Compile Data Set for Download or QSAR

Found 2412 hits of ic50 data for polymerid = 7285   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM50464991 (CHEMBL4283739) Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-c1nncn1C(C)C)S(N)(=O)=O Show InChI InChI=1S/C19H22N6O4S/c1-11(2)25-10-21-24-18(25)14-6-5-7-17(22-14)23-19(26)13-9-16(30(20,27)28)12(3)8-15(13)29-4/h5-11H,1-4H3,(H2,20,27,28)(H,22,23,26)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant full length human GST-tagged ASK1 expressed in baculovirus expression system using STK3 peptide substrate preincubated for ...				Eur J Med Chem 145: 606-621 (2018) Article DOI: 10.1016/j.ejmech.2017.12.041 BindingDB Entry DOI: 10.7270/Q25H7JXQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM443131 (US10654833, Compound 5) Show SMILES CC(C)n1cnnc1-c1cccc(n1)N1Cc2ccc(cc2C1=O)-c1cc(ccc1F)C(O)=O Show InChI InChI=1S/C25H20FN5O3/c1-14(2)31-13-27-29-23(31)21-4-3-5-22(28-21)30-12-17-7-6-15(10-19(17)24(30)32)18-11-16(25(33)34)8-9-20(18)26/h3-11,13-14H,12H2,1-2H3,(H,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Hepatikos Therapeutics, LLC US Patent					Assay Description Inhibition of ASK1 kinase activity was determined radiometrically using 33P substrate incorporation (Reaction Biology Corp., Malvern, Pa.). Briefly, ...				US Patent US10654833 (2020) BindingDB Entry DOI: 10.7270/Q2F192R3
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM50464987 (CHEMBL4290518) Show SMILES CCS(=O)(=O)Nc1ccc(OC)c(c1)C(=O)Nc1cccc(n1)-c1nncn1C(C)C Show InChI InChI=1S/C20H24N6O4S/c1-5-31(28,29)25-14-9-10-17(30-4)15(11-14)20(27)23-18-8-6-7-16(22-18)19-24-21-12-26(19)13(2)3/h6-13,25H,5H2,1-4H3,(H,22,23,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant full length human GST-tagged ASK1 expressed in baculovirus expression system using STK3 peptide substrate preincubated for ...				Eur J Med Chem 145: 606-621 (2018) Article DOI: 10.1016/j.ejmech.2017.12.041 BindingDB Entry DOI: 10.7270/Q25H7JXQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM523902 (2-amino-N-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES Nc1cc(ccn1)C(=O)NC1CCN(CC1)c1ncnc2[nH]cc(Cl)c12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.398	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...				Citation and Details BindingDB Entry DOI: 10.7270/Q2W95DB4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM187363 (US9169243, 11 | US9908875, 11) Show SMILES CNC(=O)C1CCN(CC1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1 Show InChI InChI=1S/C27H30N10O2S/c1-28-25(38)17-6-8-35(9-7-17)22-11-29-19(10-21(22)36-12-20(30-14-36)16-2-3-16)26(39)32-23-13-40-27(33-23)24-34-31-15-37(24)18-4-5-18/h10-18H,2-9H2,1H3,(H,28,38)(H,32,39)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q22F7QRX
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM50464992 (CHEMBL4294318) Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-c1nncn1C(C)C)C(N)=O Show InChI InChI=1S/C20H22N6O3/c1-11(2)26-10-22-25-19(26)15-6-5-7-17(23-15)24-20(28)14-9-13(18(21)27)12(3)8-16(14)29-4/h5-11H,1-4H3,(H2,21,27)(H,23,24,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.420	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant full length human GST-tagged ASK1 expressed in baculovirus expression system using STK3 peptide substrate preincubated for ...				Eur J Med Chem 145: 606-621 (2018) Article DOI: 10.1016/j.ejmech.2017.12.041 BindingDB Entry DOI: 10.7270/Q25H7JXQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM483418 (US10919911, Example 40) Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3cnnn3CCOc12 Show InChI InChI=1S/C24H21FN6O2/c1-14-9-18(25)17(10-21(14)30-12-20(26-13-30)15-5-6-15)24(32)28-19-4-2-3-16-22-11-27-29-31(22)7-8-33-23(16)19/h2-4,9-13,15H,5-8H2,1H3,(H,28,32)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TERNS, INC. US Patent					Assay Description Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...				US Patent US10919911 (2021) BindingDB Entry DOI: 10.7270/Q22R3VR5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM483415 (US10919911, Example 37) Show SMILES CC1(C)COc2c(NC(=O)c3cc(c(cn3)N3CCOCC3)-n3cnc(c3)C3CC3)cccc2-c2nnnn12 Show InChI InChI=1S/C27H29N9O3/c1-27(2)15-39-24-18(25-31-32-33-36(25)27)4-3-5-19(24)30-26(37)20-12-22(35-14-21(29-16-35)17-6-7-17)23(13-28-20)34-8-10-38-11-9-34/h3-5,12-14,16-17H,6-11,15H2,1-2H3,(H,30,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TERNS, INC. US Patent					Assay Description Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...				US Patent US10919911 (2021) BindingDB Entry DOI: 10.7270/Q22R3VR5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM483388 (US10919911, Example 10) Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nncn3C3(CC3)COc12 Show InChI InChI=1S/C26H23FN6O2/c1-15-9-19(27)18(10-22(15)32-11-21(28-13-32)16-5-6-16)25(34)30-20-4-2-3-17-23(20)35-12-26(7-8-26)33-14-29-31-24(17)33/h2-4,9-11,13-14,16H,5-8,12H2,1H3,(H,30,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TERNS, INC. US Patent					Assay Description Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...				US Patent US10919911 (2021) BindingDB Entry DOI: 10.7270/Q22R3VR5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM483416 (US10919911, Example 38) Show SMILES C[C@H]1COc2c(NC(=O)c3cc(c(cn3)N3CCOCC3)-n3cnc(c3)C3CC3)cccc2-c2nncn12 |r| Show InChI InChI=1S/C27H28N8O3/c1-17-14-38-25-19(26-32-30-16-35(17)26)3-2-4-20(25)31-27(36)21-11-23(34-13-22(29-15-34)18-5-6-18)24(12-28-21)33-7-9-37-10-8-33/h2-4,11-13,15-18H,5-10,14H2,1H3,(H,31,36)/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TERNS, INC. US Patent					Assay Description Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...				US Patent US10919911 (2021) BindingDB Entry DOI: 10.7270/Q22R3VR5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM483400 (US10919911, Example 22) Show SMILES C[C@H]1COc2c(NC(=O)c3cc(c(cn3)N3CCOCC3)-n3cnc(c3)C3CC3)cccc2-c2nnnn12 |r| Show InChI InChI=1S/C26H27N9O3/c1-16-14-38-24-18(25-30-31-32-35(16)25)3-2-4-19(24)29-26(36)20-11-22(34-13-21(28-15-34)17-5-6-17)23(12-27-20)33-7-9-37-10-8-33/h2-4,11-13,15-17H,5-10,14H2,1H3,(H,29,36)/t16-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TERNS, INC. US Patent					Assay Description Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...				US Patent US10919911 (2021) BindingDB Entry DOI: 10.7270/Q22R3VR5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.690	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibition of ASK1 (unknown origin) by HTRF assay				J Nat Prod 81: 949-956 (2018) Article DOI: 10.1021/acs.jnatprod.7b01058 BindingDB Entry DOI: 10.7270/Q2T1569T
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM443190 (US10654833, Compound 102) Show SMILES CC(C)n1cnnc1-c1cccc(n1)N1Cc2ccc(cc2C1=O)-c1cccc(c1)C(C)(C)C(O)=O Show InChI InChI=1S/C28H27N5O3/c1-17(2)33-16-29-31-25(33)23-9-6-10-24(30-23)32-15-20-12-11-19(14-22(20)26(32)34)18-7-5-8-21(13-18)28(3,4)27(35)36/h5-14,16-17H,15H2,1-4H3,(H,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Hepatikos Therapeutics, LLC US Patent					Assay Description Inhibition of ASK1 kinase activity was determined radiometrically using 33P substrate incorporation (Reaction Biology Corp., Malvern, Pa.). Briefly, ...				US Patent US10654833 (2020) BindingDB Entry DOI: 10.7270/Q2F192R3
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM162322 (US10307427, Compound 13 | US9051313, 13) Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCCCC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r| Show InChI InChI=1S/C25H26F3N9OS/c1-15(25(26,27)28)37-14-31-34-22(37)24-33-21(12-39-24)32-23(38)17-9-19(36-11-18(30-13-36)16-5-6-16)20(10-29-17)35-7-3-2-4-8-35/h9-16H,2-8H2,1H3,(H,32,38)/t15-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Gildead Sciences, Inc. US Patent					Assay Description The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...				US Patent US9051313 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZVX
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM50245498 (CHEMBL4083562) Show SMILES CC(n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCCCC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F Show InChI InChI=1S/C25H26F3N9OS/c1-15(25(26,27)28)37-14-31-34-22(37)24-33-21(12-39-24)32-23(38)17-9-19(36-11-18(30-13-36)16-5-6-16)20(10-29-17)35-7-3-2-4-8-35/h9-16H,2-8H2,1H3,(H,32,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Taipei Medical University Curated by ChEMBL					Assay Description Inhibition of recombinant human ASK1 using STK3 peptide as substrate incubated for 30 mins followed by ATP addition measured for 3 hrs by TR-FRET ass...				J Med Chem 60: 527-553 (2017) Article DOI: 10.1021/acs.jmedchem.6b00935 BindingDB Entry DOI: 10.7270/Q29C70V2
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM162322 (US10307427, Compound 13 | US9051313, 13) Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCCCC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r| Show InChI InChI=1S/C25H26F3N9OS/c1-15(25(26,27)28)37-14-31-34-22(37)24-33-21(12-39-24)32-23(38)17-9-19(36-11-18(30-13-36)16-5-6-16)20(10-29-17)35-7-3-2-4-8-35/h9-16H,2-8H2,1H3,(H,32,38)/t15-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Washington University					Assay Description The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...				J Med Chem 52: 2188-91 (2009) BindingDB Entry DOI: 10.7270/Q2K64MD9
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM483421 (US10919911, Example 43) Show SMILES C[C@@H]1Cn2nnnc2-c2cccc(NC(=O)c3cc(c(C)cc3F)-n3cnc(c3)C3CC3)c2O1 |r| Show InChI InChI=1S/C24H22FN7O2/c1-13-8-18(25)17(9-21(13)31-11-20(26-12-31)15-6-7-15)24(33)27-19-5-3-4-16-22(19)34-14(2)10-32-23(16)28-29-30-32/h3-5,8-9,11-12,14-15H,6-7,10H2,1-2H3,(H,27,33)/t14-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
TERNS, INC. US Patent					Assay Description Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...				US Patent US10919911 (2021) BindingDB Entry DOI: 10.7270/Q22R3VR5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM483401 (US10919911, Example 23) Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc2-c3nnnn3[C@@H](CO)COc12 |r| Show InChI InChI=1S/C24H22FN7O3/c1-13-7-18(25)17(8-21(13)31-9-20(26-12-31)14-5-6-14)24(34)27-19-4-2-3-16-22(19)35-11-15(10-33)32-23(16)28-29-30-32/h2-4,7-9,12,14-15,33H,5-6,10-11H2,1H3,(H,27,34)/t15-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
TERNS, INC. US Patent					Assay Description Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, and 1% DMSO were used for ...				US Patent US10919911 (2021) BindingDB Entry DOI: 10.7270/Q22R3VR5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM187354 (US9169243, 2 | US9908875, 2) Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CC(C1)C#N)-n1cnc(c1)C1CC1 Show InChI InChI=1S/C24H22N10OS/c25-6-14-8-32(9-14)20-7-26-17(5-19(20)33-10-18(27-12-33)15-1-2-15)23(35)29-21-11-36-24(30-21)22-31-28-13-34(22)16-3-4-16/h5,7,10-16H,1-4,8-9H2,(H,29,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q22F7QRX
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM445429 (US10683279, Example 26a | US10988458, Example 26a ...) Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1C(CO)CO Show InChI InChI=1S/C23H23FN8O3/c1-13-7-17(24)16(8-20(13)31-9-19(25-12-31)14-5-6-14)23(35)27-21-4-2-3-18(26-21)22-28-29-30-32(22)15(10-33)11-34/h2-4,7-9,12,14-15,33-34H,5-6,10-11H2,1H3,(H,26,27,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Enanta Pharmaceuticals, Inc. US Patent					Assay Description ASK1 was purchased from Thermofisher (Catalogue #PV4011), ATP was purchased from Sigma (Catalogue #A7699), HTRF® KinEASE™ Assay System was obtained f...				US Patent US10988458 (2021) BindingDB Entry DOI: 10.7270/Q2320007
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM445429 (US10683279, Example 26a | US10988458, Example 26a ...) Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1C(CO)CO Show InChI InChI=1S/C23H23FN8O3/c1-13-7-17(24)16(8-20(13)31-9-19(25-12-31)14-5-6-14)23(35)27-21-4-2-3-18(26-21)22-28-29-30-32(22)15(10-33)11-34/h2-4,7-9,12,14-15,33-34H,5-6,10-11H2,1H3,(H,26,27,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WM1JBC
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM419047 (US10450301, Example 126) Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc3CN(CCc3cn2)C(=O)OCC(F)(F)F)n1 |r| Show InChI InChI=1S/C21H21F3N8O4/c1-12(10-33)32-18(28-29-30-32)15-3-2-4-17(26-15)27-19(34)16-7-14-9-31(6-5-13(14)8-25-16)20(35)36-11-21(22,23)24/h2-4,7-8,12,33H,5-6,9-11H2,1H3,(H,26,27,34)/t12-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Enanta Pharmaceuticals, Inc. US Patent					Assay Description HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...				US Patent US10450301 (2019) BindingDB Entry DOI: 10.7270/Q2P84F7M
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM445429 (US10683279, Example 26a | US10988458, Example 26a ...) Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1C(CO)CO Show InChI InChI=1S/C23H23FN8O3/c1-13-7-17(24)16(8-20(13)31-9-19(25-12-31)14-5-6-14)23(35)27-21-4-2-3-18(26-21)22-28-29-30-32(22)15(10-33)11-34/h2-4,7-9,12,14-15,33-34H,5-6,10-11H2,1H3,(H,26,27,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Enanta Pharmaceuticals, Inc. US Patent					Assay Description ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF® KinEASE™ Assay System was obtained from Cisbio (Bedford, Mass). ½ Area pla...				US Patent US10683279 (2020) BindingDB Entry DOI: 10.7270/Q2JQ1436
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM445485 (US10683289, Example 8) Show SMILES COc1cc2CN(C(C)(C)C)S(=O)(=O)c2cc1C(=O)Nc1cccc(n1)-c1nncn1C(C)C Show InChI InChI=1S/C23H28N6O4S/c1-14(2)28-13-24-27-21(28)17-8-7-9-20(25-17)26-22(30)16-11-19-15(10-18(16)33-6)12-29(23(3,4)5)34(19,31)32/h7-11,13-14H,12H2,1-6H3,(H,25,26,30)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Enanta Pharmaceuticals, Inc. US Patent					Assay Description ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...				US Patent US10683289 (2020) BindingDB Entry DOI: 10.7270/Q2959MM2
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM445488 (US10683289, Example 10) Show SMILES COc1cc2CN(C(C)C)S(=O)(=O)c2cc1C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO |r| Show InChI InChI=1S/C21H25N7O5S/c1-12(2)27-10-14-8-17(33-4)15(9-18(14)34(27,31)32)21(30)23-19-7-5-6-16(22-19)20-24-25-26-28(20)13(3)11-29/h5-9,12-13,29H,10-11H2,1-4H3,(H,22,23,30)/t13-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Enanta Pharmaceuticals, Inc. US Patent					Assay Description ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...				US Patent US10683289 (2020) BindingDB Entry DOI: 10.7270/Q2959MM2
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM445496 (US10683289, Example 16) Show SMILES COc1cc2CN(C)S(=O)(=O)c2cc1C(=O)Nc1cccc(n1)-c1nncn1C(C)C Show InChI InChI=1S/C20H22N6O4S/c1-12(2)26-11-21-24-19(26)15-6-5-7-18(22-15)23-20(27)14-9-17-13(8-16(14)30-4)10-25(3)31(17,28)29/h5-9,11-12H,10H2,1-4H3,(H,22,23,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Enanta Pharmaceuticals, Inc. US Patent					Assay Description ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...				US Patent US10683289 (2020) BindingDB Entry DOI: 10.7270/Q2959MM2
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM445499 (US10683289, Example 18) Show SMILES COc1cc2CN(C)S(=O)(=O)c2cc1C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO |r| Show InChI InChI=1S/C19H21N7O5S/c1-11(10-27)26-18(22-23-24-26)14-5-4-6-17(20-14)21-19(28)13-8-16-12(7-15(13)31-3)9-25(2)32(16,29)30/h4-8,11,27H,9-10H2,1-3H3,(H,20,21,28)/t11-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Enanta Pharmaceuticals, Inc. US Patent					Assay Description ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...				US Patent US10683289 (2020) BindingDB Entry DOI: 10.7270/Q2959MM2
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM445504 (US10683289, Example 21) Show SMILES COCCN1Cc2cc(F)c(cc2S1(=O)=O)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO Show InChI InChI=1S/C20H22FN7O5S/c1-12(11-29)28-19(24-25-26-28)16-4-3-5-18(22-16)23-20(30)14-9-17-13(8-15(14)21)10-27(6-7-33-2)34(17,31)32/h3-5,8-9,12,29H,6-7,10-11H2,1-2H3,(H,22,23,30)/t12-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Enanta Pharmaceuticals, Inc. US Patent					Assay Description ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...				US Patent US10683289 (2020) BindingDB Entry DOI: 10.7270/Q2959MM2
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM50464985 (CHEMBL4282644) Show SMILES COc1ccc(cc1C(=O)Nc1cccc(n1)-c1nncn1C(C)C)C(N)=O Show InChI InChI=1S/C19H20N6O3/c1-11(2)25-10-21-24-18(25)14-5-4-6-16(22-14)23-19(27)13-9-12(17(20)26)7-8-15(13)28-3/h4-11H,1-3H3,(H2,20,26)(H,22,23,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant full length human GST-tagged ASK1 expressed in baculovirus expression system using STK3 peptide substrate preincubated for ...				Eur J Med Chem 145: 606-621 (2018) Article DOI: 10.1016/j.ejmech.2017.12.041 BindingDB Entry DOI: 10.7270/Q25H7JXQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM445505 (US10683289, Example 22) Show SMILES COCCN1Cc2cc(OC)c(cc2S1(=O)=O)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO Show InChI InChI=1S/C21H25N7O6S/c1-13(12-29)28-20(24-25-26-28)16-5-4-6-19(22-16)23-21(30)15-10-18-14(9-17(15)34-3)11-27(7-8-33-2)35(18,31)32/h4-6,9-10,13,29H,7-8,11-12H2,1-3H3,(H,22,23,30)/t13-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Enanta Pharmaceuticals, Inc. US Patent					Assay Description ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...				US Patent US10683289 (2020) BindingDB Entry DOI: 10.7270/Q2959MM2
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM419108 (US10450301, Example 187) Show SMILES CCn1cc(CNC(=O)N2CCc3cnc(cc3C2)C(=O)Nc2cccc(n2)-c2nnnn2[C@H](C)CO)cn1 |r| Show InChI InChI=1S/C25H29N11O3/c1-3-35-13-17(11-28-35)10-27-25(39)34-8-7-18-12-26-21(9-19(18)14-34)24(38)30-22-6-4-5-20(29-22)23-31-32-33-36(23)16(2)15-37/h4-6,9,11-13,16,37H,3,7-8,10,14-15H2,1-2H3,(H,27,39)(H,29,30,38)/t16-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Enanta Pharmaceuticals, Inc. US Patent					Assay Description HTRF KinEASE-STK is a generic method for measuring serine/threonine kinase activities using a time-resolved fluorescence resonance energy transfer (T...				US Patent US10450301 (2019) BindingDB Entry DOI: 10.7270/Q2P84F7M
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM523870 (5-(4-Cyclopropyl-1H-imidazol-1-yl)-N-(6-(5,5-dimet...) Show SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnc2CCC(C)(C)n12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...				Citation and Details BindingDB Entry DOI: 10.7270/Q2125WT1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM497494 (US11008304, Example 80) Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO)-c1ccn(n1)C(C)C |r| Show InChI InChI=1S/C24H28N8O3/c1-14(2)31-10-9-19(28-31)17-12-18(21(35-5)11-15(17)3)24(34)26-22-8-6-7-20(25-22)23-27-29-30-32(23)16(4)13-33/h6-12,14,16,33H,13H2,1-5H3,(H,25,26,34)/t16-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Enanta Pharmaceuticals, Inc. US Patent					Assay Description The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...				US Patent US11008304 (2021) BindingDB Entry DOI: 10.7270/Q2D50R3H
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM497491 (US11008304, Example 77) Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO)-c1cnn(c1)C1CC1 |r| Show InChI InChI=1S/C24H26N8O3/c1-14-9-21(35-3)19(10-18(14)16-11-25-31(12-16)17-7-8-17)24(34)27-22-6-4-5-20(26-22)23-28-29-30-32(23)15(2)13-33/h4-6,9-12,15,17,33H,7-8,13H2,1-3H3,(H,26,27,34)/t15-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Enanta Pharmaceuticals, Inc. US Patent					Assay Description The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...				US Patent US11008304 (2021) BindingDB Entry DOI: 10.7270/Q2D50R3H
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM50579557 (CHEMBL4868362) Show SMILES COc1nn(C)cc1C(=O)Nc1cccc(n1)-c1nncn1C1(CC1)C(F)(F)F Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ASK1 (unknown origin) using myelin basic protein as substrate preincubated for 20 mins followed by 33P-ATP addition and measured after ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01458 BindingDB Entry DOI: 10.7270/Q27D2ZZT
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM497489 (US11008304, Example 75) Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-c1nnnn1C(C)C)-c1cnn(c1)C1CC1 Show InChI InChI=1S/C24H26N8O2/c1-14(2)32-23(28-29-30-32)20-6-5-7-22(26-20)27-24(33)19-11-18(15(3)10-21(19)34-4)16-12-25-31(13-16)17-8-9-17/h5-7,10-14,17H,8-9H2,1-4H3,(H,26,27,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Enanta Pharmaceuticals, Inc. US Patent					Assay Description The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...				US Patent US11008304 (2021) BindingDB Entry DOI: 10.7270/Q2D50R3H
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM497490 (US11008304, Example 76) Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-n1nnnc1C(C)C)-c1cnn(c1)C1CC1 Show InChI InChI=1S/C24H26N8O2/c1-14(2)23-28-29-30-32(23)22-7-5-6-21(26-22)27-24(33)19-11-18(15(3)10-20(19)34-4)16-12-25-31(13-16)17-8-9-17/h5-7,10-14,17H,8-9H2,1-4H3,(H,26,27,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Enanta Pharmaceuticals, Inc. US Patent					Assay Description The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...				US Patent US11008304 (2021) BindingDB Entry DOI: 10.7270/Q2D50R3H
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM523904 (2-amino-N-[1-(5-cyano-3-methyl-1H-pyrrolo[2,3-b]py...) Show SMILES Cc1c[nH]c2ncc(C#N)c(N3CCC(CC3)NC(=O)c3cc(N)ncc3F)c12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.05	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...				Citation and Details BindingDB Entry DOI: 10.7270/Q2W95DB4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM523904 (2-amino-N-[1-(5-cyano-3-methyl-1H-pyrrolo[2,3-b]py...) Show SMILES Cc1c[nH]c2ncc(C#N)c(N3CCC(CC3)NC(=O)c3cc(N)ncc3F)c12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.05	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description IMAP technology provides a homogeneous assay applicable to a wide variety of kinases, phosphatases, and phosphodiesterases without regard for substra...				Citation and Details BindingDB Entry DOI: 10.7270/Q2W95DB4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM187369 (US9169243, 17 | US9908875, 17) Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CC2CC2C1)-n1cnc(c1)C1CC1 Show InChI InChI=1S/C25H25N9OS/c35-24(29-22-11-36-25(30-22)23-31-28-13-34(23)17-3-4-17)18-6-20(33-10-19(27-12-33)14-1-2-14)21(7-26-18)32-8-15-5-16(15)9-32/h6-7,10-17H,1-5,8-9H2,(H,29,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q22F7QRX
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM187385 (US9169243, 33 | US9908875, 33) Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCN(CC(F)(F)F)CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r| Show InChI InChI=1S/C26H26F6N10OS/c1-15(26(30,31)32)42-14-35-38-22(42)24-37-21(11-44-24)36-23(43)17-8-19(41-10-18(34-13-41)16-2-3-16)20(9-33-17)40-6-4-39(5-7-40)12-25(27,28)29/h8-11,13-16H,2-7,12H2,1H3,(H,36,43)/t15-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection. This is a competitive, time...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q22F7QRX
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM556193 (US11345699, Example 75) Show SMILES COc1cc2CCN(Cc2cc1C(=O)Nc1cccc(n1)-c1nncn1[C@H](C)CO)C(C)C |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description ASK1 was purchased from Thermofisher (Catalogue #PV4011), ATP was purchased from Sigma (Catalogue #A7699), HTRF® KinEASE Assay System was obtained fr...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K077H5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM556194 (US11345699, Example 76) Show SMILES COc1cc2CCN(Cc2cc1C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO)C(=O)OCc1ccccc1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description ASK1 was purchased from Thermofisher (Catalogue #PV4011), ATP was purchased from Sigma (Catalogue #A7699), HTRF® KinEASE Assay System was obtained fr...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K077H5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM556195 (US11345699, Example 77) Show SMILES COc1cc2CCN(Cc2cc1C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO)C(=O)OC(C)C |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description ASK1 was purchased from Thermofisher (Catalogue #PV4011), ATP was purchased from Sigma (Catalogue #A7699), HTRF® KinEASE Assay System was obtained fr...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K077H5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM556196 (US11345699, Example 78) Show SMILES COc1cc2CCN(Cc2cc1C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO)S(=O)(=O)C1CC1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description ASK1 was purchased from Thermofisher (Catalogue #PV4011), ATP was purchased from Sigma (Catalogue #A7699), HTRF® KinEASE Assay System was obtained fr...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K077H5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM556197 (US11345699, Example 79) Show SMILES COc1cc2CCN(Cc2cc1C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO)C(=O)c1ccc(F)cc1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description ASK1 was purchased from Thermofisher (Catalogue #PV4011), ATP was purchased from Sigma (Catalogue #A7699), HTRF® KinEASE Assay System was obtained fr...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K077H5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM556206 (US11345699, Example 88) Show SMILES COc1cc2CCN(Cc2cc1C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO)C(=O)C(C)(C)C |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description ASK1 was purchased from Thermofisher (Catalogue #PV4011), ATP was purchased from Sigma (Catalogue #A7699), HTRF® KinEASE Assay System was obtained fr...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K077H5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM556207 (US11345699, Example 89) Show SMILES COc1cc2CCN(Cc2cc1C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO)C(=O)N1CCCC1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description ASK1 was purchased from Thermofisher (Catalogue #PV4011), ATP was purchased from Sigma (Catalogue #A7699), HTRF® KinEASE Assay System was obtained fr...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K077H5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM556208 (US11345699, Example 90) Show SMILES COc1cc2CCN(Cc2cc1C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO)C(C)C |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description ASK1 was purchased from Thermofisher (Catalogue #PV4011), ATP was purchased from Sigma (Catalogue #A7699), HTRF® KinEASE Assay System was obtained fr...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K077H5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM556209 (US11345699, Example 91) Show SMILES COc1cc2CCN(Cc2cc1C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO)C(=O)C[C@H](C)O |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description ASK1 was purchased from Thermofisher (Catalogue #PV4011), ATP was purchased from Sigma (Catalogue #A7699), HTRF® KinEASE Assay System was obtained fr...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K077H5
					More data for this Ligand-Target Pair

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