Compile Data Set for Download or QSAR

Found 1924 hits of ic50 data for polymerid = 9391   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50597880 (CHEMBL5203719) Show SMILES Nc1nc2cc(CC[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)n3ccc4c(N)ncnc34)ccc2cc1Br |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01208 BindingDB Entry DOI: 10.7270/Q25X2DZR
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50462572 (CHEMBL4249337) Show SMILES Nc1nc2cc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)ccc2cc1Br |r| Show InChI InChI=1S/C22H23BrN6O2/c23-15-8-12-3-1-11(7-16(12)28-21(15)25)2-4-13-9-17(19(31)18(13)30)29-6-5-14-20(24)26-10-27-22(14)29/h1,3,5-8,10,13,17-19,30-31H,2,4,9H2,(H2,25,28)(H2,24,26,27)/t13-,17+,18+,19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
University of Jinan Curated by ChEMBL					Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5 expressed in Sf9 insect cells using histone H2A as peptide after 120 mins in presence of...				Bioorg Med Chem Lett 28: 3693-3699 (2018) Article DOI: 10.1016/j.bmcl.2018.10.026 BindingDB Entry DOI: 10.7270/Q2SB490F
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50523646 (CHEMBL4541714) Show SMILES Nc1ccc2ccc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)cc2n1 |r| Show InChI InChI=1S/C22H24N6O2/c23-18-6-5-13-3-1-12(9-16(13)27-18)2-4-14-10-17(20(30)19(14)29)28-8-7-15-21(24)25-11-26-22(15)28/h1,3,5-9,11,14,17,19-20,29-30H,2,4,10H2,(H2,23,27)(H2,24,25,26)/t14-,17+,19+,20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Curated by ChEMBL					Assay Description Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...				Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 BindingDB Entry DOI: 10.7270/Q2ZC869N
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50462572 (CHEMBL4249337) Show SMILES Nc1nc2cc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)ccc2cc1Br |r| Show InChI InChI=1S/C22H23BrN6O2/c23-15-8-12-3-1-11(7-16(12)28-21(15)25)2-4-13-9-17(19(31)18(13)30)29-6-5-14-20(24)26-10-27-22(14)29/h1,3,5-8,10,13,17-19,30-31H,2,4,9H2,(H2,25,28)(H2,24,26,27)/t13-,17+,18+,19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Curated by ChEMBL					Assay Description Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...				Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 BindingDB Entry DOI: 10.7270/Q2ZC869N
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50238541 (CHEMBL4092336) Show SMILES COC(=O)c1ccccc1NC(=O)CSc1nc2cc(OC)ccc2[nH]1 Show InChI InChI=1S/C18H17N3O4S/c1-24-11-7-8-14-15(9-11)21-18(20-14)26-10-16(22)19-13-6-4-3-5-12(13)17(23)25-2/h3-9H,10H2,1-2H3,(H,19,22)(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01208 BindingDB Entry DOI: 10.7270/Q25X2DZR
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50523641 (CHEMBL4543007) Show SMILES Nc1ncnc2n(ccc12)[C@@H]1C[C@H](CCc2ccc3ccc(NCC4CC4)nc3c2)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C26H30N6O2/c27-25-19-9-10-32(26(19)30-14-29-25)21-12-18(23(33)24(21)34)6-4-15-3-5-17-7-8-22(31-20(17)11-15)28-13-16-1-2-16/h3,5,7-11,14,16,18,21,23-24,33-34H,1-2,4,6,12-13H2,(H,28,31)(H2,27,29,30)/t18-,21+,23+,24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Curated by ChEMBL					Assay Description Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...				Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 BindingDB Entry DOI: 10.7270/Q2ZC869N
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50597881 (CHEMBL5187591) Show SMILES Nc1cccc(CCC[C@@H]2C[C@@H]([C@@H](O)[C@H]2O)n2ccc3c(N)ncnc23)n1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01208 BindingDB Entry DOI: 10.7270/Q25X2DZR
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	CHEMBL5283866 Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	0.420	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM435525 ((2R,3S,4R,5R)-2-(((2-amino-3- bromoquinolin-7-yl)o...) Show SMILES C[C@@]1(O)[C@@H](COc2ccc3cc(Br)c(N)nc3c2)O[C@H]([C@@H]1O)n1ccc2c(N)ncnc12 |r| Show InChI InChI=1S/C21H21BrN6O4/c1-21(30)15(8-31-11-3-2-10-6-13(22)18(24)27-14(10)7-11)32-20(16(21)29)28-5-4-12-17(23)25-9-26-19(12)28/h2-7,9,15-16,20,29-30H,8H2,1H3,(H2,24,27)(H2,23,25,26)/t15-,16+,20-,21-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154M69
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM435509 ((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...) Show SMILES C[C@@]1(O)[C@@H](COc2ccc3ccc(N)nc3c2)O[C@H]([C@@H]1O)n1ccc2c(N)ncnc12 |r| Show InChI InChI=1S/C21H22N6O4/c1-21(29)15(9-30-12-4-2-11-3-5-16(22)26-14(11)8-12)31-20(17(21)28)27-7-6-13-18(23)24-10-25-19(13)27/h2-8,10,15,17,20,28-29H,9H2,1H3,(H2,22,26)(H2,23,24,25)/t15-,17+,20-,21-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154M69
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50462572 (CHEMBL4249337) Show SMILES Nc1nc2cc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)ccc2cc1Br |r| Show InChI InChI=1S/C22H23BrN6O2/c23-15-8-12-3-1-11(7-16(12)28-21(15)25)2-4-13-9-17(19(31)18(13)30)29-6-5-14-20(24)26-10-27-22(14)29/h1,3,5-8,10,13,17-19,30-31H,2,4,9H2,(H2,25,28)(H2,24,26,27)/t13-,17+,18+,19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB	n/a	n/a	0.772	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM435657 ((2R,3S,4R,5R)-2-(((2-amino-3- bromoquinolin-7-yl)o...) Show SMILES Cc1ncnc2n(ccc12)[C@@H]1O[C@H](COc2ccc3cc(Br)c(N)nc3c2)[C@@](C)(O)[C@H]1O |r| Show InChI InChI=1S/C22H22BrN5O4/c1-11-14-5-6-28(20(14)26-10-25-11)21-18(29)22(2,30)17(32-21)9-31-13-4-3-12-7-15(23)19(24)27-16(12)8-13/h3-8,10,17-18,21,29-30H,9H2,1-2H3,(H2,24,27)/t17-,18+,21-,22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154M69
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM435523 ((2R,3S,4R,5R)-5-(4-amino-5-fluoro-7H- pyrrolo[2,3-...) Show SMILES C[C@@]1(O)[C@@H](COc2ccc3ccc(N)nc3c2)O[C@H]([C@@H]1O)n1cc(F)c2c(N)ncnc12 |r| Show InChI InChI=1S/C21H21FN6O4/c1-21(30)14(8-31-11-4-2-10-3-5-15(23)27-13(10)6-11)32-20(17(21)29)28-7-12(22)16-18(24)25-9-26-19(16)28/h2-7,9,14,17,20,29-30H,8H2,1H3,(H2,23,27)(H2,24,25,26)/t14-,17+,20-,21-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.850	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154M69
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM435710 ((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...) Show SMILES Cc1cnc2cc(OC[C@H]3O[C@H]([C@H](O)[C@]3(C)O)n3ccc4c(N)ncnc34)ccn12 |r| Show InChI InChI=1S/C20H22N6O4/c1-11-8-22-15-7-12(3-5-25(11)15)29-9-14-20(2,28)16(27)19(30-14)26-6-4-13-17(21)23-10-24-18(13)26/h3-8,10,14,16,19,27-28H,9H2,1-2H3,(H2,21,23,24)/t14-,16+,19-,20-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154M69
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451275 (US10709709, Example 102) Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(Cl)cc3CCNCc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C20H21ClFN5O3/c21-10-3-9-1-2-24-6-11(9)14(4-10)30-15-5-13(17(28)18(15)29)27-7-12(22)16-19(23)25-8-26-20(16)27/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451276 (US10709709, Example 103) Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(F)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C20H20F3N5O3/c21-10-3-13(9-5-25-2-1-8(9)16(10)23)31-14-4-12(17(29)18(14)30)28-6-11(22)15-19(24)26-7-27-20(15)28/h3,6-7,12,14,17-18,25,29-30H,1-2,4-5H2,(H2,24,26,27)/t12-,14+,17+,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451277 (US10709709, Example 104) Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C(F)(F)F)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C21H21F4N5O3/c22-12-7-30(20-16(12)19(26)28-8-29-20)13-5-15(18(32)17(13)31)33-14-4-10(21(23,24)25)3-9-1-2-27-6-11(9)14/h3-4,7-8,13,15,17-18,27,31-32H,1-2,5-6H2,(H2,26,28,29)/t13-,15+,17+,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451278 (US10709709, Example 105) Show SMILES Cc1cc2CCNCc2c(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2cc(F)c3c(N)ncnc23)c1 |r| Show InChI InChI=1S/C21H24FN5O3/c1-10-4-11-2-3-24-7-12(11)15(5-10)30-16-6-14(18(28)19(16)29)27-8-13(22)17-20(23)25-9-26-21(17)27/h4-5,8-9,14,16,18-19,24,28-29H,2-3,6-7H2,1H3,(H2,23,25,26)/t14-,16+,18+,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451280 (US10709709, Example 107) Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(F)cc3CCNCc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C20H21F2N5O3/c21-10-3-9-1-2-24-6-11(9)14(4-10)30-15-5-13(17(28)18(15)29)27-7-12(22)16-19(23)25-8-26-20(16)27/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451281 (US10709709, Example 108) Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(Cl)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C20H20ClF2N5O3/c21-10-3-13(9-5-25-2-1-8(9)16(10)23)31-14-4-12(17(29)18(14)30)28-6-11(22)15-19(24)26-7-27-20(15)28/h3,6-7,12,14,17-18,25,29-30H,1-2,4-5H2,(H2,24,26,27)/t12-,14+,17+,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451282 (US10709709, Example 109) Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(Br)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C20H20BrF2N5O3/c21-10-3-13(9-5-25-2-1-8(9)16(10)23)31-14-4-12(17(29)18(14)30)28-6-11(22)15-19(24)26-7-27-20(15)28/h3,6-7,12,14,17-18,25,29-30H,1-2,4-5H2,(H2,24,26,27)/t12-,14+,17+,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451286 (US10709709, Example 113) Show SMILES Cc1cc(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2cc(F)c3c(N)ncnc23)c2CNCCc2c1F |r| Show InChI InChI=1S/C21H23F2N5O3/c1-9-4-14(11-6-25-3-2-10(11)17(9)23)31-15-5-13(18(29)19(15)30)28-7-12(22)16-20(24)26-8-27-21(16)28/h4,7-8,13,15,18-19,25,29-30H,2-3,5-6H2,1H3,(H2,24,26,27)/t13-,15+,18+,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451292 (US10709709, Example 119) Show SMILES Cc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C#N)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C22H22FN5O3/c1-11-19-15(23)9-28(22(19)27-10-26-11)16-6-18(21(30)20(16)29)31-17-5-12(7-24)4-13-2-3-25-8-14(13)17/h4-5,9-10,16,18,20-21,25,29-30H,2-3,6,8H2,1H3/t16-,18+,20+,21-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451293 (US10709709, Example 120) Show SMILES Nc1ncnc2n(cc(Br)c12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C#N)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C21H21BrN6O3/c22-13-8-28(21-17(13)20(24)26-9-27-21)14-5-16(19(30)18(14)29)31-15-4-10(6-23)3-11-1-2-25-7-12(11)15/h3-4,8-9,14,16,18-19,25,29-30H,1-2,5,7H2,(H2,24,26,27)/t14-,16+,18+,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451294 (US10709709, Example 121) Show SMILES Cc1cn([C@@H]2C[C@H](Oc3ccc(F)c4CCNCc34)[C@@H](O)[C@H]2O)c2ncnc(Cl)c12 |r| Show InChI InChI=1S/C21H22ClFN4O3/c1-10-8-27(21-17(10)20(22)25-9-26-21)14-6-16(19(29)18(14)28)30-15-3-2-13(23)11-4-5-24-7-12(11)15/h2-3,8-9,14,16,18-19,24,28-29H,4-7H2,1H3/t14-,16+,18+,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451298 (US10709709, Example 125) Show SMILES Nc1ncnc2n(cc(Br)c12)[C@@H]1C[C@H](Oc2cc(F)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C20H20BrF2N5O3/c21-10-6-28(20-15(10)19(24)26-7-27-20)12-4-14(18(30)17(12)29)31-13-3-11(22)16(23)8-1-2-25-5-9(8)13/h3,6-7,12,14,17-18,25,29-30H,1-2,4-5H2,(H2,24,26,27)/t12-,14+,17+,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451299 (US10709709, Example 126) Show SMILES Cc1nc(N)c2c(F)cn([C@@H]3C[C@H](Oc4ccc(F)c5CCNCc45)[C@@H](O)[C@H]3O)c2n1 |r| Show InChI InChI=1S/C21H23F2N5O3/c1-9-26-20(24)17-13(23)8-28(21(17)27-9)14-6-16(19(30)18(14)29)31-15-3-2-12(22)10-4-5-25-7-11(10)15/h2-3,8,14,16,18-19,25,29-30H,4-7H2,1H3,(H2,24,26,27)/t14-,16+,18+,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451301 (US10709709, Example 128) Show SMILES Nc1ncnc2n(cc(Cl)c12)[C@@H]1C[C@H](Oc2cc(F)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C20H20ClF2N5O3/c21-10-6-28(20-15(10)19(24)26-7-27-20)12-4-14(18(30)17(12)29)31-13-3-11(22)16(23)8-1-2-25-5-9(8)13/h3,6-7,12,14,17-18,25,29-30H,1-2,4-5H2,(H2,24,26,27)/t12-,14+,17+,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451302 (US10709709, Example 129) Show SMILES Cc1cc2CCNCc2c(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2cc(Cl)c3c(N)ncnc23)c1 |r| Show InChI InChI=1S/C21H24ClN5O3/c1-10-4-11-2-3-24-7-12(11)15(5-10)30-16-6-14(18(28)19(16)29)27-8-13(22)17-20(23)25-9-26-21(17)27/h4-5,8-9,14,16,18-19,24,28-29H,2-3,6-7H2,1H3,(H2,23,25,26)/t14-,16+,18+,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451303 (US10709709, Example 130) Show SMILES Nc1ncnc2n(cc(Cl)c12)[C@@H]1C[C@H](Oc2cc(Cl)cc3CCNCc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C20H21Cl2N5O3/c21-10-3-9-1-2-24-6-11(9)14(4-10)30-15-5-13(17(28)18(15)29)27-7-12(22)16-19(23)25-8-26-20(16)27/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451304 (US10709709, Example 131) Show SMILES Nc1ncnc2n(cc(Br)c12)[C@@H]1C[C@H](Oc2cc(Cl)cc3CCNCc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C20H21BrClN5O3/c21-12-7-27(20-16(12)19(23)25-8-26-20)13-5-15(18(29)17(13)28)30-14-4-10(22)3-9-1-2-24-6-11(9)14/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451306 (US10709709, Example 133) Show SMILES Nc1ncnc2n(cc(Cl)c12)[C@@H]1C[C@H](Oc2ccc(F)c3CCNCc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C20H21ClFN5O3/c21-11-7-27(20-16(11)19(23)25-8-26-20)13-5-15(18(29)17(13)28)30-14-2-1-12(22)9-3-4-24-6-10(9)14/h1-2,7-8,13,15,17-18,24,28-29H,3-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451307 (US10709709, Example 134) Show SMILES Nc1ncnc2n(cc(Br)c12)[C@@H]1C[C@H](Oc2ccc(F)c3CCNCc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C20H21BrFN5O3/c21-11-7-27(20-16(11)19(23)25-8-26-20)13-5-15(18(29)17(13)28)30-14-2-1-12(22)9-3-4-24-6-10(9)14/h1-2,7-8,13,15,17-18,24,28-29H,3-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451312 (US10709709, Example 139) Show SMILES C[C@H](N)c1cc(F)c(Cl)cc1O[C@H]1C[C@H]([C@H](O)[C@@H]1O)n1ccc2c(C)ncnc12 |r| Show InChI InChI=1S/C20H22ClFN4O3/c1-9(23)12-5-14(22)13(21)6-16(12)29-17-7-15(18(27)19(17)28)26-4-3-11-10(2)24-8-25-20(11)26/h3-6,8-9,15,17-19,27-28H,7,23H2,1-2H3/t9-,15+,17-,18-,19+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50523661 (CHEMBL4547524 | US10709709, Example 154) Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C(F)F)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C22H24F2N4O3/c1-11-14-3-5-28(22(14)27-10-26-11)16-8-18(20(30)19(16)29)31-17-7-13(21(23)24)6-12-2-4-25-9-15(12)17/h3,5-7,10,16,18-21,25,29-30H,2,4,8-9H2,1H3/t16-,18+,19+,20-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM415582 (US10428104, Example 112) Show SMILES Cc1ncnc2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2cccc3CCNCc23)[C@@H](O)[C@H]1O Show InChI InChI=1S/C21H24N4O4/c1-11-13-6-8-25(20(13)24-10-23-11)21-18(28)17(27)19(29-21)16(26)14-4-2-3-12-5-7-22-9-15(12)14/h2-4,6,8,10,16-19,21-22,26-28H,5,7,9H2,1H3/t16-,17+,18-,19-,21-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10428104 (2019) BindingDB Entry DOI: 10.7270/Q2PG1V45
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM430630 (US10550096, Example 3) Show SMILES CCc1nn(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)c(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2 |r| Show InChI InChI=1S/C28H32N4O4/c1-2-24-23-11-18(27(34)32-20-8-9-21(32)16-36-15-20)7-10-22(23)28(35)31(30-24)14-26(33)25-12-17-5-3-4-6-19(17)13-29-25/h3-7,10-11,20-21,25-26,29,33H,2,8-9,12-16H2,1H3/t20?,21?,25-,26+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
CTXT PTY LTD US Patent					Assay Description The cell line TE11 was seeded at a density of 6,000 cells per well in 96 well optical quality tissue culture plates in DME medium and 10% foetal bovi...				US Patent US10550096 (2020) BindingDB Entry DOI: 10.7270/Q2T43WH2
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451251 (US10709709, Example 78) Show SMILES Cc1ncnc2n(ccc12)C1C[C@H](Oc2cccc3CCNCc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C21H24N4O3/c1-12-14-6-8-25(21(14)24-11-23-12)16-9-18(20(27)19(16)26)28-17-4-2-3-13-5-7-22-10-15(13)17/h2-4,6,8,11,16,18-20,22,26-27H,5,7,9-10H2,1H3/t16?,18-,19-,20+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM415554 ((2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidi...) Show SMILES Nc1ncnc2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2ccc(F)c(F)c2)[C@@H](O)[C@H]1O Show InChI InChI=1S/C17H16F2N4O4/c18-9-2-1-7(5-10(9)19)11(24)14-12(25)13(26)17(27-14)23-4-3-8-15(20)21-6-22-16(8)23/h1-6,11-14,17,24-26H,(H2,20,21,22)/t11-,12+,13-,14-,17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10428104 (2019) BindingDB Entry DOI: 10.7270/Q2PG1V45
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM415556 (US10428104, Example 87) Show SMILES Nc1ncnc2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2ccc(Cl)cc2)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C17H17ClN4O4/c18-9-3-1-8(2-4-9)11(23)14-12(24)13(25)17(26-14)22-6-5-10-15(19)20-7-21-16(10)22/h1-7,11-14,17,23-25H,(H2,19,20,21)/t11-,12+,13-,14-,17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10428104 (2019) BindingDB Entry DOI: 10.7270/Q2PG1V45
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM415557 (US10428104, Example 88) Show SMILES Nc1ncnc2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2ccc(Cl)c(F)c2)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C17H16ClFN4O4/c18-9-2-1-7(5-10(9)19)11(24)14-12(25)13(26)17(27-14)23-4-3-8-15(20)21-6-22-16(8)23/h1-6,11-14,17,24-26H,(H2,20,21,22)/t11-,12+,13-,14-,17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10428104 (2019) BindingDB Entry DOI: 10.7270/Q2PG1V45
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50595702 (CHEMBL5172637) Show SMILES CN(C(=O)c1coc(=O)n1Cc1ccc2cc(C)c(N)nc2c1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N51
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM452998 ((2R,3R,4S,5S)-2-(4-amino- 7H-pyrrolo[2,3-d]pyrimid...) Show SMILES Nc1ncnc2n(ccc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)[C@@H]1OCc2ccc(Cl)cc12 |r| Show InChI InChI=1S/C18H17ClN4O4/c19-9-2-1-8-6-26-14(11(8)5-9)15-12(24)13(25)18(27-15)23-4-3-10-16(20)21-7-22-17(10)23/h1-5,7,12-15,18,24-25H,6H2,(H2,20,21,22)/t12-,13+,14+,15-,18+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2KS6VR9
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM452999 ((2S,3S,4R,5R)-2-((R)-6- chloro-1,3- dihydroisobenz...) Show SMILES Cc1ncnc2n(ccc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)[C@@H]1OCc2ccc(Cl)cc12 |r| Show InChI InChI=1S/C19H18ClN3O4/c1-9-12-4-5-23(18(12)22-8-21-9)19-15(25)14(24)17(27-19)16-13-6-11(20)3-2-10(13)7-26-16/h2-6,8,14-17,19,24-25H,7H2,1H3/t14-,15+,16+,17-,19+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2KS6VR9
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM435709 ((2R,3S,4R,5R)-3-methyl-5-(4-methyl-7H- pyrrolo[2,3...) Show SMILES Cc1cnc2cc(OC[C@H]3O[C@H]([C@H](O)[C@]3(C)O)n3ccc4c(C)ncnc34)ccn12 |r| Show InChI InChI=1S/C21H23N5O4/c1-12-9-22-17-8-14(4-6-25(12)17)29-10-16-21(3,28)18(27)20(30-16)26-7-5-15-13(2)23-11-24-19(15)26/h4-9,11,16,18,20,27-28H,10H2,1-3H3/t16-,18+,20-,21-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154M69
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50523661 (CHEMBL4547524 | US10709709, Example 154) Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C(F)F)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C22H24F2N4O3/c1-11-14-3-5-28(22(14)27-10-26-11)16-8-18(20(30)19(16)29)31-17-7-13(21(23)24)6-12-2-4-25-9-15(12)17/h3,5-7,10,16,18-21,25,29-30H,2,4,8-9H2,1H3/t16-,18+,19+,20-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Curated by ChEMBL					Assay Description Inhibition of PRMT5 (unknown origin)				Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 BindingDB Entry DOI: 10.7270/Q2ZC869N
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50523654 (CHEMBL4455651 | US10709709, Example 212) Show SMILES CC1CNCc2c(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(C)ncnc34)cc(C(F)F)c(F)c12 |r| Show InChI InChI=1S/C23H25F3N4O3/c1-10-7-27-8-14-16(5-13(22(25)26)19(24)18(10)14)33-17-6-15(20(31)21(17)32)30-4-3-12-11(2)28-9-29-23(12)30/h3-5,9-10,15,17,20-22,27,31-32H,6-8H2,1-2H3/t10?,15-,17+,20+,21-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Curated by ChEMBL					Assay Description Inhibition of PRMT5 (unknown origin)				Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 BindingDB Entry DOI: 10.7270/Q2ZC869N
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451383 (US10709709, Example 213 | US10709709, Example 214) Show SMILES CC1NCCc2c(F)ccc(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(C)ncnc34)c12 |r| Show InChI InChI=1S/C22H25FN4O3/c1-11-13-6-8-27(22(13)26-10-25-11)16-9-18(21(29)20(16)28)30-17-4-3-15(23)14-5-7-24-12(2)19(14)17/h3-4,6,8,10,12,16,18,20-21,24,28-29H,5,7,9H2,1-2H3/t12?,16-,18+,20+,21-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451385 (US10709709, Example 215 | US10709709, Example 216) Show SMILES CC1CNCc2c(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3cc(F)c4c(N)ncnc34)cc(C(F)F)c(F)c12 |r| Show InChI InChI=1S/C22H23F4N5O3/c1-8-4-28-5-10-13(2-9(20(25)26)17(24)15(8)10)34-14-3-12(18(32)19(14)33)31-6-11(23)16-21(27)29-7-30-22(16)31/h2,6-8,12,14,18-20,28,32-33H,3-5H2,1H3,(H2,27,29,30)/t8?,12-,14+,18+,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM451385 (US10709709, Example 215 | US10709709, Example 216) Show SMILES CC1CNCc2c(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3cc(F)c4c(N)ncnc34)cc(C(F)F)c(F)c12 |r| Show InChI InChI=1S/C22H23F4N5O3/c1-8-4-28-5-10-13(2-9(20(25)26)17(24)15(8)10)34-14-3-12(18(32)19(14)33)31-6-11(23)16-21(27)29-7-30-22(16)31/h2,6-8,12,14,18-20,28,32-33H,3-5H2,1H3,(H2,27,29,30)/t8?,12-,14+,18+,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...				US Patent US10709709 (2020) BindingDB Entry DOI: 10.7270/Q26113CC
					More data for this Ligand-Target Pair

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