Compile Data Set for Download or QSAR

Found 1972 hits of ec50 for UniProtKB: Q14833   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166956 (CHEMBL3798517) Show SMILES CCc1cnc(Oc2ccc(NC(=O)c3ncccc3N)cc2Cl)nc1 Show InChI InChI=1S/C18H16ClN5O2/c1-2-11-9-22-18(23-10-11)26-15-6-5-12(8-13(15)19)24-17(25)16-14(20)4-3-7-21-16/h3-10H,2,20H2,1H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0650	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166956 (CHEMBL3798517) Show SMILES CCc1cnc(Oc2ccc(NC(=O)c3ncccc3N)cc2Cl)nc1 Show InChI InChI=1S/C18H16ClN5O2/c1-2-11-9-22-18(23-10-11)26-15-6-5-12(8-13(15)19)24-17(25)16-14(20)4-3-7-21-16/h3-10H,2,20H2,1H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0650	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166968 (CHEMBL3798234) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H13ClN4O3/c21-14-10-11(24-18(26)17-15(22)6-3-9-23-17)7-8-16(14)25-19(27)12-4-1-2-5-13(12)20(25)28/h1-10H,22H2,(H,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0950	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166968 (CHEMBL3798234) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H13ClN4O3/c21-14-10-11(24-18(26)17-15(22)6-3-9-23-17)7-8-16(14)25-19(27)12-4-1-2-5-13(12)20(25)28/h1-10H,22H2,(H,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0950	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166972 (CHEMBL3798197) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2Cc3ccccc3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H15ClN4O2/c21-15-10-13(24-19(26)18-16(22)6-3-9-23-18)7-8-17(15)25-11-12-4-1-2-5-14(12)20(25)27/h1-10H,11,22H2,(H,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.236	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166972 (CHEMBL3798197) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2Cc3ccccc3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H15ClN4O2/c21-15-10-13(24-19(26)18-16(22)6-3-9-23-18)7-8-17(15)25-11-12-4-1-2-5-14(12)20(25)27/h1-10H,11,22H2,(H,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.236	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166971 (CHEMBL3797445) Show SMILES COc1ccc2CN(C(=O)c2c1)c1ccc(NC(=O)c2ncccc2N)cc1Cl Show InChI InChI=1S/C21H17ClN4O3/c1-29-14-6-4-12-11-26(21(28)15(12)10-14)18-7-5-13(9-16(18)22)25-20(27)19-17(23)3-2-8-24-19/h2-10H,11,23H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.319	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166971 (CHEMBL3797445) Show SMILES COc1ccc2CN(C(=O)c2c1)c1ccc(NC(=O)c2ncccc2N)cc1Cl Show InChI InChI=1S/C21H17ClN4O3/c1-29-14-6-4-12-11-26(21(28)15(12)10-14)18-7-5-13(9-16(18)22)25-20(27)19-17(23)3-2-8-24-19/h2-10H,11,23H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.319	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166975 (CHEMBL3799261) Show SMILES Cc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ncccc2N)cc1Cl Show InChI InChI=1S/C21H15ClN4O3/c1-11-4-2-5-13-17(11)21(29)26(20(13)28)16-8-7-12(10-14(16)22)25-19(27)18-15(23)6-3-9-24-18/h2-10H,23H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.689	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166975 (CHEMBL3799261) Show SMILES Cc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ncccc2N)cc1Cl Show InChI InChI=1S/C21H15ClN4O3/c1-11-4-2-5-13-17(11)21(29)26(20(13)28)16-8-7-12(10-14(16)22)25-19(27)18-15(23)6-3-9-24-18/h2-10H,23H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.689	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166961 (CHEMBL3797923) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC(Cc3ccccc3)CC2=O)c(Cl)c1 Show InChI InChI=1S/C23H21ClN4O2/c24-18-13-17(27-23(30)22-19(25)7-4-10-26-22)8-9-20(18)28-14-16(12-21(28)29)11-15-5-2-1-3-6-15/h1-10,13,16H,11-12,14,25H2,(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.758	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166961 (CHEMBL3797923) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC(Cc3ccccc3)CC2=O)c(Cl)c1 Show InChI InChI=1S/C23H21ClN4O2/c24-18-13-17(27-23(30)22-19(25)7-4-10-26-22)8-9-20(18)28-14-16(12-21(28)29)11-15-5-2-1-3-6-15/h1-10,13,16H,11-12,14,25H2,(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.758	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166974 (CHEMBL3797463) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CCc3ccccc3C2=O)c(Cl)c1 Show InChI InChI=1S/C21H17ClN4O2/c22-16-12-14(25-20(27)19-17(23)6-3-10-24-19)7-8-18(16)26-11-9-13-4-1-2-5-15(13)21(26)28/h1-8,10,12H,9,11,23H2,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.921	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166974 (CHEMBL3797463) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CCc3ccccc3C2=O)c(Cl)c1 Show InChI InChI=1S/C21H17ClN4O2/c22-16-12-14(25-20(27)19-17(23)6-3-10-24-19)7-8-18(16)26-11-9-13-4-1-2-5-15(13)21(26)28/h1-8,10,12H,9,11,23H2,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.921	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166969 (CHEMBL3797390) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2Cc3ncccc3C2=O)c(Cl)c1 Show InChI InChI=1S/C19H14ClN5O2/c20-13-9-11(24-18(26)17-14(21)4-2-8-23-17)5-6-16(13)25-10-15-12(19(25)27)3-1-7-22-15/h1-9H,10,21H2,(H,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.25	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166958 (CHEMBL3798366) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC3(CC2=O)CCCCC3)c(Cl)c1 Show InChI InChI=1S/C21H23ClN4O2/c22-15-11-14(25-20(28)19-16(23)5-4-10-24-19)6-7-17(15)26-13-21(12-18(26)27)8-2-1-3-9-21/h4-7,10-11H,1-3,8-9,12-13,23H2,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.28	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166969 (CHEMBL3797390) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2Cc3ncccc3C2=O)c(Cl)c1 Show InChI InChI=1S/C19H14ClN5O2/c20-13-9-11(24-18(26)17-14(21)4-2-8-23-17)5-6-16(13)25-10-15-12(19(25)27)3-1-7-22-15/h1-9H,10,21H2,(H,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166958 (CHEMBL3798366) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC3(CC2=O)CCCCC3)c(Cl)c1 Show InChI InChI=1S/C21H23ClN4O2/c22-15-11-14(25-20(28)19-16(23)5-4-10-24-19)6-7-17(15)26-13-21(12-18(26)27)8-2-1-3-9-21/h4-7,10-11H,1-3,8-9,12-13,23H2,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166955 (CHEMBL3798239) Show SMILES Cc1ncc(Oc2ccc(NC(=O)c3ncccc3N)cc2Cl)cn1 Show InChI InChI=1S/C17H14ClN5O2/c1-10-21-8-12(9-22-10)25-15-5-4-11(7-13(15)18)23-17(24)16-14(19)3-2-6-20-16/h2-9H,19H2,1H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.35	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166955 (CHEMBL3798239) Show SMILES Cc1ncc(Oc2ccc(NC(=O)c3ncccc3N)cc2Cl)cn1 Show InChI InChI=1S/C17H14ClN5O2/c1-10-21-8-12(9-22-10)25-15-5-4-11(7-13(15)18)23-17(24)16-14(19)3-2-6-20-16/h2-9H,19H2,1H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.40	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166960 (CHEMBL3799708) Show SMILES CC(C)CC1CN(C(=O)C1)c1ccc(NC(=O)c2ncccc2N)cc1Cl Show InChI InChI=1S/C20H23ClN4O2/c1-12(2)8-13-9-18(26)25(11-13)17-6-5-14(10-15(17)21)24-20(27)19-16(22)4-3-7-23-19/h3-7,10,12-13H,8-9,11,22H2,1-2H3,(H,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166960 (CHEMBL3799708) Show SMILES CC(C)CC1CN(C(=O)C1)c1ccc(NC(=O)c2ncccc2N)cc1Cl Show InChI InChI=1S/C20H23ClN4O2/c1-12(2)8-13-9-18(26)25(11-13)17-6-5-14(10-15(17)21)24-20(27)19-16(22)4-3-7-23-19/h3-7,10,12-13H,8-9,11,22H2,1-2H3,(H,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.61	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166963 (CHEMBL3797777) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC(CC2=O)c2c(F)cccc2Cl)c(Cl)c1 Show InChI InChI=1S/C22H17Cl2FN4O2/c23-14-3-1-4-16(25)20(14)12-9-19(30)29(11-12)18-7-6-13(10-15(18)24)28-22(31)21-17(26)5-2-8-27-21/h1-8,10,12H,9,11,26H2,(H,28,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.86	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166963 (CHEMBL3797777) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC(CC2=O)c2c(F)cccc2Cl)c(Cl)c1 Show InChI InChI=1S/C22H17Cl2FN4O2/c23-14-3-1-4-16(25)20(14)12-9-19(30)29(11-12)18-7-6-13(10-15(18)24)28-22(31)21-17(26)5-2-8-27-21/h1-8,10,12H,9,11,26H2,(H,28,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.90	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166967 (CHEMBL3798945) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2Cc3ccccc3CC2=O)c(Cl)c1 Show InChI InChI=1S/C21H17ClN4O2/c22-16-11-15(25-21(28)20-17(23)6-3-9-24-20)7-8-18(16)26-12-14-5-2-1-4-13(14)10-19(26)27/h1-9,11H,10,12,23H2,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.19	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166967 (CHEMBL3798945) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2Cc3ccccc3CC2=O)c(Cl)c1 Show InChI InChI=1S/C21H17ClN4O2/c22-16-11-15(25-21(28)20-17(23)6-3-9-24-20)7-8-18(16)26-12-14-5-2-1-4-13(14)10-19(26)27/h1-9,11H,10,12,23H2,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.20	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166962 (CHEMBL3799281) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC(CC2=O)c2cccnc2)c(Cl)c1 Show InChI InChI=1S/C21H18ClN5O2/c22-16-10-15(26-21(29)20-17(23)4-2-8-25-20)5-6-18(16)27-12-14(9-19(27)28)13-3-1-7-24-11-13/h1-8,10-11,14H,9,12,23H2,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.5	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166962 (CHEMBL3799281) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC(CC2=O)c2cccnc2)c(Cl)c1 Show InChI InChI=1S/C21H18ClN5O2/c22-16-10-15(26-21(29)20-17(23)4-2-8-25-20)5-6-18(16)27-12-14(9-19(27)28)13-3-1-7-24-11-13/h1-8,10-11,14H,9,12,23H2,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.52	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166964 (CHEMBL3799999) Show SMILES CC1(CN(C(=O)C1)c1ccc(NC(=O)c2ncccc2N)cc1Cl)C1CC1 Show InChI InChI=1S/C20H21ClN4O2/c1-20(12-4-5-12)10-17(26)25(11-20)16-7-6-13(9-14(16)21)24-19(27)18-15(22)3-2-8-23-18/h2-3,6-9,12H,4-5,10-11,22H2,1H3,(H,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.80	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166964 (CHEMBL3799999) Show SMILES CC1(CN(C(=O)C1)c1ccc(NC(=O)c2ncccc2N)cc1Cl)C1CC1 Show InChI InChI=1S/C20H21ClN4O2/c1-20(12-4-5-12)10-17(26)25(11-20)16-7-6-13(9-14(16)21)24-19(27)18-15(22)3-2-8-23-18/h2-3,6-9,12H,4-5,10-11,22H2,1H3,(H,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.80	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166973 (CHEMBL3798583) Show SMILES CC1N(C(=O)c2ccccc12)c1ccc(NC(=O)c2ncccc2N)cc1Cl Show InChI InChI=1S/C21H17ClN4O2/c1-12-14-5-2-3-6-15(14)21(28)26(12)18-9-8-13(11-16(18)22)25-20(27)19-17(23)7-4-10-24-19/h2-12H,23H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.96	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50241577 (CHEMBL4070594) Show SMILES Cc1ncccc1N1CCC(Cc2ccc3oc(c\c(=N/O)c3c2)-c2cc3sccc3cn2)CC1 Show InChI InChI=1S/C28H26N4O2S/c1-18-25(3-2-9-29-18)32-10-6-19(7-11-32)13-20-4-5-26-22(14-20)23(31-33)15-27(34-26)24-16-28-21(17-30-24)8-12-35-28/h2-5,8-9,12,14-17,19,33H,6-7,10-11,13H2,1H3/b31-23+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Prexton Therapeutics Curated by ChEMBL					Assay Description Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...				J Med Chem 60: 8515-8537 (2017) Article DOI: 10.1021/acs.jmedchem.7b00991 BindingDB Entry DOI: 10.7270/Q2GF0WNQ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166973 (CHEMBL3798583) Show SMILES CC1N(C(=O)c2ccccc12)c1ccc(NC(=O)c2ncccc2N)cc1Cl Show InChI InChI=1S/C21H17ClN4O2/c1-12-14-5-2-3-6-15(14)21(28)26(12)18-9-8-13(11-16(18)22)25-20(27)19-17(23)7-4-10-24-19/h2-12H,23H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50116515 (CHEMBL3609729) Show SMILES Cc1sc(Nc2nccc(C)n2)nc1-c1cn[nH]c1 Show InChI InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor				Bioorg Med Chem Lett 25: 3956-60 (2015) Article DOI: 10.1016/j.bmcl.2015.07.031 BindingDB Entry DOI: 10.7270/Q28C9Z1B
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50241589 (CHEMBL4097743) Show SMILES O\N=c1/cc(oc2ccc(OC3CN(C3)c3cccnc3)cc12)-c1cc2sccc2cn1 Show InChI InChI=1S/C24H18N4O3S/c29-27-20-9-23(21-10-24-15(11-26-21)5-7-32-24)31-22-4-3-17(8-19(20)22)30-18-13-28(14-18)16-2-1-6-25-12-16/h1-12,18,29H,13-14H2/b27-20+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Prexton Therapeutics Curated by ChEMBL					Assay Description Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...				J Med Chem 60: 8515-8537 (2017) Article DOI: 10.1021/acs.jmedchem.7b00991 BindingDB Entry DOI: 10.7270/Q2GF0WNQ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50241578 (CHEMBL4105462) Show SMILES CC(=O)N1CCC(COc2ccc3oc(c\c(=N/O)c3c2)-c2cc3sccc3cn2)CC1 Show InChI InChI=1S/C24H23N3O4S/c1-15(28)27-7-4-16(5-8-27)14-30-18-2-3-22-19(10-18)20(26-29)11-23(31-22)21-12-24-17(13-25-21)6-9-32-24/h2-3,6,9-13,16,29H,4-5,7-8,14H2,1H3/b26-20+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Prexton Therapeutics Curated by ChEMBL					Assay Description Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...				J Med Chem 60: 8515-8537 (2017) Article DOI: 10.1021/acs.jmedchem.7b00991 BindingDB Entry DOI: 10.7270/Q2GF0WNQ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50353291 (CHEMBL1830711) Show SMILES C1Cc2[nH]ncc2-c2nc(Nc3ncccn3)sc2C1 Show InChI InChI=1S/C13H12N6S/c1-3-9-8(7-16-19-9)11-10(4-1)20-13(17-11)18-12-14-5-2-6-15-12/h2,5-7H,1,3-4H2,(H,16,19)(H,14,15,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Lundbeck Research USA, Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization afte...				J Med Chem 54: 5070-81 (2011) Article DOI: 10.1021/jm200290z BindingDB Entry DOI: 10.7270/Q26110P5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM368526 (1-(difluoromethyl)-N- (1H-pyrazolo [4,3-b]pyridin-...) Show SMILES FC(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 Show InChI InChI=1S/C16H11F2N5/c17-15(18)13-11-4-3-10(8-9(11)5-7-20-13)21-16-14-12(22-23-16)2-1-6-19-14/h1-8,15H,(H2,21,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HCl				Citation and Details Article DOI: 10.1016/j.bmcl.2018.10.050 BindingDB Entry DOI: 10.7270/Q2MG7T2H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM368526 (1-(difluoromethyl)-N- (1H-pyrazolo [4,3-b]pyridin-...) Show SMILES FC(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12 Show InChI InChI=1S/C16H11F2N5/c17-15(18)13-11-4-3-10(8-9(11)5-7-20-13)21-16-14-12(22-23-16)2-1-6-19-14/h1-8,15H,(H2,21,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
Universita di Napoli					Assay Description The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...				J Med Chem 51: 1764-70 (2008) BindingDB Entry DOI: 10.7270/Q2X63Q8G
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM368576 (1-(1-fluoro-1-methyl- ethyl)-N-(1H- pyrazolo[3,4-b...) Show SMILES CC(C)(F)c1nccc2cc(Nc3n[nH]c4nccnc34)ccc12 Show InChI InChI=1S/C17H15FN6/c1-17(2,18)14-12-4-3-11(9-10(12)5-6-20-14)22-16-13-15(23-24-16)21-8-7-19-13/h3-9H,1-2H3,(H2,21,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
Universita di Napoli					Assay Description The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...				J Med Chem 51: 1764-70 (2008) BindingDB Entry DOI: 10.7270/Q2X63Q8G
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50353290 (CHEMBL1830707) Show SMILES C1Cc2[nH]ncc2-c2nc(Nc3ccccn3)sc2C1 Show InChI InChI=1S/C14H13N5S/c1-2-7-15-12(6-1)17-14-18-13-9-8-16-19-10(9)4-3-5-11(13)20-14/h1-2,6-8H,3-5H2,(H,16,19)(H,15,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
Lundbeck Research USA, Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization afte...				J Med Chem 54: 5070-81 (2011) Article DOI: 10.1021/jm200290z BindingDB Entry DOI: 10.7270/Q26110P5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50353291 (CHEMBL1830711) Show SMILES C1Cc2[nH]ncc2-c2nc(Nc3ncccn3)sc2C1 Show InChI InChI=1S/C13H12N6S/c1-3-9-8(7-16-19-9)11-10(4-1)20-13(17-11)18-12-14-5-2-6-15-12/h2,5-7H,1,3-4H2,(H,16,19)(H,14,15,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor				Bioorg Med Chem Lett 25: 3956-60 (2015) Article DOI: 10.1016/j.bmcl.2015.07.031 BindingDB Entry DOI: 10.7270/Q28C9Z1B
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166966 (CHEMBL3799524) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CCCC2=O)c(Cl)c1 Show InChI InChI=1S/C16H15ClN4O2/c17-11-9-10(5-6-13(11)21-8-2-4-14(21)22)20-16(23)15-12(18)3-1-7-19-15/h1,3,5-7,9H,2,4,8,18H2,(H,20,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>10	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50241594 (CHEMBL4082573) Show SMILES CC(=O)N1CCC(CC1)Oc1ccc2oc(c\c(=N/O)c2c1)-c1cc2cccn2cn1 Show InChI InChI=1S/C23H22N4O4/c1-15(28)26-9-6-17(7-10-26)30-18-4-5-22-19(12-18)20(25-29)13-23(31-22)21-11-16-3-2-8-27(16)14-24-21/h2-5,8,11-14,17,29H,6-7,9-10H2,1H3/b25-20+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Prexton Therapeutics Curated by ChEMBL					Assay Description Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-in...				J Med Chem 60: 8515-8537 (2017) Article DOI: 10.1021/acs.jmedchem.7b00991 BindingDB Entry DOI: 10.7270/Q2GF0WNQ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166957 (CHEMBL3799087) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2C3CCC(C3)C2=O)c(Cl)c1 |TLB:13:14:16.17:19,THB:21:20:16.17:19| Show InChI InChI=1S/C18H17ClN4O2/c19-13-9-11(22-17(24)16-14(20)2-1-7-21-16)4-6-15(13)23-12-5-3-10(8-12)18(23)25/h1-2,4,6-7,9-10,12H,3,5,8,20H2,(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	>10	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166959 (CHEMBL3799197) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC3(CCCC3)CC2=O)c(Cl)c1 Show InChI InChI=1S/C20H21ClN4O2/c21-14-10-13(24-19(27)18-15(22)4-3-9-23-18)5-6-16(14)25-12-20(11-17(25)26)7-1-2-8-20/h3-6,9-10H,1-2,7-8,11-12,22H2,(H,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	>10	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166965 (CHEMBL3800516) Show SMILES CC1(C)CN(C(=O)C1)c1ccc(NC(=O)c2ncccc2N)cc1Cl Show InChI InChI=1S/C18H19ClN4O2/c1-18(2)9-15(24)23(10-18)14-6-5-11(8-12(14)19)22-17(25)16-13(20)4-3-7-21-16/h3-8H,9-10,20H2,1-2H3,(H,22,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>10	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166965 (CHEMBL3800516) Show SMILES CC1(C)CN(C(=O)C1)c1ccc(NC(=O)c2ncccc2N)cc1Cl Show InChI InChI=1S/C18H19ClN4O2/c1-18(2)9-15(24)23(10-18)14-6-5-11(8-12(14)19)22-17(25)16-13(20)4-3-7-21-16/h3-8H,9-10,20H2,1-2H3,(H,22,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>10	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166970 (CHEMBL3800490) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2Cc3ccc(Cl)cc3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H14Cl2N4O2/c21-12-4-3-11-10-26(20(28)14(11)8-12)17-6-5-13(9-15(17)22)25-19(27)18-16(23)2-1-7-24-18/h1-9H,10,23H2,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>10	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50166970 (CHEMBL3800490) Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2Cc3ccc(Cl)cc3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H14Cl2N4O2/c21-12-4-3-11-10-26(20(28)14(11)8-12)17-6-5-13(9-15(17)22)25-19(27)18-16(23)2-1-7-24-18/h1-9H,10,23H2,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>10	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay				Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V
					More data for this Ligand-Target Pair

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