Found 70 hits of ic50 for UniProtKB: Q9NWT6 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM26113
(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)Show InChI InChI=1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50580321
(CHEMBL5091848) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50580322
(CHEMBL5072902) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM26113
(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)Show InChI InChI=1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12) | PDB
UniProtKB/SwissProt
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Patents
| PDB Article PubMed
| n/a | n/a | 8.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of N-terminal His6-tagged full-length FIH (unknown origin) expressed in Escherichia coli Rosetta 2(DE3)pLysS using SMDESGLPQLTSYDCEVNAPIQG... |
J Med Chem 59: 1580-98 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01527 BindingDB Entry DOI: 10.7270/Q2P84DRX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM7460
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H | PDB
UniProtKB/SwissProt
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sejong University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant FIH1 |
Bioorg Med Chem 17: 7769-74 (2009)
Article DOI: 10.1016/j.bmc.2009.09.034 BindingDB Entry DOI: 10.7270/Q2TM7B6R |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50580320
(CHEMBL5071002) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50606683
(CHEMBL5220431) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01204 BindingDB Entry DOI: 10.7270/Q2BR8X83 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50580318
(CHEMBL5089117) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50580319
(CHEMBL5083418) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.59E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50606688
(CHEMBL5218469) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01204 BindingDB Entry DOI: 10.7270/Q2BR8X83 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50580327
(CHEMBL5089880) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.92E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50580324
(CHEMBL5081435) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 1.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50580323
(CHEMBL5076580) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50317547
(CHEMBL4163812)Show SMILES OC(=O)CNC(=O)c1c(O)n(C2CCCCC2)c(=O)n(C2CCCCC2)c1=O Show InChI InChI=1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,26H,1-11H2,(H,20,25)(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FIH using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-asco... |
Bioorg Med Chem 27: 2405-2412 (2019)
Article DOI: 10.1016/j.bmc.2019.01.018 BindingDB Entry DOI: 10.7270/Q2KK9G4R |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50606586
(DAPRODUSTAT | Daprodustat | GSK-1278863 | GSK12788...)Show SMILES OC(=O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C2CCCCC2)C1=O | PDB
UniProtKB/SwissProt
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MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00415 BindingDB Entry DOI: 10.7270/Q2CN7810 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50361473
(CHEMBL1435274)Show InChI InChI=1S/C10H7NO3/c12-8-3-1-2-6-7(10(13)14)4-5-11-9(6)8/h1-5,12H,(H,13,14) | PDB
UniProtKB/SwissProt
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CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Prefectural University of Medicine
Curated by ChEMBL
| Assay Description Inhibition of FIH |
J Med Chem 54: 8236-50 (2011)
Article DOI: 10.1021/jm201048w BindingDB Entry DOI: 10.7270/Q2D50NFR |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50361475
(CHEMBL1938900)Show SMILES ON(CCCCNCc1ccc(COC(=O)Nc2cccc3ccccc23)cc1)C(=O)C=CC(O)=O |w:31.33| Show InChI InChI=1S/C27H29N3O6/c31-25(14-15-26(32)33)30(35)17-4-3-16-28-18-20-10-12-21(13-11-20)19-36-27(34)29-24-9-5-7-22-6-1-2-8-23(22)24/h1-2,5-15,28,35H,3-4,16-19H2,(H,29,34)(H,32,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Prefectural University of Medicine
Curated by ChEMBL
| Assay Description Inhibition of FIH |
J Med Chem 54: 8236-50 (2011)
Article DOI: 10.1021/jm201048w BindingDB Entry DOI: 10.7270/Q2D50NFR |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50580325
(CHEMBL5084638) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.38E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50495472
(CHEMBL3108952)Show SMILES Cl.N[C@@H]1C[C@H]1c1ccc(NC(=O)c2ccc(O)c3ncccc23)cc1 |r| Show InChI InChI=1S/C19H17N3O2.ClH/c20-16-10-15(16)11-3-5-12(6-4-11)22-19(24)14-7-8-17(23)18-13(14)2-1-9-21-18;/h1-9,15-16,23H,10,20H2,(H,22,24);1H/t15-,16+;/m0./s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibition of FIH (unknown origin) by mass spectrometry |
J Med Chem 57: 42-55 (2014)
Article DOI: 10.1021/jm4012802 BindingDB Entry DOI: 10.7270/Q2028VHD |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM107704
(US11426393, Compound Table XV.11 | US8598210, 119 ...)Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20) | PDB
UniProtKB/SwissProt
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MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00415 BindingDB Entry DOI: 10.7270/Q2CN7810 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM107704
(US11426393, Compound Table XV.11 | US8598210, 119 ...)Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20) | PDB
UniProtKB/SwissProt
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MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FIH using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-asco... |
Bioorg Med Chem 27: 2405-2412 (2019)
Article DOI: 10.1016/j.bmc.2019.01.018 BindingDB Entry DOI: 10.7270/Q2KK9G4R |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50580326
(CHEMBL5070745) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50580328
(CHEMBL5071515) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM118339
(US8653111, 72)Show InChI InChI=1S/C13H14N8O2/c22-13-10(20-2-1-16-18-20)8-17-21(13)12-7-11(14-9-15-12)19-3-5-23-6-4-19/h1-2,7-9,17H,3-6H2 | PDB
UniProtKB/SwissProt
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MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 3.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FIH using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-asco... |
Bioorg Med Chem 27: 2405-2412 (2019)
Article DOI: 10.1016/j.bmc.2019.01.018 BindingDB Entry DOI: 10.7270/Q2KK9G4R |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50304610
(3-(5-(2-methoxybenzylidene)-4-oxo-2-thioxothiazoli...)Show SMILES COc1ccccc1\C=C1/SC(=S)N(CCC(=O)Nc2ccc(cc2)S(N)(=O)=O)C1=O Show InChI InChI=1S/C20H19N3O5S3/c1-28-16-5-3-2-4-13(16)12-17-19(25)23(20(29)30-17)11-10-18(24)22-14-6-8-15(9-7-14)31(21,26)27/h2-9,12H,10-11H2,1H3,(H,22,24)(H2,21,26,27)/b17-12- | PDB
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.21E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sejong University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant FIH1 |
Bioorg Med Chem 17: 7769-74 (2009)
Article DOI: 10.1016/j.bmc.2009.09.034 BindingDB Entry DOI: 10.7270/Q2TM7B6R |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50304612
(2-(5-((3-(4-(ethylthio)phenyl)-1-phenyl-1H-pyrazol...)Show SMILES CCSc1ccc(cc1)-c1nn(cc1\C=C1\SC(=S)N(CC(O)=O)C1=O)-c1ccccc1 Show InChI InChI=1S/C23H19N3O3S3/c1-2-31-18-10-8-15(9-11-18)21-16(13-26(24-21)17-6-4-3-5-7-17)12-19-22(29)25(14-20(27)28)23(30)32-19/h3-13H,2,14H2,1H3,(H,27,28)/b19-12+ | PDB
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.62E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sejong University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant FIH1 |
Bioorg Med Chem 17: 7769-74 (2009)
Article DOI: 10.1016/j.bmc.2009.09.034 BindingDB Entry DOI: 10.7270/Q2TM7B6R |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50606687
(CHEMBL5220246)Show SMILES CN(C)C(=O)c1ccc(Nc2ccc(O)c(n2)C(=O)NCC(O)=O)cc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01204 BindingDB Entry DOI: 10.7270/Q2BR8X83 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50304617
(6-((2-methoxyphenoxy)methyl)-3-(quinolin-2-yl)thia...)Show InChI InChI=1S/C21H16N4O2S/c1-26-18-8-4-5-9-19(18)27-13-15-12-25-20(23-24-21(25)28-15)17-11-10-14-6-2-3-7-16(14)22-17/h2-12H,13H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sejong University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant FIH1 |
Bioorg Med Chem 17: 7769-74 (2009)
Article DOI: 10.1016/j.bmc.2009.09.034 BindingDB Entry DOI: 10.7270/Q2TM7B6R |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50304614
(CHEMBL594893 | N-(benzo[c][1,2,5]oxadiazol-4-yl)-2...)Show SMILES COc1cccc(\C=C2/SC(=S)N(CC(=O)Nc3cccc4nonc34)C2=O)c1 Show InChI InChI=1S/C19H14N4O4S2/c1-26-12-5-2-4-11(8-12)9-15-18(25)23(19(28)29-15)10-16(24)20-13-6-3-7-14-17(13)22-27-21-14/h2-9H,10H2,1H3,(H,20,24)/b15-9- | PDB
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sejong University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant FIH1 |
Bioorg Med Chem 17: 7769-74 (2009)
Article DOI: 10.1016/j.bmc.2009.09.034 BindingDB Entry DOI: 10.7270/Q2TM7B6R |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50606681
(CHEMBL5219846)Show SMILES OC(=O)CNC(=O)c1nc(Nc2ccc(cc2)[N+]([O-])=O)ccc1O | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 4.59E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01204 BindingDB Entry DOI: 10.7270/Q2BR8X83 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM26106
(CHEMBL90852 | N-oxalyl glycine, 1a | NOG | Oxalylg...)Show InChI InChI=1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10) | PDB
UniProtKB/SwissProt
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| PDB Article PubMed
| n/a | n/a | 4.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00415 BindingDB Entry DOI: 10.7270/Q2CN7810 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50304616
(6-(2-methoxystyryl)-3-(quinolin-2-yl)thiazolo[2,3-...)Show SMILES COc1ccccc1\C=C\c1cn2c(nnc2s1)-c1ccc2ccccc2n1 Show InChI InChI=1S/C22H16N4OS/c1-27-20-9-5-3-7-16(20)10-12-17-14-26-21(24-25-22(26)28-17)19-13-11-15-6-2-4-8-18(15)23-19/h2-14H,1H3/b12-10+ | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.75E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sejong University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant FIH1 |
Bioorg Med Chem 17: 7769-74 (2009)
Article DOI: 10.1016/j.bmc.2009.09.034 BindingDB Entry DOI: 10.7270/Q2TM7B6R |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50304613
(CHEMBL593127 | N-(benzo[c][1,2,5]oxadiazol-4-yl)-3...)Show SMILES O=C(CCN1C(=S)S\C(=C\C=C\c2ccco2)C1=O)Nc1cccc2nonc12 Show InChI InChI=1S/C19H14N4O4S2/c24-16(20-13-6-2-7-14-17(13)22-27-21-14)9-10-23-18(25)15(29-19(23)28)8-1-4-12-5-3-11-26-12/h1-8,11H,9-10H2,(H,20,24)/b4-1+,15-8+ | PDB
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.86E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sejong University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant FIH1 |
Bioorg Med Chem 17: 7769-74 (2009)
Article DOI: 10.1016/j.bmc.2009.09.034 BindingDB Entry DOI: 10.7270/Q2TM7B6R |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50606685
(CHEMBL5219099)Show SMILES COC(=O)c1ccc(Nc2ccc(O)c(n2)C(=O)NCC(O)=O)cc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01204 BindingDB Entry DOI: 10.7270/Q2BR8X83 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50606682
(CHEMBL5220094)Show SMILES OC(=O)CNC(=O)c1nc(Nc2ccc(cn2)[N+]([O-])=O)ccc1O | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01204 BindingDB Entry DOI: 10.7270/Q2BR8X83 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50606686
(CHEMBL5219336)Show SMILES CNC(=O)c1ccc(Nc2ccc(O)c(n2)C(=O)NCC(O)=O)cc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01204 BindingDB Entry DOI: 10.7270/Q2BR8X83 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50304611
(3-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-o...)Show SMILES OC(=O)CCN1C(=S)S\C(=C\c2ccc(o2)-c2ccc(Cl)cc2)C1=O Show InChI InChI=1S/C17H12ClNO4S2/c18-11-3-1-10(2-4-11)13-6-5-12(23-13)9-14-16(22)19(17(24)25-14)8-7-15(20)21/h1-6,9H,7-8H2,(H,20,21)/b14-9+ | PDB
UniProtKB/SwissProt
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CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 6.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sejong University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant FIH1 |
Bioorg Med Chem 17: 7769-74 (2009)
Article DOI: 10.1016/j.bmc.2009.09.034 BindingDB Entry DOI: 10.7270/Q2TM7B6R |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM118338
(US8653111, 62)Show SMILES CC(C)(C)OC(=O)c1ccc(nc1)-n1[nH]cc(-n2ccnn2)c1=O Show InChI InChI=1S/C15H16N6O3/c1-15(2,3)24-14(23)10-4-5-12(16-8-10)21-13(22)11(9-18-21)20-7-6-17-19-20/h4-9,18H,1-3H3 | PDB
UniProtKB/SwissProt
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MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FIH using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-asco... |
Bioorg Med Chem 27: 2405-2412 (2019)
Article DOI: 10.1016/j.bmc.2019.01.018 BindingDB Entry DOI: 10.7270/Q2KK9G4R |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM118339
(US8653111, 72)Show InChI InChI=1S/C13H14N8O2/c22-13-10(20-2-1-16-18-20)8-17-21(13)12-7-11(14-9-15-12)19-3-5-23-6-4-19/h1-2,7-9,17H,3-6H2 | PDB
UniProtKB/SwissProt
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| PDB Article PubMed
| n/a | n/a | 6.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00415 BindingDB Entry DOI: 10.7270/Q2CN7810 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50304615
(CHEMBL593738 | N-(benzo[c][1,2,5]oxadiazol-4-yl)-3...)Show SMILES COc1cccc(\C=C2/SC(=S)N(CCC(=O)Nc3cccc4nonc34)C2=O)c1 Show InChI InChI=1S/C20H16N4O4S2/c1-27-13-5-2-4-12(10-13)11-16-19(26)24(20(29)30-16)9-8-17(25)21-14-6-3-7-15-18(14)23-28-22-15/h2-7,10-11H,8-9H2,1H3,(H,21,25)/b16-11- | PDB
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sejong University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant FIH1 |
Bioorg Med Chem 17: 7769-74 (2009)
Article DOI: 10.1016/j.bmc.2009.09.034 BindingDB Entry DOI: 10.7270/Q2TM7B6R |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50580329
(CHEMBL5084143) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM223320
(KDOAM-25)Show InChI InChI=1S/C15H25N5O2/c1-4-20(8-7-19(2)3)14(21)11-17-10-13-9-12(15(16)22)5-6-18-13/h5-6,9,17H,4,7-8,10-11H2,1-3H3,(H2,16,22) | PDB
UniProtKB/SwissProt
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MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | <1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
| Assay Description MALDI-TOF enzymatic assay |
Cell Chem Biol 24: 371-380 (2017)
Article DOI: 10.1016/j.chembiol.2017.02.006 BindingDB Entry DOI: 10.7270/Q23N2288 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50395077
(CHEMBL2164250)Show InChI InChI=1S/C8H18N4O2/c1-11(2)9-7(13)5-6-8(14)10-12(3)4/h5-6H2,1-4H3,(H,9,13)(H,10,14) | PDB
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of human FIH expressed in Escherichia coli by MALDI assay |
J Med Chem 55: 6639-43 (2012)
Article DOI: 10.1021/jm300677j BindingDB Entry DOI: 10.7270/Q2JH3N9S |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50395079
(CHEMBL2164244)Show InChI InChI=1S/C7H14N2O3/c1-9(2,3)8-6(10)4-5-7(11)12/h4-5H2,1-3H3,(H-,8,10,11,12)/p+1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of human FIH expressed in Escherichia coli by MALDI assay |
J Med Chem 55: 6639-43 (2012)
Article DOI: 10.1021/jm300677j BindingDB Entry DOI: 10.7270/Q2JH3N9S |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50395076
(CHEMBL2164243)Show InChI InChI=1S/C6H12N2O3/c1-8(2)7-5(9)3-4-6(10)11/h3-4H2,1-2H3,(H,7,9)(H,10,11) | PDB
UniProtKB/SwissProt
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Similars
| PDB Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of human FIH expressed in Escherichia coli by MALDI assay |
J Med Chem 55: 6639-43 (2012)
Article DOI: 10.1021/jm300677j BindingDB Entry DOI: 10.7270/Q2JH3N9S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50395080
(CHEMBL2164249)Show InChI InChI=1S/C6H11NO4/c1-7(2)11-6(10)4-3-5(8)9/h3-4H2,1-2H3,(H,8,9) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of human FIH expressed in Escherichia coli by MALDI assay |
J Med Chem 55: 6639-43 (2012)
Article DOI: 10.1021/jm300677j BindingDB Entry DOI: 10.7270/Q2JH3N9S |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50197063
(4,6-dioxoheptanoic acid | CHEMBL222824 | succinyla...)Show InChI InChI=1S/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11) | PDB
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of human FIH expressed in Escherichia coli by MALDI assay |
J Med Chem 55: 6639-43 (2012)
Article DOI: 10.1021/jm300677j BindingDB Entry DOI: 10.7270/Q2JH3N9S |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50395081
(CHEMBL2164248)Show InChI InChI=1S/C7H13NO3/c1-5(2)8-6(9)3-4-7(10)11/h5H,3-4H2,1-2H3,(H,8,9)(H,10,11) | PDB
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of human FIH expressed in Escherichia coli by MALDI assay |
J Med Chem 55: 6639-43 (2012)
Article DOI: 10.1021/jm300677j BindingDB Entry DOI: 10.7270/Q2JH3N9S |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50395082
(CHEMBL2164247)Show InChI InChI=1S/C7H14N2O3/c1-8(2)9(3)6(10)4-5-7(11)12/h4-5H2,1-3H3,(H,11,12) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of human FIH expressed in Escherichia coli by MALDI assay |
J Med Chem 55: 6639-43 (2012)
Article DOI: 10.1021/jm300677j BindingDB Entry DOI: 10.7270/Q2JH3N9S |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha inhibitor
(Homo sapiens (Human)) | BDBM50129197
(4-(Hydroxyamino)-4-oxobutanoic acid | CHEMBL51979 ...)Show InChI InChI=1S/C4H7NO4/c6-3(5-9)1-2-4(7)8/h9H,1-2H2,(H,5,6)(H,7,8) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of human FIH expressed in Escherichia coli by MALDI assay |
J Med Chem 55: 6639-43 (2012)
Article DOI: 10.1021/jm300677j BindingDB Entry DOI: 10.7270/Q2JH3N9S |
More data for this Ligand-Target Pair | |