90)87-63(95)50(28-16-18-30-74)79-66(98)54(34-46-35-76-48-26-14-13-25-47(46)48)83-65(97)52(32-44-21-9-5-10-22-44)82-64(96)51(31-43-19-7-4-8-20-43)81-62(94)49(80-69(56)101)27-15-17-29-73/h4-14,19-26,35,40-42,49-57,59-60,76,89-91H,15-18,27-34,36-39,73-75H2,1-3H3,(H,77,93)(H,78,92)(H,79,98)(H,80,101)(H,81,94)(H,82,96)(H,83,97)(H,84,102)(H,85,103)(H,86,100)(H,87,95)(H,88,99)(H,104,105)/t40-,41+,42+,49+,50-,51+,52-,53-,54-,55-,56+,57-,59+,60+/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of [Leu8,D-Trp22,125I-Tyr25]SRIF-28 binding to human somatostatin receptor type 4


J Med Chem 48: 507-14 (2005)


Article DOI: 10.1021/jm049520l
BindingDB Entry DOI: 10.7270/Q2QR4WNH
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM81767
PNG
(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O |r|
Show InChI InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Displacement of 125I-[LTT]-SRIF-28 from human sst4 receptor in CCL39 cells after 2 hrs by autoradiography


J Med Chem 54: 5981-7 (2011)


Article DOI: 10.1021/jm200307v
BindingDB Entry DOI: 10.7270/Q2BV7H1N
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50100728
PNG
(CHEMBL409100 | Des-Asn5-[DTrp8]-SRIF)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CSSC[C@@H](NC(=O)[C@@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O
Show InChI InChI=1S/C72H98N16O17S2/c1-40(75)61(93)77-36-58(92)78-56-38-106-107-39-57(72(104)105)86-68(100)55(37-89)85-71(103)60(42(3)91)88-67(99)53(33-45-23-11-6-12-24-45)84-70(102)59(41(2)90)87-63(95)50(28-16-18-30-74)79-66(98)54(34-46-35-76-48-26-14-13-25-47(46)48)83-65(97)52(32-44-21-9-5-10-22-44)82-64(96)51(31-43-19-7-4-8-20-43)81-62(94)49(80-69(56)101)27-15-17-29-73/h4-14,19-26,35,40-42,49-57,59-60,76,89-91H,15-18,27-34,36-39,73-75H2,1-3H3,(H,77,93)(H,78,92)(H,79,98)(H,80,101)(H,81,94)(H,82,96)(H,83,97)(H,84,102)(H,85,103)(H,86,100)(H,87,95)(H,88,99)(H,104,105)/t40-,41+,42+,49+,50+,51-,52+,53+,54-,55+,56+,57+,59-,60-/m0/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) recept...


J Med Chem 44: 2238-46 (2001)


BindingDB Entry DOI: 10.7270/Q21R6PSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136824
PNG
((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C54H66N10O10S2/c1-32(65)46-53(72)62-43(27-35-19-9-4-10-20-35)51(70)63-45(54(73)74)31-76-75-30-38(56)47(66)59-41(25-33-15-5-2-6-16-33)49(68)60-42(26-34-17-7-3-8-18-34)50(69)61-44(28-36-29-57-39-22-12-11-21-37(36)39)52(71)58-40(48(67)64-46)23-13-14-24-55/h2-12,15-22,29,32,38,40-46,57,65H,13-14,23-28,30-31,55-56H2,1H3,(H,58,71)(H,59,66)(H,60,68)(H,61,69)(H,62,72)(H,63,70)(H,64,67)(H,73,74)/t32-,38-,40+,41-,42+,43+,44+,45+,46-/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human Somatostatin receptor type 4 using 125I-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand


J Med Chem 46: 5606-18 (2003)


Article DOI: 10.1021/jm030246p
BindingDB Entry DOI: 10.7270/Q2GT5MMN
More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM50136797
PNG
((S)-25-Amino-13-(4-amino-butyl)-7,19,22-tribenzyl-...)
Show SMILES C[C@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C54H66N10O10S2/c1-32(65)46-53(72)62-43(27-35-19-9-4-10-20-35)51(70)63-45(54(73)74)31-76-75-30-38(56)47(66)59-41(25-33-15-5-2-6-16-33)49(68)60-42(26-34-17-7-3-8-18-34)50(69)61-44(28-36-29-57-39-22-12-11-21-37(36)39)52(71)58-40(48(67)64-46)23-13-14-24-55/h2-12,15-22,29,32,38,40-46,57,65H,13-14,23-28,30-31,55-56H2,1H3,(H,58,71)(H,59,66)(H,60,68)(H,61,69)(H,62,72)(H,63,70)(H,64,67)(H,73,74)/t32-,38+,40-,41+,42-,43-,44+,45-,46-/m0/s1
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n/an/a 1.80n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 4 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
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