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Compile Data Set for Download or QSAR

Found 23 hits of ec50 for UniProtKB: L7RSL3   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50242740
PNG
(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)
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n/an/an/an/a 236n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM482158
PNG
(BDBM50242742 | TAE684)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
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n/an/an/an/a 872n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of Flt1 by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM107711
PNG
(US11426393, Compound Table XV.17 | US8598210, Tabl...)
Show SMILES CNC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H14ClN3O3/c1-17-13(21)8-19-15(22)14-12(20)6-10(7-18-14)9-3-2-4-11(16)5-9/h2-7,20H,8H2,1H3,(H,17,21)(H,19,22)
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n/an/an/an/a 1.40E+3n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM107710
PNG
(US11426393, Compound Table XV.16 | US8598210, Tabl...)
Show SMILES Cc1ccc(Cl)cc1-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C15H13ClN2O4/c1-8-2-3-10(16)5-11(8)9-4-12(19)14(17-6-9)15(22)18-7-13(20)21/h2-6,19H,7H2,1H3,(H,18,22)(H,20,21)
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n/an/an/an/a 3.30E+3n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM301799
PNG
(US11426393, Compound Table XV.8 | US9598370, Examp...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C15H11N3O4/c16-6-9-1-3-10(4-2-9)11-5-12(19)14(17-7-11)15(22)18-8-13(20)21/h1-5,7,19H,8H2,(H,18,22)(H,20,21)
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n/an/an/an/a 4.30E+3n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM107704
PNG
(US11426393, Compound Table XV.11 | US8598210, 119 ...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/an/an/a 7.60E+3n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM107701
PNG
(US11426393, Compound Table XV.7 | US8598210, Table...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/an/an/a 7.70E+3n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM107700
PNG
(US11426393, Compound Table XV.6 | US8598210, Table...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(C)cc1
Show InChI InChI=1S/C16H16N2O4/c1-10-3-5-11(6-4-10)12-7-13(19)15(17-8-12)16(21)18-9-14(20)22-2/h3-8,19H,9H2,1-2H3,(H,18,21)
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n/an/an/an/a 8.20E+3n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM107695
PNG
(US11426393, Compound Table XV.1 | US8598210, Table...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-10(7-17-14)9-3-2-4-11(16)5-9/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/an/an/a 9.90E+3n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM107707
PNG
(US11426393, Compound Table XV.13 | US8598210, Tabl...)
Show SMILES CC(C)c1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C17H18N2O4/c1-10(2)11-3-5-12(6-4-11)13-7-14(20)16(18-8-13)17(23)19-9-15(21)22/h3-8,10,20H,9H2,1-2H3,(H,19,23)(H,21,22)
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n/an/an/an/a 1.50E+4n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM107698
PNG
(US11426393, Compound Table XV.4 | US8598210, Table...)
Show SMILES Cc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C15H14N2O4/c1-9-2-4-10(5-3-9)11-6-12(18)14(16-7-11)15(21)17-8-13(19)20/h2-7,18H,8H2,1H3,(H,17,21)(H,19,20)
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n/an/an/an/a 4.21E+4n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM107715
PNG
(US11426393, Compound Table XV.21 | US8598210, Tabl...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C(N)=O
Show InChI InChI=1S/C16H15N3O5/c1-24-13(21)8-19-16(23)14-12(20)6-11(7-18-14)9-3-2-4-10(5-9)15(17)22/h2-7,20H,8H2,1H3,(H2,17,22)(H,19,23)
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n/an/an/an/a 5.01E+4n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM107709
PNG
(US11426393, Compound Table XV.15 | US8598210, Tabl...)
Show SMILES CC(C)Oc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C17H18N2O5/c1-10(2)24-13-5-3-11(4-6-13)12-7-14(20)16(18-8-12)17(23)19-9-15(21)22/h3-8,10,20H,9H2,1-2H3,(H,19,23)(H,21,22)
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n/an/an/an/a>1.00E+5n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM301787
PNG
(US11426393, Compound Table XV.3 | US9598370, Examp...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)C#N |$;;;;;HN;;;;;;;;;;;;;;;;;$|
Show InChI InChI=1S/C16H13N3O4/c1-23-14(21)9-19-16(22)15-13(20)6-12(8-18-15)11-4-2-10(7-17)3-5-11/h2-6,8,20H,9H2,1H3,(H,19,22)
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n/an/an/an/a>1.00E+5n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM107696
PNG
(US11426393, Compound Table XV.2 | US8598210, Table...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-10(7-17-14)9-2-4-11(16)5-3-9/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/an/an/a>1.00E+5n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM107699
PNG
(US11426393, Compound Table XV.5 | US8598210, Table...)
Show SMILES Cc1ccc(cc1)-c1ccc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C16H15NO4/c1-10-2-4-11(5-3-10)12-6-7-13(14(18)8-12)16(21)17-9-15(19)20/h2-8,18H,9H2,1H3,(H,17,21)(H,19,20)
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n/an/an/an/a>1.00E+5n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM301820
PNG
(US11426393, Compound Table XV.19 | US9598370, Exam...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)-c1nn[nH]n1 |$;;;;;HN;;;;;;;;;;;;;;;;;;;;$|
Show InChI InChI=1S/C16H14N6O4/c1-26-13(24)8-18-16(25)14-12(23)6-11(7-17-14)9-3-2-4-10(5-9)15-19-21-22-20-15/h2-7,23H,8H2,1H3,(H,18,25)(H,19,20,21,22)
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n/an/an/an/a>1.00E+5n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM400041
PNG
(US11426393, Compound Table XV.20 | USRE47437, Exam...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C#N
Show InChI InChI=1S/C15H11N3O4/c16-6-9-2-1-3-10(4-9)11-5-12(19)14(17-7-11)15(22)18-8-13(20)21/h1-5,7,19H,8H2,(H,18,22)(H,20,21)
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n/an/an/an/a>1.00E+5n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM107716
PNG
(US11426393, Compound Table XV.22 | US8598210, Tabl...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C20H21N3O5/c1-28-17(25)12-22-19(26)18-16(24)10-15(11-21-18)13-5-4-6-14(9-13)20(27)23-7-2-3-8-23/h4-6,9-11,24H,2-3,7-8,12H2,1H3,(H,22,26)
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n/an/an/an/a>1.00E+5n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM107717
PNG
(US11426393, Compound Table XV.23 | US8598210, Tabl...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C19H19N3O5/c23-15-9-14(10-20-17(15)18(26)21-11-16(24)25)12-4-3-5-13(8-12)19(27)22-6-1-2-7-22/h3-5,8-10,23H,1-2,6-7,11H2,(H,21,26)(H,24,25)
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n/an/an/an/a>1.00E+5n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM107708
PNG
(US11426393, Compound Table XV.14 | US8598210, Tabl...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(F)cc1
Show InChI InChI=1S/C14H11FN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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Similars

US Patent
n/an/an/an/a>1.00E+5n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM301825
PNG
(US11426393, Compound Table XV.24 | US9598370, Exam...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)-c1nn[nH]n1 |$;;;;HN;;;;;;;;;;;;;;;;;;;;$|
Show InChI InChI=1S/C15H12N6O4/c22-11-5-10(6-16-13(11)15(25)17-7-12(23)24)8-2-1-3-9(4-8)14-18-20-21-19-14/h1-6,22H,7H2,(H,17,25)(H,23,24)(H,18,19,20,21)
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US Patent
n/an/an/an/a>1.00E+5n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM301819
PNG
(US11426393, Compound Table XV.18 | US9598370, Exam...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C#N |$;;;;;HN;;;;;;;;;;;;;;;;;$|
Show InChI InChI=1S/C16H13N3O4/c1-23-14(21)9-19-16(22)15-13(20)6-12(8-18-15)11-4-2-3-10(5-11)7-17/h2-6,8,20H,9H2,1H3,(H,19,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+5n/an/an/an/a


TBA

Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 ceils per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2FJ2M1T
More data for this
Ligand-Target Pair