Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM60939 (I-NBP) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 60 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50026066 (1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(tr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 187 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM26948 (8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-tr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 232 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50334150 (1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 354 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50088383 (Amlodipine | CHEBI:2668 | Norvasc) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 430 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50117922 ((1S,2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 500 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50453799 (Niguldipine) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 750 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM86722 (CAS_53772-82-0 | CAS_53772-85-3 | FLUPENTHIXOL, Al...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50017702 (1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.48E+3 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50408507 (CHLOROPROMAZINE SULFOXIDE | Chlorpromazine sulfoxi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.70E+3 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50180659 (CHEMBL3818672) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a |
Universit£ Clermont Auvergne Curated by ChEMBL | Assay Description Activation of human TREK1 expressed in CHO cells assessed as increase in channel currents at +50 mV relative to control | J Med Chem 59: 5149-57 (2016) Article DOI: 10.1021/acs.jmedchem.5b00671 BindingDB Entry DOI: 10.7270/Q2319XSS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50546010 (CHEMBL4750599) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <3.10E+3 | n/a | n/a | n/a | n/a |
TBA | Assay Description Activation of human TREK1 by thallium flux mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50546001 (CHEMBL4776102) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a |
TBA | Assay Description Activation of human TREK1 by thallium flux mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50514764 (CHEMBL4552751) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 3.91E+3 | n/a | n/a | n/a | n/a |
East China Normal University Curated by ChEMBL | Assay Description Activation of recombinant human TREK1 W290A mutant expressed in HEK293T cells assessed as increase in K+ current amplitude by whole cell voltage clam... | J Med Chem 63: 3665-3677 (2020) Article DOI: 10.1021/acs.jmedchem.9b02163 BindingDB Entry DOI: 10.7270/Q25T3PTM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50066430 (2-(4-Methyl-piperazin-1-yl)-5-(2,3,5-trichloro-phe...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 4.00E+3 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50546002 (CHEMBL4747631) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a |
TBA | Assay Description Activation of human TREK1 by thallium flux mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50546000 (CHEMBL4780579) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a |
TBA | Assay Description Activation of human TREK1 by thallium flux mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50546007 (CHEMBL4795261) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a |
TBA | Assay Description Activation of human TREK1 by thallium flux mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM78433 (2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.70E+3 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM85675 (Anandamide + PMSF | CHEMBL321585) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.10E+3 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50197060 (CHEMBL1417584) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a |
TBA | Assay Description Activation of human TREK1 by thallium flux mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50053408 (Haldol | Haldol Dec | Haloperidol Decanoate | R-13...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.50E+3 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50546003 (CHEMBL4759642) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a |
TBA | Assay Description Activation of human TREK1 by thallium flux mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50546004 (CHEMBL4759521) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a |
TBA | Assay Description Activation of human TREK1 by thallium flux mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50514764 (CHEMBL4552751) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 7.57E+3 | n/a | n/a | n/a | n/a |
East China Normal University Curated by ChEMBL | Assay Description Activation of recombinant human TREK1 T156A mutant expressed in HEK293T cells assessed as increase in K+ current amplitude by whole cell voltage clam... | J Med Chem 63: 3665-3677 (2020) Article DOI: 10.1021/acs.jmedchem.9b02163 BindingDB Entry DOI: 10.7270/Q25T3PTM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50514764 (CHEMBL4552751) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 7.98E+3 | n/a | n/a | n/a | n/a |
East China Normal University Curated by ChEMBL | Assay Description Activation of recombinant human TREK1 I293A mutant expressed in HEK293T cells assessed as increase in K+ current amplitude by whole cell voltage clam... | J Med Chem 63: 3665-3677 (2020) Article DOI: 10.1021/acs.jmedchem.9b02163 BindingDB Entry DOI: 10.7270/Q25T3PTM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50101817 (Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 8.18E+3 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50254790 ((S)-Norfluoxetine | CHEMBL465123 | NORFLUOXETINE) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.00E+3 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50545999 (CHEMBL4778307) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 9.50E+3 | n/a | n/a | n/a | n/a |
TBA | Assay Description Activation of human TREK1 by thallium flux mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50180656 (CHEMBL3818503) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a |
Universit£ Clermont Auvergne Curated by ChEMBL | Assay Description Activation of TREK1 (unknown origin) expressed in HEK293 cells assessed as increase in current density relative to control | J Med Chem 59: 5149-57 (2016) Article DOI: 10.1021/acs.jmedchem.5b00671 BindingDB Entry DOI: 10.7270/Q2319XSS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50545998 (CHEMBL4745050) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.28E+4 | n/a | n/a | n/a | n/a |
TBA | Assay Description Activation of human TREK1 by thallium flux mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50514764 (CHEMBL4552751) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.28E+4 | n/a | n/a | n/a | n/a |
East China Normal University Curated by ChEMBL | Assay Description Activation of recombinant human TREK1 expressed in HEK293T cells assessed as increase in K+ current amplitude by whole cell voltage clamp electrophys... | J Med Chem 63: 3665-3677 (2020) Article DOI: 10.1021/acs.jmedchem.9b02163 BindingDB Entry DOI: 10.7270/Q25T3PTM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50546012 (CHEMBL4761929) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.31E+4 | n/a | n/a | n/a | n/a |
TBA | Assay Description Activation of human TREK1 by thallium flux mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50546008 (CHEMBL4784090) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.37E+4 | n/a | n/a | n/a | n/a |
TBA | Assay Description Activation of human TREK1 by thallium flux mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50514764 (CHEMBL4552751) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.52E+4 | n/a | n/a | n/a | n/a |
East China Normal University Curated by ChEMBL | Assay Description Activation of recombinant human TREK1 G275C mutant expressed in HEK293T cells assessed as increase in K+ current amplitude by whole cell voltage clam... | J Med Chem 63: 3665-3677 (2020) Article DOI: 10.1021/acs.jmedchem.9b02163 BindingDB Entry DOI: 10.7270/Q25T3PTM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50546005 (CHEMBL4758530) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.65E+4 | n/a | n/a | n/a | n/a |
TBA | Assay Description Activation of human TREK1 by thallium flux mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50514764 (CHEMBL4552751) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.84E+4 | n/a | n/a | n/a | n/a |
East China Normal University Curated by ChEMBL | Assay Description Activation of recombinant human TREK1 G275C mutant expressed in HEK293T cells assessed as increase in K+ current amplitude in presence of MTSET by wh... | J Med Chem 63: 3665-3677 (2020) Article DOI: 10.1021/acs.jmedchem.9b02163 BindingDB Entry DOI: 10.7270/Q25T3PTM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM81875 (Fluoxetine-R-(-)) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.90E+4 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM22871 (13-chloro-10-(4-methylpiperazin-1-yl)-2-oxa-9-azat...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.97E+4 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50546006 (CHEMBL4747514) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.02E+4 | n/a | n/a | n/a | n/a |
TBA | Assay Description Activation of human TREK1 by thallium flux mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50546011 (CHEMBL4741659) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.24E+4 | n/a | n/a | n/a | n/a |
TBA | Assay Description Activation of human TREK1 by thallium flux mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50514764 (CHEMBL4552751) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.24E+4 | n/a | n/a | n/a | n/a |
East China Normal University Curated by ChEMBL | Assay Description Activation of recombinant human TREK1 F149A mutant expressed in HEK293T cells assessed as increase in K+ current amplitude by whole cell voltage clam... | J Med Chem 63: 3665-3677 (2020) Article DOI: 10.1021/acs.jmedchem.9b02163 BindingDB Entry DOI: 10.7270/Q25T3PTM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM190405 (US9180183, Quinidine) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.41E+4 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM181128 (US9138393, Diltiazem) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.48E+4 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50546009 (CHEMBL4750436) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
TBA | Assay Description Activation of human TREK1 by thallium flux mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50180656 (CHEMBL3818503) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a |
Universit£ Clermont Auvergne Curated by ChEMBL | Assay Description Activation of TREK1 (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currents | J Med Chem 59: 5149-57 (2016) Article DOI: 10.1021/acs.jmedchem.5b00671 BindingDB Entry DOI: 10.7270/Q2319XSS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50012957 (1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.40E+4 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM17636 (2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a |
Universit£ Clermont Auvergne Curated by ChEMBL | Assay Description Activation of TREK1 (unknown origin) expressed in COS7 cells assessed as increase in whole cell currents at +50 mV relative to control | J Med Chem 59: 5149-57 (2016) Article DOI: 10.1021/acs.jmedchem.5b00671 BindingDB Entry DOI: 10.7270/Q2319XSS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50350790 (BUPIVACAINE HYDROCHLORIDE | Bupivacaine | SAMPL3, ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.13E+5 | n/a | n/a | 7.3 | 22 |
Korea Institute of Science and Technology | Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ... | Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 2 (Homo sapiens (Human)) | BDBM50180657 (CHEMBL3819108) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.25E+5 | n/a | n/a | n/a | n/a |
Universit£ Clermont Auvergne Curated by ChEMBL | Assay Description Activation of TREK1 (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currents | J Med Chem 59: 5149-57 (2016) Article DOI: 10.1021/acs.jmedchem.5b00671 BindingDB Entry DOI: 10.7270/Q2319XSS | |||||||||||
More data for this Ligand-Target Pair |
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