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Compile Data Set for Download or QSAR

Found 49 hits of ic50 data for polymerid = 941   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50300884
PNG
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)
Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc(SC)[nH]c2-c2ccc(F)cc2)c(OC)c1
Show InChI InChI=1S/C26H23FN4O3S/c1-33-20-10-6-16(21(15-20)34-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)35-3)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32)
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n/an/a 5n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025019
PNG
(CHEMBL3337845)
Show SMILES FC(F)(F)Oc1ccccc1C(=O)Nc1nc(cs1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C20H10F5N5O5S/c21-19(22,23)33-12-4-2-1-3-8(12)15(31)30-18-28-11(7-36-18)16(32)29-17-26-9-5-13-14(6-10(9)27-17)35-20(24,25)34-13/h1-7H,(H,28,30,31)(H2,26,27,29,32)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta kinetic domain expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50300893
PNG
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)
Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc([nH]c2-c2ccc(F)cc2)S(C)=O)c(OC)c1
Show InChI InChI=1S/C26H23FN4O4S/c1-34-20-10-6-16(21(15-20)35-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)36(3)33)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32)
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Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025016
PNG
(CHEMBL3337849)
Show SMILES CN(C)c1cccc(c1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C17H14F2N4O3/c1-23(2)10-5-3-4-9(6-10)15(24)22-16-20-11-7-13-14(8-12(11)21-16)26-17(18,19)25-13/h3-8H,1-2H3,(H2,20,21,22,24)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta by radiometric protein kinase filter binding assay


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025019
PNG
(CHEMBL3337845)
Show SMILES FC(F)(F)Oc1ccccc1C(=O)Nc1nc(cs1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C20H10F5N5O5S/c21-19(22,23)33-12-4-2-1-3-8(12)15(31)30-18-28-11(7-36-18)16(32)29-17-26-9-5-13-14(6-10(9)27-17)35-20(24,25)34-13/h1-7H,(H,28,30,31)(H2,26,27,29,32)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged rat CK1delta expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025019
PNG
(CHEMBL3337845)
Show SMILES FC(F)(F)Oc1ccccc1C(=O)Nc1nc(cs1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C20H10F5N5O5S/c21-19(22,23)33-12-4-2-1-3-8(12)15(31)30-18-28-11(7-36-18)16(32)29-17-26-9-5-13-14(6-10(9)27-17)35-20(24,25)34-13/h1-7H,(H,28,30,31)(H2,26,27,29,32)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta kinetic domain expressed in Escherichia coli using alpha casein substrate by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025020
PNG
(CHEMBL3337854)
Show SMILES FC(F)(F)Oc1ccccc1C(=O)Nc1nc(cs1)C(=O)Nc1nc2ccc(cc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C20H11F6N5O3S/c21-19(22,23)9-5-6-11-12(7-9)28-17(27-11)30-16(33)13-8-35-18(29-13)31-15(32)10-3-1-2-4-14(10)34-20(24,25)26/h1-8H,(H,29,31,32)(H2,27,28,30,33)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta kinetic domain expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025015
PNG
(CHEMBL3337846)
Show SMILES COc1cccc(c1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C16H11F2N3O4/c1-23-9-4-2-3-8(5-9)14(22)21-15-19-10-6-12-13(7-11(10)20-15)25-16(17,18)24-12/h2-7H,1H3,(H2,19,20,21,22)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta by radiometric protein kinase filter binding assay


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025020
PNG
(CHEMBL3337854)
Show SMILES FC(F)(F)Oc1ccccc1C(=O)Nc1nc(cs1)C(=O)Nc1nc2ccc(cc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C20H11F6N5O3S/c21-19(22,23)9-5-6-11-12(7-9)28-17(27-11)30-16(33)13-8-35-18(29-13)31-15(32)10-3-1-2-4-14(10)34-20(24,25)26/h1-8H,(H,29,31,32)(H2,27,28,30,33)
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Post Graduate Department of Chemistry, Sree Chaitanya College, Habra, 24 Parganas 743268, India. Electronic address: debasisdas@chemconfidence.com.

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat GST-tagged CK1delta expressed in Escherichia coli using GST-p53 (1 to 64 residues) as substrate by SDS-PAGE based autor...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025020
PNG
(CHEMBL3337854)
Show SMILES FC(F)(F)Oc1ccccc1C(=O)Nc1nc(cs1)C(=O)Nc1nc2ccc(cc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C20H11F6N5O3S/c21-19(22,23)9-5-6-11-12(7-9)28-17(27-11)30-16(33)13-8-35-18(29-13)31-15(32)10-3-1-2-4-14(10)34-20(24,25)26/h1-8H,(H,29,31,32)(H2,27,28,30,33)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged rat CK1delta expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50139420
PNG
(CHEMBL3763630)
Show SMILES Fc1cc2[nH]c(NC(=O)c3csc(NC(=O)c4ccccc4OC(F)(F)F)n3)nc2cc1Cl
Show InChI InChI=1S/C19H10ClF4N5O3S/c20-9-5-11-12(6-10(9)21)26-17(25-11)28-16(31)13-7-33-18(27-13)29-15(30)8-3-1-2-4-14(8)32-19(22,23)24/h1-7H,(H,27,29,30)(H2,25,26,28,31)
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Post Graduate Department of Chemistry, Sree Chaitanya College, Habra, 24 Parganas 743268, India. Electronic address: debasisdas@chemconfidence.com.

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat GST-tagged CK1delta expressed in Escherichia coli using GST-p53 (1 to 64 residues) as substrate by SDS-PAGE based autor...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50300892
PNG
((E)-3-(2,4-dimethoxyphenyl)-N-(4-(3-(4-fluoropheny...)
Show SMILES COc1ccc(\C=C\C(=O)Nc2cc(ccn2)-c2c(noc2C(C)C)-c2ccc(F)cc2)c(OC)c1
Show InChI InChI=1S/C28H26FN3O4/c1-17(2)28-26(27(32-36-28)19-5-9-21(29)10-6-19)20-13-14-30-24(15-20)31-25(33)12-8-18-7-11-22(34-3)16-23(18)35-4/h5-17H,1-4H3,(H,30,31,33)/b12-8+
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Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025015
PNG
(CHEMBL3337846)
Show SMILES COc1cccc(c1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C16H11F2N3O4/c1-23-9-4-2-3-8(5-9)14(22)21-15-19-10-6-12-13(7-11(10)20-15)25-16(17,18)24-12/h2-7H,1H3,(H2,19,20,21,22)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta kinetic domain expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025019
PNG
(CHEMBL3337845)
Show SMILES FC(F)(F)Oc1ccccc1C(=O)Nc1nc(cs1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C20H10F5N5O5S/c21-19(22,23)33-12-4-2-1-3-8(12)15(31)30-18-28-11(7-36-18)16(32)29-17-26-9-5-13-14(6-10(9)27-17)35-20(24,25)34-13/h1-7H,(H,28,30,31)(H2,26,27,29,32)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged rat CK1delta expressed in Escherichia coli using alpha casein substrate by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50300890
PNG
(2-(4-fluorophenyl)-N-(4-(3-(4-fluorophenyl)-5-isop...)
Show SMILES CC(C)c1onc(c1-c1ccnc(NC(=O)Cc2ccc(F)cc2)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H21F2N3O2/c1-15(2)25-23(24(30-32-25)17-5-9-20(27)10-6-17)18-11-12-28-21(14-18)29-22(31)13-16-3-7-19(26)8-4-16/h3-12,14-15H,13H2,1-2H3,(H,28,29,31)
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Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025017
PNG
(CHEMBL3337855)
Show SMILES COc1ccc(cc1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C16H11F2N3O4/c1-23-9-4-2-8(3-5-9)14(22)21-15-19-10-6-12-13(7-11(10)20-15)25-16(17,18)24-12/h2-7H,1H3,(H2,19,20,21,22)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta by radiometric protein kinase filter binding assay


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025024
PNG
(CHEMBL3337850)
Show SMILES CN(C)c1cc(ccn1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C16H13F2N5O3/c1-23(2)13-5-8(3-4-19-13)14(24)22-15-20-9-6-11-12(7-10(9)21-15)26-16(17,18)25-11/h3-7H,1-2H3,(H2,20,21,22,24)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged rat CK1delta expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025015
PNG
(CHEMBL3337846)
Show SMILES COc1cccc(c1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C16H11F2N3O4/c1-23-9-4-2-3-8(5-9)14(22)21-15-19-10-6-12-13(7-11(10)20-15)25-16(17,18)24-12/h2-7H,1H3,(H2,19,20,21,22)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged rat CK1delta expressed in Escherichia coli using alpha casein substrate by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025015
PNG
(CHEMBL3337846)
Show SMILES COc1cccc(c1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C16H11F2N3O4/c1-23-9-4-2-3-8(5-9)14(22)21-15-19-10-6-12-13(7-11(10)20-15)25-16(17,18)24-12/h2-7H,1H3,(H2,19,20,21,22)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged rat CK1delta expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025015
PNG
(CHEMBL3337846)
Show SMILES COc1cccc(c1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C16H11F2N3O4/c1-23-9-4-2-3-8(5-9)14(22)21-15-19-10-6-12-13(7-11(10)20-15)25-16(17,18)24-12/h2-7H,1H3,(H2,19,20,21,22)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta kinetic domain expressed in Escherichia coli using alpha casein substrate by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025016
PNG
(CHEMBL3337849)
Show SMILES CN(C)c1cccc(c1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C17H14F2N4O3/c1-23(2)10-5-3-4-9(6-10)15(24)22-16-20-11-7-13-14(8-12(11)21-16)26-17(18,19)25-13/h3-8H,1-2H3,(H2,20,21,22,24)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta kinetic domain expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025023
PNG
(CHEMBL3337851)
Show SMILES FC(F)Oc1cccc(c1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C16H9F4N3O4/c17-14(18)25-8-3-1-2-7(4-8)13(24)23-15-21-9-5-11-12(6-10(9)22-15)27-16(19,20)26-11/h1-6,14H,(H2,21,22,23,24)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta kinetic domain expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025018
PNG
(CHEMBL3337856)
Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C17H14F2N4O3/c1-23(2)10-5-3-9(4-6-10)15(24)22-16-20-11-7-13-14(8-12(11)21-16)26-17(18,19)25-13/h3-8H,1-2H3,(H2,20,21,22,24)
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n/an/a 201n/an/an/an/an/an/a



Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta by radiometric protein kinase filter binding assay


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025016
PNG
(CHEMBL3337849)
Show SMILES CN(C)c1cccc(c1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C17H14F2N4O3/c1-23(2)10-5-3-4-9(6-10)15(24)22-16-20-11-7-13-14(8-12(11)21-16)26-17(18,19)25-13/h3-8H,1-2H3,(H2,20,21,22,24)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged rat CK1delta expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50206421
PNG
(3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)iso...)
Show SMILES CC(C)c1onc(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O/c1-11(2)17-15(12-7-9-19-10-8-12)16(20-21-17)13-3-5-14(18)6-4-13/h3-11H,1-2H3
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n/an/a 230n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025023
PNG
(CHEMBL3337851)
Show SMILES FC(F)Oc1cccc(c1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C16H9F4N3O4/c17-14(18)25-8-3-1-2-7(4-8)13(24)23-15-21-9-5-11-12(6-10(9)22-15)27-16(19,20)26-11/h1-6,14H,(H2,21,22,23,24)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged rat CK1delta expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025026
PNG
(CHEMBL3337847)
Show SMILES COc1cncc(c1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C15H10F2N4O4/c1-23-8-2-7(5-18-6-8)13(22)21-14-19-9-3-11-12(4-10(9)20-14)25-15(16,17)24-11/h2-6H,1H3,(H2,19,20,21,22)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta kinetic domain expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025024
PNG
(CHEMBL3337850)
Show SMILES CN(C)c1cc(ccn1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C16H13F2N5O3/c1-23(2)13-5-8(3-4-19-13)14(24)22-15-20-9-6-11-12(7-10(9)21-15)26-16(17,18)25-11/h3-7H,1-2H3,(H2,20,21,22,24)
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n/an/a 290n/an/an/an/an/an/a



Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta kinetic domain expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025022
PNG
(CHEMBL3337852)
Show SMILES COC(=O)c1cccc(c1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C17H11F2N3O5/c1-25-15(24)9-4-2-3-8(5-9)14(23)22-16-20-10-6-12-13(7-11(10)21-16)27-17(18,19)26-12/h2-7H,1H3,(H2,20,21,22,23)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged rat CK1delta expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50229971
PNG
(4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-...)
Show SMILES NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCCOc2c1)-c1ccccn1
Show InChI InChI=1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)
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Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat CK1delta expressed in Escherichia coli using phosphorylated peptide TFRPRTSpSNASTIS as substrate


J Med Chem 52: 7618-30 (2009)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50300889
PNG
(CHEMBL585533 | N-(4-(3-(4-fluorophenyl)-5-isopropy...)
Show SMILES CC(C)c1onc(c1-c1ccnc(NC(C)=O)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H18FN3O2/c1-11(2)19-17(14-8-9-21-16(10-14)22-12(3)24)18(23-25-19)13-4-6-15(20)7-5-13/h4-11H,1-3H3,(H,21,22,24)
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n/an/a 330n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50300891
PNG
((rac)-N-(4-(3-(4-fluorophenyl)-5-isopropylisoxazol...)
Show SMILES CC(C)c1onc(c1-c1ccnc(NC(=O)C(C)Oc2ccccc2)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H24FN3O3/c1-16(2)25-23(24(30-33-25)18-9-11-20(27)12-10-18)19-13-14-28-22(15-19)29-26(31)17(3)32-21-7-5-4-6-8-21/h4-17H,1-3H3,(H,28,29,31)
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n/an/a 340n/an/an/an/an/an/a



Eberhard-Karls-University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP


J Med Chem 52: 7618-30 (2009)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025022
PNG
(CHEMBL3337852)
Show SMILES COC(=O)c1cccc(c1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C17H11F2N3O5/c1-25-15(24)9-4-2-3-8(5-9)14(23)22-16-20-10-6-12-13(7-11(10)21-16)27-17(18,19)26-12/h2-7H,1H3,(H2,20,21,22,23)
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n/an/a 350n/an/an/an/an/an/a



Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta kinetic domain expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50229971
PNG
(4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-...)
Show SMILES NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCCOc2c1)-c1ccccn1
Show InChI InChI=1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)
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University of Edinburgh Cancer Research Centre in the Institute of Genetics and Molecular Medicine

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta in presence of 20 uM ATP


Bioorg Med Chem Lett 23: 5578-85 (2013)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025021
PNG
(CHEMBL3337853)
Show SMILES FC1(F)Oc2cc3nc(NC(=O)c4cccc(c4)-c4nnn[nH]4)[nH]c3cc2O1
Show InChI InChI=1S/C16H9F2N7O3/c17-16(18)27-11-5-9-10(6-12(11)28-16)20-15(19-9)21-14(26)8-3-1-2-7(4-8)13-22-24-25-23-13/h1-6H,(H2,19,20,21,26)(H,22,23,24,25)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta kinetic domain expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025021
PNG
(CHEMBL3337853)
Show SMILES FC1(F)Oc2cc3nc(NC(=O)c4cccc(c4)-c4nnn[nH]4)[nH]c3cc2O1
Show InChI InChI=1S/C16H9F2N7O3/c17-16(18)27-11-5-9-10(6-12(11)28-16)20-15(19-9)21-14(26)8-3-1-2-7(4-8)13-22-24-25-23-13/h1-6H,(H2,19,20,21,26)(H,22,23,24,25)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged rat CK1delta expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025026
PNG
(CHEMBL3337847)
Show SMILES COc1cncc(c1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C15H10F2N4O4/c1-23-8-2-7(5-18-6-8)13(22)21-14-19-9-3-11-12(4-10(9)20-14)25-15(16,17)24-11/h2-6H,1H3,(H2,19,20,21,22)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged rat CK1delta expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025025
PNG
(CHEMBL3337848)
Show SMILES COc1cc(ccn1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C15H10F2N4O4/c1-23-12-4-7(2-3-18-12)13(22)21-14-19-8-5-10-11(6-9(8)20-14)25-15(16,17)24-10/h2-6H,1H3,(H2,19,20,21,22)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged rat CK1delta expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM6870
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3f ...)
Show SMILES Cc1ccsc1C(=O)n1nc(Nc2ccc(cc2)S(N)(=O)=O)nc1N
Show InChI InChI=1S/C14H14N6O3S2/c1-8-6-7-24-11(8)12(21)20-13(15)18-14(19-20)17-9-2-4-10(5-3-9)25(16,22)23/h2-7H,1H3,(H2,16,22,23)(H3,15,17,18,19)
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n/an/a 570n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...


J Med Chem 48: 4208-11 (2005)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025025
PNG
(CHEMBL3337848)
Show SMILES COc1cc(ccn1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C15H10F2N4O4/c1-23-12-4-7(2-3-18-12)13(22)21-14-19-8-5-10-11(6-9(8)20-14)25-15(16,17)24-10/h2-6H,1H3,(H2,19,20,21,22)
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Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta kinetic domain expressed in Escherichia coli using GST-p53 (1 to 64 residues) by SDS-PAGE based autoradiography


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50441089
PNG
(CHEMBL2430324)
Show SMILES CC(=O)Nc1nccc(n1)-c1c(C)onc1-c1ccccc1
Show InChI InChI=1S/C16H14N4O2/c1-10-14(13-8-9-17-16(19-13)18-11(2)21)15(20-22-10)12-6-4-3-5-7-12/h3-9H,1-2H3,(H,17,18,19,21)
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University of Edinburgh Cancer Research Centre in the Institute of Genetics and Molecular Medicine

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta in presence of 20 uM ATP


Bioorg Med Chem Lett 23: 5578-85 (2013)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50441090
PNG
(CHEMBL2430323 | US9669028, 114 N-(3-(3-methyl-1H-p...)
Show SMILES CC(=O)Nc1cccc(c1)-c1cnc2[nH]nc(C)c2c1
Show InChI InChI=1S/C15H14N4O/c1-9-14-7-12(8-16-15(14)19-18-9)11-4-3-5-13(6-11)17-10(2)20/h3-8H,1-2H3,(H,17,20)(H,16,18,19)
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University of Edinburgh Cancer Research Centre in the Institute of Genetics and Molecular Medicine

Curated by ChEMBL


Assay Description
Inhibition of rat CK1delta in presence of 20 uM ATP


Bioorg Med Chem Lett 23: 5578-85 (2013)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM6878
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n ...)
Show SMILES Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=S)Nc1c(F)cccc1F
Show InChI InChI=1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23)
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Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...


J Med Chem 48: 4208-11 (2005)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM6866
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Show SMILES Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22)
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n/an/a 1.12E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...


J Med Chem 48: 4208-11 (2005)

More data for this
Ligand-Target Pair
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025019
PNG
(CHEMBL3337845)
Show SMILES FC(F)(F)Oc1ccccc1C(=O)Nc1nc(cs1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C20H10F5N5O5S/c21-19(22,23)33-12-4-2-1-3-8(12)15(31)30-18-28-11(7-36-18)16(32)29-17-26-9-5-13-14(6-10(9)27-17)35-20(24,25)34-13/h1-7H,(H,28,30,31)(H2,26,27,29,32)
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n/an/a 2.01E+4n/an/an/an/an/an/a



Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged mouse CK1delta transcription variant 1 mutant expressed in Escherichia coli at 15 degC for 14 hrs using GST-p53 (1 to 64 res...


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025019
PNG
(CHEMBL3337845)
Show SMILES FC(F)(F)Oc1ccccc1C(=O)Nc1nc(cs1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C20H10F5N5O5S/c21-19(22,23)33-12-4-2-1-3-8(12)15(31)30-18-28-11(7-36-18)16(32)29-17-26-9-5-13-14(6-10(9)27-17)35-20(24,25)34-13/h1-7H,(H,28,30,31)(H2,26,27,29,32)
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n/an/a 3.66E+4n/an/an/an/an/an/a



Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged mouse CK1delta transcription variant 2 mutant expressed in Escherichia coli at 15 degC for 14 hrs using GST-p53 (1 to 64 res...


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025019
PNG
(CHEMBL3337845)
Show SMILES FC(F)(F)Oc1ccccc1C(=O)Nc1nc(cs1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C20H10F5N5O5S/c21-19(22,23)33-12-4-2-1-3-8(12)15(31)30-18-28-11(7-36-18)16(32)29-17-26-9-5-13-14(6-10(9)27-17)35-20(24,25)34-13/h1-7H,(H,28,30,31)(H2,26,27,29,32)
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n/an/a 5.59E+4n/an/an/an/an/an/a



Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged mouse CK1delta transcription variant 2 mutant expressed in Escherichia coli at 37 degC for 2 hrs using GST-p53 (1 to 64 resi...


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM50025019
PNG
(CHEMBL3337845)
Show SMILES FC(F)(F)Oc1ccccc1C(=O)Nc1nc(cs1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1
Show InChI InChI=1S/C20H10F5N5O5S/c21-19(22,23)33-12-4-2-1-3-8(12)15(31)30-18-28-11(7-36-18)16(32)29-17-26-9-5-13-14(6-10(9)27-17)35-20(24,25)34-13/h1-7H,(H,28,30,31)(H2,26,27,29,32)
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n/an/a 8.01E+4n/an/an/an/an/an/a



Ulm University Hospital

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged mouse CK1delta transcription variant 1 mutant expressed in Escherichia coli at 37 degC for 2 hrs using GST-p53 (1 to 64 resi...


J Med Chem 57: 7933-46 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Casein kinase I delta


(Rattus norvegicus (rat))
BDBM6867
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)
Show SMILES Cc1ccc(F)c(C(=O)n2nc(Nc3ccc(cc3)S(N)(=O)=O)nc2N)c1F
Show InChI InChI=1S/C16H14F2N6O3S/c1-8-2-7-11(17)12(13(8)18)14(25)24-15(19)22-16(23-24)21-9-3-5-10(6-4-9)28(20,26)27/h2-7H,1H3,(H2,20,26,27)(H3,19,21,22,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...


J Med Chem 48: 4208-11 (2005)

More data for this
Ligand-Target Pair