BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 60 hits of ec50 for UniProtKB: P11362   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454202
PNG
(US10717708, Example 183 | US11186544, Example 183 ...)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(Cl)cc2)C1=O |r|
Show InChI InChI=1S/C28H31ClN4O4S/c1-28(2,3)32-38(36,37)25-9-5-4-7-23(25)19-10-16-22(17-11-19)33-18-6-8-24(26(33)34)31-27(35)30-21-14-12-20(29)13-15-21/h4-5,7,9-17,24,32H,6,8,18H2,1-3H3,(H2,30,31,35)/t24-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.560n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM275777
PNG
(US10071110, Compound 1-O-octadecylethanediol-2-CDV)
Show SMILES CCCCCCCCCCCCCCCCCCOCCOP(O)(=O)COC(CO)Cn1ccc(N)nc1=O
Show InChI InChI=1S/C28H54N3O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20-36-21-22-38-39(34,35)25-37-26(24-32)23-31-19-18-27(29)30-28(31)33/h18-19,26,32H,2-17,20-25H2,1H3,(H,34,35)(H2,29,30,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...

US Patent US10071110 (2018)


BindingDB Entry DOI: 10.7270/Q2NS0WX9
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454189
PNG
(US10717708, Example 77 | US11186544, Example 77 | ...)
Show SMILES OCc1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(Cl)cc2)C1=O |r|
Show InChI InChI=1S/C25H24ClN3O3/c26-19-9-11-20(12-10-19)27-25(32)28-23-6-3-15-29(24(23)31)21-13-7-17(8-14-21)22-5-2-1-4-18(22)16-30/h1-2,4-5,7-14,23,30H,3,6,15-16H2,(H2,27,28,32)/t23-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.80n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454188
PNG
(US10717708, Example 76 | US11186544, Example 76 | ...)
Show SMILES Clc1ccc(NC(=O)N[C@@H]2CCCN(C2=O)c2ccc(cc2)-c2ccccc2C#N)cc1 |r|
Show InChI InChI=1S/C25H21ClN4O2/c26-19-9-11-20(12-10-19)28-25(32)29-23-6-3-15-30(24(23)31)21-13-7-17(8-14-21)22-5-2-1-4-18(22)16-27/h1-2,4-5,7-14,23H,3,6,15H2,(H2,28,29,32)/t23-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 10n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM50403060
PNG
(CHEMBL2216830)
Show SMILES CCN(CC)CCCCNc1ncc2CN(C(=O)N(Cc3cccc(NC(=O)C=C)c3)c2n1)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C32H39Cl2N7O4/c1-6-26(42)37-23-13-11-12-21(16-23)19-41-30-22(18-36-31(38-30)35-14-9-10-15-39(7-2)8-3)20-40(32(41)43)29-27(33)24(44-4)17-25(45-5)28(29)34/h6,11-13,16-18H,1,7-10,14-15,19-20H2,2-5H3,(H,37,42)(H,35,36,38)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
PDB
UniChem

Similars
PDB
Article
PubMed
n/an/an/an/a 14n/an/an/an/a



Dalian Medical University

Curated by ChEMBL


Assay Description
Inhibition of Tel-fused FGFR1 (unknown origin) expressed in mouse Ba/F3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay

Eur J Med Chem 142: 493-505 (2017)


Article DOI: 10.1016/j.ejmech.2017.09.024
BindingDB Entry DOI: 10.7270/Q2N87DG5
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454191
PNG
(US10717708, Example 82 | US11186544, Example 82 | ...)
Show SMILES Clc1ccc(NC(=O)N[C@@H]2CCCN(C2=O)c2ccc(cc2)-c2c(Cl)cccc2Cl)cc1 |r|
Show InChI InChI=1S/C24H20Cl3N3O2/c25-16-8-10-17(11-9-16)28-24(32)29-21-5-2-14-30(23(21)31)18-12-6-15(7-13-18)22-19(26)3-1-4-20(22)27/h1,3-4,6-13,21H,2,5,14H2,(H2,28,29,32)/t21-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 14n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454196
PNG
(US10717708, Example 145 | US11186544, Example 145 ...)
Show SMILES CN(c1ncccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(cc2)C(F)(F)F)C1=O)S(C)(=O)=O |r|
Show InChI InChI=1S/C26H26F3N5O4S/c1-33(39(2,37)38)23-21(5-3-15-30-23)17-7-13-20(14-8-17)34-16-4-6-22(24(34)35)32-25(36)31-19-11-9-18(10-12-19)26(27,28)29/h3,5,7-15,22H,4,6,16H2,1-2H3,(H2,31,32,36)/t22-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 15n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM6190
PNG
(3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6...)
Show SMILES CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
MMDB
PDB
Article
PubMed
n/an/an/an/a 21n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 by cellular assay

Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454204
PNG
(US10717708, Example 188 | US11186544, Example 188 ...)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C1=O |r|
Show InChI InChI=1S/C25H24ClFN4O4S/c1-36(34,35)30-21-6-3-2-5-19(21)16-8-11-18(12-9-16)31-14-4-7-23(24(31)32)29-25(33)28-22-13-10-17(26)15-20(22)27/h2-3,5-6,8-13,15,23,30H,4,7,14H2,1H3,(H2,28,29,33)/t23-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 25n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM275769
PNG
(Hexadecyloxypropyl-cyclic cidofovir | US10071110, ...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
Show InChI InChI=1S/C27H50N3O6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-33-20-16-21-35-37(32)24-34-25(23-36-37)22-30-18-17-26(28)29-27(30)31/h17-18,25H,2-16,19-24H2,1H3,(H2,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<30n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The activity of cidofovir (CDV), cyclic cidofovir (cCDV), and 1-O-hexadecylpropanediol-3-cCDV (HDP-cCDV) were tested for antiviral activity in human ...

US Patent US10071110 (2018)


BindingDB Entry DOI: 10.7270/Q2NS0WX9
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454192
PNG
(US10717708, Example 86 | US11186544, Example 86 | ...)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(Cl)cc2)C1=O |r|
Show InChI InChI=1S/C25H25ClN4O4S/c1-35(33,34)29-22-6-3-2-5-21(22)17-8-14-20(15-9-17)30-16-4-7-23(24(30)31)28-25(32)27-19-12-10-18(26)11-13-19/h2-3,5-6,8-15,23,29H,4,7,16H2,1H3,(H2,27,28,32)/t23-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 32n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM275779
PNG
(US10071110, Compound Hexadecyl-cCDV)
Show SMILES CCCCCCCCCCCCCCCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
Show InChI InChI=1S/C24H44N3O5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-31-33(29)21-30-22(20-32-33)19-27-17-16-23(25)26-24(27)28/h16-17,22H,2-15,18-21H2,1H3,(H2,25,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 40n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...

US Patent US10071110 (2018)


BindingDB Entry DOI: 10.7270/Q2NS0WX9
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454190
PNG
(US10717708, Example 78 | US11186544, Example 78 | ...)
Show SMILES NC(=O)c1ccccc1-c1ccc(N2CCC[C@@H](NC(=O)Nc3ccc(Cl)cc3)C2=O)c(F)c1 |r|
Show InChI InChI=1S/C25H22ClFN4O3/c26-16-8-10-17(11-9-16)29-25(34)30-21-6-3-13-31(24(21)33)22-12-7-15(14-20(22)27)18-4-1-2-5-19(18)23(28)32/h1-2,4-5,7-12,14,21H,3,6,13H2,(H2,28,32)(H2,29,30,34)/t21-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 42n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM50242740
PNG
(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 80n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 by cellular assay

Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454187
PNG
(US10717708, Example 66 | US11186544, Example 66 | ...)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(cc2)C(F)(F)F)C1=O |r|
Show InChI InChI=1S/C26H25F3N4O4S/c1-38(36,37)32-22-6-3-2-5-21(22)17-8-14-20(15-9-17)33-16-4-7-23(24(33)34)31-25(35)30-19-12-10-18(11-13-19)26(27,28)29/h2-3,5-6,8-15,23,32H,4,7,16H2,1H3,(H2,30,31,35)/t23-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 100n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM275780
PNG
(US10071110, Compound 1-O-hexadecylpropanediol-3-AD...)
Show SMILES CCCCCCCCCCCCCCCCCCOCCCOP(O)(=O)COCCn1cnc2c(N)ncnc12
Show InChI InChI=1S/C29H54N5O5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20-37-21-18-22-39-40(35,36)26-38-23-19-34-25-33-27-28(30)31-24-32-29(27)34/h24-25H,2-23,26H2,1H3,(H,35,36)(H2,30,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 100n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...

US Patent US10071110 (2018)


BindingDB Entry DOI: 10.7270/Q2NS0WX9
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM275769
PNG
(Hexadecyloxypropyl-cyclic cidofovir | US10071110, ...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
Show InChI InChI=1S/C27H50N3O6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-33-20-16-21-35-37(32)24-34-25(23-36-37)22-30-18-17-26(28)29-27(30)31/h17-18,25H,2-16,19-24H2,1H3,(H2,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 110n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The activity of cidofovir (CDV), cyclic cidofovir (cCDV), and 1-O-hexadecylpropanediol-3-cCDV (HDP-cCDV) were tested for antiviral activity in human ...

US Patent US10071110 (2018)


BindingDB Entry DOI: 10.7270/Q2NS0WX9
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454206
PNG
(US10717708, Example 199 | US11186544, Example 199 ...)
Show SMILES COc1ccc(NC(=O)N[C@@H]2CCCN(C2=O)c2ccc(cc2)-c2ccccc2NS(C)(=O)=O)cc1 |r|
Show InChI InChI=1S/C26H28N4O5S/c1-35-21-15-11-19(12-16-21)27-26(32)28-24-8-5-17-30(25(24)31)20-13-9-18(10-14-20)22-6-3-4-7-23(22)29-36(2,33)34/h3-4,6-7,9-16,24,29H,5,8,17H2,1-2H3,(H2,27,28,32)/t24-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 140n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454195
PNG
(US10717708, Example 139 | US11186544, Example 139 ...)
Show SMILES NC(=O)c1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(cc2)C(F)(F)F)C1=O |r|
Show InChI InChI=1S/C26H23F3N4O3/c27-26(28,29)17-9-11-18(12-10-17)31-25(36)32-22-6-3-15-33(24(22)35)19-13-7-16(8-14-19)20-4-1-2-5-21(20)23(30)34/h1-2,4-5,7-14,22H,3,6,15H2,(H2,30,34)(H2,31,32,36)/t22-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 150n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM25118
PNG
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O
Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 166n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 phosphorylation expressed in human KM12L4A cells by Western blot analysis

J Med Chem 52: 278-92 (2009)


Article DOI: 10.1021/jm800790t
BindingDB Entry DOI: 10.7270/Q2TD9X7X
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454194
PNG
(US10717708, Example 129 | US11186544, Example 129 ...)
Show SMILES CCOc1ncccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(cc2)C(F)(F)F)C1=O |r|
Show InChI InChI=1S/C26H25F3N4O3/c1-2-36-23-21(5-3-15-30-23)17-7-13-20(14-8-17)33-16-4-6-22(24(33)34)32-25(35)31-19-11-9-18(10-12-19)26(27,28)29/h3,5,7-15,22H,2,4,6,16H2,1H3,(H2,31,32,35)/t22-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 170n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM50505006
PNG
(CHEMBL4483402)
Show SMILES COc1cc(Oc2ccccc2)ccc1-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O |(72.02,-7.51,;73.36,-8.28,;73.36,-9.82,;72.02,-10.6,;72.03,-12.14,;70.69,-12.91,;69.36,-12.15,;69.36,-10.61,;68.02,-9.84,;66.69,-10.61,;66.7,-12.16,;68.03,-12.92,;73.37,-12.91,;74.7,-12.13,;74.69,-10.6,;76.02,-9.82,;77.36,-10.59,;77.36,-12.13,;78.69,-9.82,;78.69,-8.28,;80.02,-7.52,;77.36,-7.5,;77.36,-5.96,;78.69,-5.19,;78.69,-3.65,;77.36,-2.88,;76.02,-3.66,;76.03,-5.2,;76.02,-8.28,;74.69,-7.52,)|
Show InChI InChI=1S/C22H17N3O5/c1-29-19-14-17(30-16-10-6-3-7-11-16)12-13-18(19)25-21(27)23-20(26)24(22(25)28)15-8-4-2-5-9-15/h2-14H,1H3,(H,23,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 170n/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Agonist activity at FGFR1 (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of (bFGF(FGF-2))by fl...

ACS Med Chem Lett 10: 1590-1591 (2019)


Article DOI: 10.1021/acsmedchemlett.9b00506
BindingDB Entry DOI: 10.7270/Q2GM8BKZ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454178
PNG
(US10717708, Example 17 | US11186544, Example 17 | ...)
Show SMILES COc1ccc(NC(=O)NC2CCCN(C2=O)c2ccc(cc2F)-c2ccccc2S(C)(=O)=O)cc1
Show InChI InChI=1S/C26H26FN3O5S/c1-35-19-12-10-18(11-13-19)28-26(32)29-22-7-5-15-30(25(22)31)23-14-9-17(16-21(23)27)20-6-3-4-8-24(20)36(2,33)34/h3-4,6,8-14,16,22H,5,7,15H2,1-2H3,(H2,28,29,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 170n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454176
PNG
(US10717708, Example 15 | US11186544, Example 15 | ...)
Show SMILES Cc1ccc(NC(=O)NC2CCCN(C2=O)c2ccc(cc2)-c2cccnc2)cc1
Show InChI InChI=1S/C24H24N4O2/c1-17-6-10-20(11-7-17)26-24(30)27-22-5-3-15-28(23(22)29)21-12-8-18(9-13-21)19-4-2-14-25-16-19/h2,4,6-14,16,22H,3,5,15H2,1H3,(H2,26,27,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 200n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454179
PNG
(US10717708, Example 26 | US11186544, Example 26 | ...)
Show SMILES Cc1cnc(NC(=O)NC2CCCN(C2=O)c2ccc(cc2F)-c2ccccc2S(C)(=O)=O)s1
Show InChI InChI=1S/C23H23FN4O4S2/c1-14-13-25-23(33-14)27-22(30)26-18-7-5-11-28(21(18)29)19-10-9-15(12-17(19)24)16-6-3-4-8-20(16)34(2,31)32/h3-4,6,8-10,12-13,18H,5,7,11H2,1-2H3,(H2,25,26,27,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 210n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM275781
PNG
(US10071110, Compound 1-O-octadecyl-sn-glycero-3-AD...)
Show SMILES CCCCCCCCCCCCCCCCCCOC[C@H](CO)OP(O)(=O)COCCn1cnc2c(N)ncnc12
Show InChI InChI=1S/C29H54N5O6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-38-22-26(21-35)40-41(36,37)25-39-20-18-34-24-33-27-28(30)31-23-32-29(27)34/h23-24,26,35H,2-22,25H2,1H3,(H,36,37)(H2,30,31,32)/t26-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 210n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...

US Patent US10071110 (2018)


BindingDB Entry DOI: 10.7270/Q2NS0WX9
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454205
PNG
(US10717708, Example 197 | US11186544, Example 197 ...)
Show SMILES COc1ccc(NC(=O)N[C@@H]2CCCN(C2=O)c2ccc(cc2)-c2ccccc2NS(C)(=O)=O)c(F)c1 |r|
Show InChI InChI=1S/C26H27FN4O5S/c1-36-19-13-14-23(21(27)16-19)28-26(33)29-24-8-5-15-31(25(24)32)18-11-9-17(10-12-18)20-6-3-4-7-22(20)30-37(2,34)35/h3-4,6-7,9-14,16,24,30H,5,8,15H2,1-2H3,(H2,28,29,33)/t24-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 220n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454186
PNG
(US10717708, Example 58 | US11186544, Example 58 | ...)
Show SMILES OCc1ccccc1-c1ccc(cc1)N1CCC[C@H](NC(=O)Nc2ccc(cc2)C(F)(F)F)C1=O |r|
Show InChI InChI=1S/C26H24F3N3O3/c27-26(28,29)19-9-11-20(12-10-19)30-25(35)31-23-6-3-15-32(24(23)34)21-13-7-17(8-14-21)22-5-2-1-4-18(22)16-33/h1-2,4-5,7-14,23,33H,3,6,15-16H2,(H2,30,31,35)/t23-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 280n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454182
PNG
(US10717708, Example 36 | US11186544, Example 36 | ...)
Show SMILES FC(F)(F)c1ccc(NC(=O)NC2CCCN(C2=O)c2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C25H22F3N3O2/c26-25(27,28)19-10-12-20(13-11-19)29-24(33)30-22-7-4-16-31(23(22)32)21-14-8-18(9-15-21)17-5-2-1-3-6-17/h1-3,5-6,8-15,22H,4,7,16H2,(H2,29,30,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 280n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM50505007
PNG
(CHEMBL4464037)
Show SMILES Cc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O
Show InChI InChI=1S/C22H17N3O4/c1-15-14-17(12-13-19(15)29-18-10-6-3-7-11-18)25-21(27)23-20(26)24(22(25)28)16-8-4-2-5-9-16/h2-14H,1H3,(H,23,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 290n/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Agonist activity at FGFR1 (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of (bFGF(FGF-2))by fl...

ACS Med Chem Lett 10: 1590-1591 (2019)


Article DOI: 10.1021/acsmedchemlett.9b00506
BindingDB Entry DOI: 10.7270/Q2GM8BKZ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454197
PNG
(US10717708, Example 166 | US11186544, Example 166 ...)
Show SMILES FC(F)(F)c1ccc(NC(=O)N[C@@H]2CCCN(C2=O)c2ccc(cc2)-c2cncc(c2)N2CCOCC2)cc1 |r|
Show InChI InChI=1S/C28H28F3N5O3/c29-28(30,31)21-5-7-22(8-6-21)33-27(38)34-25-2-1-11-36(26(25)37)23-9-3-19(4-10-23)20-16-24(18-32-17-20)35-12-14-39-15-13-35/h3-10,16-18,25H,1-2,11-15H2,(H2,33,34,38)/t25-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 330n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454193
PNG
(US10717708, Example 125 | US11186544, Example 125 ...)
Show SMILES Fc1cccc(c1F)-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(cc2)C(F)(F)F)C1=O |r|
Show InChI InChI=1S/C25H20F5N3O2/c26-20-4-1-3-19(22(20)27)15-6-12-18(13-7-15)33-14-2-5-21(23(33)34)32-24(35)31-17-10-8-16(9-11-17)25(28,29)30/h1,3-4,6-13,21H,2,5,14H2,(H2,31,32,35)/t21-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 330n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM50505018
PNG
(CHEMBL4464173)
Show SMILES COc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O
Show InChI InChI=1S/C22H17N3O5/c1-29-19-14-16(12-13-18(19)30-17-10-6-3-7-11-17)25-21(27)23-20(26)24(22(25)28)15-8-4-2-5-9-15/h2-14H,1H3,(H,23,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 340n/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Agonist activity at FGFR1 (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of (bFGF(FGF-2))by fl...

ACS Med Chem Lett 10: 1590-1591 (2019)


Article DOI: 10.1021/acsmedchemlett.9b00506
BindingDB Entry DOI: 10.7270/Q2GM8BKZ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454177
PNG
(US10717708, Example 16 | US11186544, Example 16 | ...)
Show SMILES Clc1ccc(NC(=O)NC2CCCN(C2=O)c2ccc(cc2)-c2cccnc2)cc1
Show InChI InChI=1S/C23H21ClN4O2/c24-18-7-9-19(10-8-18)26-23(30)27-21-4-2-14-28(22(21)29)20-11-5-16(6-12-20)17-3-1-13-25-15-17/h1,3,5-13,15,21H,2,4,14H2,(H2,26,27,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 390n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM275767
PNG
(US10071110, Compound CDV | US10071110, Compound Ci...)
Show SMILES Nc1ccn(CC(CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

KEGG
PC cid
PC sid
PDB
UniChem
US Patent
n/an/an/an/a 460n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...

US Patent US10071110 (2018)


BindingDB Entry DOI: 10.7270/Q2NS0WX9
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM275768
PNG
(CYCLIC CIDOFOVIR | Cyclic-hpmpc | US10071110, Comp...)
Show SMILES Nc1ccn(CC2COP(O)(=O)CO2)c(=O)n1
Show InChI InChI=1S/C8H12N3O5P/c9-7-1-2-11(8(12)10-7)3-6-4-16-17(13,14)5-15-6/h1-2,6H,3-5H2,(H,13,14)(H2,9,10,12)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 470n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...

US Patent US10071110 (2018)


BindingDB Entry DOI: 10.7270/Q2NS0WX9
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM50505008
PNG
(CHEMBL4518577)
Show SMILES COc1cccc(c1)-n1c(=O)[nH]c(=O)n(-c2ccc(Oc3ccccc3)cc2)c1=O
Show InChI InChI=1S/C22H17N3O5/c1-29-19-9-5-6-16(14-19)25-21(27)23-20(26)24(22(25)28)15-10-12-18(13-11-15)30-17-7-3-2-4-8-17/h2-14H,1H3,(H,23,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 580n/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Agonist activity at FGFR1 (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of (bFGF(FGF-2))by fl...

ACS Med Chem Lett 10: 1590-1591 (2019)


Article DOI: 10.1021/acsmedchemlett.9b00506
BindingDB Entry DOI: 10.7270/Q2GM8BKZ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM275768
PNG
(CYCLIC CIDOFOVIR | Cyclic-hpmpc | US10071110, Comp...)
Show SMILES Nc1ccn(CC2COP(O)(=O)CO2)c(=O)n1
Show InChI InChI=1S/C8H12N3O5P/c9-7-1-2-11(8(12)10-7)3-6-4-16-17(13,14)5-15-6/h1-2,6H,3-5H2,(H,13,14)(H2,9,10,12)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 720n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The activity of cidofovir (CDV), cyclic cidofovir (cCDV), and 1-O-hexadecylpropanediol-3-cCDV (HDP-cCDV) were tested for antiviral activity in human ...

US Patent US10071110 (2018)


BindingDB Entry DOI: 10.7270/Q2NS0WX9
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM50505009
PNG
(CHEMBL4542212)
Show SMILES O=c1[nH]c(=O)n(-c2ccc(Oc3ccccc3)cc2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C21H15N3O4/c25-19-22-20(26)24(21(27)23(19)15-7-3-1-4-8-15)16-11-13-18(14-12-16)28-17-9-5-2-6-10-17/h1-14H,(H,22,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 890n/an/an/an/a



Usona Institute

Curated by ChEMBL


Assay Description
Agonist activity at FGFR1 (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of (bFGF(FGF-2))by fl...

ACS Med Chem Lett 10: 1590-1591 (2019)


Article DOI: 10.1021/acsmedchemlett.9b00506
BindingDB Entry DOI: 10.7270/Q2GM8BKZ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454198
PNG
(US10717708, Example 174 | US11186544, Example 174 ...)
Show SMILES NC(=O)c1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(F)cc2)C1=O |r|
Show InChI InChI=1S/C25H23FN4O3/c26-17-9-11-18(12-10-17)28-25(33)29-22-6-3-15-30(24(22)32)19-13-7-16(8-14-19)20-4-1-2-5-21(20)23(27)31/h1-2,4-5,7-14,22H,3,6,15H2,(H2,27,31)(H2,28,29,33)/t22-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 900n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454184
PNG
(US10717708, Example 48 | US11186544, Example 48 | ...)
Show SMILES NC(=O)c1ccc(cc1)-c1ccc(cc1)N1CCCC(NC(=O)Nc2ccc(cc2)C(F)(F)F)C1=O
Show InChI InChI=1S/C26H23F3N4O3/c27-26(28,29)19-9-11-20(12-10-19)31-25(36)32-22-2-1-15-33(24(22)35)21-13-7-17(8-14-21)16-3-5-18(6-4-16)23(30)34/h3-14,22H,1-2,15H2,(H2,30,34)(H2,31,32,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 930n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454180
PNG
(US10717708, Example 27 | US11186544, Example 27 | ...)
Show SMILES CS(=O)(=O)c1ccccc1-c1ccc(N2CCCC(NC(=O)Nc3ccc(Cl)nn3)C2=O)c(F)c1
Show InChI InChI=1S/C23H21ClFN5O4S/c1-35(33,34)19-7-3-2-5-15(19)14-8-9-18(16(25)13-14)30-12-4-6-17(22(30)31)26-23(32)27-21-11-10-20(24)28-29-21/h2-3,5,7-11,13,17H,4,6,12H2,1H3,(H2,26,27,29,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 950n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM275768
PNG
(CYCLIC CIDOFOVIR | Cyclic-hpmpc | US10071110, Comp...)
Show SMILES Nc1ccn(CC2COP(O)(=O)CO2)c(=O)n1
Show InChI InChI=1S/C8H12N3O5P/c9-7-1-2-11(8(12)10-7)3-6-4-16-17(13,14)5-15-6/h1-2,6H,3-5H2,(H,13,14)(H2,9,10,12)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 970n/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
The activity of cidofovir (CDV), cyclic cidofovir (cCDV), and 1-O-hexadecylpropanediol-3-cCDV (HDP-cCDV) were tested for antiviral activity in human ...

US Patent US10071110 (2018)


BindingDB Entry DOI: 10.7270/Q2NS0WX9
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM482158
PNG
(BDBM50242742 | TAE684)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 by cellular assay

Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM50073587
PNG
(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6C[C@H](C)O[C@H](C)C6)cc5)n[nH]c4c3)c2c1 |r|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 1.10E+3n/an/an/an/a



Zhengzhou University

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 (unknown origin)

Eur J Med Chem 95: 35-40 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.020
BindingDB Entry DOI: 10.7270/Q2NG4SBV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454181
PNG
(US10717708, Example 28 | US11186544, Example 28 | ...)
Show SMILES CS(=O)(=O)c1ccccc1-c1ccc(N2CCCC(NC(=O)Nc3ccc(F)cc3)C2=O)c(F)c1
Show InChI InChI=1S/C25H23F2N3O4S/c1-35(33,34)23-7-3-2-5-19(23)16-8-13-22(20(27)15-16)30-14-4-6-21(24(30)31)29-25(32)28-18-11-9-17(26)10-12-18/h2-3,5,7-13,15,21H,4,6,14H2,1H3,(H2,28,29,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.20E+3n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454200
PNG
(US10717708, Example 176 | US11186544, Example 176 ...)
Show SMILES COc1ccc(NC(=O)N[C@@H]2CCCN(C2=O)c2ccc(cc2)-c2ccccc2C(N)=O)cc1Cl |r|
Show InChI InChI=1S/C26H25ClN4O4/c1-35-23-13-10-17(15-21(23)27)29-26(34)30-22-7-4-14-31(25(22)33)18-11-8-16(9-12-18)19-5-2-3-6-20(19)24(28)32/h2-3,5-6,8-13,15,22H,4,7,14H2,1H3,(H2,28,32)(H2,29,30,34)/t22-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.20E+3n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454203
PNG
(US10717708, Example 184 | US11186544, Example 184 ...)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(cn2)C(F)(F)F)C1=O |r|
Show InChI InChI=1S/C25H24F3N5O4S/c1-38(36,37)32-20-6-3-2-5-19(20)16-8-11-18(12-9-16)33-14-4-7-21(23(33)34)30-24(35)31-22-13-10-17(15-29-22)25(26,27)28/h2-3,5-6,8-13,15,21,32H,4,7,14H2,1H3,(H2,29,30,31,35)/t21-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.50E+3n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454183
PNG
(US10717708, Example 47 | US11186544, Example 47 | ...)
Show SMILES Cc1ccncc1-c1ccc(cc1)N1CCCC(NC(=O)Nc2ccc(cc2)C(F)(F)F)C1=O
Show InChI InChI=1S/C25H23F3N4O2/c1-16-12-13-29-15-21(16)17-4-10-20(11-5-17)32-14-2-3-22(23(32)33)31-24(34)30-19-8-6-18(7-9-19)25(26,27)28/h4-13,15,22H,2-3,14H2,1H3,(H2,30,31,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.60E+3n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM454201
PNG
(US10717708, Example 177 | US11186544, Example 177 ...)
Show SMILES NC(=O)c1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(F)c(F)c2)C1=O |r|
Show InChI InChI=1S/C25H22F2N4O3/c26-20-12-9-16(14-21(20)27)29-25(34)30-22-6-3-13-31(24(22)33)17-10-7-15(8-11-17)18-4-1-2-5-19(18)23(28)32/h1-2,4-5,7-12,14,22H,3,6,13H2,(H2,28,32)(H2,29,30,34)/t22-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.70E+3n/an/an/an/a


TBA

Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VQ36JD
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 60 total )  |  Next  |  Last  >>
Jump to: