BindingDB PrimarySearch

Found 316 hits of ic50 for UniProtKB: P62593
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Beta-lactamase TEM (Escherichia coli)	BDBM178163 (US9120808, Example 41 \| US9120808, Example 42) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.0	37
NABRIVA THERAPEUTICS AG US Patent					Assay Description The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...				US Patent US9120808 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BT5
NABRIVA THERAPEUTICS AG US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM178167 (US9120808, Example 46 \| US9120808, Example 47) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	37
NABRIVA THERAPEUTICS AG US Patent					Assay Description The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...				US Patent US9120808 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BT5
NABRIVA THERAPEUTICS AG US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50149468 (CHEMBL263746 \| Sodium; (R)-6-[1-(5,6-dihydro-8H-im...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class A (TEM-1) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50191378 (CHEMBL212163 \| sodium (R,E)-6-((6,8-dihydro-5H-imi...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 49: 4623-37 (2006) Article DOI: 10.1021/jm060021p BindingDB Entry DOI: 10.7270/Q2TX3F1B
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM467000 (2-(((2S,5R)-2-carbamoyl-4-methyl-7-oxo-1,6-diazabi...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.470	n/a	n/a	n/a	n/a	n/a	n/a
Entasis Therapeutics Limited US Patent					Assay Description A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...				US Patent US10800778 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V9G
Entasis Therapeutics Limited US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50191390 ((5R),(6Z)-6-(5,5-dioxo-4,5,6,7-tetrahydro-5'6-pyra...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 49: 4623-37 (2006) Article DOI: 10.1021/jm060021p BindingDB Entry DOI: 10.7270/Q2TX3F1B
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50191389 (6-(6,7-dihydro-4H-thieno[3,2-c]pyran-2-ylmethylene...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 49: 4623-37 (2006) Article DOI: 10.1021/jm060021p BindingDB Entry DOI: 10.7270/Q2TX3F1B
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50191379 ((5R)(6Z)-6-(6,7-dihydro-4H-pyrazolo[5,1-c][1,4]-th...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 49: 4623-37 (2006) Article DOI: 10.1021/jm060021p BindingDB Entry DOI: 10.7270/Q2TX3F1B
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50191377 ((5R),(6Z)-7-oxo-6-(4,5,6,7-tetrahydropyrazolo[1,5-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 49: 4623-37 (2006) Article DOI: 10.1021/jm060021p BindingDB Entry DOI: 10.7270/Q2TX3F1B
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50149467 ((5R,6Z)-6-(6,7-dihydro-5H-cyclopenta-[d]imidazo[2,...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 47: 6556-68 (2004) Article DOI: 10.1021/jm049680x BindingDB Entry DOI: 10.7270/Q2542N22
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50149466 (CHEMBL124416 \| Sodium; (R)-6-[1-(5,6-dihydro-4H-py...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class A (TEM-1) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50149467 ((5R,6Z)-6-(6,7-dihydro-5H-cyclopenta-[d]imidazo[2,...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against Class A (TEM-1) beta-Lactamases				J Med Chem 47: 3674-88 (2004) Article DOI: 10.1021/jm049903j BindingDB Entry DOI: 10.7270/Q2MK6CCT
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM467003 (US10800778, Comparator 98) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Entasis Therapeutics Limited US Patent					Assay Description A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...				US Patent US10800778 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V9G
Entasis Therapeutics Limited US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM466965 ((2R)-{[(2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diaz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.35	n/a	n/a	n/a	n/a	n/a	n/a
Entasis Therapeutics Limited US Patent					Assay Description A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...				US Patent US10800778 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V9G
Entasis Therapeutics Limited US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM178215 (US9120808, Example 58) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.0	37
NABRIVA THERAPEUTICS AG US Patent					Assay Description The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...				US Patent US9120808 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BT5
NABRIVA THERAPEUTICS AG US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM466967 (US10800778, Example 8 \| {[(2S,5R)-2-carbamoyl-3-me...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Entasis Therapeutics Limited US Patent					Assay Description A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...				US Patent US10800778 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V9G
Entasis Therapeutics Limited US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM178167 (US9120808, Example 46 \| US9120808, Example 47) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.0	37
NABRIVA THERAPEUTICS AG US Patent					Assay Description The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...				US Patent US9120808 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BT5
NABRIVA THERAPEUTICS AG US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM178163 (US9120808, Example 41 \| US9120808, Example 42) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.0	37
NABRIVA THERAPEUTICS AG US Patent					Assay Description The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...				US Patent US9120808 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BT5
NABRIVA THERAPEUTICS AG US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM178170 (US9120808, Example 49) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.0	37
NABRIVA THERAPEUTICS AG US Patent					Assay Description The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...				US Patent US9120808 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BT5
NABRIVA THERAPEUTICS AG US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50339145 (CHEMBL1689063 \| trans-7-oxo-6-(sulfooxy)-1,6-diaza...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of bacterial Beta-lactamase TEM-1 (24 - 286) (unknown origin) expressed in Escherichia coli Transetta (DE3)				Citation and Details Article DOI: 10.1016/j.bmcl.2021.127956 BindingDB Entry DOI: 10.7270/Q2B85CX1
TBA					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50191386 ((5R)(6Z)-7-oxo-6-(4,5,6,7-tetrahydropyrazolo-[1,5-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 49: 4623-37 (2006) Article DOI: 10.1021/jm060021p BindingDB Entry DOI: 10.7270/Q2TX3F1B
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50191381 ((5R,6Z)-6-{[5-(4-methoxybenzyl)-4,5,6,7-tetrahydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 49: 4623-37 (2006) Article DOI: 10.1021/jm060021p BindingDB Entry DOI: 10.7270/Q2TX3F1B
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM178169 (US9120808, Example 48) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.0	37
NABRIVA THERAPEUTICS AG US Patent					Assay Description The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...				US Patent US9120808 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BT5
NABRIVA THERAPEUTICS AG US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50284790 (CHEMBL35987 \| Sodium; (2S,5R)-3,3-dimethyl-7-oxo-6...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against beta-Lactamase enzyme derived from Escherichia coli WC3310 TEM-2				Bioorg Med Chem Lett 5: 1513-1518 (1995) Article DOI: 10.1016/0960-894X(95)00249-S BindingDB Entry DOI: 10.7270/Q2ZW1MDG
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50157688 ((5R,6Z)-6-[(7-methylimidazo[2,1-b][1,3]-benzothiaz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 47: 6556-68 (2004) Article DOI: 10.1021/jm049680x BindingDB Entry DOI: 10.7270/Q2542N22
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50191383 ((5R),(6Z)-6-(5,6-dihydro-8H-imidazo[2,1-c]-[1,4]th...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 49: 4623-37 (2006) Article DOI: 10.1021/jm060021p BindingDB Entry DOI: 10.7270/Q2TX3F1B
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50505403 (CHEMBL4533632) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of recombinant bacterial class A serine beta-lactamase TEM-1 expressed in Escherichia coli assessed as reduction in breakdown of cephalosp...				J Med Chem 62: 8544-8556 (2019) Article DOI: 10.1021/acs.jmedchem.9b00911 BindingDB Entry DOI: 10.7270/Q2P272DC
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM466972 ((2R)-2-(((2S,5R)-2-carbamoyl-4-methyl-7-oxo-1,6-di...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Entasis Therapeutics Limited US Patent					Assay Description A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...				US Patent US10800778 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V9G
Entasis Therapeutics Limited US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM178165 (US9120808, Mixture of Example 43 and Example 44) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	7.0	37
NABRIVA THERAPEUTICS AG US Patent					Assay Description The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...				US Patent US9120808 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BT5
NABRIVA THERAPEUTICS AG US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM466974 ((2R)-2-(((2S,5R)-2-carbamoyl-3-cyclopropyl-7-oxo-1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Entasis Therapeutics Limited US Patent					Assay Description A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...				US Patent US10800778 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V9G
Entasis Therapeutics Limited US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50191387 ((5R),(6Z)-6-(7-methyl-5,6,7,8-tetrahydroimidazo[1,...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 49: 4623-37 (2006) Article DOI: 10.1021/jm060021p BindingDB Entry DOI: 10.7270/Q2TX3F1B
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50191385 ((5R,6Z)-6-(6,7-dihydro-4H-pyrazolo[5,1-c]-[1,4]oxa...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 49: 4623-37 (2006) Article DOI: 10.1021/jm060021p BindingDB Entry DOI: 10.7270/Q2TX3F1B
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM178171 (US9120808, Example 50) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	7.0	37
NABRIVA THERAPEUTICS AG US Patent					Assay Description The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...				US Patent US9120808 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BT5
NABRIVA THERAPEUTICS AG US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM466966 (US10800778, Example 5 \| {[(2S,5R)-2-carbamoyl-3-me...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Entasis Therapeutics Limited US Patent					Assay Description A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...				US Patent US10800778 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V9G
Entasis Therapeutics Limited US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50191380 (CHEMBL379440 \| sodium (R,E)-7-oxo-6-((5,6,7,8-tetr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 49: 4623-37 (2006) Article DOI: 10.1021/jm060021p BindingDB Entry DOI: 10.7270/Q2TX3F1B
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50033680 (CHEMBL268919 \| Sodium; (R)-3-acetoxymethyl-7-[1-te...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Southern Methodist University Curated by ChEMBL					Assay Description The concentration of compound to inhibit beta-lactamase was measured on E. coli WC3310				J Med Chem 38: 1022-34 (1995) BindingDB Entry DOI: 10.7270/Q29S1Q29
Southern Methodist University Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50033680 (CHEMBL268919 \| Sodium; (R)-3-acetoxymethyl-7-[1-te...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against beta-Lactamase enzyme derived from Escherichia coli WC3310 TEM-2				Bioorg Med Chem Lett 5: 1513-1518 (1995) Article DOI: 10.1016/0960-894X(95)00249-S BindingDB Entry DOI: 10.7270/Q2ZW1MDG
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50157693 ((5R,6Z)-6-[(7-chloroimidazo[2,1-b][1,3]-benzothiaz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 47: 6556-68 (2004) Article DOI: 10.1021/jm049680x BindingDB Entry DOI: 10.7270/Q2542N22
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50191388 ((5R)(6Z)-6-(6,7-5H-dihydropyrazolo[5,1-b]-oxazin-2...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 49: 4623-37 (2006) Article DOI: 10.1021/jm060021p BindingDB Entry DOI: 10.7270/Q2TX3F1B
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50076683 (CHEMBL6533 \| Sodium; (2S,3S,5R,6R)-6-hydroxymethyl...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibitory activity of the compound against TEM-1 (class A) beta-lactamase				Bioorg Med Chem Lett 9: 997-1002 (1999) BindingDB Entry DOI: 10.7270/Q2PK0FBJ
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50076678 ((2S,5R,6R)-6-Hydroxymethyl-3,3-dimethyl-4,4,7-trio...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibitory activity of the compound against TEM-1 (class A) beta-lactamase				Bioorg Med Chem Lett 9: 991-6 (1999) BindingDB Entry DOI: 10.7270/Q2TB163Q
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50157694 ((5R,6Z)-6-[(7-fluoroimidazo[2,1-b][1,3]-benzothiaz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 47: 6556-68 (2004) Article DOI: 10.1021/jm049680x BindingDB Entry DOI: 10.7270/Q2542N22
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50157687 ((5R,6Z)-6-[(5-methylimidazo[2,1-b][1,3]-benzothiaz...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 47: 6556-68 (2004) Article DOI: 10.1021/jm049680x BindingDB Entry DOI: 10.7270/Q2542N22
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM178201 (US9120808, Example 26) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.20	n/a	n/a	n/a	n/a	7.0	37
NABRIVA THERAPEUTICS AG US Patent					Assay Description The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...				US Patent US9120808 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BT5
NABRIVA THERAPEUTICS AG US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50157689 ((5R,6Z)-6-(imidazo[2,1-b][1,3]benzothiazol-2-ylmet...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 47: 6556-68 (2004) Article DOI: 10.1021/jm049680x BindingDB Entry DOI: 10.7270/Q2542N22
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50191382 ((5R,6Z)-7-oxo-6-{[5-(pyridin-3-ylmethyl)-4,5,6,7-t...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 49: 4623-37 (2006) Article DOI: 10.1021/jm060021p BindingDB Entry DOI: 10.7270/Q2TX3F1B
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50212634 (CHEMBL309009) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	10.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against Escherichia coli HA58R Class-III TEM-1 type beta-lactamase enzyme				Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T
TBA					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM178214 (US9120808, Example 57) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10.6	n/a	n/a	n/a	n/a	7.0	37
NABRIVA THERAPEUTICS AG US Patent					Assay Description The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...				US Patent US9120808 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BT5
NABRIVA THERAPEUTICS AG US Patent					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50218932 (CHEMBL396998 \| sodium (8R,9R)-10(S)-[1(R)-hydroxye...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Lek Pharmaceuticals d.d. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli TEM1				J Med Chem 50: 4113-21 (2007) Article DOI: 10.1021/jm0703237 BindingDB Entry DOI: 10.7270/Q2FF3T5F
Lek Pharmaceuticals d.d. Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50212641 (Brobactam) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars		n/a	n/a	14.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against Escherichia coli HA58R Class-III TEM-1 type beta-lactamase enzyme				Citation and Details BindingDB Entry DOI: 10.7270/Q2ZW1P2T
TBA					More data for this Ligand-Target Pair

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