Found 15 hits of ki for UniProtKB: Q99250 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50171290
(5-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl...)Show SMILES CCc1c(nn(c1-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 Show InChI InChI=1S/C23H23BrCl2N4O/c1-2-18-21(23(31)28-29-12-4-3-5-13-29)27-30(20-11-10-17(25)14-19(20)26)22(18)15-6-8-16(24)9-7-15/h6-11,14H,2-5,12-13H2,1H3,(H,28,31) | PDB
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| Article
PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-Synthelabo Recherche
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 310: 905-14 (2004)
Article DOI: 10.1124/jpet.104.067884
BindingDB Entry DOI: 10.7270/Q2RR1WTX |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50049750
((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)Show InChI InChI=1S/C9H12N2O/c1-2-9(6-10-4-1)12-7-8-3-5-11-8/h1-2,4,6,8,11H,3,5,7H2/t8-/m0/s1 | PDB
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| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by PDSP Ki Database
| |
Neuropharmacology 35: 725-34 (1996)
Article DOI: 10.1016/0028-3908(96)84644-2
BindingDB Entry DOI: 10.7270/Q237777N |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM21280
(5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)met...)Show SMILES Cc1ccc(Cn2nc(cc2-c2ccc(Cl)c(C)c2)C(=O)NC2[C@@]3(C)CCC(C3)C2(C)C)cc1 |r,TLB:21:22:28:26.25| Show InChI InChI=1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)/t22?,27?,29-/m0/s1 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Recherche
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 284: 644-50 (1998)
BindingDB Entry DOI: 10.7270/Q2D50KHT |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM152638
(4-(1,3-Dioxoisoindolin-2-yl)benzenesulphonamide (1...)Show InChI InChI=1S/C30H24N4S/c35-30(33-21-8-2-1-3-9-21)34-22-16-14-20(15-17-22)29(25-18-31-27-12-6-4-10-23(25)27)26-19-32-28-13-7-5-11-24(26)28/h1-19,29,31-32H,(H2,33,34,35) | PDB
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| 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to Nav 1.2 (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0256-y
BindingDB Entry DOI: 10.7270/Q20P12XT |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50488718
(CHEMBL2298874)Show InChI InChI=1S/C16H12N2O3/c1-10(19)17-11-6-8-12(9-7-11)18-15(20)13-4-2-3-5-14(13)16(18)21/h2-9H,1H3,(H,17,19) | PDB
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| Article
| 1.83E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to Nav 1.2 (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0256-y
BindingDB Entry DOI: 10.7270/Q20P12XT |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50488723
(CHEMBL2298877)Show InChI InChI=1S/C15H12N2O3/c1-20-9-6-7-13(12(16)8-9)17-14(18)10-4-2-3-5-11(10)15(17)19/h2-8H,16H2,1H3 | PDB
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| Article
| 2.03E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to Nav 1.2 (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0256-y
BindingDB Entry DOI: 10.7270/Q20P12XT |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50488721
(CHEMBL2430974)Show InChI InChI=1S/C14H8N2O4/c17-13-11-6-1-2-7-12(11)14(18)15(13)9-4-3-5-10(8-9)16(19)20/h1-8H | PDB
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| 2.18E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to Nav 1.2 (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0256-y
BindingDB Entry DOI: 10.7270/Q20P12XT |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM45791
(4-(1,3-dioxo-2-isoindolyl)benzoic acid | 4-(1,3-di...)Show InChI InChI=1S/C15H9NO4/c17-13-11-3-1-2-4-12(11)14(18)16(13)10-7-5-9(6-8-10)15(19)20/h1-8H,(H,19,20) | PDB
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| 5.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to Nav 1.2 (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0256-y
BindingDB Entry DOI: 10.7270/Q20P12XT |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50101816
(CHEBI:8107 | Dilabid | Dilantin | Dilantin-125 | D...)Show InChI InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19) | PDB
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| 5.34E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to Nav 1.2 (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0256-y
BindingDB Entry DOI: 10.7270/Q20P12XT |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50488724
(CHEMBL2298875)Show InChI InChI=1S/C10H6N4O4S2/c11-20(17,18)10-13-12-9(19-10)14-7(15)5-3-1-2-4-6(5)8(14)16/h1-4H,(H2,11,17,18) | PDB
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| 6.11E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to Nav 1.2 (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0256-y
BindingDB Entry DOI: 10.7270/Q20P12XT |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50488720
(CHEMBL27783)Show InChI InChI=1S/C14H8N2O4/c17-13-11-3-1-2-4-12(11)14(18)15(13)9-5-7-10(8-6-9)16(19)20/h1-8H | PDB
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| 6.56E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to Nav 1.2 (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0256-y
BindingDB Entry DOI: 10.7270/Q20P12XT |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50488717
(CHEMBL1972820)Show InChI InChI=1S/C15H9NO5/c17-12-7-8(5-6-11(12)15(20)21)16-13(18)9-3-1-2-4-10(9)14(16)19/h1-7,17H,(H,20,21) | PDB
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| 7.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to Nav 1.2 (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0256-y
BindingDB Entry DOI: 10.7270/Q20P12XT |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50488719
(CHEMBL2298876)Show SMILES COc1ccc(N2C(=O)c3ccccc3C2=O)c(c1)[N+]([O-])=O Show InChI InChI=1S/C15H10N2O5/c1-22-9-6-7-12(13(8-9)17(20)21)16-14(18)10-4-2-3-5-11(10)15(16)19/h2-8H,1H3 | PDB
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| 1.08E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to Nav 1.2 (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0256-y
BindingDB Entry DOI: 10.7270/Q20P12XT |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50488722
(CHEMBL97672)Show InChI InChI=1S/C14H8N2O4/c17-13-9-5-1-2-6-10(9)14(18)15(13)11-7-3-4-8-12(11)16(19)20/h1-8H | PDB
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| 1.34E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to Nav 1.2 (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0256-y
BindingDB Entry DOI: 10.7270/Q20P12XT |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 2 subunit alpha
(Homo sapiens (Human)) | BDBM50488725
(N-Phthaloylanthranilic Acid)Show InChI InChI=1S/C15H9NO4/c17-13-9-5-1-2-6-10(9)14(18)16(13)12-8-4-3-7-11(12)15(19)20/h1-8H,(H,19,20) | PDB
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| 3.38E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to Nav 1.2 (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-012-0256-y
BindingDB Entry DOI: 10.7270/Q20P12XT |
More data for this
Ligand-Target Pair | |
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