Compile Data Set for Download or QSAR

Found 2136 hits of ec50 for UniProtKB: Q03181   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50213701 ((R)-2-(2-methyl-4-(2-((4-(trifluoromethyl)phenoxy)...) Show SMILES CC[C@H](COc1ccc(cc1)C(F)(F)F)CSc1ccc(OCC(O)=O)c(C)c1 Show InChI InChI=1S/C21H23F3O4S/c1-3-15(11-27-17-6-4-16(5-7-17)21(22,23)24)13-29-18-8-9-19(14(2)10-18)28-12-20(25)26/h4-10,15H,3,11-13H2,1-2H3,(H,25,26)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0300	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Agonist activity at human PPARdelta receptor by cell based transactivation assay				Bioorg Med Chem Lett 17: 3855-9 (2007) Article DOI: 10.1016/j.bmcl.2007.05.007 BindingDB Entry DOI: 10.7270/Q28W3D05
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50213701 ((R)-2-(2-methyl-4-(2-((4-(trifluoromethyl)phenoxy)...) Show SMILES CC[C@H](COc1ccc(cc1)C(F)(F)F)CSc1ccc(OCC(O)=O)c(C)c1 Show InChI InChI=1S/C21H23F3O4S/c1-3-15(11-27-17-6-4-16(5-7-17)21(22,23)24)13-29-18-8-9-19(14(2)10-18)28-12-20(25)26/h4-10,15H,3,11-13H2,1-2H3,(H,25,26)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0300	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Agonist activity at human PPARdelta receptor by cell based transactivation assay				Bioorg Med Chem Lett 17: 3855-9 (2007) Article DOI: 10.1016/j.bmcl.2007.05.007 BindingDB Entry DOI: 10.7270/Q28W3D05
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50213715 (2-(2-methyl-4-(2-((4-(trifluoromethyl)phenoxy)meth...) Show SMILES CCC(COc1ccc(cc1)C(F)(F)F)CSc1ccc(OCC(O)=O)c(C)c1 |w:2.15| Show InChI InChI=1S/C21H23F3O4S/c1-3-15(11-27-17-6-4-16(5-7-17)21(22,23)24)13-29-18-8-9-19(14(2)10-18)28-12-20(25)26/h4-10,15H,3,11-13H2,1-2H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0600	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Agonist activity at human PPARdelta receptor by cell based transactivation assay				Bioorg Med Chem Lett 17: 3855-9 (2007) Article DOI: 10.1016/j.bmcl.2007.05.007 BindingDB Entry DOI: 10.7270/Q28W3D05
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM412355 (US10399958, Comparator Compound 1) Show SMILES Cc1cnc(-c2ccc(cc2)C(F)(F)F)n1Cc1ccccc1OCCCCCC(O)=O Show InChI InChI=1S/C24H25F3N2O3/c1-17-15-28-23(18-10-12-20(13-11-18)24(25,26)27)29(17)16-19-7-4-5-8-21(19)32-14-6-2-3-9-22(30)31/h4-5,7-8,10-13,15H,2-3,6,9,14,16H2,1H3,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a
Mitobridge, Inc. US Patent					Assay Description Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...				US Patent US10399958 (2019) BindingDB Entry DOI: 10.7270/Q26Q20MJ
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM412339 (US10399958, Compound 2d) Show SMILES CC(CCCOc1ccccc1Cn1c(C)cnc1-c1ccc(cc1)C(F)(F)F)CC(O)=O Show InChI InChI=1S/C25H27F3N2O3/c1-17(14-23(31)32)6-5-13-33-22-8-4-3-7-20(22)16-30-18(2)15-29-24(30)19-9-11-21(12-10-19)25(26,27)28/h3-4,7-12,15,17H,5-6,13-14,16H2,1-2H3,(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PDB UniChem	PDB US Patent	n/a	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a
Mitobridge, Inc. US Patent					Assay Description Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...				US Patent US10399958 (2019) BindingDB Entry DOI: 10.7270/Q26Q20MJ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM28661 (2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...) Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.180	n/a	n/a	n/a	n/a
Phenex Pharmaceuticals AG Curated by ChEMBL					Assay Description Agonist activity at human PPARbeta expressed in HEK293 cells by luciferase reporter gene assay				Bioorg Med Chem Lett 24: 5265-7 (2014) Article DOI: 10.1016/j.bmcl.2014.09.053 BindingDB Entry DOI: 10.7270/Q2S46TKZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM412340 (US10399958, Compound 2e) Show SMILES C\C(CCC(O)=O)=C/COc1ccccc1Cn1c(C)cnc1-c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C25H25F3N2O4/c1-17(7-12-23(31)32)13-14-33-22-6-4-3-5-20(22)16-30-18(2)15-29-24(30)19-8-10-21(11-9-19)34-25(26,27)28/h3-6,8-11,13,15H,7,12,14,16H2,1-2H3,(H,31,32)/b17-13+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
Mitobridge, Inc. US Patent					Assay Description Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...				US Patent US10399958 (2019) BindingDB Entry DOI: 10.7270/Q26Q20MJ
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM412340 (US10399958, Compound 2e) Show SMILES C\C(CCC(O)=O)=C/COc1ccccc1Cn1c(C)cnc1-c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C25H25F3N2O4/c1-17(7-12-23(31)32)13-14-33-22-6-4-3-5-20(22)16-30-18(2)15-29-24(30)19-8-10-21(11-9-19)34-25(26,27)28/h3-6,8-11,13,15H,7,12,14,16H2,1-2H3,(H,31,32)/b17-13+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a
TBA					Assay Description Modulator activity at GAL4-fused human PPARdelta LBD (128 to residue at C-terminus) transfected in African green monkey CV1 cells assessed as recepto...				Citation and Details Article DOI: 10.1021/acsmedchemlett.8b00287 BindingDB Entry DOI: 10.7270/Q2H998WR
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50539514 (CHEMBL4649683) Show SMILES C[C@H](CCCOc1ccccc1Cn1c(C)cnc1-c1ccc(OC(F)(F)F)cc1)CC(O)=O |r| Show InChI InChI=1S/C25H27F3N2O4/c1-17(14-23(31)32)6-5-13-33-22-8-4-3-7-20(22)16-30-18(2)15-29-24(30)19-9-11-21(12-10-19)34-25(26,27)28/h3-4,7-12,15,17H,5-6,13-14,16H2,1-2H3,(H,31,32)/t17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a
TBA					Assay Description Modulator activity at GAL4-fused human PPARdelta LBD (128 to residue at C-terminus) transfected in African green monkey CV1 cells assessed as recepto...				Citation and Details Article DOI: 10.1021/acsmedchemlett.8b00287 BindingDB Entry DOI: 10.7270/Q2H998WR
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM28661 (2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...) Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
University of Oslo Curated by ChEMBL					Assay Description Agonist activity at pSG5-Gal4-tagged human PPAR-beta/delta ligand binding domain expressed in COS1 cells assessed as receptor activation incubated fo...				Eur J Med Chem 94: 229-36 (2015) Article DOI: 10.1016/j.ejmech.2015.03.006 BindingDB Entry DOI: 10.7270/Q25H7HZR
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50334843 ((R)-2-(4-((3-(2,4-dichlorophenylcarbamoyl)-3,4-dih...) Show SMILES Cc1cc(CN2Cc3ccccc3C[C@@H]2C(=O)Nc2ccc(Cl)cc2Cl)ccc1OCC(O)=O |r| Show InChI InChI=1S/C26H24Cl2N2O4/c1-16-10-17(6-9-24(16)34-15-25(31)32)13-30-14-19-5-3-2-4-18(19)11-23(30)26(33)29-22-8-7-20(27)12-21(22)28/h2-10,12,23H,11,13-15H2,1H3,(H,29,33)(H,31,32)/t23-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
AstraZeneca R&D Charnwood Curated by ChEMBL					Assay Description Agonist activity at GAL4-fused human PPARdelta DNA binding domain expressed in HEK293 cells by luciferase reporter gene assay				Bioorg Med Chem Lett 21: 492-6 (2010) Article DOI: 10.1016/j.bmcl.2010.10.117 BindingDB Entry DOI: 10.7270/Q2ST7Q3Q
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM412348 (US10399958, Compound 2m) Show SMILES CC(CCCOc1ccc(C)cc1Cn1c(C)cnc1-c1ccc(OC(F)(F)F)cc1)CC(O)=O Show InChI InChI=1S/C26H29F3N2O4/c1-17(14-24(32)33)5-4-12-34-23-11-6-18(2)13-21(23)16-31-19(3)15-30-25(31)20-7-9-22(10-8-20)35-26(27,28)29/h6-11,13,15,17H,4-5,12,14,16H2,1-3H3,(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
Mitobridge, Inc. US Patent					Assay Description Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...				US Patent US10399958 (2019) BindingDB Entry DOI: 10.7270/Q26Q20MJ
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM28661 (2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...) Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at PPARdelta (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02002 BindingDB Entry DOI: 10.7270/Q2VQ36KV
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM21787 (2-[(1S)-5-{3-[2-methoxy-4-(1,3-thiazol-2-yl)phenox...) Show SMILES COc1cc(ccc1OCCCOc1ccc2[C@H](CC(O)=O)CCc2c1)-c1nccs1 |r| Show InChI InChI=1S/C24H25NO5S/c1-28-22-14-18(24-25-9-12-31-24)5-8-21(22)30-11-2-10-29-19-6-7-20-16(13-19)3-4-17(20)15-23(26)27/h5-9,12-14,17H,2-4,10-11,15H2,1H3,(H,26,27)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.580	n/a	n/a	n/a	25
Bayer HealthCare Pharmaceuticals Corporation					Assay Description Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...				J Med Chem 50: 984-1000 (2007) Article DOI: 10.1021/jm061299k BindingDB Entry DOI: 10.7270/Q2NK3C93
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50539513 (CHEMBL4640515) Show SMILES Cc1cnc(-c2ccc(cc2)-c2ccco2)n1Cc1ccccc1OCCCCCC(O)=O Show InChI InChI=1S/C27H28N2O4/c1-20-18-28-27(22-14-12-21(13-15-22)24-10-7-17-33-24)29(20)19-23-8-4-5-9-25(23)32-16-6-2-3-11-26(30)31/h4-5,7-10,12-15,17-18H,2-3,6,11,16,19H2,1H3,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	0.700	n/a	n/a	n/a	n/a
TBA					Assay Description Modulator activity at GAL4-fused human PPARdelta LBD (128 to residue at C-terminus) transfected in African green monkey CV1 cells assessed as recepto...				Citation and Details Article DOI: 10.1021/acsmedchemlett.8b00287 BindingDB Entry DOI: 10.7270/Q2H998WR
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50539512 (CHEMBL4635689) Show SMILES C[C@H](CCCOc1ccccc1Cn1c(ncc1C(F)(F)F)-c1ccc(cc1)-c1ccco1)CC(O)=O |r| Show InChI InChI=1S/C28H27F3N2O4/c1-19(16-26(34)35)6-4-14-37-24-8-3-2-7-22(24)18-33-25(28(29,30)31)17-32-27(33)21-12-10-20(11-13-21)23-9-5-15-36-23/h2-3,5,7-13,15,17,19H,4,6,14,16,18H2,1H3,(H,34,35)/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.700	n/a	n/a	n/a	n/a
Mitobridge, Inc. Curated by ChEMBL					Assay Description Transactivation of GAL4-fused human PPARdelta expressed in African green monkey CV1 cells by luciferase reporter gene assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126928 BindingDB Entry DOI: 10.7270/Q29G5RBQ
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50463280 (CHEMBL4249571) Show SMILES Cc1cc(S[C@H](Cc2ccccc2)c2ccc(cc2)-c2ccc(cc2)C(F)(F)F)ccc1OCC(O)=O |r| Show InChI InChI=1S/C30H25F3O3S/c1-20-17-26(15-16-27(20)36-19-29(34)35)37-28(18-21-5-3-2-4-6-21)24-9-7-22(8-10-24)23-11-13-25(14-12-23)30(31,32)33/h2-17,28H,18-19H2,1H3,(H,34,35)/t28-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.700	n/a	n/a	n/a	n/a
Daegu-Gyeongbuk Medical Innovation Foundation Curated by ChEMBL					Assay Description Transactivation of human PPARdelta expressed in monkey CV-1 cells coexpressing TK-PPRE-Luc after 24 hrs by luciferase reporter gene assay				Bioorg Med Chem 26: 4382-4389 (2018) Article DOI: 10.1016/j.bmc.2018.06.044 BindingDB Entry DOI: 10.7270/Q2DJ5J8Z
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50214207 ((2S)-2-{4-butoxy-3-[({[2-fluoro-4-(trifluoromethyl...) Show SMILES CCCCOc1ccc(C[C@H](CC)C(O)=O)cc1CNC(=O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C24H27F4NO4/c1-3-5-10-33-21-9-6-15(11-16(4-2)23(31)32)12-17(21)14-29-22(30)19-8-7-18(13-20(19)25)24(26,27)28/h6-9,12-13,16H,3-5,10-11,14H2,1-2H3,(H,29,30)(H,31,32)/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.720	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Agonist activity at PPARdelta receptor expressed in HEK293 cells cotransfected with GAL4 by transactivation assay				Bioorg Med Chem Lett 19: 6595-9 (2009) Article DOI: 10.1016/j.bmcl.2009.10.021 BindingDB Entry DOI: 10.7270/Q2736R23
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50214207 ((2S)-2-{4-butoxy-3-[({[2-fluoro-4-(trifluoromethyl...) Show SMILES CCCCOc1ccc(C[C@H](CC)C(O)=O)cc1CNC(=O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C24H27F4NO4/c1-3-5-10-33-21-9-6-15(11-16(4-2)23(31)32)12-17(21)14-29-22(30)19-8-7-18(13-20(19)25)24(26,27)28/h6-9,12-13,16H,3-5,10-11,14H2,1-2H3,(H,29,30)(H,31,32)/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.720	n/a	n/a	n/a	n/a
Okayama University Curated by ChEMBL					Assay Description Transactivation of Gal4-fused human PPARdelta expressed in HEK293 cells after 16 to 20 hrs by luciferase reporter gene assay				J Med Chem 54: 331-41 (2011) Article DOI: 10.1021/jm101233f BindingDB Entry DOI: 10.7270/Q2TM7C3T
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50558888 (CHEMBL4739884) Show SMILES C[C@H](CCCOc1ccccc1Cn1c(C)cnc1-c1ccc(Cl)c(F)c1)CC(O)=O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.800	n/a	n/a	n/a	n/a
TBA					Assay Description Modulator activity at GAL4-fused human PPARdelta LBD (128 to residue at C-terminus) transfected in African green monkey CV1 cells assessed as recepto...				Citation and Details Article DOI: 10.1021/acsmedchemlett.8b00287 BindingDB Entry DOI: 10.7270/Q2H998WR
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM412345 (US10399958, Compound 2j) Show SMILES CC(CCCOc1ccccc1Cn1c(C)cnc1-c1ccc(Cl)c(F)c1)CC(O)=O Show InChI InChI=1S/C24H26ClFN2O3/c1-16(12-23(29)30)6-5-11-31-22-8-4-3-7-19(22)15-28-17(2)14-27-24(28)18-9-10-20(25)21(26)13-18/h3-4,7-10,13-14,16H,5-6,11-12,15H2,1-2H3,(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	n/a	n/a	0.800	n/a	n/a	n/a	n/a
Mitobridge, Inc. US Patent					Assay Description Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...				US Patent US10399958 (2019) BindingDB Entry DOI: 10.7270/Q26Q20MJ
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50332462 (2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phe...) Show SMILES Cc1nc(sc1C[Se]c1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H18F3NO3SSe/c1-12-9-16(7-8-17(12)28-10-19(26)27)30-11-18-13(2)25-20(29-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.900	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Agonist activity at human PPAR-delta expressed in african green monkey CV-1 cells after 24 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 20: 7239-42 (2010) Article DOI: 10.1016/j.bmcl.2010.10.103 BindingDB Entry DOI: 10.7270/Q2SN0975
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50214207 ((2S)-2-{4-butoxy-3-[({[2-fluoro-4-(trifluoromethyl...) Show SMILES CCCCOc1ccc(C[C@H](CC)C(O)=O)cc1CNC(=O)c1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C24H27F4NO4/c1-3-5-10-33-21-9-6-15(11-16(4-2)23(31)32)12-17(21)14-29-22(30)19-8-7-18(13-20(19)25)24(26,27)28/h6-9,12-13,16H,3-5,10-11,14H2,1-2H3,(H,29,30)(H,31,32)/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.910	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Effect on PPARdelta transactivation activity in HEK293 cells				Bioorg Med Chem 15: 5177-90 (2007) Article DOI: 10.1016/j.bmc.2007.05.023 BindingDB Entry DOI: 10.7270/Q2QZ29P7
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM21785 (2-[(1S)-5-(3-{4-[5-(trifluoromethyl)pyridin-2-yl]p...) Show SMILES OC(=O)C[C@@H]1CCc2cc(OCCCOc3ccc(cc3)-c3ccc(cn3)C(F)(F)F)ccc12 |r| Show InChI InChI=1S/C26H24F3NO4/c27-26(28,29)20-6-11-24(30-16-20)17-4-7-21(8-5-17)33-12-1-13-34-22-9-10-23-18(14-22)2-3-19(23)15-25(31)32/h4-11,14,16,19H,1-3,12-13,15H2,(H,31,32)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.950	n/a	n/a	n/a	25
Bayer HealthCare Pharmaceuticals Corporation					Assay Description Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...				J Med Chem 50: 984-1000 (2007) Article DOI: 10.1021/jm061299k BindingDB Entry DOI: 10.7270/Q2NK3C93
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM28661 (2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...) Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM28661 (2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...) Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description The confluent HEK293 cells were co-transfected with DNA construct containing PPARdelta-Gal4 chimeric receptor and Gal4-luciferase reporter. The lucif...				J Med Chem 50: 3954-63 (2007) Article DOI: 10.1021/jm070511x BindingDB Entry DOI: 10.7270/Q2H41PR5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM28661 (2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...) Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
GSK					Assay Description The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...				J Med Chem 50: 685-95 (2007) Article DOI: 10.1021/jm058056x BindingDB Entry DOI: 10.7270/Q2RN3669
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM28661 (2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...) Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Maximum transcriptional activation of human PPAR delta receptor				Bioorg Med Chem Lett 13: 1517-21 (2003) BindingDB Entry DOI: 10.7270/Q2VQ322G
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50127222 (CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...) Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(c(F)c1)C(F)(F)F Show InChI InChI=1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Maximum transcriptional activation of human PPAR delta receptor				Bioorg Med Chem Lett 13: 1517-21 (2003) BindingDB Entry DOI: 10.7270/Q2VQ322G
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM232290 (US9346770, 3) Show SMILES CCc1cc(OCCc2nc(oc2C)-c2ccc(cc2)C(F)(F)F)ccc1CCC(O)=O Show InChI InChI=1S/C24H24F3NO4/c1-3-16-14-20(10-6-17(16)7-11-22(29)30)31-13-12-21-15(2)32-23(28-21)18-4-8-19(9-5-18)24(25,26)27/h4-6,8-10,14H,3,7,11-13H2,1-2H3,(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1	n/a	n/a	n/a	n/a
ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. US Patent					Assay Description After 24 h treatment with the medicament, the cells were lysed with a lysis solution (Cell Culture Lysis buffer, Promega) and centrifuged, and the su...				US Patent US9346770 (2016) BindingDB Entry DOI: 10.7270/Q21Z438X
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50194627 ((R)-3-(4-(3-(2-benzoyl-4-ethylphenoxy)butoxy)-2-me...) Show SMILES CCc1ccc(O[C@H](C)CCOc2ccc(CCC(O)=O)c(C)c2)c(c1)C(=O)c1ccccc1 Show InChI InChI=1S/C29H32O5/c1-4-22-10-14-27(26(19-22)29(32)24-8-6-5-7-9-24)34-21(3)16-17-33-25-13-11-23(20(2)18-25)12-15-28(30)31/h5-11,13-14,18-19,21H,4,12,15-17H2,1-3H3,(H,30,31)/t21-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at human Gal4-PPARdelta expressed in CV1 cells by transactivation assay				Bioorg Med Chem Lett 17: 1052-5 (2007) Article DOI: 10.1016/j.bmcl.2006.11.029 BindingDB Entry DOI: 10.7270/Q2BP02F8
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM28661 (2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...) Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Université d'Orléans Curated by ChEMBL					Assay Description Activity at PPARbeta/delta by luciferase reporter gene transactivation assay in COS7 cells				Bioorg Med Chem Lett 16: 4528-32 (2006) Article DOI: 10.1016/j.bmcl.2006.06.028 BindingDB Entry DOI: 10.7270/Q28915HC
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50194628 ((R)-3-{2-methyl-4-[3-(2-phenoxy-4-trifluoromethyl-...) Show SMILES C[C@H](CCOc1ccc(CCC(O)=O)c(C)c1)Oc1ccc(cc1Oc1ccccc1)C(F)(F)F Show InChI InChI=1S/C27H27F3O5/c1-18-16-23(11-8-20(18)9-13-26(31)32)33-15-14-19(2)34-24-12-10-21(27(28,29)30)17-25(24)35-22-6-4-3-5-7-22/h3-8,10-12,16-17,19H,9,13-15H2,1-2H3,(H,31,32)/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Transactivation of human PPARdelta in CV1 cells by luciferase reporter gene assay				J Med Chem 49: 5649-52 (2006) Article DOI: 10.1021/jm060617c BindingDB Entry DOI: 10.7270/Q2K073WF
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM232289 (US9346770, 2) Show SMILES CCc1cc(OCCc2coc(n2)-c2ccc(cc2)C(F)(F)F)ccc1CCC(O)=O Show InChI InChI=1S/C23H22F3NO4/c1-2-15-13-20(9-5-16(15)6-10-21(28)29)30-12-11-19-14-31-22(27-19)17-3-7-18(8-4-17)23(24,25)26/h3-5,7-9,13-14H,2,6,10-12H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1	n/a	n/a	n/a	n/a
ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. US Patent					Assay Description After 24 h treatment with the medicament, the cells were lysed with a lysis solution (Cell Culture Lysis buffer, Promega) and centrifuged, and the su...				US Patent US9346770 (2016) BindingDB Entry DOI: 10.7270/Q21Z438X
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM28661 (2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...) Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Daegu-Gyeongbuk Medical Innovation Foundation Curated by ChEMBL					Assay Description Agonist activity at PPARdelta (unknown origin)				J Med Chem 63: 10109-10134 (2020) Article DOI: 10.1021/acs.jmedchem.9b01882 BindingDB Entry DOI: 10.7270/Q2HH6PNH
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50558897 (CHEMBL4743546) Show SMILES C\C(CCC(O)=O)=C/COc1ccccc1Cn1c(C)cnc1-c1ccc(cc1)-c1ccco1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
TBA					Assay Description Modulator activity at GAL4-fused human PPARdelta LBD (128 to residue at C-terminus) transfected in African green monkey CV1 cells assessed as recepto...				Citation and Details Article DOI: 10.1021/acsmedchemlett.8b00287 BindingDB Entry DOI: 10.7270/Q2H998WR
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50127222 (CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...) Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(c(F)c1)C(F)(F)F Show InChI InChI=1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Guangdong Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at PPARdelta (unknown origin)				Eur J Med Chem 159: 267-276 (2018) Article DOI: 10.1016/j.ejmech.2018.09.071 BindingDB Entry DOI: 10.7270/Q27D2XTM
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM412336 (US10399958, Compound 2a) Show SMILES CC(CCCOc1ccccc1Cn1c(C)cnc1-c1ccc(OC(F)(F)F)cc1)CC(O)=O Show InChI InChI=1S/C25H27F3N2O4/c1-17(14-23(31)32)6-5-13-33-22-8-4-3-7-20(22)16-30-18(2)15-29-24(30)19-9-11-21(12-10-19)34-25(26,27)28/h3-4,7-12,15,17H,5-6,13-14,16H2,1-2H3,(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Mitobridge, Inc. US Patent					Assay Description Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...				US Patent US10399958 (2019) BindingDB Entry DOI: 10.7270/Q26Q20MJ
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50172358 (Biphenyl-4-carboxylic acid (2,2-dimethyl-2H-chrome...) Show SMILES CC(C)N(Cc1cccc2C=CC(C)(C)Oc12)C(=O)c1ccc(cc1)-c1ccccc1 |c:10| Show InChI InChI=1S/C28H29NO2/c1-20(2)29(19-25-12-8-11-23-17-18-28(3,4)31-26(23)25)27(30)24-15-13-22(14-16-24)21-9-6-5-7-10-21/h5-18,20H,19H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Effective concentration against PPAR delta receptor				J Med Chem 48: 5613-38 (2005) Article DOI: 10.1021/jm050524f BindingDB Entry DOI: 10.7270/Q2V988V1
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50384971 (CHEMBL2035069) Show SMILES CCCC(Sc1ccc(OCC(O)=O)c(C)c1)c1sc(nc1C)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C24H24F3NO3S2/c1-4-5-20(32-18-10-11-19(14(2)12-18)31-13-21(29)30)22-15(3)28-23(33-22)16-6-8-17(9-7-16)24(25,26)27/h6-12,20H,4-5,13H2,1-3H3,(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Transactivation activity at human PPARdelta expressed in african green monkey CV1 cells after 24 hrs by luciferase reporter gene assay				Eur J Med Chem 53: 190-202 (2012) Article DOI: 10.1016/j.ejmech.2012.03.055 BindingDB Entry DOI: 10.7270/Q2JW8FX2
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50312419 (2-(4-((4-(4-(N-Isopropyl-N-methyl)benzamide)-5-(4-...) Show SMILES CC(C)N(C)C(=O)c1ccc(cc1)-c1nc(COc2ccc(OCC(O)=O)c(C)c2)oc1-c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C31H29F3N2O7/c1-18(2)36(4)30(39)22-7-5-20(6-8-22)28-29(21-9-11-23(12-10-21)43-31(32,33)34)42-26(35-28)16-40-24-13-14-25(19(3)15-24)41-17-27(37)38/h5-15,18H,16-17H2,1-4H3,(H,37,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Agonist activity at human PPARdelta ligand binding domain expressed in human 293T cells cotransfected with Gal4-DBD by luciferase transactivation ass...				J Med Chem 53: 77-105 (2010) Article DOI: 10.1021/jm9007399 BindingDB Entry DOI: 10.7270/Q28052RP
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50332466 (2-(4-((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-me...) Show SMILES Cc1nc(sc1C[Se]c1ccc(OCC(O)=O)c(C)c1)-c1ccc(c(F)c1)C(F)(F)F Show InChI InChI=1S/C21H17F4NO3SSe/c1-11-7-14(4-6-17(11)29-9-19(27)28)31-10-18-12(2)26-20(30-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Agonist activity at human PPAR-delta expressed in african green monkey CV-1 cells after 24 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 20: 7239-42 (2010) Article DOI: 10.1016/j.bmcl.2010.10.103 BindingDB Entry DOI: 10.7270/Q2SN0975
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50160404 (CHEMBL3786533) Show SMILES Cc1cc(SCc2cnc(s2)-c2ccc(c(F)c2)C(F)(F)F)ccc1OCC(O)=O Show InChI InChI=1S/C20H15F4NO3S2/c1-11-6-13(3-5-17(11)28-9-18(26)27)29-10-14-8-25-19(30-14)12-2-4-15(16(21)7-12)20(22,23)24/h2-8H,9-10H2,1H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Texas Tech University Health Sciences Center Curated by ChEMBL					Assay Description Agonist activity at human PPAR delta by cell based reporter assay				Bioorg Med Chem Lett 26: 1889-93 (2016) Article DOI: 10.1016/j.bmcl.2016.03.028 BindingDB Entry DOI: 10.7270/Q2NK3GZV
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50160404 (CHEMBL3786533) Show SMILES Cc1cc(SCc2cnc(s2)-c2ccc(c(F)c2)C(F)(F)F)ccc1OCC(O)=O Show InChI InChI=1S/C20H15F4NO3S2/c1-11-6-13(3-5-17(11)28-9-18(26)27)29-10-14-8-25-19(30-14)12-2-4-15(16(21)7-12)20(22,23)24/h2-8H,9-10H2,1H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Texas Tech University Health Sciences Center Curated by ChEMBL					Assay Description Agonist activity at PPAR delta (unknown origin) transfected in HEK293 cells after 24 hrs by dual-luciferase reporter gene assay				Bioorg Med Chem Lett 26: 1889-93 (2016) Article DOI: 10.1016/j.bmcl.2016.03.028 BindingDB Entry DOI: 10.7270/Q2NK3GZV
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50312480 (2-(4-((4-(2-Isopropoxypyrimidin-5-yl)-5-(4-(triflu...) Show SMILES CC(C)Oc1ncc(cn1)-c1nc(COc2ccc(OCC(O)=O)c(C)c2)oc1-c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C27H24F3N3O7/c1-15(2)38-26-31-11-18(12-32-26)24-25(17-4-6-19(7-5-17)40-27(28,29)30)39-22(33-24)13-36-20-8-9-21(16(3)10-20)37-14-23(34)35/h4-12,15H,13-14H2,1-3H3,(H,34,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Agonist activity at human PPARdelta ligand binding domain expressed in human 293T cells cotransfected with Gal4-DBD by luciferase transactivation ass...				J Med Chem 53: 77-105 (2010) Article DOI: 10.1021/jm9007399 BindingDB Entry DOI: 10.7270/Q28052RP
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50312481 (2-(4-((4-(2-Morpholinopyrimidin-5-yl)-5-(4-(triflu...) Show SMILES Cc1cc(OCc2nc(c(o2)-c2ccc(OC(F)(F)F)cc2)-c2cnc(nc2)N2CCOCC2)ccc1OCC(O)=O Show InChI InChI=1S/C28H25F3N4O7/c1-17-12-21(6-7-22(17)40-16-24(36)37)39-15-23-34-25(19-13-32-27(33-14-19)35-8-10-38-11-9-35)26(41-23)18-2-4-20(5-3-18)42-28(29,30)31/h2-7,12-14H,8-11,15-16H2,1H3,(H,36,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Agonist activity at human PPARdelta ligand binding domain expressed in human 293T cells cotransfected with Gal4-DBD by luciferase transactivation ass...				J Med Chem 53: 77-105 (2010) Article DOI: 10.1021/jm9007399 BindingDB Entry DOI: 10.7270/Q28052RP
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50227763 ((R)-3-(4-(3-(1-(5-chloro-1,3-dimethyl-1H-indole-2-...) Show SMILES CCc1cc(Oc2cc(F)cc(c2)[C@@H](C)NC(=O)c2c(C)c3cc(Cl)ccc3n2C)ccc1CCC(O)=O Show InChI InChI=1S/C30H30ClFN2O4/c1-5-19-13-24(9-6-20(19)7-11-28(35)36)38-25-14-21(12-23(32)16-25)18(3)33-30(37)29-17(2)26-15-22(31)8-10-27(26)34(29)4/h6,8-10,12-16,18H,5,7,11H2,1-4H3,(H,33,37)(H,35,36)/t18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Agonist activity at human PPARdelta expressed in CV1 cells by receptor transactivation assay				Bioorg Med Chem Lett 17: 6744-9 (2008) Article DOI: 10.1016/j.bmcl.2007.10.047 BindingDB Entry DOI: 10.7270/Q2VT1RTW
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50384973 (CHEMBL2035057) Show SMILES Cc1nc(sc1C(CC1CC1)Sc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H24F3NO3S2/c1-14-11-19(9-10-20(14)32-13-22(30)31)33-21(12-16-3-4-16)23-15(2)29-24(34-23)17-5-7-18(8-6-17)25(26,27)28/h5-11,16,21H,3-4,12-13H2,1-2H3,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Transactivation activity at human PPARdelta expressed in african green monkey CV1 cells after 24 hrs by luciferase reporter gene assay				Eur J Med Chem 53: 190-202 (2012) Article DOI: 10.1016/j.ejmech.2012.03.055 BindingDB Entry DOI: 10.7270/Q2JW8FX2
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50160403 (CHEMBL3786754) Show SMILES Cc1cc(SCc2cnc(s2)-c2ccc(cc2)C(F)(F)F)ccc1OCC(O)=O Show InChI InChI=1S/C20H16F3NO3S2/c1-12-8-15(6-7-17(12)27-10-18(25)26)28-11-16-9-24-19(29-16)13-2-4-14(5-3-13)20(21,22)23/h2-9H,10-11H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a
Texas Tech University Health Sciences Center Curated by ChEMBL					Assay Description Agonist activity at human PPAR delta by cell based reporter assay				Bioorg Med Chem Lett 26: 1889-93 (2016) Article DOI: 10.1016/j.bmcl.2016.03.028 BindingDB Entry DOI: 10.7270/Q2NK3GZV
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human))	BDBM50384972 (CHEMBL2035071) Show SMILES CC(C)CC(Sc1ccc(OCC(O)=O)c(C)c1)c1sc(nc1C)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H26F3NO3S2/c1-14(2)11-21(33-19-9-10-20(15(3)12-19)32-13-22(30)31)23-16(4)29-24(34-23)17-5-7-18(8-6-17)25(26,27)28/h5-10,12,14,21H,11,13H2,1-4H3,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Transactivation activity at human PPARdelta expressed in african green monkey CV1 cells after 24 hrs by luciferase reporter gene assay				Eur J Med Chem 53: 190-202 (2012) Article DOI: 10.1016/j.ejmech.2012.03.055 BindingDB Entry DOI: 10.7270/Q2JW8FX2
					More data for this Ligand-Target Pair

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