Compile Data Set for Download or QSAR

Found 96 hits of ic50 data for polymerid = 9626   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM588052 ((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...) Show SMILES CN(C)[C@H]1CC[C@@H](CC1)[C@@]1(C)Oc2c(O1)c(C)c(cc2Cl)C(=O)NCc1c(C)cc(C)[nH]c1=O |r,wU:6.6,wD:9.10,3.2,(5.78,-4.8,;4.69,-5.89,;5.09,-7.38,;3.2,-5.49,;2.8,-4.01,;1.32,-3.61,;.23,-4.7,;.63,-6.18,;2.11,-6.58,;-1.26,-4.3,;-2.03,-5.63,;-2.79,-4.14,;-3.11,-2.63,;-1.78,-1.86,;-.63,-2.89,;-1.78,-.32,;-.44,.45,;-3.11,.45,;-4.45,-.32,;-4.45,-1.86,;-5.78,-2.63,;-3.11,1.99,;-4.45,2.76,;-1.78,2.76,;-1.78,4.3,;-.44,5.07,;-.44,6.61,;-1.78,7.38,;.89,7.38,;2.22,6.61,;3.56,7.38,;2.22,5.07,;.89,4.3,;.89,2.76,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE UniChem	Article PubMed	n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00047 BindingDB Entry DOI: 10.7270/Q27D3059
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50594132 (CHEMBL5197386) Show SMILES [H][C@@]1(CC[C@@H](CC1)N(C)C)[C@@]1(C)Oc2c(O1)c(C)c(cc2Br)C(=O)NCc1c(C)cc(C)[nH]c1=O |r,wU:4.7,1.0,wD:10.11,(3.73,.93,;5.06,.16,;6.39,-.61,;7.73,.16,;7.73,1.7,;6.39,2.47,;5.06,1.7,;9.06,2.47,;9.06,4.01,;10.4,1.7,;3.97,-.93,;5.31,-1.7,;3.07,-2.18,;1.6,-1.7,;1.6,-.16,;3.07,.32,;.27,.61,;.27,2.15,;-1.06,-.16,;-1.06,-1.71,;.28,-2.47,;.28,-4.01,;-2.4,.61,;-2.4,2.15,;-3.73,-.16,;-5.06,.6,;-6.4,-.17,;-6.4,-1.71,;-5.06,-2.48,;-7.73,-2.48,;-9.06,-1.71,;-10.4,-2.48,;-9.06,-.17,;-7.73,.6,;-7.73,2.14,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.470	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00047 BindingDB Entry DOI: 10.7270/Q27D3059
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50594116 (CHEMBL5185991) Show SMILES [H][C@@]1(CC[C@@H](CC1)N(C)C)C1(C)Oc2c(O1)c(Br)c1CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c1c2C |r,wU:4.7,1.0,(4.02,.48,;5.35,-.29,;6.84,-.69,;7.93,.4,;7.53,1.89,;6.04,2.28,;4.95,1.2,;8.62,2.97,;8.22,4.46,;10.11,2.58,;4.26,-1.38,;5.6,-2.15,;3.36,-.14,;1.89,-.61,;1.89,-2.15,;3.36,-2.63,;.57,-2.92,;.57,-4.46,;-.77,-2.16,;-2.11,-2.94,;-3.45,-2.16,;-3.44,-.62,;-4.77,.15,;-6.11,-.62,;-6.1,-2.16,;-4.77,-2.93,;-7.44,-2.93,;-8.77,-2.16,;-10.11,-2.93,;-8.77,-.62,;-7.44,.15,;-7.44,1.69,;-2.11,.15,;-2.11,1.69,;-.77,-.61,;.56,.16,;.56,1.7,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00047 BindingDB Entry DOI: 10.7270/Q27D3059
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM588043 ((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...) Show SMILES CN(C)[C@H]1CC[C@@H](CC1)[C@]1(C)Oc2c(O1)c(-c1ccco1)c1CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c1c2C |r,wU:9.10,3.2,wD:6.5,(10.11,2.58,;8.62,2.97,;8.22,4.46,;7.53,1.89,;7.93,.4,;6.84,-.69,;5.35,-.29,;4.96,1.19,;6.04,2.28,;4.26,-1.38,;5.35,-2.47,;3.36,-2.63,;1.9,-2.15,;1.9,-.61,;3.36,-.14,;.56,.16,;.56,1.7,;1.81,2.6,;1.33,4.07,;-.21,4.07,;-.68,2.6,;-.77,-.61,;-2.11,.16,;-3.44,-.61,;-3.44,-2.15,;-4.77,-2.92,;-6.11,-2.15,;-7.44,-2.92,;-7.44,-4.46,;-8.77,-2.15,;-8.77,-.61,;-10.11,.16,;-7.44,.16,;-6.11,-.61,;-4.77,.16,;-2.11,-2.92,;-2.11,-4.46,;-.77,-2.15,;.56,-2.92,;.56,-4.46,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	8.31	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6Q7J
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM588044 ((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...) Show SMILES CN(C)[C@H]1CC[C@@H](CC1)[C@]1(C)Oc2c(O1)c(-c1cccs1)c1CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c1c2C |r,wU:9.10,3.2,wD:6.5,(10.11,2.58,;8.62,2.97,;8.22,4.46,;7.53,1.89,;7.93,.4,;6.84,-.69,;5.35,-.29,;4.96,1.19,;6.04,2.28,;4.26,-1.38,;5.35,-2.47,;3.36,-2.63,;1.9,-2.15,;1.9,-.61,;3.36,-.14,;.56,.16,;.56,1.7,;1.81,2.6,;1.33,4.07,;-.21,4.07,;-.68,2.6,;-.77,-.61,;-2.11,.16,;-3.44,-.61,;-3.44,-2.15,;-4.77,-2.92,;-6.11,-2.15,;-7.44,-2.92,;-7.44,-4.46,;-8.77,-2.15,;-8.77,-.61,;-10.11,.16,;-7.44,.16,;-6.11,-.61,;-4.77,.16,;-2.11,-2.92,;-2.11,-4.46,;-.77,-2.15,;.56,-2.92,;.56,-4.46,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6Q7J
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM588042 (6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)me...) Show SMILES CN(C)C12CCC(CC1)(CC2)C1(C)Oc2c(O1)c(C)c1C(=O)N(Cc3c(C)cc(C)[nH]c3=O)CCc1c2C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6Q7J
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50075054 (CHEMBL3414574) Show SMILES CCC(CC)n1ccc2c(cc(cc12)C#N)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C23H26N4O2/c1-5-17(6-2)27-8-7-18-19(10-16(12-24)11-21(18)27)22(28)25-13-20-14(3)9-15(4)26-23(20)29/h7-11,17H,5-6,13H2,1-4H3,(H,25,28)(H,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00047 BindingDB Entry DOI: 10.7270/Q27D3059
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM588047 ((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...) Show SMILES CN(C)[C@H]1CC[C@@H](CC1)[C@]1(C)Oc2c(O1)c(-c1cccnc1)c1CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c1c2C |r,wU:9.10,3.2,wD:6.6,(10.3,1.64,;8.9,2.26,;8.74,3.8,;7.65,1.36,;7.81,-.17,;6.57,-1.08,;5.16,-.45,;5,1.08,;6.24,1.99,;4.07,-1.54,;5.16,-2.63,;3.16,-2.79,;1.7,-2.31,;1.7,-.77,;3.16,-.29,;.37,,;.37,1.54,;-.97,2.31,;-.97,3.85,;.37,4.62,;1.7,3.85,;1.7,2.31,;-.97,-.77,;-2.3,,;-3.63,-.77,;-3.63,-2.31,;-4.97,-3.08,;-6.3,-2.31,;-7.64,-3.08,;-7.64,-4.62,;-8.97,-2.31,;-8.97,-.77,;-10.3,,;-7.64,,;-6.3,-.77,;-4.97,,;-2.3,-3.08,;-2.3,-4.62,;-.97,-2.31,;.37,-3.08,;.37,-4.62,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6Q7J
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM588031 (9-chloro-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridi...) Show SMILES CN(C)C12CCC(CC1)(CC2)C1(C)Oc2c(O1)c(Cl)c1CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c1c2C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6Q7J
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM588041 (9-bromo-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin...) Show SMILES CN(C)C12CCC(CC1)(CC2)C1(C)Oc2c(O1)c(Br)c1CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c1c2C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6Q7J
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM588032 (9-chloro-2-(4- (dimethylamino)bicyclo[2.2.2]octan-...) Show SMILES COc1cc(C)[nH]c(=O)c1CN1CCc2c(Cl)c3OC(C)(Oc3c(C)c2C1=O)C12CCC(CC1)(CC2)N(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6Q7J
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM588050 ((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...) Show SMILES CN(C)[C@H]1CC[C@@H](CC1)[C@]1(C)Oc2c(O1)c(-c1cncs1)c1CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c1c2C |r,wU:9.10,3.2,wD:6.6,(10.3,1.99,;8.9,2.62,;8.74,4.15,;7.65,1.71,;7.81,.18,;6.57,-.72,;5.16,-.1,;5,1.44,;6.24,2.34,;4.07,-1.18,;5.16,-2.27,;3.16,-2.43,;1.7,-1.95,;1.7,-.41,;3.16,.06,;.37,.36,;.37,1.9,;1.61,2.8,;1.14,4.26,;-.4,4.26,;-.88,2.8,;-.97,-.41,;-2.3,.36,;-3.63,-.41,;-3.63,-1.95,;-4.97,-2.72,;-6.3,-1.95,;-7.64,-2.72,;-7.64,-4.26,;-8.97,-1.95,;-8.97,-.41,;-10.3,.36,;-7.64,.36,;-6.3,-.41,;-4.97,.36,;-2.3,-2.72,;-2.3,-4.26,;-.97,-1.95,;.37,-2.72,;.37,-4.26,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6Q7J
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM588048 ((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...) Show SMILES CN(C)[C@H]1CC[C@@H](CC1)[C@]1(C)Oc2c(O1)c(-c1cccn1C)c1CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c1c2C |r,wU:9.10,3.2,wD:6.6,(10.3,1.99,;8.9,2.62,;8.74,4.15,;7.65,1.71,;7.81,.18,;6.57,-.72,;5.16,-.1,;5,1.44,;6.24,2.34,;4.07,-1.18,;5.16,-2.27,;3.16,-2.43,;1.7,-1.95,;1.7,-.41,;3.16,.06,;.37,.36,;.37,1.9,;1.61,2.8,;1.14,4.26,;-.4,4.26,;-.88,2.8,;-2.34,2.32,;-.97,-.41,;-2.3,.36,;-3.63,-.41,;-3.63,-1.95,;-4.97,-2.72,;-6.3,-1.95,;-7.64,-2.72,;-7.64,-4.26,;-8.97,-1.95,;-8.97,-.41,;-10.3,.36,;-7.64,.36,;-6.3,-.41,;-4.97,.36,;-2.3,-2.72,;-2.3,-4.26,;-.97,-1.95,;.37,-2.72,;.37,-4.26,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6Q7J
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50590375 (CHEMBL5187396) Show SMILES CN(C)C1CCC(CC1)C1(C)Oc2c(O1)c(C)c(cc2Br)C(=O)NCc1c(C)cc(C)[nH]c1=O |(2.94,-8.67,;1.46,-8.27,;.37,-9.36,;1.06,-6.79,;2.15,-5.7,;1.75,-4.21,;.26,-3.81,;-.83,-4.9,;-.43,-6.39,;-.14,-2.32,;1.4,-2.32,;-1.67,-2.17,;-1.99,-.66,;-.66,.11,;.49,-.92,;-.66,1.66,;.67,2.43,;-2,2.43,;-3.34,1.66,;-3.34,.11,;-4.67,-.66,;-2,3.97,;-3.33,4.74,;-.66,4.74,;-.66,6.28,;.67,7.05,;.67,8.59,;-.66,9.36,;2,9.36,;3.34,8.59,;4.67,9.36,;3.34,7.05,;2,6.28,;2,4.74,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114419 BindingDB Entry DOI: 10.7270/Q2PR80Z0
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM588049 ((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...) Show SMILES CN(C)[C@H]1CC[C@@H](CC1)[C@]1(C)Oc2c(O1)c(-c1ccsc1)c1CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c1c2C |r,wU:9.10,3.2,wD:6.6,(10.3,1.99,;8.9,2.62,;8.74,4.15,;7.65,1.71,;7.81,.18,;6.57,-.72,;5.16,-.1,;5,1.44,;6.24,2.34,;4.07,-1.18,;5.16,-2.27,;3.16,-2.43,;1.7,-1.95,;1.7,-.41,;3.16,.06,;.37,.36,;.37,1.9,;1.61,2.8,;1.14,4.26,;-.4,4.26,;-.88,2.8,;-.97,-.41,;-2.3,.36,;-3.63,-.41,;-3.63,-1.95,;-4.97,-2.72,;-6.3,-1.95,;-7.64,-2.72,;-7.64,-4.26,;-8.97,-1.95,;-8.97,-.41,;-10.3,.36,;-7.64,.36,;-6.3,-.41,;-4.97,.36,;-2.3,-2.72,;-2.3,-4.26,;-.97,-1.95,;.37,-2.72,;.37,-4.26,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6Q7J
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM588046 ((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...) Show SMILES CN(C)[C@H]1CC[C@@H](CC1)[C@]1(C)Oc2c(O1)c(-c1ccc(C)o1)c1CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c1c2C |r,wU:9.10,3.2,wD:6.6,(10.3,1.37,;8.9,2,;8.74,3.53,;7.65,1.09,;7.81,-.44,;6.57,-1.35,;5.16,-.72,;5,.81,;6.24,1.72,;4.07,-1.81,;5.16,-2.9,;3.16,-3.05,;1.7,-2.58,;1.7,-1.04,;3.16,-.56,;.37,-.27,;.37,1.27,;1.61,2.18,;1.14,3.64,;-.4,3.64,;-1.31,4.89,;-.88,2.18,;-.97,-1.04,;-2.3,-.27,;-3.63,-1.04,;-3.63,-2.58,;-4.97,-3.35,;-6.3,-2.58,;-7.64,-3.35,;-7.64,-4.89,;-8.97,-2.58,;-8.97,-1.04,;-10.3,-.27,;-7.64,-.27,;-6.3,-1.04,;-4.97,-.27,;-2.3,-3.35,;-2.3,-4.89,;-.97,-2.58,;.37,-3.35,;.37,-4.89,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6Q7J
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50590376 (CHEMBL5193486) Show SMILES CN(C)C1CCC(CC1)C1(C)Oc2c(O1)c(C)c(cc2Cl)C(=O)NCc1c(C)cc(C)[nH]c1=O |(2.94,-8.67,;1.46,-8.27,;.37,-9.36,;1.06,-6.79,;2.15,-5.7,;1.75,-4.21,;.26,-3.81,;-.83,-4.9,;-.43,-6.39,;-.14,-2.32,;1.4,-2.32,;-1.67,-2.17,;-1.99,-.66,;-.66,.11,;.49,-.92,;-.66,1.66,;.67,2.43,;-2,2.43,;-3.34,1.66,;-3.34,.11,;-4.67,-.66,;-2,3.97,;-3.33,4.74,;-.66,4.74,;-.66,6.28,;.67,7.05,;.67,8.59,;-.66,9.36,;2,9.36,;3.34,8.59,;4.67,9.36,;3.34,7.05,;2,6.28,;2,4.74,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114419 BindingDB Entry DOI: 10.7270/Q2PR80Z0
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM588052 ((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...) Show SMILES CN(C)[C@H]1CC[C@@H](CC1)[C@@]1(C)Oc2c(O1)c(C)c(cc2Cl)C(=O)NCc1c(C)cc(C)[nH]c1=O |r,wU:6.6,wD:9.10,3.2,(5.78,-4.8,;4.69,-5.89,;5.09,-7.38,;3.2,-5.49,;2.8,-4.01,;1.32,-3.61,;.23,-4.7,;.63,-6.18,;2.11,-6.58,;-1.26,-4.3,;-2.03,-5.63,;-2.79,-4.14,;-3.11,-2.63,;-1.78,-1.86,;-.63,-2.89,;-1.78,-.32,;-.44,.45,;-3.11,.45,;-4.45,-.32,;-4.45,-1.86,;-5.78,-2.63,;-3.11,1.99,;-4.45,2.76,;-1.78,2.76,;-1.78,4.3,;-.44,5.07,;-.44,6.61,;-1.78,7.38,;.89,7.38,;2.22,6.61,;3.56,7.38,;2.22,5.07,;.89,4.3,;.89,2.76,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE UniChem	US Patent	n/a	n/a	31.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6Q7J
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM588045 ((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...) Show SMILES CN(C)[C@H]1CC[C@@H](CC1)[C@]1(C)Oc2c(O1)c(-c1ccncc1)c1CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c1c2C |r,wU:9.10,3.2,wD:6.6,(10.3,1.64,;8.9,2.26,;8.74,3.8,;7.65,1.36,;7.81,-.17,;6.57,-1.08,;5.16,-.45,;5,1.08,;6.24,1.99,;4.07,-1.54,;5.16,-2.63,;3.16,-2.79,;1.7,-2.31,;1.7,-.77,;3.16,-.29,;.37,,;.37,1.54,;1.7,2.31,;1.7,3.85,;.37,4.62,;-.97,3.85,;-.97,2.31,;-.97,-.77,;-2.3,,;-3.63,-.77,;-3.63,-2.31,;-4.97,-3.08,;-6.3,-2.31,;-7.64,-3.08,;-7.64,-4.62,;-8.97,-2.31,;-8.97,-.77,;-10.3,,;-7.64,,;-6.3,-.77,;-4.97,,;-2.3,-3.08,;-2.3,-4.62,;-.97,-2.31,;.37,-3.08,;.37,-4.62,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6Q7J
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50594130 (CHEMBL5196227) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2N(NCc12)C(C)C)-c1ccc(nc1)N1CCN(CC1)C(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00047 BindingDB Entry DOI: 10.7270/Q27D3059
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50075051 (CHEMBL3360855 | EPZ005687 | US10273223, Compound C...) Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)-c2ccc(CN3CCOCC3)cc2)c(=O)[nH]1 Show InChI InChI=1S/C32H37N5O3/c1-21-15-22(2)35-32(39)28(21)18-33-31(38)27-16-25(17-30-29(27)19-34-37(30)26-5-3-4-6-26)24-9-7-23(8-10-24)20-36-11-13-40-14-12-36/h7-10,15-17,19,26H,3-6,11-14,18,20H2,1-2H3,(H,33,38)(H,35,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of EZH1 in PRC2 complex (unknown origin) using biotinylated peptide as substrate in presence of S-adenosylmethionine				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01344 BindingDB Entry DOI: 10.7270/Q23R0XMC
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50541920 (Cpi-1205 | Lirametostat) Show SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCN(CC(F)(F)F)CC2)c2ccccc12 Show InChI InChI=1S/C27H33F3N4O3/c1-16-13-23(37-4)21(25(35)32-16)14-31-26(36)24-18(3)34(22-8-6-5-7-20(22)24)17(2)19-9-11-33(12-10-19)15-27(28,29)30/h5-8,13,17,19H,9-12,14-15H2,1-4H3,(H,31,36)(H,32,35)/t17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of EZH1 (unknown origin)				Citation and Details BindingDB Entry DOI: 10.7270/Q2QZ2FQB
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536604 (CHEMBL4594174) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccc(nc1)N1CCNCC1 Show InChI InChI=1S/C30H37N7O2/c1-5-6-21-13-20(4)35-30(39)25(21)17-33-29(38)24-14-23(15-27-26(24)18-34-37(27)19(2)3)22-7-8-28(32-16-22)36-11-9-31-10-12-36/h7-8,13-16,18-19,31H,5-6,9-12,17H2,1-4H3,(H,33,38)(H,35,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50075071 (CHEMBL3414619) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccc(nc1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C33H43N7O2/c1-7-8-24-15-23(6)37-33(42)28(24)19-35-32(41)27-16-26(17-30-29(27)20-36-40(30)22(4)5)25-9-10-31(34-18-25)39-13-11-38(12-14-39)21(2)3/h9-10,15-18,20-22H,7-8,11-14,19H2,1-6H3,(H,35,41)(H,37,42)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50594155 (CHEMBL5203667) Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c3CCCCc3c(C)[nH]c2=O)c1C)-c1ccc(cc1)N1CCN(C)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00047 BindingDB Entry DOI: 10.7270/Q27D3059
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50544756 (CHEMBL4637350) Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c3CCCCc3c(C)[nH]c2=O)c1C)-c1ccc(CN2CCN(C)CC2)cc1 Show InChI InChI=1S/C38H51N5O3/c1-5-43(31-14-20-46-21-15-31)36-23-30(29-12-10-28(11-13-29)25-42-18-16-41(4)17-19-42)22-34(26(36)2)37(44)39-24-35-33-9-7-6-8-32(33)27(3)40-38(35)45/h10-13,22-23,31H,5-9,14-21,24-25H2,1-4H3,(H,39,44)(H,40,45)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00047 BindingDB Entry DOI: 10.7270/Q27D3059
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536560 (CHEMBL4567859) Show SMILES CC(C)N1CCN(CC1)c1ccc(cn1)-c1cc(C(=O)NCc2c(cc(C)[nH]c2=O)C2CCCC2)c2cnn(C(C)C)c2c1 Show InChI InChI=1S/C35H45N7O2/c1-22(2)40-12-14-41(15-13-40)33-11-10-26(19-36-33)27-17-29(30-21-38-42(23(3)4)32(30)18-27)34(43)37-20-31-28(25-8-6-7-9-25)16-24(5)39-35(31)44/h10-11,16-19,21-23,25H,6-9,12-15,20H2,1-5H3,(H,37,43)(H,39,44)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536579 (CHEMBL4557033) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccc(nc1)N1CCN(CC)CC1 Show InChI InChI=1S/C32H41N7O2/c1-6-8-23-15-22(5)36-32(41)27(23)19-34-31(40)26-16-25(17-29-28(26)20-35-39(29)21(3)4)24-9-10-30(33-18-24)38-13-11-37(7-2)12-14-38/h9-10,15-18,20-21H,6-8,11-14,19H2,1-5H3,(H,34,40)(H,36,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50590382 (CHEMBL5197902) Show SMILES CCN1CCN(CC1)c1ccc(cn1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c(C)c2O[C@@](C)(CN3CCOCC3)Oc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	91	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00047 BindingDB Entry DOI: 10.7270/Q27D3059
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536573 (CHEMBL4559875) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C1CCCC1)-c1ccc(nc1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C35H45N7O2/c1-5-8-25-17-24(4)39-35(44)30(25)21-37-34(43)29-18-27(19-32-31(29)22-38-42(32)28-9-6-7-10-28)26-11-12-33(36-20-26)41-15-13-40(14-16-41)23(2)3/h11-12,17-20,22-23,28H,5-10,13-16,21H2,1-4H3,(H,37,43)(H,39,44)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	108	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536589 (CHEMBL4545986) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(CC)CC)-c1ccc(nc1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C35H47N7O2/c1-7-10-25-17-24(6)39-35(44)30(25)21-37-34(43)29-18-27(19-32-31(29)22-38-42(32)28(8-2)9-3)26-11-12-33(36-20-26)41-15-13-40(14-16-41)23(4)5/h11-12,17-20,22-23,28H,7-10,13-16,21H2,1-6H3,(H,37,43)(H,39,44)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536572 (CHEMBL4539055) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)(C)C)-c1ccc(nc1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C34H45N7O2/c1-8-9-24-16-23(4)38-33(43)28(24)20-36-32(42)27-17-26(18-30-29(27)21-37-41(30)34(5,6)7)25-10-11-31(35-19-25)40-14-12-39(13-15-40)22(2)3/h10-11,16-19,21-22H,8-9,12-15,20H2,1-7H3,(H,36,42)(H,38,43)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	127	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50594154 (CHEMBL5178720) Show SMILES CCN(C1CCCCC1)c1cc(cc(C(=O)NCc2c3CCCCc3c(C)[nH]c2=O)c1C)-c1ccc(CN2CCN(C)CC2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00047 BindingDB Entry DOI: 10.7270/Q27D3059
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM172038 (US10155002, Compound 44 | US10647700, Compound EPZ...) Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6Q7J
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536585 (CHEMBL4554286) Show SMILES CCCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccc(nc1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C34H45N7O2/c1-7-8-9-25-16-24(6)38-34(43)29(25)20-36-33(42)28-17-27(18-31-30(28)21-37-41(31)23(4)5)26-10-11-32(35-19-26)40-14-12-39(13-15-40)22(2)3/h10-11,16-19,21-23H,7-9,12-15,20H2,1-6H3,(H,36,42)(H,38,43)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM588033 (9-chloro-2-(4- (dimethylamino)bicyclo[2.2.2]octan-...) Show SMILES CSc1cc(C)[nH]c(=O)c1CN1CCc2c(Cl)c3OC(C)(Oc3c(C)c2C1=O)C12CCC(CC1)(CC2)N(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	167	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6Q7J
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50582389 (CHEMBL5089835) Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCN(CCCCCCCOc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)CC2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	179	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant full length human N-terminal FLAG-tagged EZH1 in PRC2 complex expressed in baculovirus system using SAM as substrate preinc...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02234 BindingDB Entry DOI: 10.7270/Q22V2M02
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536598 (CHEMBL4551319) Show SMILES CC(C)Cc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccc(nc1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C34H45N7O2/c1-21(2)14-27-15-24(7)38-34(43)29(27)19-36-33(42)28-16-26(17-31-30(28)20-37-41(31)23(5)6)25-8-9-32(35-18-25)40-12-10-39(11-13-40)22(3)4/h8-9,15-18,20-23H,10-14,19H2,1-7H3,(H,36,42)(H,38,43)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	211	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536574 (CHEMBL4521710) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C1CCCCC1)-c1ccc(nc1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C36H47N7O2/c1-5-9-26-18-25(4)40-36(45)31(26)22-38-35(44)30-19-28(20-33-32(30)23-39-43(33)29-10-7-6-8-11-29)27-12-13-34(37-21-27)42-16-14-41(15-17-42)24(2)3/h12-13,18-21,23-24,29H,5-11,14-17,22H2,1-4H3,(H,38,44)(H,40,45)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	315	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536563 (CHEMBL4559801) Show SMILES CC(C)N1CCN(CC1)c1ccc(cn1)-c1cc(C(=O)NCc2c(cc(C)[nH]c2=O)C(C)C)c2cnn(C(C)C)c2c1 Show InChI InChI=1S/C33H43N7O2/c1-20(2)26-14-23(7)37-33(42)29(26)18-35-32(41)27-15-25(16-30-28(27)19-36-40(30)22(5)6)24-8-9-31(34-17-24)39-12-10-38(11-13-39)21(3)4/h8-9,14-17,19-22H,10-13,18H2,1-7H3,(H,35,41)(H,37,42)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536578 (CHEMBL4529085) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(CCCCCCO)ncc12)-c1ccc(nc1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C36H49N7O3/c1-5-10-27-19-26(4)40-36(46)31(27)23-38-35(45)30-20-29(21-33-32(30)24-39-43(33)13-8-6-7-9-18-44)28-11-12-34(37-22-28)42-16-14-41(15-17-42)25(2)3/h11-12,19-22,24-25,44H,5-10,13-18,23H2,1-4H3,(H,38,45)(H,40,46)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	394	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536593 (CHEMBL4569399) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)C1CCNCC1 Show InChI InChI=1S/C26H35N5O2/c1-5-6-19-11-17(4)30-26(33)22(19)14-28-25(32)21-12-20(18-7-9-27-10-8-18)13-24-23(21)15-29-31(24)16(2)3/h11-13,15-16,18,27H,5-10,14H2,1-4H3,(H,28,32)(H,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	613	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536562 (CHEMBL4542135) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccccn1 Show InChI InChI=1S/C26H29N5O2/c1-5-8-18-11-17(4)30-26(33)21(18)14-28-25(32)20-12-19(23-9-6-7-10-27-23)13-24-22(20)15-29-31(24)16(2)3/h6-7,9-13,15-16H,5,8,14H2,1-4H3,(H,28,32)(H,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	681	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536581 (CHEMBL4593352) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccc(F)cn1 Show InChI InChI=1S/C26H28FN5O2/c1-5-6-17-9-16(4)31-26(34)21(17)13-29-25(33)20-10-18(23-8-7-19(27)12-28-23)11-24-22(20)14-30-32(24)15(2)3/h7-12,14-15H,5-6,13H2,1-4H3,(H,29,33)(H,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	773	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536584 (CHEMBL4544978) Show SMILES CCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccc(nc1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C32H41N7O2/c1-7-23-14-22(6)36-32(41)27(23)18-34-31(40)26-15-25(16-29-28(26)19-35-39(29)21(4)5)24-8-9-30(33-17-24)38-12-10-37(11-13-38)20(2)3/h8-9,14-17,19-21H,7,10-13,18H2,1-6H3,(H,34,40)(H,36,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536582 (CHEMBL4575460) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)N1CCNCC1 Show InChI InChI=1S/C25H34N6O2/c1-5-6-18-11-17(4)29-25(33)21(18)14-27-24(32)20-12-19(30-9-7-26-8-10-30)13-23-22(20)15-28-31(23)16(2)3/h11-13,15-16,26H,5-10,14H2,1-4H3,(H,27,32)(H,29,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	880	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536554 (CHEMBL4535507) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccccc1 Show InChI InChI=1S/C27H30N4O2/c1-5-9-20-12-18(4)30-27(33)23(20)15-28-26(32)22-13-21(19-10-7-6-8-11-19)14-25-24(22)16-29-31(25)17(2)3/h6-8,10-14,16-17H,5,9,15H2,1-4H3,(H,28,32)(H,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536580 (CHEMBL4566302) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C28H29F3N4O2/c1-5-6-19-11-17(4)34-27(37)23(19)14-32-26(36)22-12-20(13-25-24(22)15-33-35(25)16(2)3)18-7-9-21(10-8-18)28(29,30)31/h7-13,15-16H,5-6,14H2,1-4H3,(H,32,36)(H,34,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536595 (CHEMBL4535178) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(NC2CCNCC2)cc2n(ncc12)C(C)C Show InChI InChI=1S/C26H36N6O2/c1-5-6-18-11-17(4)30-26(34)22(18)14-28-25(33)21-12-20(31-19-7-9-27-10-8-19)13-24-23(21)15-29-32(24)16(2)3/h11-13,15-16,19,27,31H,5-10,14H2,1-4H3,(H,28,33)(H,30,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH1 (Homo sapiens (Human))	BDBM50536596 (CHEMBL4534613) Show SMILES CCC(C)c1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C(C)C)-c2ccc(nc2)N2CCN(CC2)C(C)C)c(=O)[nH]1 Show InChI InChI=1S/C34H45N7O2/c1-8-23(6)30-15-24(7)28(34(43)38-30)19-36-33(42)27-16-26(17-31-29(27)20-37-41(31)22(4)5)25-9-10-32(35-18-25)40-13-11-39(12-14-40)21(2)3/h9-10,15-18,20-23H,8,11-14,19H2,1-7H3,(H,36,42)(H,38,43)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...				J Med Chem 59: 7617-33 (2016) Article DOI: 10.1021/acs.jmedchem.6b00855 BindingDB Entry DOI: 10.7270/Q2JW8JC4
					More data for this Ligand-Target Pair

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