Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50546897 (CHEMBL4753470) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of NaV1.5 (unknown origin) | Citation and Details Article DOI: 10.1021/acs.jnatprod.0c00623 BindingDB Entry DOI: 10.7270/Q2H41W17 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50582057 (CHEMBL5077579) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 28 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulator activity at human Nav1.5 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el... | Citation and Details Article DOI: 10.1021/acs.jnatprod.1c00104 BindingDB Entry DOI: 10.7270/Q29K4G3X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50582056 (CHEMBL5091623) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 108 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulator activity at human Nav1.5 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el... | Citation and Details Article DOI: 10.1021/acs.jnatprod.1c00104 BindingDB Entry DOI: 10.7270/Q29K4G3X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50582058 (CHEMBL5093878) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 133 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulator activity at human Nav1.5 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el... | Citation and Details Article DOI: 10.1021/acs.jnatprod.1c00104 BindingDB Entry DOI: 10.7270/Q29K4G3X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50582054 (CHEMBL5091679) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 138 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulator activity at human Nav1.5 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el... | Citation and Details Article DOI: 10.1021/acs.jnatprod.1c00104 BindingDB Entry DOI: 10.7270/Q29K4G3X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50582055 (CHEMBL5083412) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 149 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulator activity at human Nav1.5 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el... | Citation and Details Article DOI: 10.1021/acs.jnatprod.1c00104 BindingDB Entry DOI: 10.7270/Q29K4G3X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50582060 (CHEMBL5084333) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 156 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulator activity at human Nav1.5 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el... | Citation and Details Article DOI: 10.1021/acs.jnatprod.1c00104 BindingDB Entry DOI: 10.7270/Q29K4G3X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50582059 (CHEMBL5082582) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 215 | n/a | n/a | n/a | n/a |
TBA | Assay Description Modulator activity at human Nav1.5 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el... | Citation and Details Article DOI: 10.1021/acs.jnatprod.1c00104 BindingDB Entry DOI: 10.7270/Q29K4G3X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM168436 (US9675591, SKA-19) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | US Patent | n/a | n/a | n/a | n/a | 5.80E+3 | n/a | n/a | 7.35 | 25 |
The Regents of the University of California US Patent | Assay Description All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh... | US Patent US9675591 (2017) BindingDB Entry DOI: 10.7270/Q26T0JSP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50538344 (CHEMBL4633246) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | >3.30E+4 | n/a | n/a | n/a | n/a |
University of Washington Curated by ChEMBL | Assay Description Inhibition of human Nav1.5 expressed in HEK293 cells by IonWorks patch clamp electrophysiology assay | J Med Chem 63: 4929-4956 (2020) Article DOI: 10.1021/acs.jmedchem.0c00311 BindingDB Entry DOI: 10.7270/Q2M90D6Z | |||||||||||
More data for this Ligand-Target Pair |