Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50050546 (CHEMBL3182699) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50050542 (CHEMBL3183497) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50050547 (CHEMBL3182449) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM458964 ((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com... | US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50312125 (3-chloro-N-(3-(3-methylbenzamido)phenyl)benzamide ...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50312105 (2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50050541 (CHEMBL3188749) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM458965 ((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com... | US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM458969 (US10759794, Example 54) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com... | US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM458968 (US10759794, Example 47) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com... | US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50050538 (CHEMBL3182091) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50123519 (2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Talca Curated by ChEMBL | Assay Description Inhibition of human TASK1 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay | J Med Chem 62: 10044-10058 (2019) Article DOI: 10.1021/acs.jmedchem.9b00248 BindingDB Entry DOI: 10.7270/Q2TT4V7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50050544 (CHEMBL3187764) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50123519 (2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM532166 (US11208422, Example 15 | US11208422, Example 16 | ...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.54 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Xenopus laevis oocytes were selected as described elsewhere by way of illustration [Decher et al., FEBS Lett. 492, 84-89 (2001)]. Subsequently, the o... | Citation and Details BindingDB Entry DOI: 10.7270/Q2CR5XHD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM458963 ((4-{[2-(4-Bromophenyl)imidazo[,2-a]pyridin-3-yl]me...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com... | US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50050503 (CHEMBL3187482) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM413514 (US10414765, Example 17) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub... | US Patent US10414765 (2019) BindingDB Entry DOI: 10.7270/Q2QJ7KNV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM458966 ((4-{[2-(4-Bromophenyl)imidazo [1,2-a]pyridin-3-yl]...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com... | US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50050534 (CHEMBL3183773) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50050547 (CHEMBL3182449) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50050540 (CHEMBL3182359) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50050545 (CHEMBL3186000) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50050503 (CHEMBL3187482) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM532051 (3-{[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl]m...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11.4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Xenopus laevis oocytes were selected as described elsewhere by way of illustration [Decher et al., FEBS Lett. 492, 84-89 (2001)]. Subsequently, the o... | Citation and Details BindingDB Entry DOI: 10.7270/Q2CR5XHD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM218623 (US9284333, 16mb | US9884860, Example 16mb) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | 25 |
Sanofi US Patent | Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,... | US Patent US9884860 (2018) BindingDB Entry DOI: 10.7270/Q2862JGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM218442 (US9284333, 16hb | US9884860, Example 16hb) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | 25 |
Sanofi US Patent | Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,... | US Patent US9884860 (2018) BindingDB Entry DOI: 10.7270/Q2862JGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM282814 (6-((S)-2-Methyl-pyrrolidine-1-carbonyl)-3,4-dihydr...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | 25 |
Sanofi US Patent | Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,... | US Patent US9884860 (2018) BindingDB Entry DOI: 10.7270/Q2862JGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM218623 (US9284333, 16mb | US9884860, Example 16mb) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | 25 |
Sanofi US Patent | Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,... | US Patent US9284333 (2016) BindingDB Entry DOI: 10.7270/Q2FJ2FMC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM218253 (US9284333, 16c) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | 25 |
Sanofi US Patent | Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,... | US Patent US9284333 (2016) BindingDB Entry DOI: 10.7270/Q2FJ2FMC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM218442 (US9284333, 16hb | US9884860, Example 16hb) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | 25 |
Sanofi US Patent | Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,... | US Patent US9284333 (2016) BindingDB Entry DOI: 10.7270/Q2FJ2FMC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM458967 (US10759794, Example 39) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13.4 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com... | US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50050530 (CHEMBL3188857) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM218341 (US9284333, 16cg | US9884860, Example 16cg) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | 25 |
Sanofi US Patent | Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,... | US Patent US9284333 (2016) BindingDB Entry DOI: 10.7270/Q2FJ2FMC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM218341 (US9284333, 16cg | US9884860, Example 16cg) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | 25 |
Sanofi US Patent | Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,... | US Patent US9884860 (2018) BindingDB Entry DOI: 10.7270/Q2862JGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50312105 (2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00378 BindingDB Entry DOI: 10.7270/Q2959NH4 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50312105 (2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50312105 (2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Talca Curated by ChEMBL | Assay Description Inhibition of human TASK1 expressed in CHO cells by Qpatch HT platform based assay | J Med Chem 62: 10044-10058 (2019) Article DOI: 10.1021/acs.jmedchem.9b00248 BindingDB Entry DOI: 10.7270/Q2TT4V7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM532051 (3-{[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl]m...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Xenopus laevis oocytes were selected as described elsewhere by way of illustration [Decher et al., FEBS Lett. 492, 84-89 (2001)]. Subsequently, the o... | Citation and Details BindingDB Entry DOI: 10.7270/Q2CR5XHD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM515511 ((5-Cyclopropyl-1,3-oxazol-4-yl)(5-{[2-(4-isopropyl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O... | Citation and Details BindingDB Entry DOI: 10.7270/Q2T43X7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM179693 (US9127001, 8b | US9598410, Compound 8b) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI US Patent | Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA... | US Patent US9598410 (2017) BindingDB Entry DOI: 10.7270/Q2377BRM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM179693 (US9127001, 8b | US9598410, Compound 8b) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | 25 |
Sanofi US Patent | Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,... | US Patent US9127001 (2015) BindingDB Entry DOI: 10.7270/Q2HM576Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM515509 ((3-Chloro-6-methoxypyridin-2-yl)(3-{[2-(4-chloroph...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 19.2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O... | Citation and Details BindingDB Entry DOI: 10.7270/Q2T43X7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM515512 ((3-Fluoro-6-methoxypyridin-2-yl)(3-{[2-(4-isopropy...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 20.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O... | Citation and Details BindingDB Entry DOI: 10.7270/Q2T43X7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM532162 (3-{[2-(4-Chlorophenyl)imidazo[1,2-a]pyrimidin-3-yl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 20.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Xenopus laevis oocytes were selected as described elsewhere by way of illustration [Decher et al., FEBS Lett. 492, 84-89 (2001)]. Subsequently, the o... | Citation and Details BindingDB Entry DOI: 10.7270/Q2CR5XHD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM515513 ((3-Chloro-6-methoxypyridin-2-yl)(3-{[2-(4-isopropy...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O... | Citation and Details BindingDB Entry DOI: 10.7270/Q2T43X7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM50050433 (CHEMBL3186489) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Specialized Chemistry Center Curated by ChEMBL | Assay Description Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay | Bioorg Med Chem Lett 24: 3968-73 (2014) Article DOI: 10.1016/j.bmcl.2014.06.032 BindingDB Entry DOI: 10.7270/Q2805487 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM218340 (US9284333, 16cf | US9884860, Example 16cf) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | 25 |
Sanofi US Patent | Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,... | US Patent US9284333 (2016) BindingDB Entry DOI: 10.7270/Q2FJ2FMC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM218340 (US9284333, 16cf | US9884860, Example 16cf) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | 25 |
Sanofi US Patent | Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,... | US Patent US9884860 (2018) BindingDB Entry DOI: 10.7270/Q2862JGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM515515 (US11098063, Example 51) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 21.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O... | Citation and Details BindingDB Entry DOI: 10.7270/Q2T43X7W | |||||||||||
More data for this Ligand-Target Pair |
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