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Compile Data Set for Download or QSAR

Found 23 hits of ec50 data for polymerid = 694   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275777
PNG
(US10071110, Compound 1-O-octadecylethanediol-2-CDV)
Show SMILES CCCCCCCCCCCCCCCCCCOCCOP(O)(=O)COC(CO)Cn1ccc(N)nc1=O
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n/an/an/an/a>1n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM6190
PNG
(3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6...)
Show SMILES CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
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n/an/an/an/a 21n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275769
PNG
(Hexadecyloxypropyl-cyclic cidofovir | US10071110, ...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
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n/an/an/an/a<30n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275779
PNG
(US10071110, Compound Hexadecyl-cCDV)
Show SMILES CCCCCCCCCCCCCCCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
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n/an/an/an/a 40n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50242740
PNG
(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)
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n/an/an/an/a 80n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275780
PNG
(US10071110, Compound 1-O-hexadecylpropanediol-3-AD...)
Show SMILES CCCCCCCCCCCCCCCCCCOCCCOP(O)(=O)COCCn1cnc2c(N)ncnc12
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n/an/an/an/a 100n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275769
PNG
(Hexadecyloxypropyl-cyclic cidofovir | US10071110, ...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
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n/an/an/an/a 110n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM25118
PNG
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O
Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)
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n/an/an/an/a 166n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 phosphorylation expressed in human KM12L4A cells by Western blot analysis


J Med Chem 52: 278-92 (2009)


Article DOI: 10.1021/jm800790t
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275781
PNG
(US10071110, Compound 1-O-octadecyl-sn-glycero-3-AD...)
Show SMILES CCCCCCCCCCCCCCCCCCOC[C@H](CO)OP(O)(=O)COCCn1cnc2c(N)ncnc12
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n/an/an/an/a 210n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275767
PNG
(US10071110, Compound CDV | US10071110, Compound Ci...)
Show SMILES Nc1ccn(CC(CO)OCP(O)(O)=O)c(=O)n1
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n/an/an/an/a 460n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275768
PNG
(CYCLIC CIDOFOVIR | Cyclic-hpmpc | US10071110, Comp...)
Show SMILES Nc1ccn(CC2COP(O)(=O)CO2)c(=O)n1
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n/an/an/an/a 470n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275768
PNG
(CYCLIC CIDOFOVIR | Cyclic-hpmpc | US10071110, Comp...)
Show SMILES Nc1ccn(CC2COP(O)(=O)CO2)c(=O)n1
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n/an/an/an/a 720n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275768
PNG
(CYCLIC CIDOFOVIR | Cyclic-hpmpc | US10071110, Comp...)
Show SMILES Nc1ccn(CC2COP(O)(=O)CO2)c(=O)n1
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n/an/an/an/a 970n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50242742
PNG
(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50073587
PNG
(CHEMBL3408947)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6C[C@H](C)O[C@H](C)C6)cc5)n[nH]c4c3)c2c1 |r|
Show InChI InChI=1/C33H34N4O3/c1-20-17-37(18-21(2)40-20)19-23-6-4-22(5-7-23)8-12-29-26-11-9-24(14-31(26)36-35-29)28-16-33(28)27-15-25(39-3)10-13-30(27)34-32(33)38/h4-15,20-21,28H,16-19H2,1-3H3,(H,34,38)(H,35,36)/b12-8+/t20-,21+,28-,33-/s2
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n/an/an/an/a 1.10E+3n/an/an/an/a



Zhengzhou University

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 (unknown origin)


Eur J Med Chem 95: 35-40 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.020
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275767
PNG
(US10071110, Compound CDV | US10071110, Compound Ci...)
Show SMILES Nc1ccn(CC(CO)OCP(O)(O)=O)c(=O)n1
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n/an/an/an/a 1.80E+3n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275773
PNG
(US10071110, Compound 1-O-hexadecylpropanediol-3-CD...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP(O)(=O)COC(CO)Cn1ccc(N)nc1=O
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n/an/an/an/a 2.00E+3n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275767
PNG
(US10071110, Compound CDV | US10071110, Compound Ci...)
Show SMILES Nc1ccn(CC(CO)OCP(O)(O)=O)c(=O)n1
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n/an/an/an/a 2.10E+3n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275775
PNG
(US10071110, Compound 1-O-octadecylpropanediol-3-CD...)
Show SMILES CCCCCCCCCCCCCCCCCCOCCCOP(O)(=O)COC(CO)Cn1ccc(N)nc1=O
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n/an/an/an/a 3.00E+4n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50001103
PNG
((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Show SMILES Nc1ncnc2n(CCOCP(O)(O)=O)cnc12
Show InChI InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)
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n/an/an/an/a 5.50E+4n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275778
PNG
(US10071110, Compound 1-O-octadecylethanediol-2-cCD...)
Show SMILES CCCCCCCCCCCCCCCCCCOCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
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n/an/an/an/a 3.00E+5n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275776
PNG
(US10071110, Compound 1-O-octadecylpropanediol-3-cC...)
Show SMILES CCCCCCCCCCCCCCCCCCOCCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
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n/an/an/an/a 3.00E+5n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM275769
PNG
(Hexadecyloxypropyl-cyclic cidofovir | US10071110, ...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP1(=O)COC(Cn2ccc(N)nc2=O)CO1
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n/an/an/an/a 3.00E+5n/an/an/an/a



University of Auckland





J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1016/j.bmcl.2005.04.028
More data for this
Ligand-Target Pair