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Compile Data Set for Download or QSAR

Found 51 hits of ic50 data for polymerid = 8418   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Endothelial lipase


(Mus musculus (Mouse))		BDBM50443626
PNG
(CHEMBL3092451)
Show SMILES Nc1cc2CCCn3c(CCCc4ccccc4)c(c(c1)c23)C(F)(F)F
Show InChI InChI=1S/C21H21F3N2/c22-21(23,24)19-17-13-16(25)12-15-9-5-11-26(20(15)17)18(19)10-4-8-14-6-2-1-3-7-14/h1-3,6-7,12-13H,4-5,8-11,25H2
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n/an/a 4n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of mouse endothelial lipase using PLAi as substrate measured for 30 mins by cell-based fluorescence assay

ACS Med Chem Lett 4: 1016-7 (2013)


Article DOI: 10.1021/ml400361q
BindingDB Entry DOI: 10.7270/Q22J6DBG
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199225
PNG
(US9216998, 8)
Show SMILES Nc1cc2CCCn3c(CCCOc4ccccc4)c(c(c1)c23)C(F)(F)F
Show InChI InChI=1S/C21H21F3N2O/c22-21(23,24)19-17-13-15(25)12-14-6-4-10-26(20(14)17)18(19)9-5-11-27-16-7-2-1-3-8-16/h1-3,7-8,12-13H,4-6,9-11,25H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50443627
PNG
(CHEMBL3092450 | US9216998, 5)
Show SMILES COc1cc2CCCn3c(CCc4ccccc4)c(c(c1)c23)C(F)(F)F
Show InChI InChI=1S/C21H20F3NO/c1-26-16-12-15-8-5-11-25-18(10-9-14-6-3-2-4-7-14)19(21(22,23)24)17(13-16)20(15)25/h2-4,6-7,12-13H,5,8-11H2,1H3
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50443627
PNG
(CHEMBL3092450 | US9216998, 5)
Show SMILES COc1cc2CCCn3c(CCc4ccccc4)c(c(c1)c23)C(F)(F)F
Show InChI InChI=1S/C21H20F3NO/c1-26-16-12-15-8-5-11-25-18(10-9-14-6-3-2-4-7-14)19(21(22,23)24)17(13-16)20(15)25/h2-4,6-7,12-13H,5,8-11H2,1H3
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Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of mouse endothelial lipase using PLAi as substrate measured for 30 mins by cell-based fluorescence assay

ACS Med Chem Lett 4: 1016-7 (2013)


Article DOI: 10.1021/ml400361q
BindingDB Entry DOI: 10.7270/Q22J6DBG
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199219
PNG
(US9216998, 7 | US9216998, Reference Compound 2)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCCc3cccc1c23
Show InChI InChI=1S/C20H18F3N/c21-20(22,23)18-16-10-4-8-15-9-5-13-24(19(15)16)17(18)12-11-14-6-2-1-3-7-14/h1-4,6-8,10H,5,9,11-13H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50443625
PNG
(CHEMBL3092448 | US9216998, 25)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCOc3cccc1c23
Show InChI InChI=1S/C19H16F3NO/c20-19(21,22)17-14-7-4-8-16-18(14)23(11-12-24-16)15(17)10-9-13-5-2-1-3-6-13/h1-8H,9-12H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50443625
PNG
(CHEMBL3092448 | US9216998, 25)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCOc3cccc1c23
Show InChI InChI=1S/C19H16F3NO/c20-19(21,22)17-14-7-4-8-16-18(14)23(11-12-24-16)15(17)10-9-13-5-2-1-3-6-13/h1-8H,9-12H2
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Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of mouse endothelial lipase using PLAi as substrate measured for 30 mins by cell-based fluorescence assay

ACS Med Chem Lett 4: 1016-7 (2013)


Article DOI: 10.1021/ml400361q
BindingDB Entry DOI: 10.7270/Q22J6DBG
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50443625
PNG
(CHEMBL3092448 | US9216998, 25)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCOc3cccc1c23
Show InChI InChI=1S/C19H16F3NO/c20-19(21,22)17-14-7-4-8-16-18(14)23(11-12-24-16)15(17)10-9-13-5-2-1-3-6-13/h1-8H,9-12H2
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University of Calabria

Curated by ChEMBL


Assay Description
Inhibition of endothelial lipase in mouse cells after 30 mins by fluorescence assay

Eur J Med Chem 151: 121-144 (2018)


Article DOI: 10.1016/j.ejmech.2018.03.061
BindingDB Entry DOI: 10.7270/Q2HM5C4Q
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199205
PNG
(US9216998, 9)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCCCc3cccc1c23
Show InChI InChI=1S/C21H20F3N/c22-21(23,24)19-17-11-6-10-16-9-4-5-14-25(20(16)17)18(19)13-12-15-7-2-1-3-8-15/h1-3,6-8,10-11H,4-5,9,12-14H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199219
PNG
(US9216998, 7 | US9216998, Reference Compound 2)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCCc3cccc1c23
Show InChI InChI=1S/C20H18F3N/c21-20(22,23)18-16-10-4-8-15-9-5-13-24(19(15)16)17(18)12-11-14-6-2-1-3-7-14/h1-4,6-8,10H,5,9,11-13H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199226
PNG
(US9216998, 10)
Show SMILES FC(F)(F)c1c(Cc2ccccc2)n2CCCCc3cccc1c23
Show InChI InChI=1S/C20H18F3N/c21-20(22,23)18-16-11-6-10-15-9-4-5-12-24(19(15)16)17(18)13-14-7-2-1-3-8-14/h1-3,6-8,10-11H,4-5,9,12-13H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199207
PNG
(US9216998, 19)
Show SMILES NS(=O)(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C20H20F3N3O2S/c21-20(22,23)18-16-8-4-7-15-13-25(29(24,27)28)11-12-26(19(15)16)17(18)10-9-14-5-2-1-3-6-14/h1-8H,9-13H2,(H2,24,27,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50522804
PNG
(CHEMBL4437751)
Show SMILES Fc1ccc(cn1)-c1ccc2nc(sc2c1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C26H23FN4O4S2/c27-22-11-7-18(13-28-22)17-6-10-20-21(12-17)36-26(31-20)24(25(33)29-14-23(32)30-19-8-9-19)37(34,35)15-16-4-2-1-3-5-16/h1-7,10-13,19,24H,8-9,14-15H2,(H,29,33)(H,30,32)
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n/an/a 94n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of mouse endothelial lipase expressed in HEK293F cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of mouse plasma by ...

Bioorg Med Chem Lett 29: 1918-1921 (2019)


Article DOI: 10.1016/j.bmcl.2019.05.048
BindingDB Entry DOI: 10.7270/Q2JH3QMN
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199221
PNG
(US9216998, 3)
Show SMILES FC(F)(F)c1c(Cc2ccccc2)n2CCCc3cccc1c23
Show InChI InChI=1S/C19H16F3N/c20-19(21,22)17-15-10-4-8-14-9-5-11-23(18(14)15)16(17)12-13-6-2-1-3-7-13/h1-4,6-8,10H,5,9,11-12H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50458640
PNG
(CHEMBL4203934)
Show SMILES CCN1CC(C(=O)NC(C)CCc2ccc(Cl)c(Cl)c2)=C(O)C1=O |t:20|
Show InChI InChI=1S/C17H20Cl2N2O3/c1-3-21-9-12(15(22)17(21)24)16(23)20-10(2)4-5-11-6-7-13(18)14(19)8-11/h6-8,10,22H,3-5,9H2,1-2H3,(H,20,23)
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Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of recombinant mouse endothelial lipase expressed in HEK293F cells using HDL as substrate pretreated for 10 mins followed by substrate add...

ACS Med Chem Lett 9: 673-678 (2018)


Article DOI: 10.1021/acsmedchemlett.8b00138
BindingDB Entry DOI: 10.7270/Q2JS9T2R
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50522808
PNG
(CHEMBL4520847)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C18H19N3O5S3/c1-28(23,24)16(17(22)20-9-10-29(19,25)26)18-21-14-8-7-13(11-15(14)27-18)12-5-3-2-4-6-12/h2-8,11,16H,9-10H2,1H3,(H,20,22)(H2,19,25,26)
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Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of mouse endothelial lipase expressed in HEK293F cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of mouse plasma by ...

Bioorg Med Chem Lett 29: 1918-1921 (2019)


Article DOI: 10.1016/j.bmcl.2019.05.048
BindingDB Entry DOI: 10.7270/Q2JH3QMN
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199229
PNG
(US9216998, 27)
Show SMILES FC(F)(F)c1c(CCCOc2ccccc2)n2CCOc3cccc1c23
Show InChI InChI=1S/C20H18F3NO2/c21-20(22,23)18-15-8-4-10-17-19(15)24(11-13-26-17)16(18)9-5-12-25-14-6-2-1-3-7-14/h1-4,6-8,10H,5,9,11-13H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50522805
PNG
(CHEMBL4514272)
Show SMILES COCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C22H23FN4O5S2/c1-32-8-9-34(30,31)20(21(29)25-12-19(28)26-15-4-5-15)22-27-16-6-2-13(10-17(16)33-22)14-3-7-18(23)24-11-14/h2-3,6-7,10-11,15,20H,4-5,8-9,12H2,1H3,(H,25,29)(H,26,28)
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Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of mouse endothelial lipase expressed in HEK293F cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of mouse plasma by ...

Bioorg Med Chem Lett 29: 1918-1921 (2019)


Article DOI: 10.1016/j.bmcl.2019.05.048
BindingDB Entry DOI: 10.7270/Q2JH3QMN
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199209
PNG
(US9216998, 13)
Show SMILES CC(C)(C)OC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C25H27F3N2O2/c1-24(2,3)32-23(31)29-14-15-30-20(13-12-17-8-5-4-6-9-17)21(25(26,27)28)19-11-7-10-18(16-29)22(19)30/h4-11H,12-16H2,1-3H3
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199208
PNG
(US9216998, 12)
Show SMILES CC(C)NC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C24H26F3N3O/c1-16(2)28-23(31)29-13-14-30-20(12-11-17-7-4-3-5-8-17)21(24(25,26)27)19-10-6-9-18(15-29)22(19)30/h3-10,16H,11-15H2,1-2H3,(H,28,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199223
PNG
(US9216998, 6)
Show SMILES Oc1cc2CCCn3c(CCc4ccccc4)c(c(c1)c23)C(F)(F)F
Show InChI InChI=1S/C20H18F3NO/c21-20(22,23)18-16-12-15(25)11-14-7-4-10-24(19(14)16)17(18)9-8-13-5-2-1-3-6-13/h1-3,5-6,11-12,25H,4,7-10H2
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199216
PNG
(US9216998, 22)
Show SMILES CC(CC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H24F6N2O/c1-16(24(26,27)28)14-21(34)32-12-13-33-20(11-10-17-6-3-2-4-7-17)22(25(29,30)31)19-9-5-8-18(15-32)23(19)33/h2-9,16H,10-15H2,1H3
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Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199210
PNG
(US9216998, 14)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCN(Cc3cccc1c23)C(=O)Nc1ccccc1
Show InChI InChI=1S/C27H24F3N3O/c28-27(29,30)24-22-13-7-10-20-18-32(26(34)31-21-11-5-2-6-12-21)16-17-33(25(20)22)23(24)15-14-19-8-3-1-4-9-19/h1-13H,14-18H2,(H,31,34)
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n/an/a 162n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM151238
PNG
(US8987314, B34)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1cnn(CCN2CCOCC2)c1
Show InChI InChI=1S/C21H28N6O6S3/c1-35(29,30)19(20(28)23-4-11-36(22,31)32)21-25-17-3-2-15(12-18(17)34-21)16-13-24-27(14-16)6-5-26-7-9-33-10-8-26/h2-3,12-14,19H,4-11H2,1H3,(H,23,28)(H2,22,31,32)
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n/an/a 190n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of mouse endothelial lipase expressed in HEK293F cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of mouse plasma by ...

Bioorg Med Chem Lett 29: 1918-1921 (2019)


Article DOI: 10.1016/j.bmcl.2019.05.048
BindingDB Entry DOI: 10.7270/Q2JH3QMN
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199220
PNG
(US9216998, 1)
Show SMILES FC(F)(F)c1c(CCCc2ccccc2)n2CCc3cccc1c23
Show InChI InChI=1S/C20H18F3N/c21-20(22,23)18-16-10-5-9-15-12-13-24(19(15)16)17(18)11-4-8-14-6-2-1-3-7-14/h1-3,5-7,9-10H,4,8,11-13H2
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n/an/a 195n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50506505
PNG
(CHEMBL4460376)
Show SMILES NS(=O)(=O)NCc1nnc(o1)C(=O)c1nc2cc(c(F)cc2s1)-c1ccc(cc1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C20H14F4N6O5S2/c21-12-6-14-13(5-11(12)9-1-3-10(4-2-9)17(32)26-8-20(22,23)24)28-19(36-14)16(31)18-30-29-15(35-18)7-27-37(25,33)34/h1-6,27H,7-8H2,(H,26,32)(H2,25,33,34)
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n/an/a 200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of endothelial lipase in hepatic lipase knock-out mouse plasma

J Med Chem 63: 1660-1670 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01831
BindingDB Entry DOI: 10.7270/Q28G8PZS
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50506504
PNG
(CHEMBL4460663)
Show SMILES NS(=O)(=O)NCc1nnc(o1)C(=O)c1nc2cc(F)c(cc2s1)-c1ccc2C(=O)NCc2c1
Show InChI InChI=1S/C19H13FN6O5S2/c20-12-5-13-14(4-11(12)8-1-2-10-9(3-8)6-22-17(10)28)32-19(24-13)16(27)18-26-25-15(31-18)7-23-33(21,29)30/h1-5,23H,6-7H2,(H,22,28)(H2,21,29,30)
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n/an/a 200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of endothelial lipase in hepatic lipase knock-out mouse plasma

J Med Chem 63: 1660-1670 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01831
BindingDB Entry DOI: 10.7270/Q28G8PZS
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM151212
PNG
(US8987314, B3)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C17H17FN4O5S3/c1-29(24,25)15(16(23)20-6-7-30(19,26)27)17-22-12-4-2-10(8-13(12)28-17)11-3-5-14(18)21-9-11/h2-5,8-9,15H,6-7H2,1H3,(H,20,23)(H2,19,26,27)
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n/an/a 200n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of mouse endothelial lipase expressed in HEK293F cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of mouse plasma by ...

Bioorg Med Chem Lett 29: 1918-1921 (2019)


Article DOI: 10.1016/j.bmcl.2019.05.048
BindingDB Entry DOI: 10.7270/Q2JH3QMN
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50506498
PNG
(CHEMBL4581886)
Show SMILES NS(=O)(=O)NCc1nnc(o1)C(=O)c1nc2cc(c(F)cc2s1)-c1ccc2C(=O)NCc2c1
Show InChI InChI=1S/C19H13FN6O5S2/c20-12-5-14-13(4-11(12)8-1-2-10-9(3-8)6-22-17(10)28)24-19(32-14)16(27)18-26-25-15(31-18)7-23-33(21,29)30/h1-5,23H,6-7H2,(H,22,28)(H2,21,29,30)
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n/an/a 200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of endothelial lipase in hepatic lipase knock-out mouse plasma

J Med Chem 63: 1660-1670 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01831
BindingDB Entry DOI: 10.7270/Q28G8PZS
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50506506
PNG
(CHEMBL4465833)
Show SMILES NS(=O)(=O)NCc1nnc(o1)C(=O)c1nc2cc(F)c(cc2s1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C14H10F4N6O5S2/c15-6-2-7-8(1-5(6)11(26)20-4-14(16,17)18)30-13(22-7)10(25)12-24-23-9(29-12)3-21-31(19,27)28/h1-2,21H,3-4H2,(H,20,26)(H2,19,27,28)
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n/an/a 200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of endothelial lipase in hepatic lipase knock-out mouse plasma

J Med Chem 63: 1660-1670 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01831
BindingDB Entry DOI: 10.7270/Q28G8PZS
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199222
PNG
(US9216998, 4)
Show SMILES FC(F)(F)c1c(CCCc2ccccc2)n2CCCc3cccc1c23
Show InChI InChI=1S/C21H20F3N/c22-21(23,24)19-17-12-5-10-16-11-6-14-25(20(16)17)18(19)13-4-9-15-7-2-1-3-8-15/h1-3,5,7-8,10,12H,4,6,9,11,13-14H2
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n/an/a 205n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199215
PNG
(US9216998, 21)
Show SMILES FC(F)(F)CC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C23H20F6N2O/c24-22(25,26)13-19(32)30-11-12-31-18(10-9-15-5-2-1-3-6-15)20(23(27,28)29)17-8-4-7-16(14-30)21(17)31/h1-8H,9-14H2
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n/an/a 237n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM319015
PNG
(N-[(cyclopropyl- carbamoyl) methyl]-2-[6-(6- fluor...)
Show SMILES CS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C20H19FN4O4S2/c1-31(28,29)18(19(27)23-10-17(26)24-13-4-5-13)20-25-14-6-2-11(8-15(14)30-20)12-3-7-16(21)22-9-12/h2-3,6-9,13,18H,4-5,10H2,1H3,(H,23,27)(H,24,26)
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n/an/a 290n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of mouse endothelial lipase expressed in HEK293F cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of mouse plasma by ...

Bioorg Med Chem Lett 29: 1918-1921 (2019)


Article DOI: 10.1016/j.bmcl.2019.05.048
BindingDB Entry DOI: 10.7270/Q2JH3QMN
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50522805
PNG
(CHEMBL4514272)
Show SMILES COCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C22H23FN4O5S2/c1-32-8-9-34(30,31)20(21(29)25-12-19(28)26-15-4-5-15)22-27-16-6-2-13(10-17(16)33-22)14-3-7-18(23)24-11-14/h2-3,6-7,10-11,15,20H,4-5,8-9,12H2,1H3,(H,25,29)(H,26,28)
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n/an/a 310n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of endothelial lipase in hepatic lipase knock-out mouse plasma using D31-POPC-HDL as substrate incubated for 2 hrs by LC/MS analysis

Bioorg Med Chem Lett 29: 1918-1921 (2019)


Article DOI: 10.1016/j.bmcl.2019.05.048
BindingDB Entry DOI: 10.7270/Q2JH3QMN
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM151303
PNG
(US8987314, B101)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C23H26N4O7S3/c1-36(30,31)20(21(28)25-8-13-37(24,32)33)22-26-18-7-6-17(14-19(18)35-22)15-2-4-16(5-3-15)23(29)27-9-11-34-12-10-27/h2-7,14,20H,8-13H2,1H3,(H,25,28)(H2,24,32,33)
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n/an/a 320n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of mouse endothelial lipase expressed in HEK293F cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of mouse plasma by ...

Bioorg Med Chem Lett 29: 1918-1921 (2019)


Article DOI: 10.1016/j.bmcl.2019.05.048
BindingDB Entry DOI: 10.7270/Q2JH3QMN
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199218
PNG
(US9216998, 24)
Show SMILES CS(=O)(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C21H21F3N2O2S/c1-29(27,28)25-12-13-26-18(11-10-15-6-3-2-4-7-15)19(21(22,23)24)17-9-5-8-16(14-25)20(17)26/h2-9H,10-14H2,1H3
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n/an/a 340n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199217
PNG
(US9216998, 23)
Show SMILES OCCN1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C22H23F3N2O/c23-22(24,25)20-18-8-4-7-17-15-26(13-14-28)11-12-27(21(17)18)19(20)10-9-16-5-2-1-3-6-16/h1-8,28H,9-15H2
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n/an/a 346n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50433475
PNG
(CHEMBL2381067)
Show SMILES Fc1ccccc1OC(=O)NCCCCCCc1ccccc1
Show InChI InChI=1S/C19H22FNO2/c20-17-13-7-8-14-18(17)23-19(22)21-15-9-2-1-4-10-16-11-5-3-6-12-16/h3,5-8,11-14H,1-2,4,9-10,15H2,(H,21,22)
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n/an/a 470n/an/an/an/an/an/a



Janssen Research and Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of mouse EL expressed in HEK293 cells using PED-A1 as substrate by spectrophotometry

Bioorg Med Chem Lett 23: 2595-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.113
BindingDB Entry DOI: 10.7270/Q24T6KQV
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199214
PNG
(US9216998, 20)
Show SMILES CC(=O)OCC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C24H23F3N2O3/c1-16(30)32-15-21(31)28-12-13-29-20(11-10-17-6-3-2-4-7-17)22(24(25,26)27)19-9-5-8-18(14-28)23(19)29/h2-9H,10-15H2,1H3
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n/an/a 479n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM319014
PNG
(N-[(cyclopropyl- carbamoyl) methyl]-2-[6-(6- fluor...)
Show SMILES Fc1ccc(cn1)-c1ccc2nc(sc2c1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CCC(F)(F)F
Show InChI InChI=1S/C22H20F4N4O4S2/c23-17-6-2-13(10-27-17)12-1-5-15-16(9-12)35-21(30-15)19(36(33,34)8-7-22(24,25)26)20(32)28-11-18(31)29-14-3-4-14/h1-2,5-6,9-10,14,19H,3-4,7-8,11H2,(H,28,32)(H,29,31)
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n/an/a 600n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of mouse endothelial lipase expressed in HEK293F cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of mouse plasma by ...

Bioorg Med Chem Lett 29: 1918-1921 (2019)


Article DOI: 10.1016/j.bmcl.2019.05.048
BindingDB Entry DOI: 10.7270/Q2JH3QMN
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199228
PNG
(US9216998, 26)
Show SMILES FC(F)(F)c1c(CCCc2ccccc2)n2CCOc3cccc1c23
Show InChI InChI=1S/C20H18F3NO/c21-20(22,23)18-15-9-5-11-17-19(15)24(12-13-25-17)16(18)10-4-8-14-6-2-1-3-7-14/h1-3,5-7,9,11H,4,8,10,12-13H2
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n/an/a 618n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199206
PNG
(US9216998, 15)
Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCNCc3cccc1c23
Show InChI InChI=1S/C20H19F3N2/c21-20(22,23)18-16-8-4-7-15-13-24-11-12-25(19(15)16)17(18)10-9-14-5-2-1-3-6-14/h1-8,24H,9-13H2
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n/an/a 677n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50433472
PNG
(CHEMBL2381069)
Show SMILES Fc1ccccc1CSC(=O)NCCCCCCc1ccccc1
Show InChI InChI=1S/C20H24FNOS/c21-19-14-8-7-13-18(19)16-24-20(23)22-15-9-2-1-4-10-17-11-5-3-6-12-17/h3,5-8,11-14H,1-2,4,9-10,15-16H2,(H,22,23)
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n/an/a 680n/an/an/an/an/an/a



Janssen Research and Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of mouse EL expressed in HEK293 cells using PED-A1 as substrate by spectrophotometry

Bioorg Med Chem Lett 23: 2595-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.113
BindingDB Entry DOI: 10.7270/Q24T6KQV
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199211
PNG
(US9216998, 16)
Show SMILES CN(C)CC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C24H26F3N3O/c1-28(2)16-21(31)29-13-14-30-20(12-11-17-7-4-3-5-8-17)22(24(25,26)27)19-10-6-9-18(15-29)23(19)30/h3-10H,11-16H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199227
PNG
(US9216998, 11)
Show SMILES FC(F)(F)c1c(CCCc2ccccc2)n2CCCCc3cccc1c23
Show InChI InChI=1S/C22H22F3N/c23-22(24,25)20-18-13-7-12-17-11-4-5-15-26(21(17)18)19(20)14-6-10-16-8-2-1-3-9-16/h1-3,7-9,12-13H,4-6,10-11,14-15H2
UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 1.20E+3n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199213
PNG
(US9216998, 18)
Show SMILES NCC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C22H22F3N3O/c23-22(24,25)20-17-8-4-7-16-14-27(19(29)13-26)11-12-28(21(16)17)18(20)10-9-15-5-2-1-3-6-15/h1-8H,9-14,26H2
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US Patent
n/an/a 1.89E+3n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM199212
PNG
(US9216998, 17)
Show SMILES NC(=N)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Show InChI InChI=1S/C21H21F3N4/c22-21(23,24)18-16-8-4-7-15-13-27(20(25)26)11-12-28(19(15)16)17(18)10-9-14-5-2-1-3-6-14/h1-8H,9-13H2,(H3,25,26)
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n/an/a 3.62E+3n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50522805
PNG
(CHEMBL4514272)
Show SMILES COCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C22H23FN4O5S2/c1-32-8-9-34(30,31)20(21(29)25-12-19(28)26-15-4-5-15)22-27-16-6-2-13(10-17(16)33-22)14-3-7-18(23)24-11-14/h2-3,6-7,10-11,15,20H,4-5,8-9,12H2,1H3,(H,25,29)(H,26,28)
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Article
PubMed
n/an/a 2.60E+4n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of hepatic lipase in endothelial lipase knock-out mouse plasma using D31-POPC-HDL as substrate incubated for 2 hrs by LC/MS analysis

Bioorg Med Chem Lett 29: 1918-1921 (2019)


Article DOI: 10.1016/j.bmcl.2019.05.048
BindingDB Entry DOI: 10.7270/Q2JH3QMN
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50433474
PNG
(CHEMBL2381068)
Show SMILES Fc1ccccc1COC(=O)NCCCCCCc1ccccc1
Show InChI InChI=1S/C20H24FNO2/c21-19-14-8-7-13-18(19)16-24-20(23)22-15-9-2-1-4-10-17-11-5-3-6-12-17/h3,5-8,11-14H,1-2,4,9-10,15-16H2,(H,22,23)
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n/an/a>3.30E+4n/an/an/an/an/an/a



Janssen Research and Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of mouse EL expressed in HEK293 cells using PED-A1 as substrate by spectrophotometry

Bioorg Med Chem Lett 23: 2595-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.113
BindingDB Entry DOI: 10.7270/Q24T6KQV
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))		BDBM50443624
PNG
(CHEMBL3092449 | US9216998, 28)
Show SMILES FC(F)(F)c1c(CCCc2ccccc2)n2CCSc3cccc1c23
Show InChI InChI=1S/C20H18F3NS/c21-20(22,23)18-15-9-5-11-17-19(15)24(12-13-25-17)16(18)10-4-8-14-6-2-1-3-7-14/h1-3,5-7,9,11H,4,8,10,12-13H2
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n/an/a 3.33E+4n/an/an/an/a7.2n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...

US Patent US9216998 (2015)


BindingDB Entry DOI: 10.7270/Q22N513F
More data for this
Ligand-Target Pair
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