Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77055 (US10093697, 8. | US10487111, Example 8. | US969401...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10093697 (2018) BindingDB Entry DOI: 10.7270/Q2N018KT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77055 (US10093697, 8. | US10487111, Example 8. | US969401...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a |
Albireo AB US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric—SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10487111 (2019) BindingDB Entry DOI: 10.7270/Q2542R0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77086 (US10093697, 13. | US10487111, Example 13. | US9694...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Albireo AB US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric—SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10487111 (2019) BindingDB Entry DOI: 10.7270/Q2542R0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77086 (US10093697, 13. | US10487111, Example 13. | US9694...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10093697 (2018) BindingDB Entry DOI: 10.7270/Q2N018KT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM420288 (US10487111, Example 11.) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
Albireo AB US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric—SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10487111 (2019) BindingDB Entry DOI: 10.7270/Q2542R0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77080 (US10093697, 11. | US9694018, 11) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10093697 (2018) BindingDB Entry DOI: 10.7270/Q2N018KT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77040 (US10093697, 5. | US10487111, Example 5. | US969401...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Albireo AB US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric—SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10487111 (2019) BindingDB Entry DOI: 10.7270/Q2542R0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77040 (US10093697, 5. | US10487111, Example 5. | US969401...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10093697 (2018) BindingDB Entry DOI: 10.7270/Q2N018KT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77029 (US10093697, 3. | US10487111, Example 3. | US969401...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
Albireo AB US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric—SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10487111 (2019) BindingDB Entry DOI: 10.7270/Q2542R0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77029 (US10093697, 3. | US10487111, Example 3. | US969401...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10093697 (2018) BindingDB Entry DOI: 10.7270/Q2N018KT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77074 (US10093697, 10. | US10487111, Example 10. | US9694...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Albireo AB US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric—SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10487111 (2019) BindingDB Entry DOI: 10.7270/Q2542R0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77074 (US10093697, 10. | US10487111, Example 10. | US9694...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10093697 (2018) BindingDB Entry DOI: 10.7270/Q2N018KT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50140282 (1-{4-[4-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hyd...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | J Med Chem 48: 5853-68 (2005) Article DOI: 10.1021/jm0402162 BindingDB Entry DOI: 10.7270/Q22V2GW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77083 (US10093697, 12. | US10487111, Example 12. | US9694...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10093697 (2018) BindingDB Entry DOI: 10.7270/Q2N018KT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50172695 (CHEMBL370103 | {2-[3-((4R,5R)-3,3-Dibutyl-7-dimeth...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | J Med Chem 48: 5853-68 (2005) Article DOI: 10.1021/jm0402162 BindingDB Entry DOI: 10.7270/Q22V2GW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77083 (US10093697, 12. | US10487111, Example 12. | US9694...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Albireo AB US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric—SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10487111 (2019) BindingDB Entry DOI: 10.7270/Q2542R0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77033 (US10093697, 4. | US10487111, Example 4. | US969401...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a |
Albireo AB US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric—SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10487111 (2019) BindingDB Entry DOI: 10.7270/Q2542R0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77033 (US10093697, 4. | US10487111, Example 4. | US969401...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10093697 (2018) BindingDB Entry DOI: 10.7270/Q2N018KT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77051 (US10093697, 7. | US10487111, Example 7. | US969401...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a |
Albireo AB US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric—SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10487111 (2019) BindingDB Entry DOI: 10.7270/Q2542R0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77051 (US10093697, 7. | US10487111, Example 7. | US969401...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10093697 (2018) BindingDB Entry DOI: 10.7270/Q2N018KT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77074 (US10093697, 10. | US10487111, Example 10. | US9694...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10093697 (2018) BindingDB Entry DOI: 10.7270/Q2N018KT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM76996 (US10487111, Example 2. | US9694018, 2) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
Albireo AB US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric—SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10487111 (2019) BindingDB Entry DOI: 10.7270/Q2542R0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM76994 (US10093697, 1. | US10487111, Example 1. | US969401...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10093697 (2018) BindingDB Entry DOI: 10.7270/Q2N018KT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM76994 (US10093697, 1. | US10487111, Example 1. | US969401...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a |
Albireo AB US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric—SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10487111 (2019) BindingDB Entry DOI: 10.7270/Q2542R0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50172649 (1-{5-[4-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hyd...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | J Med Chem 48: 5853-68 (2005) Article DOI: 10.1021/jm0402162 BindingDB Entry DOI: 10.7270/Q22V2GW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50172702 (4-[4-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hydrox...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | J Med Chem 48: 5853-68 (2005) Article DOI: 10.1021/jm0402162 BindingDB Entry DOI: 10.7270/Q22V2GW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50370667 (CHEMBL555246) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.760 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | J Med Chem 48: 5853-68 (2005) Article DOI: 10.1021/jm0402162 BindingDB Entry DOI: 10.7270/Q22V2GW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM159835 (US9040518, 68) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | 25 |
GlaxoSmithKline LLC US Patent | Assay Description On the day of the uptake experiment, 10 mM HEPES was added to Hank's Balanced Salt Solution, and the pH was adjusted to 7.4 with TRIS (HBSSH). The as... | US Patent US9040518 (2015) BindingDB Entry DOI: 10.7270/Q2T72G58 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50172709 (1-{4-[4-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hyd...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | J Med Chem 48: 5853-68 (2005) Article DOI: 10.1021/jm0402162 BindingDB Entry DOI: 10.7270/Q22V2GW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50172668 (1-{4-[4-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hyd...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | J Med Chem 48: 5853-68 (2005) Article DOI: 10.1021/jm0402162 BindingDB Entry DOI: 10.7270/Q22V2GW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77088 (US10093697, 14. | US10487111, Example 14. | US9694...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10093697 (2018) BindingDB Entry DOI: 10.7270/Q2N018KT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM77088 (US10093697, 14. | US10487111, Example 14. | US9694...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Albireo AB US Patent | Assay Description ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric—SPA Inhibitor IC50 Mean IC50 (nM) was... | US Patent US10487111 (2019) BindingDB Entry DOI: 10.7270/Q2542R0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50134416 (CHEMBL332974 | Trifluoro-acetate{4-[3-((8R,9R)-7,7...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description In vitro inhibitory activity against uptake of [14C]-taurocholate in baby hamster kidney cells transfected with cDNA from human Apical Sodium-Codepen... | Bioorg Med Chem Lett 13: 3727-30 (2003) BindingDB Entry DOI: 10.7270/Q2M044T4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50172681 ((Carboxymethyl-{4-[4-((4R,5R)-3,3-dibutyl-7-dimeth...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | J Med Chem 48: 5853-68 (2005) Article DOI: 10.1021/jm0402162 BindingDB Entry DOI: 10.7270/Q22V2GW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50434847 (CHEMBL2387421 | US9040518, 3) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | 25 |
GlaxoSmithKline LLC US Patent | Assay Description On the day of the uptake experiment, 10 mM HEPES was added to Hank's Balanced Salt Solution, and the pH was adjusted to 7.4 with TRIS (HBSSH). The as... | US Patent US9040518 (2015) BindingDB Entry DOI: 10.7270/Q2T72G58 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50172652 ((4R,5R)-5-(3-Amino-phenyl)-3,3-dibutyl-7-dimethyla...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | J Med Chem 48: 5853-68 (2005) Article DOI: 10.1021/jm0402162 BindingDB Entry DOI: 10.7270/Q22V2GW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50370669 (CHEMBL555022) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | J Med Chem 48: 5853-68 (2005) Article DOI: 10.1021/jm0402162 BindingDB Entry DOI: 10.7270/Q22V2GW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50370670 (CHEMBL540126) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | J Med Chem 48: 5853-68 (2005) Article DOI: 10.1021/jm0402162 BindingDB Entry DOI: 10.7270/Q22V2GW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50434847 (CHEMBL2387421 | US9040518, 3) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research& Development Curated by ChEMBL | Assay Description Inhibition of human ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi... | J Med Chem 56: 5094-114 (2013) Article DOI: 10.1021/jm400459m BindingDB Entry DOI: 10.7270/Q2MC91D6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50434848 (CHEMBL2387520) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research& Development Curated by ChEMBL | Assay Description Inhibition of human ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi... | J Med Chem 56: 5094-114 (2013) Article DOI: 10.1021/jm400459m BindingDB Entry DOI: 10.7270/Q2MC91D6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50172667 (4-[3-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hydrox...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | J Med Chem 48: 5853-68 (2005) Article DOI: 10.1021/jm0402162 BindingDB Entry DOI: 10.7270/Q22V2GW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM159806 (US9040518, 23) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | 25 |
GlaxoSmithKline LLC US Patent | Assay Description On the day of the uptake experiment, 10 mM HEPES was added to Hank's Balanced Salt Solution, and the pH was adjusted to 7.4 with TRIS (HBSSH). The as... | US Patent US9040518 (2015) BindingDB Entry DOI: 10.7270/Q2T72G58 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM159822 (US9040518, 46) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | 25 |
GlaxoSmithKline LLC US Patent | Assay Description On the day of the uptake experiment, 10 mM HEPES was added to Hank's Balanced Salt Solution, and the pH was adjusted to 7.4 with TRIS (HBSSH). The as... | US Patent US9040518 (2015) BindingDB Entry DOI: 10.7270/Q2T72G58 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50172608 ((4R,5R)-3,3-Dibutyl-7-dimethylamino-9-methoxy-5-(4...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia Curated by ChEMBL | Assay Description In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in Baby hamster cells expressing human IBAT | J Med Chem 48: 5837-52 (2005) Article DOI: 10.1021/jm040215+ BindingDB Entry DOI: 10.7270/Q26M37MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50172661 ((4R,5R)-3,3-Dibutyl-7-dimethylamino-5-(4-hydroxy-p...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | J Med Chem 48: 5853-68 (2005) Article DOI: 10.1021/jm0402162 BindingDB Entry DOI: 10.7270/Q22V2GW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50172690 ((Carboxymethyl-{5-[4-((4R,5R)-3,3-dibutyl-7-dimeth...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | J Med Chem 48: 5853-68 (2005) Article DOI: 10.1021/jm0402162 BindingDB Entry DOI: 10.7270/Q22V2GW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50134424 (CHEMBL332973 | [2-(2-{2-[4-((8R,9R)-7,7-Dibutyl-2-...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description In vitro inhibitory activity against uptake of [14C]-taurocholate in baby hamster kidney cells transfected with cDNA from human Apical Sodium-Codepen... | Bioorg Med Chem Lett 13: 3727-30 (2003) BindingDB Entry DOI: 10.7270/Q2M044T4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50370665 (CHEMBL555024) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | J Med Chem 48: 5853-68 (2005) Article DOI: 10.1021/jm0402162 BindingDB Entry DOI: 10.7270/Q22V2GW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM159795 (US9040518, 9) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | 25 |
GlaxoSmithKline LLC US Patent | Assay Description On the day of the uptake experiment, 10 mM HEPES was added to Hank's Balanced Salt Solution, and the pH was adjusted to 7.4 with TRIS (HBSSH). The as... | US Patent US9040518 (2015) BindingDB Entry DOI: 10.7270/Q2T72G58 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ileal sodium/bile acid cotransporter (Homo sapiens (Human)) | BDBM50172675 (1-[2-(2-{2-[4-((4R,5R)-3,3-Dibutyl-7-dimethylamino...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBAT | J Med Chem 48: 5853-68 (2005) Article DOI: 10.1021/jm0402162 BindingDB Entry DOI: 10.7270/Q22V2GW2 | |||||||||||
More data for this Ligand-Target Pair |
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