Found 1383 hits of ic50 data for polymerid = 690 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM25117
(AG-013736 | AXITINIB | N-methyl-2-({3-[(E)-2-(pyri...)Show SMILES CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1 Show InChI InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+ | PDB
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| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Fuzhou University
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 (unknown origin) |
Eur J Med Chem 179: 916-935 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.070
BindingDB Entry DOI: 10.7270/Q2KD224D |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50206389
(CHEMBL3939307)Show SMILES CNC(=O)c1ccccc1Sc1ccc2c(CCc3ccccn3)n[nH]c2c1 Show InChI InChI=1S/C22H20N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-8,10-11,13-14H,9,12H2,1H3,(H,23,27)(H,25,26) | PDB
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| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Taiwan National Health Research Institutes
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 (unknown origin) |
Eur J Med Chem 124: 186-199 (2016)
Article DOI: 10.1016/j.ejmech.2016.08.026
BindingDB Entry DOI: 10.7270/Q2668G5M |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM25117
(AG-013736 | AXITINIB | N-methyl-2-({3-[(E)-2-(pyri...)Show SMILES CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1 Show InChI InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+ | PDB
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| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF)
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 (unknown origin) |
Eur J Med Chem 142: 383-392 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.007
BindingDB Entry DOI: 10.7270/Q2WS8WZZ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50331095
(CHEMBL1289494 | Tivozanib | US10464902, Tivozanib)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC Show InChI InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28) | PDB
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| n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 |
J Med Chem 55: 10797-822 (2012)
Article DOI: 10.1021/jm301085w
BindingDB Entry DOI: 10.7270/Q2BP03XZ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50236362
(CHEMBL429743 | N-(4-chlorophenyl)-6-(6,7-dimethoxy...)Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC Show InChI InChI=1S/C28H21ClN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-13-12-25(23)35-20-10-11-21-17(14-20)4-3-5-22(21)28(32)31-19-8-6-18(29)7-9-19/h3-16H,1-2H3,(H,31,32) | PDB
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| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 |
J Med Chem 51: 1649-67 (2008)
Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50399540
(FORETINIB | US10464902, Foretinib | US10882853, Co...)Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42) | PDB
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| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 |
J Med Chem 55: 10797-822 (2012)
Article DOI: 10.1021/jm301085w
BindingDB Entry DOI: 10.7270/Q2BP03XZ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50185178
(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)Show SMILES CC(C)(C)NC(=O)Nc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1 Show InChI InChI=1S/C29H38N8O/c1-29(2,3)33-28(38)30-19-7-9-23-22(17-19)26(35-34-23)27-31-24-10-8-21(18-25(24)32-27)37-15-11-20(12-16-37)36-13-5-4-6-14-36/h7-10,17-18,20H,4-6,11-16H2,1-3H3,(H,31,32)(H,34,35)(H2,30,33,38) | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiron Corporation
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 |
Bioorg Med Chem Lett 16: 3595-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.069
BindingDB Entry DOI: 10.7270/Q2BZ65N7 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50375642
(CHEMBL406381 | KRN-633)Show SMILES CCCNC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1Cl Show InChI InChI=1S/C20H21ClN4O4/c1-4-7-22-20(26)25-15-6-5-12(8-14(15)21)29-19-13-9-17(27-2)18(28-3)10-16(13)23-11-24-19/h5-6,8-11H,4,7H2,1-3H3,(H2,22,25,26) | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Inhibition of human VEGFR1 in HUVEC cells |
Proc Natl Acad Sci USA 104: 20523-8 (2007)
Checked by Author
Article DOI: 10.1073/pnas.0708800104
BindingDB Entry DOI: 10.7270/Q2DB82RH |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM4814
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C Show InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Exelixis
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged Flt1 using poly(Glu,Tyr) as substrate after 60 mins by alphascreen assay |
Bioorg Med Chem Lett 22: 4979-85 (2012)
Article DOI: 10.1016/j.bmcl.2012.06.029
BindingDB Entry DOI: 10.7270/Q2XG9SD4 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50240780
(CHEMBL4062877)Show SMILES Cc1n[nH]c2ccc(cc12)-c1cc(N[C@@H](CO)c2ccccc2)cnc1-c1cc(F)ccc1O |r| Show InChI InChI=1S/C27H23FN4O2/c1-16-21-11-18(7-9-24(21)32-31-16)22-13-20(30-25(15-33)17-5-3-2-4-6-17)14-29-27(22)23-12-19(28)8-10-26(23)34/h2-14,25,30,33-34H,15H2,1H3,(H,31,32)/t25-/m0/s1 | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant VEGFR-1 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISA |
J Med Chem 60: 6018-6035 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00076
BindingDB Entry DOI: 10.7270/Q2K939NC |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50595124
(CHEBI:49960 | Caprelsa | GNF-PF-2188 | NSC-744325 ...)Show SMILES COc1cc2c(cc1OCC1CCN(C)CC1)[nH]cn\c2=N/c1ccc(Br)cc1F | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02167
BindingDB Entry DOI: 10.7270/Q22R3WQ4 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50381716
(ABT-348 | ILORASERTIB | US8722890, 1 | US8722890, ...)Show SMILES Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 Show InChI InChI=1S/C25H21FN6O2S/c26-17-2-1-3-19(10-17)31-25(34)30-18-6-4-15(5-7-18)21-14-35-23-20(12-28-24(27)22(21)23)16-11-29-32(13-16)8-9-33/h1-7,10-14,33H,8-9H2,(H2,27,28)(H2,30,31,34) | PDB
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| US Patent
| n/a | n/a | 1.25 | n/a | n/a | n/a | n/a | 7.1 | 25 |
AbbVie Inc.
US Patent
| Assay Description
To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)... |
US Patent US8722890 (2014)
BindingDB Entry DOI: 10.7270/Q21Z4327 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM121390
(US8722890, 5)Show SMILES COc1ccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cnn(C[C@H](O)CO)c2)cc1 Show InChI InChI=1S/C27H26N6O4S/c1-37-21-8-6-19(7-9-21)32-27(36)31-18-4-2-16(3-5-18)23-15-38-25-22(11-29-26(28)24(23)25)17-10-30-33(12-17)13-20(35)14-34/h2-12,15,20,34-35H,13-14H2,1H3,(H2,28,29)(H2,31,32,36)/t20-/m0/s1 | PDB
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| n/a | n/a | 1.45 | n/a | n/a | n/a | n/a | 7.1 | 25 |
AbbVie Inc.
US Patent
| Assay Description
To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)... |
US Patent US8722890 (2014)
BindingDB Entry DOI: 10.7270/Q21Z4327 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50363397
(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1 Show InChI InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32) | PDB
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| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 (unknown origin) |
Eur J Med Chem 179: 707-722 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.063
BindingDB Entry DOI: 10.7270/Q2PC35S4 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50381698
(CHEMBL1969102 | US8722890, 6)Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cn[nH]c2)c1 Show InChI InChI=1S/C24H20N6OS/c1-14-3-2-4-18(9-14)30-24(31)29-17-7-5-15(6-8-17)20-13-32-22-19(16-10-27-28-11-16)12-26-23(25)21(20)22/h2-13H,1H3,(H2,25,26)(H,27,28)(H2,29,30,31) | PDB
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| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | 7.1 | 25 |
AbbVie Inc.
US Patent
| Assay Description
To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)... |
US Patent US8722890 (2014)
BindingDB Entry DOI: 10.7270/Q21Z4327 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM24773
(AMG 706 | AMG-706 | Motesanib | N-(3,3-dimethyl-1,...)Show SMILES CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 Show InChI InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of VEGFR1 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00678
BindingDB Entry DOI: 10.7270/Q2Q2443B |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM24773
(AMG 706 | AMG-706 | Motesanib | N-(3,3-dimethyl-1,...)Show SMILES CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 Show InChI InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) | PDB
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University of Genoa
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 |
J Med Chem 55: 10797-822 (2012)
Article DOI: 10.1021/jm301085w
BindingDB Entry DOI: 10.7270/Q2BP03XZ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM110647
(US8614234, 115 | US9725433, 115)Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(O)=O)cc2)c1 Show InChI InChI=1S/C24H20N4O4/c1-15-3-2-4-18(11-15)28-24(31)27-17-5-7-19(8-6-17)32-20-9-10-25-22(13-20)21-12-16(14-26-21)23(29)30/h2-14,26H,1H3,(H,29,30)(H2,27,28,31) | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
ALLERGAN, INC.
US Patent
| Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us... |
US Patent US9725433 (2017)
BindingDB Entry DOI: 10.7270/Q2ZP4875 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50210272
(6-((4-methylpiperazin-1-yl)methyl)-3-(5-(3-phenoxy...)Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCOc3ccccc3)c2)CC1 Show InChI InChI=1S/C29H28N4OS/c1-32-11-13-33(14-12-32)19-21-9-10-26-22(16-21)18-27-28(30-31-29(26)27)23-17-25(35-20-23)8-5-15-34-24-6-3-2-4-7-24/h2-4,6-7,9-10,16-17,20H,11-15,18-19H2,1H3,(H,30,31) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Flt1 |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o
BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM24773
(AMG 706 | AMG-706 | Motesanib | N-(3,3-dimethyl-1,...)Show SMILES CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 Show InChI InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) | PDB
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Swiss Federal Institute of Technology (ETH)
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 (unknown origin) |
J Med Chem 59: 4077-86 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01849
BindingDB Entry DOI: 10.7270/Q2FN184P |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50329885
(4-(6-(4-(2-morpholinoethoxy)phenyl)pyrazolo[1,5-a]...)Show SMILES Oc1ccc(cc1O)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCOCC2)cc1 Show InChI InChI=1S/C24H24N4O4/c29-22-6-3-18(13-23(22)30)21-15-26-28-16-19(14-25-24(21)28)17-1-4-20(5-2-17)32-12-9-27-7-10-31-11-8-27/h1-6,13-16,29-30H,7-12H2 | PDB
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Ansaris
Curated by ChEMBL
| Assay Description
Inhibition of FLT1 by Hot Spot filtration binding assay |
Bioorg Med Chem Lett 20: 6394-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.088
BindingDB Entry DOI: 10.7270/Q2NP24NB |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50137208
(1-{4-[4-(1H-Indol-5-ylamino)-thieno[3,2-d]pyrimidi...)Show SMILES NC(=O)C1CCN(Cc2ccc(cc2)-c2cc3ncnc(Nc4ccc5[nH]ccc5c4)c3s2)CC1 Show InChI InChI=1S/C27H26N6OS/c28-26(34)19-8-11-33(12-9-19)15-17-1-3-18(4-2-17)24-14-23-25(35-24)27(31-16-30-23)32-21-5-6-22-20(13-21)7-10-29-22/h1-7,10,13-14,16,19,29H,8-9,11-12,15H2,(H2,28,34)(H,30,31,32) | PDB
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Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor |
Bioorg Med Chem Lett 14: 21-4 (2003)
BindingDB Entry DOI: 10.7270/Q2FT8KFT |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM110647
(US8614234, 115 | US9725433, 115)Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(O)=O)cc2)c1 Show InChI InChI=1S/C24H20N4O4/c1-15-3-2-4-18(11-15)28-24(31)27-17-5-7-19(8-6-17)32-20-9-10-25-22(13-20)21-12-16(14-26-21)23(29)30/h2-14,26H,1H3,(H,29,30)(H2,27,28,31) | PDB
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Allergan, Inc.
US Patent
| Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30.mu.g of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered S... |
US Patent US8614234 (2013)
BindingDB Entry DOI: 10.7270/Q20Z71XF |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM8826
(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...)Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ncnc(N)c23)c1 Show InChI InChI=1S/C20H17N5OS/c1-12-3-2-4-15(9-12)25-20(26)24-14-7-5-13(6-8-14)16-10-27-19-17(16)18(21)22-11-23-19/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of FLT1 |
Bioorg Med Chem Lett 16: 4326-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.057
BindingDB Entry DOI: 10.7270/Q2W958S9 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50185181
(5-(4-(piperidin-1-yl)piperidin-1-yl)-2-(6-(trifluo...)Show SMILES FC(F)(F)c1ccc2c(n[nH]c2c1)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1 Show InChI InChI=1S/C25H27F3N6/c26-25(27,28)16-4-6-19-21(14-16)31-32-23(19)24-29-20-7-5-18(15-22(20)30-24)34-12-8-17(9-13-34)33-10-2-1-3-11-33/h4-7,14-15,17H,1-3,8-13H2,(H,29,30)(H,31,32) | PDB
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Chiron Corporation
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 |
Bioorg Med Chem Lett 16: 3595-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.069
BindingDB Entry DOI: 10.7270/Q2BZ65N7 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM4630
(2-chloro-4-fluoro-5-{[6-methoxy-7-(2-methoxyethoxy...)Show InChI InChI=1S/C18H17ClFN3O4/c1-25-3-4-27-17-8-13-10(5-16(17)26-2)18(22-9-21-13)23-14-7-15(24)11(19)6-12(14)20/h5-9,24H,3-4H2,1-2H3,(H,21,22,23) | PDB
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| n/a | n/a | <2 | n/a | n/a | n/a | n/a | 7.4 | 22 |
AstraZeneca
| Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room... |
J Med Chem 42: 5369-89 (1999)
Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM24773
(AMG 706 | AMG-706 | Motesanib | N-(3,3-dimethyl-1,...)Show SMILES CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 Show InChI InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Amgen
| Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ... |
Cancer Res 66: 8715-21 (2006)
Article DOI: 10.1158/0008-5472.CAN-05-4665
BindingDB Entry DOI: 10.7270/Q2057D73 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM121388
(US8722890, 3)Show SMILES C[C@H](O)Cn1cc(cn1)-c1cnc(N)c2c(csc12)-c1ccc(NC(=O)Nc2cccc(C)c2)cc1 Show InChI InChI=1S/C27H26N6O2S/c1-16-4-3-5-21(10-16)32-27(35)31-20-8-6-18(7-9-20)23-15-36-25-22(12-29-26(28)24(23)25)19-11-30-33(14-19)13-17(2)34/h3-12,14-15,17,34H,13H2,1-2H3,(H2,28,29)(H2,31,32,35)/t17-/m0/s1 | PDB
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| n/a | n/a | 2.04 | n/a | n/a | n/a | n/a | 7.1 | 25 |
AbbVie Inc.
US Patent
| Assay Description
To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)... |
US Patent US8722890 (2014)
BindingDB Entry DOI: 10.7270/Q21Z4327 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50381716
(ABT-348 | ILORASERTIB | US8722890, 1 | US8722890, ...)Show SMILES Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 Show InChI InChI=1S/C25H21FN6O2S/c26-17-2-1-3-19(10-17)31-25(34)30-18-6-4-15(5-7-18)21-14-35-23-20(12-28-24(27)22(21)23)16-11-29-32(13-16)8-9-33/h1-7,10-14,33H,8-9H2,(H2,27,28)(H2,30,31,34) | PDB
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| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | 7.1 | 25 |
AbbVie Inc.
US Patent
| Assay Description
To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)... |
US Patent US8722890 (2014)
BindingDB Entry DOI: 10.7270/Q21Z4327 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM21079
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) | PDB
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University of South Australia
Curated by ChEMBL
| Assay Description
Inhibition of FLT1 (unknown origin) |
J Med Chem 61: 5073-5092 (2018)
Article DOI: 10.1021/acs.jmedchem.7b00901
BindingDB Entry DOI: 10.7270/Q29W0J3B |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50137202
(2-(Methyl-{4-[7-(2-methyl-1H-indol-5-ylamino)-thie...)Show SMILES CN(CCO)Cc1ccc(cc1)-c1cc2nccc(Nc3ccc4[nH]c(C)cc4c3)c2s1 Show InChI InChI=1S/C26H26N4OS/c1-17-13-20-14-21(7-8-22(20)28-17)29-23-9-10-27-24-15-25(32-26(23)24)19-5-3-18(4-6-19)16-30(2)11-12-31/h3-10,13-15,28,31H,11-12,16H2,1-2H3,(H,27,29) | PDB
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Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor |
Bioorg Med Chem Lett 14: 21-4 (2003)
BindingDB Entry DOI: 10.7270/Q2FT8KFT |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM144589
(US8969583, 5)Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2nsc(NC(=O)NCCCN3CCOCC3)c2C(N)=O)c1 Show InChI InChI=1S/C26H31N7O4S/c1-17-4-2-5-20(16-17)30-26(36)29-19-8-6-18(7-9-19)22-21(23(27)34)24(38-32-22)31-25(35)28-10-3-11-33-12-14-37-15-13-33/h2,4-9,16H,3,10-15H2,1H3,(H2,27,34)(H2,28,31,35)(H2,29,30,36) | PDB
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Allergan, Inc.
US Patent
| Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug/well of poly-Glu-Tyr (4:1) in 10 mM P... |
US Patent US8969583 (2015)
BindingDB Entry DOI: 10.7270/Q2RN36JS |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM110607
(US8614234, 76)Show SMILES Cc1cccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(O)=O)cc2F)c1 Show InChI InChI=1S/C24H19FN4O4/c1-14-3-2-4-16(9-14)28-24(32)29-20-6-5-17(11-19(20)25)33-18-7-8-26-22(12-18)21-10-15(13-27-21)23(30)31/h2-13,27H,1H3,(H,30,31)(H2,28,29,32) | PDB
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Allergan, Inc.
US Patent
| Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30.mu.g of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered S... |
US Patent US8614234 (2013)
BindingDB Entry DOI: 10.7270/Q20Z71XF |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50379186
(CEP-11981 | CHEMBL2010872)Show SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12 Show InChI InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32) | PDB
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Cephalon, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human VEGFR1 using ATP as substrate |
J Med Chem 55: 903-13 (2012)
Article DOI: 10.1021/jm201449n
BindingDB Entry DOI: 10.7270/Q2ZS2XHW |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM110598
(US8614234, 66 | US9725433, 66)Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(O)=O)cc2F)c1 Show InChI InChI=1S/C28H25F2N5O5/c1-16-4-6-20(29)23(11-16)35-28(39)34-22-7-5-18(13-21(22)30)40-19-8-10-31-25(14-19)24-12-17(15-33-24)27(38)32-9-2-3-26(36)37/h4-8,10-15,33H,2-3,9H2,1H3,(H,32,38)(H,36,37)(H2,34,35,39) | PDB
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ALLERGAN, INC.
US Patent
| Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us... |
US Patent US9725433 (2017)
BindingDB Entry DOI: 10.7270/Q2ZP4875 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM110608
(US8614234, 76 | US9725433, 76)Show SMILES COC(=O)c1c[nH]c(c1)-c1cc(Oc2ccc(NC(=O)Nc3cccc(C)c3)c(F)c2)ccn1 Show InChI InChI=1S/C25H21FN4O4/c1-15-4-3-5-17(10-15)29-25(32)30-21-7-6-18(12-20(21)26)34-19-8-9-27-23(13-19)22-11-16(14-28-22)24(31)33-2/h3-14,28H,1-2H3,(H2,29,30,32) | PDB
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ALLERGAN, INC.
US Patent
| Assay Description
The cytoplasmic domain of the human VEGF receptor (VEGFR-2) was expressed as a Histidine-tagged fusion protein following infection of insect cells us... |
US Patent US9725433 (2017)
BindingDB Entry DOI: 10.7270/Q2ZP4875 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM21079
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of FLT1 by HTRF assay |
J Med Chem 50: 1584-97 (2007)
Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50243417
(1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo...)Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cnc3c(ccn3c2N)-c2cnn(C)c2)c1 Show InChI InChI=1S/C25H23N7O/c1-16-4-3-5-20(12-16)30-25(33)29-19-8-6-17(7-9-19)22-14-27-24-21(10-11-32(24)23(22)26)18-13-28-31(2)15-18/h3-15H,26H2,1-2H3,(H2,29,30,33) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Flt1 (unknown origin) by HTRF assay |
J Med Chem 51: 3777-87 (2008)
Article DOI: 10.1021/jm701397k
BindingDB Entry DOI: 10.7270/Q22R3RFW |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM25118
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) | PDB
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Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t
BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50146165
(CHEMBL3764474)Show SMILES Cn1ccnc1-c1cc2c(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)ccnc2s1 Show InChI InChI=1S/C26H20FN5O2S2/c1-32-12-11-28-24(32)22-15-18-20(9-10-29-25(18)36-22)34-21-8-7-17(14-19(21)27)30-26(35)31-23(33)13-16-5-3-2-4-6-16/h2-12,14-15H,13H2,1H3,(H2,30,31,33,35) | PDB
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Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR-1 (unknown origin) by tumor cell growth inhibition assay |
Eur J Med Chem 108: 495-504 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM228532
(US9340555, 15)Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc4cc(sc34)C(=O)NCCCN3CCCC(CO)C3)cc2)c1 Show InChI InChI=1S/C31H34FN5O4S/c1-20-5-10-24(32)25(16-20)36-31(40)35-22-6-8-23(9-7-22)41-27-11-13-33-26-17-28(42-29(26)27)30(39)34-12-3-15-37-14-2-4-21(18-37)19-38/h5-11,13,16-17,21,38H,2-4,12,14-15,18-19H2,1H3,(H,34,39)(H2,35,36,40) | PDB
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| US Patent
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Allergan, Inc.
US Patent
| Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ... |
US Patent US9340555 (2016)
BindingDB Entry DOI: 10.7270/Q2K64GZT |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50137206
((2-Methyl-1H-indol-5-yl)-(2-{4-[(2-pyridin-1-yl-et...)Show SMILES Cc1cc2cc(Nc3ccnc4cc(sc34)-c3ccc(CNCCN4CCNCC4)cc3)ccc2[nH]1 Show InChI InChI=1S/C29H32N6S/c1-20-16-23-17-24(6-7-25(23)33-20)34-26-8-9-32-27-18-28(36-29(26)27)22-4-2-21(3-5-22)19-31-12-15-35-13-10-30-11-14-35/h2-9,16-18,30-31,33H,10-15,19H2,1H3,(H,32,34) | PDB
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Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory activity against Vascular endothelial growth factor receptor |
Bioorg Med Chem Lett 14: 21-4 (2003)
BindingDB Entry DOI: 10.7270/Q2FT8KFT |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50181308
(4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]i...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccncc2[nH]c1=O Show InChI InChI=1S/C20H21N7O/c1-26-6-8-27(9-7-26)12-2-3-14-15(10-12)24-19(23-14)17-18(21)13-4-5-22-11-16(13)25-20(17)28/h2-5,10-11H,6-9H2,1H3,(H,23,24)(H3,21,25,28) | PDB
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Chiron Corporation
Curated by ChEMBL
| Assay Description
Inhibitory activity against VEGFR1 |
Bioorg Med Chem Lett 16: 2247-51 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.020
BindingDB Entry DOI: 10.7270/Q2NZ8777 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50185182
(2-(5-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)Show SMILES C(Oc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1)c1ccccc1 Show InChI InChI=1S/C31H34N6O/c1-3-7-22(8-4-1)21-38-25-10-12-27-26(20-25)30(35-34-27)31-32-28-11-9-24(19-29(28)33-31)37-17-13-23(14-18-37)36-15-5-2-6-16-36/h1,3-4,7-12,19-20,23H,2,5-6,13-18,21H2,(H,32,33)(H,34,35) | PDB
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Chiron Corporation
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 |
Bioorg Med Chem Lett 16: 3595-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.069
BindingDB Entry DOI: 10.7270/Q2BZ65N7 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM228573
(US9340555, 70)Show SMILES CCN(CC)CCCNC(=O)c1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)c2s1 Show InChI InChI=1S/C29H32FN5O3S/c1-4-35(5-2)16-6-14-32-28(36)26-18-24-27(39-26)25(13-15-31-24)38-21-10-8-20(9-11-21)33-29(37)34-23-17-19(3)7-12-22(23)30/h7-13,15,17-18H,4-6,14,16H2,1-3H3,(H,32,36)(H2,33,34,37) | PDB
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| US Patent
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Allergan, Inc.
US Patent
| Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30 μg of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered ... |
US Patent US9340555 (2016)
BindingDB Entry DOI: 10.7270/Q2K64GZT |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50210271
(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(5-(3-(2-metho...)Show SMILES COCCOCC#Cc1cc(cs1)-c1[nH]nc-2c1Cc1ccc(Cn3cncn3)cc-21 Show InChI InChI=1S/C23H21N5O2S/c1-29-7-8-30-6-2-3-19-10-18(13-31-19)22-21-11-17-5-4-16(12-28-15-24-14-25-28)9-20(17)23(21)27-26-22/h4-5,9-10,13-15H,6-8,11-12H2,1H3,(H,26,27) | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Flt1 |
J Med Chem 50: 2011-29 (2007)
Article DOI: 10.1021/jm061223o
BindingDB Entry DOI: 10.7270/Q2TB16K0 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM4633
(2-chloro-4-fluoro-5-{[6-methoxy-7-(2-methoxyethoxy...)Show InChI InChI=1S/C19H18ClFN2O4/c1-25-5-6-27-19-10-15-11(7-18(19)26-2)14(3-4-22-15)23-16-9-17(24)12(20)8-13(16)21/h3-4,7-10,24H,5-6H2,1-2H3,(H,22,23) | PDB
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AstraZeneca
| Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room... |
J Med Chem 42: 5369-89 (1999)
Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM21079
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) | PDB
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Abbott Laboratories
| Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor... |
J Med Chem 51: 1231-41 (2008)
Article DOI: 10.1021/jm701096v
BindingDB Entry DOI: 10.7270/Q2HX19Z7 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM110598
(US8614234, 66 | US9725433, 66)Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3cc(c[nH]3)C(=O)NCCCC(O)=O)cc2F)c1 Show InChI InChI=1S/C28H25F2N5O5/c1-16-4-6-20(29)23(11-16)35-28(39)34-22-7-5-18(13-21(22)30)40-19-8-10-31-25(14-19)24-12-17(15-33-24)27(38)32-9-2-3-26(36)37/h4-8,10-15,33H,2-3,9H2,1H3,(H,32,38)(H,36,37)(H2,34,35,39) | PDB
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Allergan, Inc.
US Patent
| Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30.mu.g of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered S... |
US Patent US8614234 (2013)
BindingDB Entry DOI: 10.7270/Q20Z71XF |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50399537
(CHEMBL2180604)Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2C)n(C)n1 Show InChI InChI=1S/C23H23N7O3/c1-13-4-7-16(11-17(13)24-23(32)18-10-14(2)27-29(18)3)33-21-9-8-20-25-19(12-30(20)28-21)26-22(31)15-5-6-15/h4,7-12,15H,5-6H2,1-3H3,(H,24,32)(H,26,31) | PDB
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| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR1 |
J Med Chem 55: 10797-822 (2012)
Article DOI: 10.1021/jm301085w
BindingDB Entry DOI: 10.7270/Q2BP03XZ |
More data for this
Ligand-Target Pair | |
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