Found 5 hits of ec50 data for polymerid = 7499 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM50393082
(CHEMBL2152858)Show SMILES Clc1ccc2[nH]cc(CCNC(=O)c3ccc(cc3)-c3cccc(c3)C#N)c2c1 Show InChI InChI=1S/C24H18ClN3O/c25-21-8-9-23-22(13-21)20(15-28-23)10-11-27-24(29)18-6-4-17(5-7-18)19-3-1-2-16(12-19)14-26/h1-9,12-13,15,28H,10-11H2,(H,27,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 24 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Tau phosphorylation by cell based assay |
ACS Med Chem Lett 3: 788-788 (2012)
Article DOI: 10.1021/ml3002488 BindingDB Entry DOI: 10.7270/Q2H9968V |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM50241461
(3,7-bis(dimethylamino)phenothiazin-5-ium chloride ...)Show SMILES CN(C)c1ccc2nc3ccc(cc3sc2c1)=[N+](C)C |(17.73,-40.24,;19.06,-41.01,;19.06,-42.55,;20.39,-40.24,;20.4,-38.7,;21.73,-37.93,;23.06,-38.69,;24.39,-37.91,;25.73,-38.69,;27.06,-37.93,;28.39,-38.69,;28.39,-40.23,;27.06,-41,;25.73,-40.23,;24.39,-41.01,;23.06,-40.24,;21.73,-41.01,;29.73,-41,;29.73,-42.54,;31.06,-40.23,)| Show InChI InChI=1S/C16H18N3S/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13/h5-10H,1-4H3/q+1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a |
Jining Medical University
Curated by ChEMBL
| Assay Description Inhibition of tau-tau binding (unknown origin) assessed as increase in dissolved paired helical filaments |
Eur J Med Chem 169: 200-223 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.076 BindingDB Entry DOI: 10.7270/Q2MS3X47 |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM50393081
(CHEMBL2152857)Show SMILES Clc1ccc2[nH]cc(CCNC(=O)c3cccc(c3)-c3ccccc3C#N)c2c1 Show InChI InChI=1S/C24H18ClN3O/c25-20-8-9-23-22(13-20)19(15-28-23)10-11-27-24(29)17-6-3-5-16(12-17)21-7-2-1-4-18(21)14-26/h1-9,12-13,15,28H,10-11H2,(H,27,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 169 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Tau phosphorylation by cell based assay |
ACS Med Chem Lett 3: 788-788 (2012)
Article DOI: 10.1021/ml3002488 BindingDB Entry DOI: 10.7270/Q2H9968V |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM50393083
(CHEMBL2152859)Show SMILES Clc1ccc2[nH]cc(CCNC(=O)c3ccccc3-c3ccc(cc3)C#N)c2c1 Show InChI InChI=1S/C24H18ClN3O/c25-19-9-10-23-22(13-19)18(15-28-23)11-12-27-24(29)21-4-2-1-3-20(21)17-7-5-16(14-26)6-8-17/h1-10,13,15,28H,11-12H2,(H,27,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 325 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Tau phosphorylation by cell based assay |
ACS Med Chem Lett 3: 788-788 (2012)
Article DOI: 10.1021/ml3002488 BindingDB Entry DOI: 10.7270/Q2H9968V |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM50241461
(3,7-bis(dimethylamino)phenothiazin-5-ium chloride ...)Show SMILES CN(C)c1ccc2nc3ccc(cc3sc2c1)=[N+](C)C |(17.73,-40.24,;19.06,-41.01,;19.06,-42.55,;20.39,-40.24,;20.4,-38.7,;21.73,-37.93,;23.06,-38.69,;24.39,-37.91,;25.73,-38.69,;27.06,-37.93,;28.39,-38.69,;28.39,-40.23,;27.06,-41,;25.73,-40.23,;24.39,-41.01,;23.06,-40.24,;21.73,-41.01,;29.73,-41,;29.73,-42.54,;31.06,-40.23,)| Show InChI InChI=1S/C16H18N3S/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13/h5-10H,1-4H3/q+1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 590 | n/a | n/a | n/a | n/a |
Jining Medical University
Curated by ChEMBL
| Assay Description Inhibition of tau aggregation (unknown origin) |
Eur J Med Chem 169: 200-223 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.076 BindingDB Entry DOI: 10.7270/Q2MS3X47 |
More data for this Ligand-Target Pair | |