Found 692 hits of ic50 data for polymerid = 8407 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM434315
(US10562891, Example 235 | US11008308, Example 235)Show SMILES O[C@H]1CC[C@@H](CC1)SCc1nc2cc(OCC3CC3)cc(F)c2c(=O)[nH]1 |r,wU:4.7,wD:1.0,(8.77,-4.62,;7.44,-3.85,;7.44,-2.31,;6.1,-1.54,;4.77,-2.31,;4.77,-3.85,;6.1,-4.62,;3.44,-1.54,;3.44,,;2.1,.77,;.77,,;-.56,.77,;-1.9,,;-3.23,.77,;-4.56,,;-5.9,.77,;-7.23,,;-8.77,,;-8,-1.33,;-3.23,2.31,;-1.9,3.08,;-1.9,4.62,;-.56,2.31,;.77,3.08,;.77,4.62,;2.1,2.31,)| | PDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00281
BindingDB Entry DOI: 10.7270/Q26D5Z03 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM434315
(US10562891, Example 235 | US11008308, Example 235)Show SMILES O[C@H]1CC[C@@H](CC1)SCc1nc2cc(OCC3CC3)cc(F)c2c(=O)[nH]1 |r,wU:4.7,wD:1.0,(8.77,-4.62,;7.44,-3.85,;7.44,-2.31,;6.1,-1.54,;4.77,-2.31,;4.77,-3.85,;6.1,-4.62,;3.44,-1.54,;3.44,,;2.1,.77,;.77,,;-.56,.77,;-1.9,,;-3.23,.77,;-4.56,,;-5.9,.77,;-7.23,,;-8.77,,;-8,-1.33,;-3.23,2.31,;-1.9,3.08,;-1.9,4.62,;-.56,2.31,;.77,3.08,;.77,4.62,;2.1,2.31,)| | PDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114362
BindingDB Entry DOI: 10.7270/Q20V8HSS |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50594259
(CHEMBL5180081)Show SMILES Fc1cc(NC2CCCC2)cc2nc(CSC3CCN(CC(=O)NCCCCCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)[nH]c(=O)c12 | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00281
BindingDB Entry DOI: 10.7270/Q26D5Z03 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM434254
(US10562891, Example 176 | US11008308, Example 176)Show SMILES Fc1cc(NC2CCCC2)cc2nc(CSC3CCNCC3)[nH]c(=O)c12 Show InChI InChI=1S/C19H25FN4OS/c20-15-9-13(22-12-3-1-2-4-12)10-16-18(15)19(25)24-17(23-16)11-26-14-5-7-21-8-6-14/h9-10,12,14,21-22H,1-8,11H2,(H,23,24,25) | PDB
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| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00281
BindingDB Entry DOI: 10.7270/Q26D5Z03 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50594258
(CHEMBL5178541) | PDB
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| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00281
BindingDB Entry DOI: 10.7270/Q26D5Z03 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242631
(CHEMBL4068366)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCN(CC2)c2ccc(Cl)cc2)c1 Show InChI InChI=1S/C21H21ClN4O3/c22-16-4-6-18(7-5-16)25-10-12-26(13-11-25)20(28)9-8-19(27)24-17-3-1-2-15(14-17)21(23)29/h1-9,14H,10-13H2,(H2,23,29)(H,24,27)/b9-8- | PDB
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| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant His6-tagged PARP14 catalytic domain (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence ba... |
Bioorg Med Chem Lett 28: 2050-2054 (2018)
Article DOI: 10.1016/j.bmcl.2018.04.056
BindingDB Entry DOI: 10.7270/Q2RR21R2 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242631
(CHEMBL4068366)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCN(CC2)c2ccc(Cl)cc2)c1 Show InChI InChI=1S/C21H21ClN4O3/c22-16-4-6-18(7-5-16)25-10-12-26(13-11-25)20(28)9-8-19(27)24-17-3-1-2-15(14-17)21(23)29/h1-9,14H,10-13H2,(H2,23,29)(H,24,27)/b9-8- | PDB
UniProtKB/SwissProt
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AffyNet
| CHEMBL
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ... |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242631
(CHEMBL4068366)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCN(CC2)c2ccc(Cl)cc2)c1 Show InChI InChI=1S/C21H21ClN4O3/c22-16-4-6-18(7-5-16)25-10-12-26(13-11-25)20(28)9-8-19(27)24-17-3-1-2-15(14-17)21(23)29/h1-9,14H,10-13H2,(H2,23,29)(H,24,27)/b9-8- | PDB
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ... |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242653
(CHEMBL4074448)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCC(CC2)c2ccc(F)cc2)c1 Show InChI InChI=1S/C22H22FN3O3/c23-18-6-4-15(5-7-18)16-10-12-26(13-11-16)21(28)9-8-20(27)25-19-3-1-2-17(14-19)22(24)29/h1-9,14,16H,10-13H2,(H2,24,29)(H,25,27)/b9-8- | PDB
UniProtKB/SwissProt
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ... |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242653
(CHEMBL4074448)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCC(CC2)c2ccc(F)cc2)c1 Show InChI InChI=1S/C22H22FN3O3/c23-18-6-4-15(5-7-18)16-10-12-26(13-11-16)21(28)9-8-20(27)25-19-3-1-2-17(14-19)22(24)29/h1-9,14,16H,10-13H2,(H2,24,29)(H,25,27)/b9-8- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 275 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ... |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM434101
(US10562891, Example 23 | US11008308, Example 23)Show SMILES Cc1cccc2c1nc(CS[C@H]1CC[C@H](O)CC1)[nH]c2=O |r,wU:11.11,wD:14.15,(5.33,1.54,;5.33,,;6.67,-.77,;6.67,-2.31,;5.33,-3.08,;4,-2.31,;4,-.77,;2.67,,;1.33,-.77,;;-1.33,-.77,;-2.67,,;-4,-.77,;-5.33,,;-5.33,1.54,;-6.67,2.31,;-4,2.31,;-2.67,1.54,;1.33,-2.31,;2.67,-3.08,;2.67,-4.62,)| | PDB
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| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00281
BindingDB Entry DOI: 10.7270/Q26D5Z03 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50594256
(CHEMBL5196898) | PDB
UniProtKB/SwissProt
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GoogleScholar
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| PC cid
PC sid
UniChem
| Article
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| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00281
BindingDB Entry DOI: 10.7270/Q26D5Z03 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242657
(CHEMBL4104938)Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)C(=O)\C=C/C(=O)Nc1cccc(c1)C(N)=O Show InChI InChI=1S/C20H26N4O5/c1-20(2,3)29-19(28)24-11-9-23(10-12-24)17(26)8-7-16(25)22-15-6-4-5-14(13-15)18(21)27/h4-8,13H,9-12H2,1-3H3,(H2,21,27)(H,22,25)/b8-7- | PDB
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ... |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242657
(CHEMBL4104938)Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)C(=O)\C=C/C(=O)Nc1cccc(c1)C(N)=O Show InChI InChI=1S/C20H26N4O5/c1-20(2,3)29-19(28)24-11-9-23(10-12-24)17(26)8-7-16(25)22-15-6-4-5-14(13-15)18(21)27/h4-8,13H,9-12H2,1-3H3,(H2,21,27)(H,22,25)/b8-7- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 372 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ... |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242661
(CHEMBL4079213)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCN(CC2)c2ccccc2F)c1 Show InChI InChI=1S/C21H21FN4O3/c22-17-6-1-2-7-18(17)25-10-12-26(13-11-25)20(28)9-8-19(27)24-16-5-3-4-15(14-16)21(23)29/h1-9,14H,10-13H2,(H2,23,29)(H,24,27)/b9-8- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 407 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ... |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242661
(CHEMBL4079213)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCN(CC2)c2ccccc2F)c1 Show InChI InChI=1S/C21H21FN4O3/c22-17-6-1-2-7-18(17)25-10-12-26(13-11-25)20(28)9-8-19(27)24-16-5-3-4-15(14-16)21(23)29/h1-9,14H,10-13H2,(H2,23,29)(H,24,27)/b9-8- | PDB
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ... |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242654
(CHEMBL4104503)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCC(Cc3ccccc3)CC2)c1 Show InChI InChI=1S/C23H25N3O3/c24-23(29)19-7-4-8-20(16-19)25-21(27)9-10-22(28)26-13-11-18(12-14-26)15-17-5-2-1-3-6-17/h1-10,16,18H,11-15H2,(H2,24,29)(H,25,27)/b10-9- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 447 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ... |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242654
(CHEMBL4104503)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCC(Cc3ccccc3)CC2)c1 Show InChI InChI=1S/C23H25N3O3/c24-23(29)19-7-4-8-20(16-19)25-21(27)9-10-22(28)26-13-11-18(12-14-26)15-17-5-2-1-3-6-17/h1-10,16,18H,11-15H2,(H2,24,29)(H,25,27)/b10-9- | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet
| CHEMBL
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ... |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50594244
(CHEMBL5205408)Show SMILES NC(=O)c1cccc(NC(=O)CCC(=O)NCCc2cn(CCNS(=O)(=O)c3cccc(c3)C(O)=O)nn2)c1 | PDB
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UniChem
| PDB
Article
PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00281
BindingDB Entry DOI: 10.7270/Q26D5Z03 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50594255
(CHEMBL5199759)Show SMILES C(COc1ccc2nncn2n1)CN1CCC(CC1)OC(c1ccccc1)c1ccccc1 | PDB
UniProtKB/SwissProt
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| PC cid
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| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00281
BindingDB Entry DOI: 10.7270/Q26D5Z03 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50594257
(CHEMBL5191979)Show SMILES C(CCN1CCC(CC1)OC(c1ccccc1)c1ccccc1)CNc1ccc2nncn2n1 | PDB
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| PC cid
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UniChem
| PDB
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PubMed
| n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00281
BindingDB Entry DOI: 10.7270/Q26D5Z03 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50468597
(CHEMBL4293771)Show InChI InChI=1S/C14H12BrNO2/c15-12-3-1-2-10(8-12)9-18-13-6-4-11(5-7-13)14(16)17/h1-8H,9H2,(H2,16,17) | PDB
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UniChem
| Article
PubMed
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PARP14 (unknown origin) using NAD+ as substrate incubated for 18 hrs by fluorescence based assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116511
BindingDB Entry DOI: 10.7270/Q24B3566 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242655
(CHEMBL4080281)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCC(CCc3ccccc3)CC2)c1 Show InChI InChI=1S/C24H27N3O3/c25-24(30)20-7-4-8-21(17-20)26-22(28)11-12-23(29)27-15-13-19(14-16-27)10-9-18-5-2-1-3-6-18/h1-8,11-12,17,19H,9-10,13-16H2,(H2,25,30)(H,26,28)/b12-11- | PDB
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UniChem
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| n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ... |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50460988
(CHEMBL4226482)Show SMILES O=S(=O)(Cc1cccc(c1)C#N)Nc1ccccc1-c1cccc2c1[nH]c1ccccc21 Show InChI InChI=1S/C26H19N3O2S/c27-16-18-7-5-8-19(15-18)17-32(30,31)29-25-14-4-2-10-21(25)23-12-6-11-22-20-9-1-3-13-24(20)28-26(22)23/h1-15,28-29H,17H2 | PDB
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| n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Displacement of ARTK(Bio)QTARK(Aoa-RADP)S from His6-tagged PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression sys... |
Bioorg Med Chem 26: 2965-2972 (2018)
Article DOI: 10.1016/j.bmc.2018.03.020
BindingDB Entry DOI: 10.7270/Q24T6N1Q |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242655
(CHEMBL4080281)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCC(CCc3ccccc3)CC2)c1 Show InChI InChI=1S/C24H27N3O3/c25-24(30)20-7-4-8-21(17-20)26-22(28)11-12-23(29)27-15-13-19(14-16-27)10-9-18-5-2-1-3-6-18/h1-8,11-12,17,19H,9-10,13-16H2,(H2,25,30)(H,26,28)/b12-11- | PDB
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 676 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ... |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242658
(CHEMBL4085694)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCCC(C2)c2ccccc2)c1 Show InChI InChI=1S/C22H23N3O3/c23-22(28)17-8-4-10-19(14-17)24-20(26)11-12-21(27)25-13-5-9-18(15-25)16-6-2-1-3-7-16/h1-4,6-8,10-12,14,18H,5,9,13,15H2,(H2,23,28)(H,24,26)/b12-11- | PDB
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UniChem
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PubMed
| n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ... |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242658
(CHEMBL4085694)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCCC(C2)c2ccccc2)c1 Show InChI InChI=1S/C22H23N3O3/c23-22(28)17-8-4-10-19(14-17)24-20(26)11-12-21(27)25-13-5-9-18(15-25)16-6-2-1-3-7-16/h1-4,6-8,10-12,14,18H,5,9,13,15H2,(H2,23,28)(H,24,26)/b12-11- | PDB
UniProtKB/SwissProt
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 692 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ... |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50272968
(CHEMBL4126260)Show SMILES NC(=O)c1ccc(Oc2cccc(c2)C(=O)N2CCN(CC2)c2ccc(F)c(F)c2)cc1 Show InChI InChI=1S/C24H21F2N3O3/c25-21-9-6-18(15-22(21)26)28-10-12-29(13-11-28)24(31)17-2-1-3-20(14-17)32-19-7-4-16(5-8-19)23(27)30/h1-9,14-15H,10-13H2,(H2,27,30) | PDB
UniProtKB/SwissProt
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| PC cid
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 692 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant His6-tagged human PARP14 WWA/catalytic domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins ... |
Bioorg Med Chem Lett 28: 2050-2054 (2018)
Article DOI: 10.1016/j.bmcl.2018.04.056
BindingDB Entry DOI: 10.7270/Q2RR21R2 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242630
(CHEMBL4089522)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCN(CC2)c2ccc(F)cc2)c1 Show InChI InChI=1S/C21H21FN4O3/c22-16-4-6-18(7-5-16)25-10-12-26(13-11-25)20(28)9-8-19(27)24-17-3-1-2-15(14-17)21(23)29/h1-9,14H,10-13H2,(H2,23,29)(H,24,27)/b9-8- | PDB
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibitory concentration against radioligand [3H](+)-NAN binding to haloperidol-sensitive sigma binding site in whole guinea pig brain |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242630
(CHEMBL4089522)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCN(CC2)c2ccc(F)cc2)c1 Show InChI InChI=1S/C21H21FN4O3/c22-16-4-6-18(7-5-16)25-10-12-26(13-11-25)20(28)9-8-19(27)24-17-3-1-2-15(14-17)21(23)29/h1-9,14H,10-13H2,(H2,23,29)(H,24,27)/b9-8- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant His6-tagged PARP14 catalytic domain (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence ba... |
Bioorg Med Chem Lett 28: 2050-2054 (2018)
Article DOI: 10.1016/j.bmcl.2018.04.056
BindingDB Entry DOI: 10.7270/Q2RR21R2 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50272968
(CHEMBL4126260)Show SMILES NC(=O)c1ccc(Oc2cccc(c2)C(=O)N2CCN(CC2)c2ccc(F)c(F)c2)cc1 Show InChI InChI=1S/C24H21F2N3O3/c25-21-9-6-18(15-22(21)26)28-10-12-29(13-11-28)24(31)17-2-1-3-20(14-17)32-19-7-4-16(5-8-19)23(27)30/h1-9,14-15H,10-13H2,(H2,27,30) | PDB
UniProtKB/SwissProt
antibodypedia
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| PC cid
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant His6-tagged human PARP14 WWA/catalytic domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins ... |
Bioorg Med Chem Lett 28: 2050-2054 (2018)
Article DOI: 10.1016/j.bmcl.2018.04.056
BindingDB Entry DOI: 10.7270/Q2RR21R2 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242630
(CHEMBL4089522)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCN(CC2)c2ccc(F)cc2)c1 Show InChI InChI=1S/C21H21FN4O3/c22-16-4-6-18(7-5-16)25-10-12-26(13-11-25)20(28)9-8-19(27)24-17-3-1-2-15(14-17)21(23)29/h1-9,14H,10-13H2,(H2,23,29)(H,24,27)/b9-8- | PDB
UniProtKB/SwissProt
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 708 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ... |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50461016
(CHEMBL4226393)Show InChI InChI=1S/C20H16N2O/c1-13(23)21-18-11-4-2-7-14(18)16-9-6-10-17-15-8-3-5-12-19(15)22-20(16)17/h2-12,22H,1H3,(H,21,23) | PDB
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| n/a | n/a | 710 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00281
BindingDB Entry DOI: 10.7270/Q26D5Z03 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50461016
(CHEMBL4226393)Show InChI InChI=1S/C20H16N2O/c1-13(23)21-18-11-4-2-7-14(18)16-9-6-10-17-15-8-3-5-12-19(15)22-20(16)17/h2-12,22H,1H3,(H,21,23) | PDB
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| n/a | n/a | 720 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Displacement of ARTK(Bio)QTARK(Aoa-RADP)S from His6-tagged PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression sys... |
Bioorg Med Chem 26: 2965-2972 (2018)
Article DOI: 10.1016/j.bmc.2018.03.020
BindingDB Entry DOI: 10.7270/Q24T6N1Q |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50594245
(CHEMBL5186947)Show SMILES CC(c1ccccc1)n1cc(CNC(=O)CCCC(=O)Nc2cccc(c2)C(N)=O)nn1 | PDB
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| n/a | n/a | 760 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00281
BindingDB Entry DOI: 10.7270/Q26D5Z03 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50594246
(CHEMBL5181342)Show SMILES CC(C)NC(=O)[C@H](CCCCNC(=O)CCC(=O)Nc1cccc(c1)C(N)=O)NS(=O)(=O)c1cc(ccc1C)[N+]([O-])=O |r| | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00281
BindingDB Entry DOI: 10.7270/Q26D5Z03 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50272955
(CHEMBL4129001)Show SMILES NC(=O)c1ccc(Oc2cccc(c2)C(=O)N2CCN(CC2)c2ccc(F)cc2)cc1 Show InChI InChI=1S/C24H22FN3O3/c25-19-6-8-20(9-7-19)27-12-14-28(15-13-27)24(30)18-2-1-3-22(16-18)31-21-10-4-17(5-11-21)23(26)29/h1-11,16H,12-15H2,(H2,26,29) | PDB
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| PC cid
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| Article
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| n/a | n/a | 776 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant His6-tagged human PARP14 WWA/catalytic domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins ... |
Bioorg Med Chem Lett 28: 2050-2054 (2018)
Article DOI: 10.1016/j.bmcl.2018.04.056
BindingDB Entry DOI: 10.7270/Q2RR21R2 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50272955
(CHEMBL4129001)Show SMILES NC(=O)c1ccc(Oc2cccc(c2)C(=O)N2CCN(CC2)c2ccc(F)cc2)cc1 Show InChI InChI=1S/C24H22FN3O3/c25-19-6-8-20(9-7-19)27-12-14-28(15-13-27)24(30)18-2-1-3-22(16-18)31-21-10-4-17(5-11-21)23(26)29/h1-11,16H,12-15H2,(H2,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant His6-tagged human PARP14 WWA/catalytic domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins ... |
Bioorg Med Chem Lett 28: 2050-2054 (2018)
Article DOI: 10.1016/j.bmcl.2018.04.056
BindingDB Entry DOI: 10.7270/Q2RR21R2 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242660
(CHEMBL4087082)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCN(CC2)c2ccccc2)c1 Show InChI InChI=1S/C21H22N4O3/c22-21(28)16-5-4-6-17(15-16)23-19(26)9-10-20(27)25-13-11-24(12-14-25)18-7-2-1-3-8-18/h1-10,15H,11-14H2,(H2,22,28)(H,23,26)/b10-9- | PDB
UniProtKB/SwissProt
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 891 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ... |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50242660
(CHEMBL4087082)Show SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCN(CC2)c2ccccc2)c1 Show InChI InChI=1S/C21H22N4O3/c22-21(28)16-5-4-6-17(15-16)23-19(26)9-10-20(27)25-13-11-24(12-14-25)18-7-2-1-3-8-18/h1-10,15H,11-14H2,(H2,22,28)(H,23,26)/b10-9- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
McDaniel College
Curated by ChEMBL
| Assay Description
Inhibitory concentration against radioligand [3H](+)-NAN binding to haloperidol-sensitive sigma binding site in whole guinea pig brain |
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.089
BindingDB Entry DOI: 10.7270/Q24X5B5F |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50461015
(CHEMBL4228040)Show InChI InChI=1S/C19H16N2O2S/c1-24(22,23)21-18-12-5-3-8-14(18)16-10-6-9-15-13-7-2-4-11-17(13)20-19(15)16/h2-12,20-21H,1H3 | PDB
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PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Displacement of ARTK(Bio)QTARK(Aoa-RADP)S from His6-tagged PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression sys... |
Bioorg Med Chem 26: 2965-2972 (2018)
Article DOI: 10.1016/j.bmc.2018.03.020
BindingDB Entry DOI: 10.7270/Q24T6N1Q |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50460999
(CHEMBL4226081)Show InChI InChI=1S/C22H20N2O/c1-2-8-21(25)23-19-13-5-3-9-15(19)17-11-7-12-18-16-10-4-6-14-20(16)24-22(17)18/h3-7,9-14,24H,2,8H2,1H3,(H,23,25) | PDB
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| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Displacement of ARTK(Bio)QTARK(Aoa-RADP)S from His6-tagged PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression sys... |
Bioorg Med Chem 26: 2965-2972 (2018)
Article DOI: 10.1016/j.bmc.2018.03.020
BindingDB Entry DOI: 10.7270/Q24T6N1Q |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50594250
(CHEMBL5207717)Show SMILES CC#Cc1ccc2c(nc(CSc3ccc(cc3)C(O)=O)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 917 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00281
BindingDB Entry DOI: 10.7270/Q26D5Z03 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50461017
(CHEMBL4229283)Show SMILES Cc1ccc(CC(=O)Nc2ccccc2-c2cccc3c4ccccc4[nH]c23)cn1 Show InChI InChI=1S/C26H21N3O/c1-17-13-14-18(16-27-17)15-25(30)28-23-11-4-2-7-19(23)21-9-6-10-22-20-8-3-5-12-24(20)29-26(21)22/h2-14,16,29H,15H2,1H3,(H,28,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Displacement of ARTK(Bio)QTARK(Aoa-RADP)S from His6-tagged PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression sys... |
Bioorg Med Chem 26: 2965-2972 (2018)
Article DOI: 10.1016/j.bmc.2018.03.020
BindingDB Entry DOI: 10.7270/Q24T6N1Q |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50461040
(CHEMBL4227680)Show InChI InChI=1S/C21H18N2O/c1-2-20(24)22-18-12-5-3-8-14(18)16-10-7-11-17-15-9-4-6-13-19(15)23-21(16)17/h3-13,23H,2H2,1H3,(H,22,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Displacement of ARTK(Bio)QTARK(Aoa-RADP)S from His6-tagged PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression sys... |
Bioorg Med Chem 26: 2965-2972 (2018)
Article DOI: 10.1016/j.bmc.2018.03.020
BindingDB Entry DOI: 10.7270/Q24T6N1Q |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM434080
(US10562891, Example 2 | US11008308, Example 2)Show InChI InChI=1S/C15H18N2O2S/c1-10-3-2-4-12-14(10)16-13(17-15(12)18)9-20-11-5-7-19-8-6-11/h2-4,11H,5-9H2,1H3,(H,16,17,18) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ribon Therapeutics Inc.
US Patent
| Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati... |
US Patent US11008308 (2021)
BindingDB Entry DOI: 10.7270/Q28D00C5 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM434086
(US10562891, Example 8 | US11008308, Example 8)Show InChI InChI=1S/C15H17FN2O2S/c1-9-2-3-11(16)13-14(9)17-12(18-15(13)19)8-21-10-4-6-20-7-5-10/h2-3,10H,4-8H2,1H3,(H,17,18,19) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ribon Therapeutics Inc.
US Patent
| Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati... |
US Patent US11008308 (2021)
BindingDB Entry DOI: 10.7270/Q28D00C5 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM434091
(US10562891, Example 13 | US11008308, Example 13)Show InChI InChI=1S/C15H19N3OS/c1-10-3-2-4-12-14(10)17-13(18-15(12)19)9-20-11-5-7-16-8-6-11/h2-4,11,16H,5-9H2,1H3,(H,17,18,19) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ribon Therapeutics Inc.
US Patent
| Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati... |
US Patent US11008308 (2021)
BindingDB Entry DOI: 10.7270/Q28D00C5 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM434096
(US10562891, Example 18 | US11008308, Example 18)Show SMILES Cc1cccc2c1nc(CSC1CCN(Cc3ccccn3)CC1)[nH]c2=O Show InChI InChI=1S/C21H24N4OS/c1-15-5-4-7-18-20(15)23-19(24-21(18)26)14-27-17-8-11-25(12-9-17)13-16-6-2-3-10-22-16/h2-7,10,17H,8-9,11-14H2,1H3,(H,23,24,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ribon Therapeutics Inc.
US Patent
| Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati... |
US Patent US11008308 (2021)
BindingDB Entry DOI: 10.7270/Q28D00C5 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM434098
(US10562891, Example 20 | US11008308, Example 20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ribon Therapeutics Inc.
US Patent
| Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati... |
US Patent US11008308 (2021)
BindingDB Entry DOI: 10.7270/Q28D00C5 |
More data for this
Ligand-Target Pair | |
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