Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Protein-glutamine gamma-glutamyltransferase 6 (Homo sapiens (Human)) | BDBM577483 (US11472838, Compound 5) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The most relevant off-targets are the transglutaminase isoenzymes especially tissue transglutaminase (TG2) because the enzyme is ubiquitously express... | Citation and Details BindingDB Entry DOI: 10.7270/Q2WW7MZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-glutamine gamma-glutamyltransferase 6 (Homo sapiens (Human)) | BDBM50420459 (CHEMBL2086528) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 840 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (UK) Ltd. Curated by ChEMBL | Assay Description Inhibition of human recombinant TG6 by fluorescent transamidation assay | J Med Chem 55: 1021-46 (2012) Article DOI: 10.1021/jm201310y BindingDB Entry DOI: 10.7270/Q2CN7560 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-glutamine gamma-glutamyltransferase 6 (Homo sapiens (Human)) | BDBM185173 (N-[2-[4-(adamantane-1-carbonyl)piperazin-1-yl]-2-o...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Aston University | Assay Description For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa... | Chem Biol 22: 1347-61 (2015) Article DOI: 10.1016/j.chembiol.2015.08.013 BindingDB Entry DOI: 10.7270/Q2222SJC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-glutamine gamma-glutamyltransferase 6 (Homo sapiens (Human)) | BDBM185181 (N-[2-[4-[[5-(dimethylamino)-1-naphthyl]sulfonyl]pi...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Aston University | Assay Description For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa... | Chem Biol 22: 1347-61 (2015) Article DOI: 10.1016/j.chembiol.2015.08.013 BindingDB Entry DOI: 10.7270/Q2222SJC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-glutamine gamma-glutamyltransferase 6 (Homo sapiens (Human)) | BDBM50392881 (CHEMBL2152090) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human TGM6 | ACS Med Chem Lett 3: 731-735 (2012) Article DOI: 10.1021/ml3001352 BindingDB Entry DOI: 10.7270/Q2Q241B7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-glutamine gamma-glutamyltransferase 6 (Homo sapiens (Human)) | BDBM185176 ([2-[[2-[4-(1-Adamantylmethoxycarbonyl)piperazin-1-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Aston University | Assay Description For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa... | Chem Biol 22: 1347-61 (2015) Article DOI: 10.1016/j.chembiol.2015.08.013 BindingDB Entry DOI: 10.7270/Q2222SJC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-glutamine gamma-glutamyltransferase 6 (Homo sapiens (Human)) | BDBM185177 (1-Adamantylmethyl 4-[2-(prop-2-enoylamino)acetyl]p...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Aston University | Assay Description For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa... | Chem Biol 22: 1347-61 (2015) Article DOI: 10.1016/j.chembiol.2015.08.013 BindingDB Entry DOI: 10.7270/Q2222SJC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-glutamine gamma-glutamyltransferase 6 (Homo sapiens (Human)) | BDBM185182 ([2-[[2-[4-[[5-(Dimethylamino)-1-naphthyl]sulfonyl]...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Aston University | Assay Description For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa... | Chem Biol 22: 1347-61 (2015) Article DOI: 10.1016/j.chembiol.2015.08.013 BindingDB Entry DOI: 10.7270/Q2222SJC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-glutamine gamma-glutamyltransferase 6 (Homo sapiens (Human)) | BDBM185172 ([2-[[2-[4-(Adamantane-1-carbonyl)piperazin-1-yl]-2...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Aston University | Assay Description For measurement of TG2 activity, the incorporation of biotinylated cadaverineinto immobilized N,N-dimethylcasein was used as described previously (Wa... | Chem Biol 22: 1347-61 (2015) Article DOI: 10.1016/j.chembiol.2015.08.013 BindingDB Entry DOI: 10.7270/Q2222SJC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-glutamine gamma-glutamyltransferase 6 (Homo sapiens (Human)) | BDBM50392906 (CHEMBL2152204) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human TGM6 | ACS Med Chem Lett 3: 731-735 (2012) Article DOI: 10.1021/ml3001352 BindingDB Entry DOI: 10.7270/Q2Q241B7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-glutamine gamma-glutamyltransferase 6 (Homo sapiens (Human)) | BDBM50400625 (CHEMBL2203469) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of transglutaminase 6 | ACS Med Chem Lett 3: 1024-1028 (2012) Article DOI: 10.1021/ml300241m BindingDB Entry DOI: 10.7270/Q2TB1823 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-glutamine gamma-glutamyltransferase 6 (Homo sapiens (Human)) | BDBM50400621 (CHEMBL2203451) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of transglutaminase 6 | ACS Med Chem Lett 3: 1024-1028 (2012) Article DOI: 10.1021/ml300241m BindingDB Entry DOI: 10.7270/Q2TB1823 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-glutamine gamma-glutamyltransferase 6 (Homo sapiens (Human)) | BDBM50400619 (CHEMBL2203476) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of transglutaminase 6 | ACS Med Chem Lett 3: 1024-1028 (2012) Article DOI: 10.1021/ml300241m BindingDB Entry DOI: 10.7270/Q2TB1823 | |||||||||||
More data for this Ligand-Target Pair |