Found 869 hits of ic50 for UniProtKB: Q96KQ7 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50281305
(CHEMBL4162206)Show SMILES COc1cc2c(NC3CCN(CC3)C(C)C)cc(nc2cc1OCCCN1CCCC1)C1CCCCC1 Show InChI InChI=1S/C31H48N4O2/c1-23(2)35-17-12-25(13-18-35)32-28-21-27(24-10-5-4-6-11-24)33-29-22-31(30(36-3)20-26(28)29)37-19-9-16-34-14-7-8-15-34/h20-25H,4-19H2,1-3H3,(H,32,33) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Oviedo-Principado de Asturias
Curated by ChEMBL
| Assay Description
Non-competitive inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of 2 to 640 uM SAM by TR-FRET assay |
J Med Chem 61: 6518-6545 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01926
BindingDB Entry DOI: 10.7270/Q23X895V |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50281300
(CHEMBL4170225)Show SMILES COc1cc2c(NC3CCN(C)CC3)cc(nc2cc1OCCCN1CCCC1)-c1ccc(C)[nH]1 Show InChI InChI=1S/C28H39N5O2/c1-20-7-8-23(29-20)26-18-24(30-21-9-14-32(2)15-10-21)22-17-27(34-3)28(19-25(22)31-26)35-16-6-13-33-11-4-5-12-33/h7-8,17-19,21,29H,4-6,9-16H2,1-3H3,(H,30,31) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Oviedo-Principado de Asturias
Curated by ChEMBL
| Assay Description
Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assay |
J Med Chem 61: 6518-6545 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01926
BindingDB Entry DOI: 10.7270/Q23X895V |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50281305
(CHEMBL4162206)Show SMILES COc1cc2c(NC3CCN(CC3)C(C)C)cc(nc2cc1OCCCN1CCCC1)C1CCCCC1 Show InChI InChI=1S/C31H48N4O2/c1-23(2)35-17-12-25(13-18-35)32-28-21-27(24-10-5-4-6-11-24)33-29-22-31(30(36-3)20-26(28)29)37-19-9-16-34-14-7-8-15-34/h20-25H,4-19H2,1-3H3,(H,32,33) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Oviedo-Principado de Asturias
Curated by ChEMBL
| Assay Description
Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assay |
J Med Chem 61: 6518-6545 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01926
BindingDB Entry DOI: 10.7270/Q23X895V |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50281305
(CHEMBL4162206)Show SMILES COc1cc2c(NC3CCN(CC3)C(C)C)cc(nc2cc1OCCCN1CCCC1)C1CCCCC1 Show InChI InChI=1S/C31H48N4O2/c1-23(2)35-17-12-25(13-18-35)32-28-21-27(24-10-5-4-6-11-24)33-29-22-31(30(36-3)20-26(28)29)37-19-9-16-34-14-7-8-15-34/h20-25H,4-19H2,1-3H3,(H,32,33) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Oviedo-Principado de Asturias
Curated by ChEMBL
| Assay Description
Competitive inhibition of human G9a using 40 to 2560 nM biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assay |
J Med Chem 61: 6518-6545 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01926
BindingDB Entry DOI: 10.7270/Q23X895V |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50446378
(CHEMBL3109639)Show SMILES COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C2(C)C |t:19| Show InChI InChI=1S/C18H27N3O2/c1-18(2)13-11-15(22-3)16(12-14(13)20-17(18)19)23-10-6-9-21-7-4-5-8-21/h11-12H,4-10H2,1-3H3,(H2,19,20) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc.
Curated by ChEMBL
| Assay Description
Inhibition of G9a (unknown origin) using biotinylated-histone H3(1-21) peptide as substrate after 3 hrs by AlphaLISA assay |
ACS Med Chem Lett 5: 205-9 (2014)
Article DOI: 10.1021/ml400496h
BindingDB Entry DOI: 10.7270/Q2FT8NJ0 |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50446386
(CHEMBL3109631)Show SMILES COc1cc2c(cc1OCC1CCN(C)C1)N=C(N)C21CCC1 |t:18| Show InChI InChI=1S/C18H25N3O2/c1-21-7-4-12(10-21)11-23-16-9-14-13(8-15(16)22-2)18(5-3-6-18)17(19)20-14/h8-9,12H,3-7,10-11H2,1-2H3,(H2,19,20) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc.
Curated by ChEMBL
| Assay Description
Inhibition of G9a (unknown origin) using biotinylated-histone H3(1-21) peptide as substrate after 3 hrs by AlphaLISA assay |
ACS Med Chem Lett 5: 205-9 (2014)
Article DOI: 10.1021/ml400496h
BindingDB Entry DOI: 10.7270/Q2FT8NJ0 |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50592391
(CHEMBL5187766) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128858
BindingDB Entry DOI: 10.7270/Q2RX9H28 |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50281304
(CHEMBL4160008)Show SMILES CCc1ccc(o1)-c1cc(NC2CCN(C)CC2)c2cc(OC)c(OCCCN3CCCC3)cc2n1 Show InChI InChI=1S/C29H40N4O3/c1-4-22-8-9-27(36-22)26-19-24(30-21-10-15-32(2)16-11-21)23-18-28(34-3)29(20-25(23)31-26)35-17-7-14-33-12-5-6-13-33/h8-9,18-21H,4-7,10-17H2,1-3H3,(H,30,31) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
WuXi Apptec (Tianjin) Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assay |
J Med Chem 61: 6546-6573 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01925
BindingDB Entry DOI: 10.7270/Q2BP05CM |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50281311
(CHEMBL4159604)Show SMILES COc1cc2c(NC3CCN(C)CC3)cc(nc2cc1OCCCN1CCCC1)C1CCCCC1 Show InChI InChI=1S/C29H44N4O2/c1-32-16-11-23(12-17-32)30-26-20-25(22-9-4-3-5-10-22)31-27-21-29(28(34-2)19-24(26)27)35-18-8-15-33-13-6-7-14-33/h19-23H,3-18H2,1-2H3,(H,30,31) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Oviedo-Principado de Asturias
Curated by ChEMBL
| Assay Description
Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assay |
J Med Chem 61: 6518-6545 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01926
BindingDB Entry DOI: 10.7270/Q23X895V |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50281304
(CHEMBL4160008)Show SMILES CCc1ccc(o1)-c1cc(NC2CCN(C)CC2)c2cc(OC)c(OCCCN3CCCC3)cc2n1 Show InChI InChI=1S/C29H40N4O3/c1-4-22-8-9-27(36-22)26-19-24(30-21-10-15-32(2)16-11-21)23-18-28(34-3)29(20-25(23)31-26)35-17-7-14-33-12-5-6-13-33/h8-9,18-21H,4-7,10-17H2,1-3H3,(H,30,31) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Oviedo-Principado de Asturias
Curated by ChEMBL
| Assay Description
Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assay |
J Med Chem 61: 6518-6545 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01926
BindingDB Entry DOI: 10.7270/Q23X895V |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50353121
(CHEMBL1829295)Show SMILES COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN1CCCC1)N1CCCN(CC1)C(C)C Show InChI InChI=1S/C32H53N7O2/c1-24(2)37-15-8-16-39(20-19-37)32-34-28-23-30(41-21-9-14-36-12-6-7-13-36)29(40-5)22-27(28)31(35-32)33-26-10-17-38(18-11-26)25(3)4/h22-26H,6-21H2,1-5H3,(H,33,34,35) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina at Chapel Hill
Curated by ChEMBL
| Assay Description
Inhibition of G9a assessed as hydrolysis of S-adenosyl-L-homocysteine after 2 mins by SAHH-coupled fluorescence assay |
J Med Chem 54: 6139-50 (2011)
Article DOI: 10.1021/jm200903z
BindingDB Entry DOI: 10.7270/Q237793P |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50592384
(CHEMBL5195846) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128858
BindingDB Entry DOI: 10.7270/Q2RX9H28 |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50353128
(CHEMBL1231795)Show SMILES COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN1CCCC1)C1CCCCC1 Show InChI InChI=1S/C30H47N5O2/c1-22(2)35-17-12-24(13-18-35)31-30-25-20-27(36-3)28(37-19-9-16-34-14-7-8-15-34)21-26(25)32-29(33-30)23-10-5-4-6-11-23/h20-24H,4-19H2,1-3H3,(H,31,32,33) | PDB
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MMDB
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| PDB
Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of G9a (unknown origin) using [histone H3 1 to 25 residues] and SAM substrate by scintillation proximity assay |
Medchemcomm 5: 1821-1828 (2014)
Article DOI: 10.1039/c4md00274a
BindingDB Entry DOI: 10.7270/Q2V127VK |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50442103
(CHEMBL2441082)Show SMILES COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN1CCCC1)N1CCC(F)(F)CC1 Show InChI InChI=1S/C29H44F2N6O2/c1-21(2)36-14-7-22(8-15-36)32-27-23-19-25(38-3)26(39-18-6-13-35-11-4-5-12-35)20-24(23)33-28(34-27)37-16-9-29(30,31)10-17-37/h19-22H,4-18H2,1-3H3,(H,32,33,34) | PDB
UniProtKB/SwissProt
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MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of G9a (unknown origin) |
Bioorg Med Chem 24: 6102-6108 (2016)
Article DOI: 10.1016/j.bmc.2016.09.071
BindingDB Entry DOI: 10.7270/Q29C70D7 |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50442103
(CHEMBL2441082)Show SMILES COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN1CCCC1)N1CCC(F)(F)CC1 Show InChI InChI=1S/C29H44F2N6O2/c1-21(2)36-14-7-22(8-15-36)32-27-23-19-25(38-3)26(39-18-6-13-35-11-4-5-12-35)20-24(23)33-28(34-27)37-16-9-29(30,31)10-17-37/h19-22H,4-18H2,1-3H3,(H,32,33,34) | PDB
UniProtKB/SwissProt
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CHEMBL
MCE
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | <2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Oviedo-Principado de Asturias
Curated by ChEMBL
| Assay Description
Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assay |
J Med Chem 61: 6518-6545 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01926
BindingDB Entry DOI: 10.7270/Q23X895V |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50446376
(CHEMBL3109630)Show SMILES COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCC1 |t:19| Show InChI InChI=1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21) | PDB
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| PDB
Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128858
BindingDB Entry DOI: 10.7270/Q2RX9H28 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50446376
(CHEMBL3109630)Show SMILES COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCC1 |t:19| Show InChI InChI=1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21) | PDB
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| PDB
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PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
| Assay Description
Inhibition of G9a (unknown origin) |
J Med Chem 62: 8996-9007 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00522
BindingDB Entry DOI: 10.7270/Q2JM2F0X |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50281303
(CHEMBL4171233)Show SMILES COc1cc2c(NC3CCN(CC3)C(C)C)cc(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1 Show InChI InChI=1S/C30H42N4O3/c1-21(2)34-15-10-23(11-16-34)31-25-19-27(28-9-8-22(3)37-28)32-26-20-30(29(35-4)18-24(25)26)36-17-7-14-33-12-5-6-13-33/h8-9,18-21,23H,5-7,10-17H2,1-4H3,(H,31,32) | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Oviedo-Principado de Asturias
Curated by ChEMBL
| Assay Description
Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assay |
J Med Chem 61: 6518-6545 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01926
BindingDB Entry DOI: 10.7270/Q23X895V |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50446376
(CHEMBL3109630)Show SMILES COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCC1 |t:19| Show InChI InChI=1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21) | PDB
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| PDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc.
Curated by ChEMBL
| Assay Description
Inhibition of G9a (unknown origin)-mediated incorporation of methyl group from [3H]-SAM into peptide substrate by scintillation proximity assay |
ACS Med Chem Lett 5: 205-9 (2014)
Article DOI: 10.1021/ml400496h
BindingDB Entry DOI: 10.7270/Q2FT8NJ0 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50442106
(CHEMBL2441078)Show SMILES COc1cc2c(NC3CCN(CC3)C3CC3)nc(nc2cc1OCCCN1CCCC1)N1CCC(F)(F)CC1 Show InChI InChI=1S/C29H42F2N6O2/c1-38-25-19-23-24(20-26(25)39-18-4-13-35-11-2-3-12-35)33-28(37-16-9-29(30,31)10-17-37)34-27(23)32-21-7-14-36(15-8-21)22-5-6-22/h19-22H,2-18H2,1H3,(H,32,33,34) | PDB
UniProtKB/SwissProt
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| CHEMBL
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UniChem
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina at Chapel Hill
Curated by ChEMBL
| Assay Description
Inhibition of lysine methyltransferase G9a (unknown origin) using [3H]-SAM as substrate after 0.25 hrs by scintillation proximity assay |
J Med Chem 56: 8931-42 (2013)
Article DOI: 10.1021/jm401480r
BindingDB Entry DOI: 10.7270/Q2NZ892T |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50281296
(CHEMBL4173626)Show SMILES CCc1ccc(o1)-c1cc(NC2CCN(CC2)C(C)C)c2cc(OC)c(OCCCN3CCCC3)cc2n1 Show InChI InChI=1S/C31H44N4O3/c1-5-24-9-10-29(38-24)28-20-26(32-23-11-16-35(17-12-23)22(2)3)25-19-30(36-4)31(21-27(25)33-28)37-18-8-15-34-13-6-7-14-34/h9-10,19-23H,5-8,11-18H2,1-4H3,(H,32,33) | PDB
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Universidad de Oviedo-Principado de Asturias
Curated by ChEMBL
| Assay Description
Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assay |
J Med Chem 61: 6518-6545 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01926
BindingDB Entry DOI: 10.7270/Q23X895V |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50446376
(CHEMBL3109630)Show SMILES COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCC1 |t:19| Show InChI InChI=1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21) | PDB
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CNRS-Pierre Fabre
Curated by ChEMBL
| Assay Description
Inhibition of G9a (unknown origin) |
J Med Chem 58: 2569-83 (2015)
Article DOI: 10.1021/jm500843d
BindingDB Entry DOI: 10.7270/Q24T6M36 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50446376
(CHEMBL3109630)Show SMILES COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCC1 |t:19| Show InChI InChI=1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21) | PDB
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China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of G9a (unknown origin) |
Bioorg Med Chem 24: 6102-6108 (2016)
Article DOI: 10.1016/j.bmc.2016.09.071
BindingDB Entry DOI: 10.7270/Q29C70D7 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50446376
(CHEMBL3109630)Show SMILES COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCC1 |t:19| Show InChI InChI=1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21) | PDB
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AbbVie Inc.
Curated by ChEMBL
| Assay Description
Inhibition of G9a (unknown origin) using biotinylated-histone H3(1-21) peptide as substrate after 3 hrs by AlphaLISA assay |
ACS Med Chem Lett 5: 205-9 (2014)
Article DOI: 10.1021/ml400496h
BindingDB Entry DOI: 10.7270/Q2FT8NJ0 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50560578
(CHEMBL4795328)Show SMILES CNc1cc(C)nc(Nc2ccc(OC(F)F)c(c2)C2=CCNCCC2)n1 |t:20| | PDB
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TBA
| Assay Description
Inhibition G9a (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127475
BindingDB Entry DOI: 10.7270/Q24F1VFW |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50446380
(CHEMBL3109637)Show SMILES COc1cc2c(cc1OCCCN1CC[C@@H](F)C1)N=C(N)C21CCC1 |r,t:20| Show InChI InChI=1S/C19H26FN3O2/c1-24-16-10-14-15(22-18(21)19(14)5-2-6-19)11-17(16)25-9-3-7-23-8-4-13(20)12-23/h10-11,13H,2-9,12H2,1H3,(H2,21,22)/t13-/m1/s1 | PDB
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AbbVie Inc.
Curated by ChEMBL
| Assay Description
Inhibition of G9a (unknown origin) using biotinylated-histone H3(1-21) peptide as substrate after 3 hrs by AlphaLISA assay |
ACS Med Chem Lett 5: 205-9 (2014)
Article DOI: 10.1021/ml400496h
BindingDB Entry DOI: 10.7270/Q2FT8NJ0 |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50353132
(CHEMBL1829305)Show SMILES COc1cc2c(NC3CCN(CC4CCCCC4)CC3)nc(nc2cc1OCCCN1CCCCC1)N1CCCN(CC1)C(C)C Show InChI InChI=1S/C37H61N7O2/c1-29(2)43-19-10-20-44(24-23-43)37-39-33-27-35(46-25-11-18-41-16-8-5-9-17-41)34(45-3)26-32(33)36(40-37)38-31-14-21-42(22-15-31)28-30-12-6-4-7-13-30/h26-27,29-31H,4-25,28H2,1-3H3,(H,38,39,40) | PDB
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University of North Carolina at Chapel Hill
Curated by ChEMBL
| Assay Description
Inhibition of G9a assessed as hydrolysis of S-adenosyl-L-homocysteine after 2 mins by SAHH-coupled fluorescence assay |
J Med Chem 54: 6139-50 (2011)
Article DOI: 10.1021/jm200903z
BindingDB Entry DOI: 10.7270/Q237793P |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50442105
(CHEMBL2441077)Show SMILES COc1cc2c(NC3CCN(CC3)C3CC3)nc(nc2cc1OCCCN1CCCC1)N1CCS(=O)(=O)CC1 Show InChI InChI=1S/C28H42N6O4S/c1-37-25-19-23-24(20-26(25)38-16-4-11-32-9-2-3-10-32)30-28(34-14-17-39(35,36)18-15-34)31-27(23)29-21-7-12-33(13-8-21)22-5-6-22/h19-22H,2-18H2,1H3,(H,29,30,31) | PDB
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University of North Carolina at Chapel Hill
Curated by ChEMBL
| Assay Description
Inhibition of lysine methyltransferase G9a (unknown origin) using [3H]-SAM as substrate after 0.25 hrs by scintillation proximity assay |
J Med Chem 56: 8931-42 (2013)
Article DOI: 10.1021/jm401480r
BindingDB Entry DOI: 10.7270/Q2NZ892T |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50575621
(CHEMBL4865830)Show SMILES COc1cc2c(NCC3CCN(CC3)c3ncc(cn3)C(=O)NO)cc(C)nc2cc1OCCCN1CCCC1 | PDB
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TBA
| Assay Description
Inhibition of human G9a enzyme using histone monomethyl-H3K9 peptide as substrate incubated for 1 hr in presence of SAM by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02255
BindingDB Entry DOI: 10.7270/Q2JS9V8V |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50353132
(CHEMBL1829305)Show SMILES COc1cc2c(NC3CCN(CC4CCCCC4)CC3)nc(nc2cc1OCCCN1CCCCC1)N1CCCN(CC1)C(C)C Show InChI InChI=1S/C37H61N7O2/c1-29(2)43-19-10-20-44(24-23-43)37-39-33-27-35(46-25-11-18-41-16-8-5-9-17-41)34(45-3)26-32(33)36(40-37)38-31-14-21-42(22-15-31)28-30-12-6-4-7-13-30/h26-27,29-31H,4-25,28H2,1-3H3,(H,38,39,40) | PDB
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University of North Carolina at Chapel Hill
Curated by ChEMBL
| Assay Description
Inhibition of G9a assessed as hydrolysis of S-adenosyl-L-homocysteine after 2 mins by SAHH-coupled fluorescence assay |
J Med Chem 54: 6139-50 (2011)
Article DOI: 10.1021/jm200903z
BindingDB Entry DOI: 10.7270/Q237793P |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50560569
(CHEMBL4741874)Show SMILES CNc1cc(C)nc(Nc2ccc(OC)c(c2)C2=CCNCCC2)n1 |t:18| | PDB
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| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition G9a (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127475
BindingDB Entry DOI: 10.7270/Q24F1VFW |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50446383
(CHEMBL3109634)Show SMILES COc1cc2c(cc1OCCCN1CC(F)C1)N=C(N)C21CCC1 |t:19| Show InChI InChI=1S/C18H24FN3O2/c1-23-15-8-13-14(21-17(20)18(13)4-2-5-18)9-16(15)24-7-3-6-22-10-12(19)11-22/h8-9,12H,2-7,10-11H2,1H3,(H2,20,21) | PDB
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| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc.
Curated by ChEMBL
| Assay Description
Inhibition of G9a (unknown origin) using biotinylated-histone H3(1-21) peptide as substrate after 3 hrs by AlphaLISA assay |
ACS Med Chem Lett 5: 205-9 (2014)
Article DOI: 10.1021/ml400496h
BindingDB Entry DOI: 10.7270/Q2FT8NJ0 |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50353120
(CHEMBL1829294)Show SMILES CCN1CCCN(CC1)c1nc(NC2CCN(CC2)C(C)C)c2cc(OC)c(OCCCN3CCCC3)cc2n1 Show InChI InChI=1S/C31H51N7O2/c1-5-35-14-8-16-38(20-19-35)31-33-27-23-29(40-21-9-15-36-12-6-7-13-36)28(39-4)22-26(27)30(34-31)32-25-10-17-37(18-11-25)24(2)3/h22-25H,5-21H2,1-4H3,(H,32,33,34) | PDB
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina at Chapel Hill
Curated by ChEMBL
| Assay Description
Inhibition of G9a assessed as hydrolysis of S-adenosyl-L-homocysteine after 2 mins by SAHH-coupled fluorescence assay |
J Med Chem 54: 6139-50 (2011)
Article DOI: 10.1021/jm200903z
BindingDB Entry DOI: 10.7270/Q237793P |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50446385
(CHEMBL3109632)Show SMILES COc1cc2c(cc1OCC1CCCN1C)N=C(N)C21CCC1 |t:18| Show InChI InChI=1S/C18H25N3O2/c1-21-8-3-5-12(21)11-23-16-10-14-13(9-15(16)22-2)18(6-4-7-18)17(19)20-14/h9-10,12H,3-8,11H2,1-2H3,(H2,19,20) | PDB
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AbbVie Inc.
Curated by ChEMBL
| Assay Description
Inhibition of G9a (unknown origin) using biotinylated-histone H3(1-21) peptide as substrate after 3 hrs by AlphaLISA assay |
ACS Med Chem Lett 5: 205-9 (2014)
Article DOI: 10.1021/ml400496h
BindingDB Entry DOI: 10.7270/Q2FT8NJ0 |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50457750
(CHEMBL4211688)Show SMILES CCc1ccc(o1)-c1cc(NCC2C3CCC2CN(C)C3)c2cc(OC)c(OCCCN3CCCC3)cc2n1 Show InChI InChI=1S/C32H44N4O3/c1-4-24-10-11-30(39-24)29-17-27(33-19-26-22-8-9-23(26)21-35(2)20-22)25-16-31(37-3)32(18-28(25)34-29)38-15-7-14-36-12-5-6-13-36/h10-11,16-18,22-23,26H,4-9,12-15,19-21H2,1-3H3,(H,33,34) | PDB
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WuXi Apptec (Tianjin) Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assay |
J Med Chem 61: 6546-6573 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01925
BindingDB Entry DOI: 10.7270/Q2BP05CM |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50592392
(CHEMBL5193402) | PDB
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| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128858
BindingDB Entry DOI: 10.7270/Q2RX9H28 |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50592390
(CHEMBL5172085) | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128858
BindingDB Entry DOI: 10.7270/Q2RX9H28 |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50446376
(CHEMBL3109630)Show SMILES COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCC1 |t:19| Show InChI InChI=1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21) | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128858
BindingDB Entry DOI: 10.7270/Q2RX9H28 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50281298
(CHEMBL4173668)Show SMILES COc1cc2c(NC3CCN(C)CC3)cc(nc2cc1OCCCN1CCCC1)C1=CCCCC1 |t:33| Show InChI InChI=1S/C29H42N4O2/c1-32-16-11-23(12-17-32)30-26-20-25(22-9-4-3-5-10-22)31-27-21-29(28(34-2)19-24(26)27)35-18-8-15-33-13-6-7-14-33/h9,19-21,23H,3-8,10-18H2,1-2H3,(H,30,31) | PDB
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Universidad de Oviedo-Principado de Asturias
Curated by ChEMBL
| Assay Description
Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assay |
J Med Chem 61: 6518-6545 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01926
BindingDB Entry DOI: 10.7270/Q23X895V |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50281307
(CHEMBL4163329)Show SMILES COc1cc2c(NC3CCNCC3)cc(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1 Show InChI InChI=1S/C27H36N4O3/c1-19-6-7-25(34-19)24-17-22(29-20-8-10-28-11-9-20)21-16-26(32-2)27(18-23(21)30-24)33-15-5-14-31-12-3-4-13-31/h6-7,16-18,20,28H,3-5,8-15H2,1-2H3,(H,29,30) | PDB
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Universidad de Oviedo-Principado de Asturias
Curated by ChEMBL
| Assay Description
Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assay |
J Med Chem 61: 6518-6545 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01926
BindingDB Entry DOI: 10.7270/Q23X895V |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50353131
(CHEMBL1829304)Show SMILES COc1cc2c(NC3CCN(CC3)C3CCCCC3)nc(nc2cc1OCCCN1CCCCC1)N1CCCN(CC1)C(C)C Show InChI InChI=1S/C36H59N7O2/c1-28(2)41-19-10-20-43(24-23-41)36-38-32-27-34(45-25-11-18-40-16-8-5-9-17-40)33(44-3)26-31(32)35(39-36)37-29-14-21-42(22-15-29)30-12-6-4-7-13-30/h26-30H,4-25H2,1-3H3,(H,37,38,39) | PDB
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University of North Carolina at Chapel Hill
Curated by ChEMBL
| Assay Description
Inhibition of G9a assessed as hydrolysis of S-adenosyl-L-homocysteine after 2 mins by SAHH-coupled fluorescence assay |
J Med Chem 54: 6139-50 (2011)
Article DOI: 10.1021/jm200903z
BindingDB Entry DOI: 10.7270/Q237793P |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50281281
(CHEMBL4163369)Show SMILES COc1cc2c(NC3CCN(C)CC3)cc(C)nc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C24H36N4O2/c1-18-15-21(26-19-7-12-27(2)13-8-19)20-16-23(29-3)24(17-22(20)25-18)30-14-6-11-28-9-4-5-10-28/h15-17,19H,4-14H2,1-3H3,(H,25,26) | PDB
UniProtKB/SwissProt
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UniChem
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| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Oviedo-Principado de Asturias
Curated by ChEMBL
| Assay Description
Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assay |
J Med Chem 61: 6518-6545 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01926
BindingDB Entry DOI: 10.7270/Q23X895V |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50505576
(CHEMBL4458252)Show SMILES COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCCC1 |t:19| Show InChI InChI=1S/C20H29N3O2/c1-24-17-13-15-16(22-19(21)20(15)7-2-3-8-20)14-18(17)25-12-6-11-23-9-4-5-10-23/h13-14H,2-12H2,1H3,(H2,21,22) | PDB
UniProtKB/SwissProt
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| PC cid
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UniChem
| Article
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| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Inhibition of G9a (unknown origin) by scintillation proximity Assay |
J Med Chem 62: 9008-9025 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00562
BindingDB Entry DOI: 10.7270/Q27S7S2S |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50560575
(CHEMBL4756618)Show SMILES CNc1cc(C)nc(Nc2ccc(Cl)c(c2)C2=CCNCCC2)n1 |t:17| | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition G9a (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127475
BindingDB Entry DOI: 10.7270/Q24F1VFW |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50281321
(CHEMBL4173662)Show SMILES COc1cc2c(NC3CCN(C)CC3)cc(nc2cc1OCCCN1CCCC1)-c1ccoc1 Show InChI InChI=1S/C27H36N4O3/c1-30-12-6-21(7-13-30)28-24-17-23(20-8-15-33-19-20)29-25-18-27(26(32-2)16-22(24)25)34-14-5-11-31-9-3-4-10-31/h8,15-19,21H,3-7,9-14H2,1-2H3,(H,28,29) | PDB
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| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Oviedo-Principado de Asturias
Curated by ChEMBL
| Assay Description
Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assay |
J Med Chem 61: 6518-6545 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01926
BindingDB Entry DOI: 10.7270/Q23X895V |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50353123
(CHEMBL1829297)Show SMILES COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN1CCCC1)N1CCCN(CC2CCCCC2)CC1 Show InChI InChI=1S/C36H59N7O2/c1-28(2)42-20-13-30(14-21-42)37-35-31-25-33(44-3)34(45-24-10-18-40-15-7-8-16-40)26-32(31)38-36(39-35)43-19-9-17-41(22-23-43)27-29-11-5-4-6-12-29/h25-26,28-30H,4-24,27H2,1-3H3,(H,37,38,39) | PDB
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PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina at Chapel Hill
Curated by ChEMBL
| Assay Description
Inhibition of G9a assessed as hydrolysis of S-adenosyl-L-homocysteine after 2 mins by SAHH-coupled fluorescence assay |
J Med Chem 54: 6139-50 (2011)
Article DOI: 10.1021/jm200903z
BindingDB Entry DOI: 10.7270/Q237793P |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50457744
(CHEMBL4204482)Show SMILES COc1cc2c(NC3CC4(C3)CCN(CC4)C(C)C)cc(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1 Show InChI InChI=1S/C33H46N4O3/c1-23(2)37-15-10-33(11-16-37)21-25(22-33)34-27-19-29(30-9-8-24(3)40-30)35-28-20-32(31(38-4)18-26(27)28)39-17-7-14-36-12-5-6-13-36/h8-9,18-20,23,25H,5-7,10-17,21-22H2,1-4H3,(H,34,35) | PDB
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| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
WuXi Apptec (Tianjin) Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assay |
J Med Chem 61: 6546-6573 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01925
BindingDB Entry DOI: 10.7270/Q2BP05CM |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50575636
(CHEMBL4848955)Show SMILES COc1cc2nc(C)cc(NCC3CCN(CC3)c3ncc(cn3)C(=O)NO)c2cc1OC | PDB
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| PC cid
PC sid
UniChem
| Article
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| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human G9a enzyme using histone monomethyl-H3K9 peptide as substrate incubated for 1 hr in presence of SAM by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02255
BindingDB Entry DOI: 10.7270/Q2JS9V8V |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50281297
(CHEMBL4170114)Show SMILES COc1cc2c(NC3CCN(C)CC3)cc(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1 Show InChI InChI=1S/C28H38N4O3/c1-20-7-8-26(35-20)25-18-23(29-21-9-14-31(2)15-10-21)22-17-27(33-3)28(19-24(22)30-25)34-16-6-13-32-11-4-5-12-32/h7-8,17-19,21H,4-6,9-16H2,1-3H3,(H,29,30) | PDB
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of G9a (unknown origin) using biotinylated histone monomethyl-H3K9 peptide by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01609
BindingDB Entry DOI: 10.7270/Q2GH9NVM |
More data for this
Ligand-Target Pair | |
Histone-lysine N-methyltransferase EHMT2
(Homo sapiens (Human)) | BDBM50457746
(CHEMBL4208004)Show SMILES COc1cc2c(NCC3CCN(C)CC3)cc(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1 Show InChI InChI=1S/C29H40N4O3/c1-21-7-8-27(36-21)26-18-24(30-20-22-9-14-32(2)15-10-22)23-17-28(34-3)29(19-25(23)31-26)35-16-6-13-33-11-4-5-12-33/h7-8,17-19,22H,4-6,9-16,20H2,1-3H3,(H,30,31) | PDB
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PC cid
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of G9a (unknown origin) by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02255
BindingDB Entry DOI: 10.7270/Q2JS9V8V |
More data for this
Ligand-Target Pair | |
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