Found 5 hits of ec50 for UniProtKB: Q99250 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50233221
(CHEMBL4064160)Show SMILES CCCCCCCCCC[C@H]1NC(=N)N[C@@]2(CCCO2)[C@H]1C(O)=O |r| Show InChI InChI=1S/C18H33N3O3/c1-2-3-4-5-6-7-8-9-11-14-15(16(22)23)18(12-10-13-24-18)21-17(19)20-14/h14-15H,2-13H2,1H3,(H,22,23)(H3,19,20,21)/t14-,15-,18-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a |
Tohoku University
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.2 (unknown origin) by cell based assay |
Bioorg Med Chem Lett 27: 1247-1251 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.054
BindingDB Entry DOI: 10.7270/Q2XG9TC3 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50233223
(CHEMBL4060338)Show InChI InChI=1S/C17H33N3O/c1-2-3-4-5-6-7-8-9-11-15-14-17(12-10-13-21-17)20-16(18)19-15/h15H,2-14H2,1H3,(H3,18,19,20)/t15-,17-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
Tohoku University
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.2 (unknown origin) by cell based assay |
Bioorg Med Chem Lett 27: 1247-1251 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.054
BindingDB Entry DOI: 10.7270/Q2XG9TC3 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50233222
(CHEMBL4082248)Show SMILES CCCCCCCCCC[C@@H]1NC(=N)N[C@]2(CCCO2)[C@@H]1C(O)=O |r| Show InChI InChI=1S/C18H33N3O3/c1-2-3-4-5-6-7-8-9-11-14-15(16(22)23)18(12-10-13-24-18)21-17(19)20-14/h14-15H,2-13H2,1H3,(H,22,23)(H3,19,20,21)/t14-,15-,18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 79 | n/a | n/a | n/a | n/a |
Tohoku University
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.2 (unknown origin) by cell based assay |
Bioorg Med Chem Lett 27: 1247-1251 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.054
BindingDB Entry DOI: 10.7270/Q2XG9TC3 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50233224
(CHEMBL4070670)Show InChI InChI=1S/C17H33N3O/c1-2-3-4-5-6-7-8-9-11-15-14-17(12-10-13-21-17)20-16(18)19-15/h15H,2-14H2,1H3,(H3,18,19,20)/t15-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
Tohoku University
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.2 (unknown origin) by cell based assay |
Bioorg Med Chem Lett 27: 1247-1251 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.054
BindingDB Entry DOI: 10.7270/Q2XG9TC3 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM168436
(US9675591, SKA-19)Show InChI InChI=1S/C8H5F3N2S2/c9-8(10,11)15-4-1-2-5-6(3-4)14-7(12)13-5/h1-3H,(H2,12,13) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 7.90E+3 | n/a | n/a | 7.35 | 25 |
The Regents of the University of California
US Patent
| Assay Description
All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh... |
US Patent US9675591 (2017)
BindingDB Entry DOI: 10.7270/Q26T0JSP |
More data for this
Ligand-Target Pair | |
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