Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM223314 (YPYSCWARHVRIREN | piHA-D1) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | 7.0 | n/a |
The University of Tokyo | Assay Description The release of 2-chloro-4-nitrophenol resulting from the HPA-catalyzed hydrolysis of 2-chloro-4-nitrophenyl a-maltotrioside (CNPG3) was monitored at ... | Cell Chem Biol 24: 381-390 (2017) Article DOI: 10.1016/j.chembiol.2017.02.001 BindingDB Entry DOI: 10.7270/Q27D2T0M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM223315 (YPYSCWVRHSDPHKF | piHA-D3) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | 7.0 | n/a |
The University of Tokyo | Assay Description The release of 2-chloro-4-nitrophenol resulting from the HPA-catalyzed hydrolysis of 2-chloro-4-nitrophenyl a-maltotrioside (CNPG3) was monitored at ... | Cell Chem Biol 24: 381-390 (2017) Article DOI: 10.1016/j.chembiol.2017.02.001 BindingDB Entry DOI: 10.7270/Q27D2T0M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM223316 (YPYSCWVRH | piHA-Dm) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 7 | n/a | n/a | n/a | n/a | n/a | n/a | 7.0 | n/a |
The University of Tokyo | Assay Description The release of 2-chloro-4-nitrophenol resulting from the HPA-catalyzed hydrolysis of 2-chloro-4-nitrophenyl a-maltotrioside (CNPG3) was monitored at ... | Cell Chem Biol 24: 381-390 (2017) Article DOI: 10.1016/j.chembiol.2017.02.001 BindingDB Entry DOI: 10.7270/Q27D2T0M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM50120854 (CHEMBL3618493) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Competitive inhibition of human pancreatic alpha-amylase by double reciprocal plot analysis | Bioorg Med Chem 23: 6725-32 (2015) Article DOI: 10.1016/j.bmc.2015.09.007 BindingDB Entry DOI: 10.7270/Q21G0P2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM163646 (Montbretin A (MbA)) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 8.10 | -11.2 | n/a | n/a | n/a | n/a | n/a | n/a | 30 |
University of British Columbia | Assay Description Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor... | Nat Chem Biol 11: 691-6 (2015) Article DOI: 10.1038/nchembio.1865 BindingDB Entry DOI: 10.7270/Q2KD1WP4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM163647 (MbA-G (1)) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 9.10 | -11.1 | n/a | n/a | n/a | n/a | n/a | n/a | 30 |
University of British Columbia | Assay Description Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor... | Nat Chem Biol 11: 691-6 (2015) Article DOI: 10.1038/nchembio.1865 BindingDB Entry DOI: 10.7270/Q2KD1WP4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM50120850 (CHEMBL3618491) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Inhibition of human pancreatic alpha-amylase | Bioorg Med Chem 23: 6725-32 (2015) Article DOI: 10.1016/j.bmc.2015.09.007 BindingDB Entry DOI: 10.7270/Q21G0P2X | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM50120851 (CHEMBL1233515) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Inhibition of human pancreatic alpha-amylase | Bioorg Med Chem 23: 6725-32 (2015) Article DOI: 10.1016/j.bmc.2015.09.007 BindingDB Entry DOI: 10.7270/Q21G0P2X | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM50120843 (CHEMBL3616594) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Inhibition of human pancreatic alpha-amylase expressed in Pichia pastoris using amylase as substrate preincubated with substrate for 10 mins followed... | Bioorg Med Chem 23: 6725-32 (2015) Article DOI: 10.1016/j.bmc.2015.09.007 BindingDB Entry DOI: 10.7270/Q21G0P2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM50120842 (CHEMBL3618489) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Inhibition of human pancreatic alpha-amylase expressed in Pichia pastoris using amylase as substrate preincubated with substrate for 10 mins followed... | Bioorg Med Chem 23: 6725-32 (2015) Article DOI: 10.1016/j.bmc.2015.09.007 BindingDB Entry DOI: 10.7270/Q21G0P2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM163648 (MbA-R (2)) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 21.3 | -10.6 | n/a | n/a | n/a | n/a | n/a | n/a | 30 |
University of British Columbia | Assay Description Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor... | Nat Chem Biol 11: 691-6 (2015) Article DOI: 10.1038/nchembio.1865 BindingDB Entry DOI: 10.7270/Q2KD1WP4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM50120844 (CHEMBL3616595) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 42 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Inhibition of human pancreatic alpha-amylase expressed in Pichia pastoris using amylase as substrate preincubated with substrate for 10 mins followed... | Bioorg Med Chem 23: 6725-32 (2015) Article DOI: 10.1016/j.bmc.2015.09.007 BindingDB Entry DOI: 10.7270/Q21G0P2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM163649 (MbA-RX (3)) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 42.4 | -10.2 | n/a | n/a | n/a | n/a | n/a | n/a | 30 |
University of British Columbia | Assay Description Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor... | Nat Chem Biol 11: 691-6 (2015) Article DOI: 10.1038/nchembio.1865 BindingDB Entry DOI: 10.7270/Q2KD1WP4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM50120852 (CHEMBL1230193) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Inhibition of human pancreatic alpha-amylase | Bioorg Med Chem 23: 6725-32 (2015) Article DOI: 10.1016/j.bmc.2015.09.007 BindingDB Entry DOI: 10.7270/Q21G0P2X | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM163650 (MbA-GR (4)) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 79.3 | -9.84 | n/a | n/a | n/a | n/a | n/a | n/a | 30 |
University of British Columbia | Assay Description Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor... | Nat Chem Biol 11: 691-6 (2015) Article DOI: 10.1038/nchembio.1865 BindingDB Entry DOI: 10.7270/Q2KD1WP4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM163651 (MbA-GRX (5) | mini-MbA) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 93.3 | -9.74 | n/a | n/a | n/a | n/a | n/a | n/a | 30 |
University of British Columbia | Assay Description Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor... | Nat Chem Biol 11: 691-6 (2015) Article DOI: 10.1038/nchembio.1865 BindingDB Entry DOI: 10.7270/Q2KD1WP4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM163652 (MbA-C (6)) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 730 | -8.51 | n/a | n/a | n/a | n/a | n/a | n/a | 30 |
University of British Columbia | Assay Description Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor... | Nat Chem Biol 11: 691-6 (2015) Article DOI: 10.1038/nchembio.1865 BindingDB Entry DOI: 10.7270/Q2KD1WP4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM50120848 (CHEMBL3618488) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Inhibition of human pancreatic alpha-amylase expressed in Pichia pastoris using amylase as substrate preincubated with substrate for 10 mins followed... | Bioorg Med Chem 23: 6725-32 (2015) Article DOI: 10.1016/j.bmc.2015.09.007 BindingDB Entry DOI: 10.7270/Q21G0P2X | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM163653 (MbA-CG (7)) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 2.24E+3 | -7.83 | n/a | n/a | n/a | n/a | n/a | n/a | 30 |
University of British Columbia | Assay Description Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor... | Nat Chem Biol 11: 691-6 (2015) Article DOI: 10.1038/nchembio.1865 BindingDB Entry DOI: 10.7270/Q2KD1WP4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM50120855 (CHEMBL3618494) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Competitive inhibition of human pancreatic alpha-amylase by double reciprocal plot analysis | Bioorg Med Chem 23: 6725-32 (2015) Article DOI: 10.1016/j.bmc.2015.09.007 BindingDB Entry DOI: 10.7270/Q21G0P2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM50120856 (CHEMBL3618495) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Competitive inhibition of human pancreatic alpha-amylase by double reciprocal plot analysis | Bioorg Med Chem 23: 6725-32 (2015) Article DOI: 10.1016/j.bmc.2015.09.007 BindingDB Entry DOI: 10.7270/Q21G0P2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM163656 (3-O-(6-(4-(Caffeamidomethyl)-triazolyl)hexyl)querc...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.39E+4 | -6.73 | n/a | n/a | n/a | n/a | n/a | n/a | 30 |
University of British Columbia | Assay Description Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor... | Nat Chem Biol 11: 691-6 (2015) Article DOI: 10.1038/nchembio.1865 BindingDB Entry DOI: 10.7270/Q2KD1WP4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM50120839 (CHEMBL1234040) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Inhibition of human pancreatic alpha-amylase assessed as hydrolysis of G3F by Dixon plot analysis | Bioorg Med Chem 23: 6725-32 (2015) Article DOI: 10.1016/j.bmc.2015.09.007 BindingDB Entry DOI: 10.7270/Q21G0P2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM163654 (MbA-CR (8)) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 4.68E+4 | -6.00 | n/a | n/a | n/a | n/a | n/a | n/a | 30 |
University of British Columbia | Assay Description Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor... | Nat Chem Biol 11: 691-6 (2015) Article DOI: 10.1038/nchembio.1865 BindingDB Entry DOI: 10.7270/Q2KD1WP4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM163655 (MbA-CGR (9)) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 1.28E+5 | -5.40 | n/a | n/a | n/a | n/a | n/a | n/a | 30 |
University of British Columbia | Assay Description Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor... | Nat Chem Biol 11: 691-6 (2015) Article DOI: 10.1038/nchembio.1865 BindingDB Entry DOI: 10.7270/Q2KD1WP4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM50120838 (CHEMBL1233953) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | 1.80E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Inhibition of human pancreatic alpha-amylase assessed as hydrolysis of G3F by Dixon plot analysis | Bioorg Med Chem 23: 6725-32 (2015) Article DOI: 10.1016/j.bmc.2015.09.007 BindingDB Entry DOI: 10.7270/Q21G0P2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pancreatic alpha-amylase (Homo sapiens (Human)) | BDBM50120840 (CHEMBL1213470) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.80E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Freie Universit£t Berlin Curated by ChEMBL | Assay Description Inhibition of human pancreatic alpha-amylase assessed as hydrolysis of G3F by Dixon plot analysis | Bioorg Med Chem 23: 6725-32 (2015) Article DOI: 10.1016/j.bmc.2015.09.007 BindingDB Entry DOI: 10.7270/Q21G0P2X | |||||||||||
More data for this Ligand-Target Pair |