Found 11 hits of ec50 for UniProtKB: P26358 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
DNA (cytosine-5)-methyltransferase 1 (DNMT1)
(Homo sapiens (Human)) | BDBM50430056
(CHEMBL2336409 | SGI-1027)Show SMILES Cc1cc(Nc2ccc(NC(=O)c3ccc(Nc4ccnc5ccccc45)cc3)cc2)nc(N)n1 Show InChI InChI=1S/C27H23N7O/c1-17-16-25(34-27(28)30-17)32-20-10-12-21(13-11-20)33-26(35)18-6-8-19(9-7-18)31-24-14-15-29-23-5-3-2-4-22(23)24/h2-16H,1H3,(H,29,31)(H,33,35)(H3,28,30,32,34) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | n/a | n/a | 1.02E+4 | n/a | n/a | n/a | n/a |
Unit£ de Service et de Recherche CNRS-Pierre Fabre n£3388
Curated by ChEMBL
| Assay Description
Inhibition of human His-DNMT1 using [methyl-3H]SAM as substrate after 2 hrs |
Bioorg Med Chem 23: 5946-53 (2015)
BindingDB Entry DOI: 10.7270/Q2P270X8 |
More data for this
Ligand-Target Pair | |
DNA (cytosine-5)-methyltransferase 1
(Homo sapiens (Human)) | BDBM50239292
(CHEMBL4070549)Show SMILES C(CNc1ncnc2cc(OCC3CCN(CCNc4ccnc5ccccc45)CC3)ccc12)Cc1cccc2ccccc12 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a |
CNRS-Pierre Fabre USR3388
Curated by ChEMBL
| |
J Med Chem 60: 4665-4679 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00176 |
More data for this
Ligand-Target Pair | |
DNA (cytosine-5)-methyltransferase 1
(Homo sapiens (Human)) | BDBM50239291
(CHEMBL4091463)Show SMILES C(CNc1ncnc2cc(OCC3CCN(CCNc4ccnc5ccccc45)CC3)ccc12)Nc1cccc2ccccc12 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a |
CNRS-Pierre Fabre USR3388
Curated by ChEMBL
| |
J Med Chem 60: 4665-4679 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00176 |
More data for this
Ligand-Target Pair | |
DNA (cytosine-5)-methyltransferase 1
(Homo sapiens (Human)) | BDBM50239285
(CHEMBL4096869)Show SMILES Cc1cc(NCCN2CCC(COc3ccc4c(NCCCc5ccccc5)ncnc4c3)CC2)c2ccccc2n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a |
CNRS-Pierre Fabre USR3388
Curated by ChEMBL
| |
J Med Chem 60: 4665-4679 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00176 |
More data for this
Ligand-Target Pair | |
DNA (cytosine-5)-methyltransferase 1
(Homo sapiens (Human)) | BDBM50239288
(CHEMBL4097685)Show SMILES Clc1ccc(CCNc2ncnc3cc(OCC4CCN(CCNc5ccnc6ccccc56)CC4)ccc23)cc1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a |
CNRS-Pierre Fabre USR3388
Curated by ChEMBL
| |
J Med Chem 60: 4665-4679 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00176 |
More data for this
Ligand-Target Pair | |
DNA (cytosine-5)-methyltransferase 1
(Homo sapiens (Human)) | BDBM50239289
(CHEMBL4096752)Show SMILES COc1ccc(CCNc2ncnc3cc(OCC4CCN(CCNc5ccnc6ccccc56)CC4)ccc23)cc1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a |
CNRS-Pierre Fabre USR3388
Curated by ChEMBL
| |
J Med Chem 60: 4665-4679 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00176 |
More data for this
Ligand-Target Pair | |
DNA (cytosine-5)-methyltransferase 1
(Homo sapiens (Human)) | BDBM50239293
(CHEMBL4076088)Show SMILES COc1cc2nccc(NCCN3CCC(COc4ccc5c(NCCCc6ccccc6)ncnc5c4)CC3)c2cc1OC | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a |
CNRS-Pierre Fabre USR3388
Curated by ChEMBL
| |
J Med Chem 60: 4665-4679 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00176 |
More data for this
Ligand-Target Pair | |
DNA (cytosine-5)-methyltransferase 1
(Homo sapiens (Human)) | BDBM50239286
(CHEMBL4084601)Show SMILES C(CN1CCC(COc2ccc3c(NCCc4ccccc4)ncnc3c2)CC1)Nc1ccnc2ccccc12 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a |
CNRS-Pierre Fabre USR3388
Curated by ChEMBL
| |
J Med Chem 60: 4665-4679 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00176 |
More data for this
Ligand-Target Pair | |
DNA (cytosine-5)-methyltransferase 1
(Homo sapiens (Human)) | BDBM50239284
(CHEMBL4096360)Show SMILES C(CNc1ncnc2cc(OCC3CCN(CCNc4ccnc5ccccc45)CC3)ccc12)Cc1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 4.60E+4 | n/a | n/a | n/a | n/a |
CNRS-Pierre Fabre USR3388
Curated by ChEMBL
| |
J Med Chem 60: 4665-4679 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00176 |
More data for this
Ligand-Target Pair | |
DNA (cytosine-5)-methyltransferase 1
(Homo sapiens (Human)) | BDBM50239287
(CHEMBL4100095)Show SMILES C(CNc1ncnc2cc(OCC3CCN(CCNc4ccnc5ccccc45)CC3)ccc12)Nc1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.30E+4 | n/a | n/a | n/a | n/a |
CNRS-Pierre Fabre USR3388
Curated by ChEMBL
| |
J Med Chem 60: 4665-4679 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00176 |
More data for this
Ligand-Target Pair | |
DNA (cytosine-5)-methyltransferase 1
(Homo sapiens (Human)) | BDBM50239290
(CHEMBL4099197)Show SMILES C(CN1CCC(COc2ccc3c(NCc4ccc(cc4)-c4ccccc4)ncnc3c2)CC1)Nc1ccnc2ccccc12 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a |
CNRS-Pierre Fabre USR3388
Curated by ChEMBL
| |
J Med Chem 60: 4665-4679 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00176 |
More data for this
Ligand-Target Pair | |
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