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Compile Data Set for Download or QSAR

Found 148 hits of kd for UniProtKB: P08172   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50228565
PNG
(CHEMBL108557)
Show SMILES CN(C)CC#CC1CCCCCN1C(C)=O
PDB
MMDB

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n/an/an/a 7.00E+3n/an/an/an/an/a



Uppsala University

Curated by ChEMBL




J Med Chem 33: 3182-9 (1990)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50228566
PNG
(CHEMBL2092932)
Show SMILES C[C@@H](C#CCN1CCCC1)N(C)C(C)=O |r|
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n/an/an/a 3.23E+3n/an/an/an/an/a



Uppsala University

Curated by ChEMBL




J Med Chem 33: 3182-9 (1990)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50228567
PNG
(CHEMBL2092931)
Show SMILES CC(=O)N1CCCCC[C@H]1C#CCN1CCCC1 |r|
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n/an/an/a 7.85E+3n/an/an/an/an/a



Uppsala University

Curated by ChEMBL




J Med Chem 33: 3182-9 (1990)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50228568
PNG
(CHEMBL322126)
Show SMILES CC(=O)N1CCC[C@H]1C#CCN1CCCC1 |r|
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n/an/an/a 1.60E+4n/an/an/an/an/a



Uppsala University

Curated by ChEMBL




J Med Chem 33: 3182-9 (1990)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50228569
PNG
(CHEMBL1788225)
Show SMILES CC(=O)N1CCCCC[C@@H]1C#CCN1CCCC1 |r|
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n/an/an/a 161n/an/an/an/an/a



Uppsala University

Curated by ChEMBL




J Med Chem 33: 3182-9 (1990)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50228570
PNG
(CHEMBL1788202)
Show SMILES C[C@H](C#CCN1CCCC1)N(C)C(C)=O |r|
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n/an/an/a 200n/an/an/an/an/a



Uppsala University

Curated by ChEMBL




J Med Chem 33: 3182-9 (1990)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50228571
PNG
(CHEMBL107456)
Show SMILES CC(=O)N1CCCCC1C#CCN1CCCC1
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n/an/an/a 97n/an/an/an/an/a



Uppsala University

Curated by ChEMBL




J Med Chem 33: 3182-9 (1990)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50228572
PNG
(CHEMBL432629)
Show SMILES CC(=O)N1CCCCCC1C#CCN1CCCC1
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n/an/an/a 110n/an/an/an/an/a



Uppsala University

Curated by ChEMBL




J Med Chem 33: 3182-9 (1990)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50228573
PNG
(CHEMBL106056)
Show SMILES CC(=O)N1CCCCCC1C#CC[N+](C)(C)C
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n/an/an/a 3.55E+3n/an/an/an/an/a



Uppsala University

Curated by ChEMBL




J Med Chem 33: 3182-9 (1990)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50228071
PNG
(CHEMBL110892)
Show SMILES CC(=O)N1CCCC1C#CCN1CCCC1
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n/an/an/a 1.40E+3n/an/an/an/an/a



Uppsala University

Curated by ChEMBL




J Med Chem 33: 3182-9 (1990)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50228574
PNG
(CHEMBL108582)
Show SMILES CN(C)CC#CC1CCCCN1C(C)=O
PDB
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n/an/an/a 8.30E+3n/an/an/an/an/a



Uppsala University

Curated by ChEMBL




J Med Chem 33: 3182-9 (1990)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50228087
PNG
(CHEMBL323032)
Show SMILES CN(C)CC#CC1CCCN1C(C)=O
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n/an/an/a 1.25E+5n/an/an/an/an/a



Uppsala University

Curated by ChEMBL




J Med Chem 33: 3182-9 (1990)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50228576
PNG
(CHEMBL2092930)
Show SMILES CC(=O)N1CCCC[C@@H]1C#CCN1CCCC1 |r|
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n/an/an/a 80n/an/an/an/an/a



Uppsala University

Curated by ChEMBL




J Med Chem 33: 3182-9 (1990)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50228577
PNG
(CHEMBL1788224)
Show SMILES CC(=O)N1CCC[C@@H]1C#CCN1CCCC1 |r|
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n/an/an/a 1.16E+3n/an/an/an/an/a



Uppsala University

Curated by ChEMBL




J Med Chem 33: 3182-9 (1990)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50228578
PNG
(CHEMBL111327)
Show SMILES CC(=O)N1CCCC1C#CC[N+](C)(C)C
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n/an/an/a 4.95E+4n/an/an/an/an/a



Uppsala University

Curated by ChEMBL




J Med Chem 33: 3182-9 (1990)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50228579
PNG
(CHEMBL1788219)
Show SMILES CC(=O)N1CCCC[C@H]1C#CCN1CCCC1 |r|
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n/an/an/a 6.32E+3n/an/an/an/an/a



Uppsala University

Curated by ChEMBL




J Med Chem 33: 3182-9 (1990)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50403547
PNG
(ATROPEN | ATROPINE)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c1ccccc1 |r,THB:9:7:1:3.4|
Show InChI InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
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n/an/an/a 0.900n/an/an/an/an/a



Uppsala University

Curated by ChEMBL




J Med Chem 33: 3182-9 (1990)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50280521
PNG
((4R,5S)-5-Methyl-4-[(E)-3-((R)-1-methyl-piperidin-...)
Show SMILES C[C@@H]1OC(=O)C[C@H]1C\C=C\[C@H]1CCCCN1C
Show InChI InChI=1S/C14H23NO2/c1-11-12(10-14(16)17-11)6-5-8-13-7-3-4-9-15(13)2/h5,8,11-13H,3-4,6-7,9-10H2,1-2H3/b8-5+/t11-,12+,13+/m0/s1
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Article
n/an/an/a 4.40E+3n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Dissociation constant of the compound for human Muscarinic acetylcholine receptor M2 was determined.


Bioorg Med Chem Lett 2: 797-802 (1992)


Article DOI: 10.1016/S0960-894X(00)80534-X
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50083651
PNG
((S)-3-Hydroxy-2-(2-tetradecanoylamino-acetylamino)...)
Show SMILES CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1
Show InChI InChI=1S/C26H42N2O5/c1-2-3-4-5-6-7-8-9-10-11-15-18-24(30)27-19-25(31)28-23(20-29)26(32)33-21-22-16-13-12-14-17-22/h12-14,16-17,23,29H,2-11,15,18-21H2,1H3,(H,27,30)(H,28,31)/t23-/m0/s1
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n/an/an/a 0.150n/an/an/an/an/a



University of Toledo

Curated by ChEMBL


Assay Description
Binding of [3H]-QNB to HM2 receptor was evaluated by saturation binding assay


Bioorg Med Chem Lett 9: 3363-8 (2000)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50083652
PNG
(CHEMBL112297 | Hexadecanoic acid (S)-2-benzyloxyca...)
Show SMILES CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1
Show InChI InChI=1S/C42H72N2O6/c1-3-5-7-9-11-13-15-16-18-20-22-24-29-33-41(47)49-36-38(42(48)50-35-37-30-26-25-27-31-37)44-40(46)34-43-39(45)32-28-23-21-19-17-14-12-10-8-6-4-2/h25-27,30-31,38H,3-24,28-29,32-36H2,1-2H3,(H,43,45)(H,44,46)/t38-/m0/s1
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n/an/an/a 1.80n/an/an/an/an/a



University of Toledo

Curated by ChEMBL




Bioorg Med Chem Lett 9: 3363-8 (2000)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405739
PNG
(CHEMBL168616)
Show SMILES Cc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1C
Show InChI InChI=1S/C36H62N4/c1-33-21-11-13-23-35(33)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-36-24-14-12-22-34(36)2/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3
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n/an/an/a 58.9n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405740
PNG
(CHEMBL294613)
Show SMILES COc1ccccc1CN(C)CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(C)Cc1ccccc1OC
Show InChI InChI=1S/C40H70N4O2/c1-41(31-21-11-13-23-33-43(3)35-37-25-15-17-27-39(37)45-5)29-19-9-7-8-10-20-30-42(2)32-22-12-14-24-34-44(4)36-38-26-16-18-28-40(38)46-6/h15-18,25-28H,7-14,19-24,29-36H2,1-6H3
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n/an/an/a 162n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405743
PNG
(CHEMBL166232)
Show SMILES C(CCCCNCCCCCCNCc1ccccc1)CCCNCCCCCCNCc1ccccc1
Show InChI InChI=1S/C34H58N4/c1(3-15-25-35-27-17-5-7-19-29-37-31-33-21-11-9-12-22-33)2-4-16-26-36-28-18-6-8-20-30-38-32-34-23-13-10-14-24-34/h9-14,21-24,35-38H,1-8,15-20,25-32H2
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n/an/an/a 83.2n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405745
PNG
(CHEMBL168736)
Show SMILES COc1ccccc1CNCCCCCNCCCCCCCCNCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C34H58N4O2/c1-39-33-21-11-9-19-31(33)29-37-27-17-7-15-25-35-23-13-5-3-4-6-14-24-36-26-16-8-18-28-38-30-32-20-10-12-22-34(32)40-2/h9-12,19-22,35-38H,3-8,13-18,23-30H2,1-2H3
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n/an/an/a 162n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405747
PNG
(CHEMBL168304)
Show SMILES Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)cc2)cc1
Show InChI InChI=1S/C36H62N4/c1-33-17-21-35(22-18-33)31-39-29-15-9-7-13-27-37-25-11-5-3-4-6-12-26-38-28-14-8-10-16-30-40-32-36-23-19-34(2)20-24-36/h17-24,37-40H,3-16,25-32H2,1-2H3
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n/an/an/a 166n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405748
PNG
(CHEMBL352334)
Show SMILES COc1ccccc1CNCCCCCCCNCCCCCCCCNCCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C38H66N4O2/c1-43-37-25-15-13-23-35(37)33-41-31-21-11-5-9-19-29-39-27-17-7-3-4-8-18-28-40-30-20-10-6-12-22-32-42-34-36-24-14-16-26-38(36)44-2/h13-16,23-26,39-42H,3-12,17-22,27-34H2,1-2H3
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n/an/an/a 27.5n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50403547
PNG
(ATROPEN | ATROPINE)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c1ccccc1 |r,THB:9:7:1:3.4|
Show InChI InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
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n/an/an/a 1.35n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405750
PNG
(CHEMBL166229)
Show SMILES C(CCCCNCCCCCCNCc1ccco1)CCCNCCCCCCNCc1ccco1
Show InChI InChI=1S/C30H54N4O2/c1(3-9-19-31-21-11-5-7-13-23-33-27-29-17-15-25-35-29)2-4-10-20-32-22-12-6-8-14-24-34-28-30-18-16-26-36-30/h15-18,25-26,31-34H,1-14,19-24,27-28H2
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n/an/an/a 9.12n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405746
PNG
(CHEMBL166803)
Show SMILES [O-][N+](=O)c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(cc2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C34H56N6O4/c41-39(42)33-19-15-31(16-20-33)29-37-27-13-7-5-11-25-35-23-9-3-1-2-4-10-24-36-26-12-6-8-14-28-38-30-32-17-21-34(22-18-32)40(43)44/h15-22,35-38H,1-14,23-30H2
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n/an/an/a 95.5n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405753
PNG
(CHEMBL170113)
Show SMILES Clc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C34H56Cl2N4/c35-33-19-15-31(16-20-33)29-39-27-13-7-5-11-25-37-23-9-3-1-2-4-10-24-38-26-12-6-8-14-28-40-30-32-17-21-34(36)22-18-32/h15-22,37-40H,1-14,23-30H2
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n/an/an/a 178n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405754
PNG
(CHEMBL354855)
Show SMILES COc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(OC)c2)c1
Show InChI InChI=1S/C36H62N4O2/c1-41-35-21-17-19-33(29-35)31-39-27-15-9-7-13-25-37-23-11-5-3-4-6-12-24-38-26-14-8-10-16-28-40-32-34-20-18-22-36(30-34)42-2/h17-22,29-30,37-40H,3-16,23-28,31-32H2,1-2H3
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n/an/an/a 151n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405755
PNG
(CHEMBL168235)
Show SMILES COc1ccccc1CN(C)CCCCCCNCCCCCCCCNCCCCCCN(C)Cc1ccccc1OC
Show InChI InChI=1S/C38H66N4O2/c1-41(33-35-23-13-15-25-37(35)43-3)31-21-11-9-19-29-39-27-17-7-5-6-8-18-28-40-30-20-10-12-22-32-42(2)34-36-24-14-16-26-38(36)44-4/h13-16,23-26,39-40H,5-12,17-22,27-34H2,1-4H3
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n/an/an/a 166n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405744
PNG
(CHEMBL114885)
Show SMILES COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C38H66N4O2/c1-41(31-21-11-7-17-27-39-33-35-23-13-15-25-37(35)43-3)29-19-9-5-6-10-20-30-42(2)32-22-12-8-18-28-40-34-36-24-14-16-26-38(36)44-4/h13-16,23-26,39-40H,5-12,17-22,27-34H2,1-4H3
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n/an/an/a 10.2n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405741
PNG
(CHEMBL167587)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCCNCCCCCCNCc1ccccc1C
Show InChI InChI=1S/C42H74N4O/c1-39-27-17-18-28-40(39)37-45-35-25-15-13-23-33-43-31-21-11-9-7-5-3-4-6-8-10-12-22-32-44-34-24-14-16-26-36-46-38-41-29-19-20-30-42(41)47-2/h17-20,27-30,43-46H,3-16,21-26,31-38H2,1-2H3
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n/an/an/a 135n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405751
PNG
(CHEMBL165700)
Show SMILES Clc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1Cl
Show InChI InChI=1S/C34H56Cl2N4/c35-33-21-11-9-19-31(33)29-39-27-17-7-5-15-25-37-23-13-3-1-2-4-14-24-38-26-16-6-8-18-28-40-30-32-20-10-12-22-34(32)36/h9-12,19-22,37-40H,1-8,13-18,23-30H2
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n/an/an/a 66.1n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405749
PNG
(CHEMBL170793)
Show SMILES Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)o2)o1
Show InChI InChI=1S/C32H58N4O2/c1-29-17-19-31(37-29)27-35-25-15-9-7-13-23-33-21-11-5-3-4-6-12-22-34-24-14-8-10-16-26-36-28-32-20-18-30(2)38-32/h17-20,33-36H,3-16,21-28H2,1-2H3
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n/an/an/a 8.91n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405756
PNG
(CHEMBL169290)
Show SMILES C(CCCCNCCCCCCNCc1cccnc1)CCCNCCCCCCNCc1cccnc1
Show InChI InChI=1S/C32H56N6/c1(3-9-19-33-21-11-5-7-13-23-35-27-31-17-15-25-37-29-31)2-4-10-20-34-22-12-6-8-14-24-36-28-32-18-16-26-38-30-32/h15-18,25-26,29-30,33-36H,1-14,19-24,27-28H2
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n/an/an/a 288n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405759
PNG
(CHEMBL168841)
Show SMILES CSc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1SC
Show InChI InChI=1S/C36H62N4S2/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3
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n/an/an/a 26.9n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405758
PNG
(CHEMBL166544)
Show SMILES Fc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(F)cc2)cc1
Show InChI InChI=1S/C34H56F2N4/c35-33-19-15-31(16-20-33)29-39-27-13-7-5-11-25-37-23-9-3-1-2-4-10-24-38-26-12-6-8-14-28-40-30-32-17-21-34(36)22-18-32/h15-22,37-40H,1-14,23-30H2
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n/an/an/a 129n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50064176
PNG
(CHEMBL27673 | CHEMBL500996 | METHOCTRAMINE | N,N''...)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C36H62N4O2/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3
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n/an/an/a 19.5n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405752
PNG
(CHEMBL169523)
Show SMILES C(CCCCNCCCCCCNCc1ccccn1)CCCNCCCCCCNCc1ccccn1
Show InChI InChI=1S/C32H56N6/c1(3-11-21-33-23-13-5-7-15-25-35-29-31-19-9-17-27-37-31)2-4-12-22-34-24-14-6-8-16-26-36-30-32-20-10-18-28-38-32/h9-10,17-20,27-28,33-36H,1-8,11-16,21-26,29-30H2
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n/an/an/a 53.7n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405760
PNG
(CHEMBL167690)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCCCCCCNCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C39H68N4O2/c1-44-38-26-16-14-24-36(38)34-42-32-22-12-10-20-30-40-28-18-8-6-4-3-5-7-9-19-29-41-31-21-11-13-23-33-43-35-37-25-15-17-27-39(37)45-2/h14-17,24-27,40-43H,3-13,18-23,28-35H2,1-2H3
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n/an/an/a 37.1n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405761
PNG
(CHEMBL168322)
Show SMILES Clc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(Cl)c2)c1
Show InChI InChI=1S/C34H56Cl2N4/c35-33-19-15-17-31(27-33)29-39-25-13-7-5-11-23-37-21-9-3-1-2-4-10-22-38-24-12-6-8-14-26-40-30-32-18-16-20-34(36)28-32/h15-20,27-28,37-40H,1-14,21-26,29-30H2
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n/an/an/a 186n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405757
PNG
(CHEMBL168786)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCNCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C41H72N4O2/c1-46-40-28-18-16-26-38(40)36-44-34-24-14-12-22-32-42-30-20-10-8-6-4-3-5-7-9-11-21-31-43-33-23-13-15-25-35-45-37-39-27-17-19-29-41(39)47-2/h16-19,26-29,42-45H,3-15,20-25,30-37H2,1-2H3
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n/an/an/a 95.5n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50405742
PNG
(CHEMBL170554)
Show SMILES COc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(OC)cc2)cc1
Show InChI InChI=1S/C36H62N4O2/c1-41-35-21-17-33(18-22-35)31-39-29-15-9-7-13-27-37-25-11-5-3-4-6-12-26-38-28-14-8-10-16-30-40-32-34-19-23-36(42-2)24-20-34/h17-24,37-40H,3-16,25-32H2,1-2H3
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n/an/an/a 141n/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor


J Med Chem 32: 79-84 (1989)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50412728
PNG
(CHEMBL521523)
Show SMILES C[C@H]1CN(Cc2cccc(c2)-c2cc(CNC(=O)c3cccc(CC4CCNCC4)c3)ccc2F)CCN1 |r|
Show InChI InChI=1S/C32H39FN4O/c1-23-21-37(15-14-35-23)22-27-5-3-6-28(18-27)30-19-26(8-9-31(30)33)20-36-32(38)29-7-2-4-25(17-29)16-24-10-12-34-13-11-24/h2-9,17-19,23-24,34-35H,10-16,20-22H2,1H3,(H,36,38)/t23-/m0/s1
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n/an/an/a 5.01n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosol...


J Med Chem 51: 5915-8 (2008)


Article DOI: 10.1021/jm800935u
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50412733
PNG
(CHEMBL538864 | CHEMBL555476)
Show SMILES C[C@H]1CN(Cc2cccc(c2)-c2cc(CNC(=O)c3cccc(CN4CC[N+](C)(C)CC4)c3)ccc2F)CCN1 |r|
Show InChI InChI=1S/C33H42FN5O/c1-25-22-38(13-12-35-25)24-27-6-4-8-29(18-27)31-20-26(10-11-32(31)34)21-36-33(40)30-9-5-7-28(19-30)23-37-14-16-39(2,3)17-15-37/h4-11,18-20,25,35H,12-17,21-24H2,1-3H3/p+1/t25-/m0/s1
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n/an/an/a 12.6n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosol...


J Med Chem 51: 5915-8 (2008)


Article DOI: 10.1021/jm800935u
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50412729
PNG
(CHEMBL492437)
Show SMILES C[C@H]1CN(Cc2cccc(c2)-c2cc(CNC(=O)c3cccc(CN4CCNCC4)c3)ccc2F)CCN1 |r|
Show InChI InChI=1S/C31H38FN5O/c1-23-20-37(15-12-34-23)22-25-4-2-6-27(16-25)29-18-24(8-9-30(29)32)19-35-31(38)28-7-3-5-26(17-28)21-36-13-10-33-11-14-36/h2-9,16-18,23,33-34H,10-15,19-22H2,1H3,(H,35,38)/t23-/m0/s1
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n/an/an/a 63.1n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosol...


J Med Chem 51: 5915-8 (2008)


Article DOI: 10.1021/jm800935u
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50412730
PNG
(CHEMBL493465)
Show SMILES C[C@H]1CN(Cc2cccc(c2)-c2cc(CNC(=O)c3cccc(c3)C#N)ccc2F)CCN1 |r|
Show InChI InChI=1S/C27H27FN4O/c1-19-17-32(11-10-30-19)18-22-5-3-6-23(13-22)25-14-21(8-9-26(25)28)16-31-27(33)24-7-2-4-20(12-24)15-29/h2-9,12-14,19,30H,10-11,16-18H2,1H3,(H,31,33)/t19-/m0/s1
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n/an/an/a 316n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosol...


J Med Chem 51: 5915-8 (2008)


Article DOI: 10.1021/jm800935u
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50412731
PNG
(CHEMBL493266)
Show SMILES CCC(=O)c1cccc(c1)C(=O)NCc1ccc(F)c(c1)-c1cccc(CN2CCN[C@@H](C)C2)c1 |r|
Show InChI InChI=1S/C29H32FN3O2/c1-3-28(34)24-8-5-9-25(16-24)29(35)32-17-21-10-11-27(30)26(15-21)23-7-4-6-22(14-23)19-33-13-12-31-20(2)18-33/h4-11,14-16,20,31H,3,12-13,17-19H2,1-2H3,(H,32,35)/t20-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 25.1n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosol...


J Med Chem 51: 5915-8 (2008)


Article DOI: 10.1021/jm800935u
More data for this
Ligand-Target Pair
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