BindingDB PrimarySearch

Found 37 hits of ec50 data for complexid = 50000720
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50019057 ((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...) Show SMILES CNCC(O)c1cc(O)c(O)cc1F Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria				J Med Chem 31: 1972-7 (1988) BindingDB Entry DOI: 10.7270/Q2V69K54
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50476638 (CHEMBL75389) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	166	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Agonist activity at human brain adrenergic alpha2 receptor by [35S]GTPgammaS binding assay				J Med Chem 50: 4516-27 (2007) Article DOI: 10.1021/jm070229q BindingDB Entry DOI: 10.7270/Q2571FSN
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50029050 ((-)-(R)-epinephrine \| (-)-3,4-dihydroxy-alpha-((me...) Show SMILES CNC[C@H](O)c1ccc(O)c(O)c1 \|r\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Agonistic potency at alpha 2-Adrenergic receptor for inhibition of 10 uM forskolin-elicited stimulation of adenylate cyclase in human platelet membra...				J Med Chem 31: 1972-7 (1988) BindingDB Entry DOI: 10.7270/Q2V69K54
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50270853 (CHEMBL4128374) Show SMILES Cl.NC(=N)Nc1cc2CCCc2s1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Activity at alpha2 adrenergic receptor in human brain prefrontal cortex membranes assessed as effect on UK14304-induced [35S]GTPgammaS binding by mea...				Eur J Med Chem 138: 38-50 (2017) Article DOI: 10.1016/j.ejmech.2017.06.008 BindingDB Entry DOI: 10.7270/Q2BV7K3C
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50270852 (CHEMBL4125770) Show SMILES Cl.NC(=N)Nc1cc2CCCCc2s1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	800	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Activity at alpha2 adrenergic receptor in human brain prefrontal cortex membranes assessed as effect on UK14304-induced [35S]GTPgammaS binding by mea...				Eur J Med Chem 138: 38-50 (2017) Article DOI: 10.1016/j.ejmech.2017.06.008 BindingDB Entry DOI: 10.7270/Q2BV7K3C
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50020819 (CHEMBL543126 \| N-[2-Hydroxy-5-(2-methylamino-ethyl...) Show SMILES CNCCc1ccc(O)c(NS(C)(=O)=O)c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Effective concentration (EC50) against alpha-2-adrenoceptor in the guinea pig atrium				J Med Chem 28: 245-8 (1985) BindingDB Entry DOI: 10.7270/Q2XK8G31
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50270781 (CHEMBL4129213) Show SMILES Cl.NC(=N)Nc1nc2CCCc2s1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Activity at alpha2 adrenergic receptor in human brain prefrontal cortex membranes assessed as effect on UK14304-induced [35S]GTPgammaS binding by mea...				Eur J Med Chem 138: 38-50 (2017) Article DOI: 10.1016/j.ejmech.2017.06.008 BindingDB Entry DOI: 10.7270/Q2BV7K3C
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50270855 (CHEMBL4129427) Show SMILES Cl.NC(=N)NCCc1cccs1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Activity at alpha2 adrenergic receptor in human brain prefrontal cortex membranes assessed as effect on UK14304-induced [35S]GTPgammaS binding by mea...				Eur J Med Chem 138: 38-50 (2017) Article DOI: 10.1016/j.ejmech.2017.06.008 BindingDB Entry DOI: 10.7270/Q2BV7K3C
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50479675 (CHEMBL473567) Show SMILES CCN(C)c1ccc(NC2=NCCN2)cc1 \|t:9\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Agonist activity at alpha2 adrenoceptor in human cortical membrane after 2 hrs by [35S]GTPgammaS binding assay				J Med Chem 52: 601-9 (2009) Article DOI: 10.1021/jm800838r BindingDB Entry DOI: 10.7270/Q26M39MM
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50070076 (CHEMBL3407828) Show SMILES Cl.NC(=N)Nc1ccc2CCCCc2n1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.71E+3	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Antagonist activity at human alpha-2 adrenergic receptor in brain prefrontal cortex membrane assessed as inhibition of UK14304-induced [35S]-GTPgamma...				J Med Chem 58: 963-77 (2015) Article DOI: 10.1021/jm501635e BindingDB Entry DOI: 10.7270/Q280549P
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50476631 (CHEMBL230861) Show SMILES CCN(CC)c1ccc(NC2=NCCN2)cc1 \|t:10\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.76E+3	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Agonist activity at human brain adrenergic alpha2 receptor by [35S]GTPgammaS binding assay				J Med Chem 50: 4516-27 (2007) Article DOI: 10.1021/jm070229q BindingDB Entry DOI: 10.7270/Q2571FSN
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50070101 (CHEMBL3407840) Show SMILES Cl.C1CN=C(Nc2ccc3CCCCc3n2)N1 \|t:2\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.57E+3	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Antagonist activity at human alpha-2 adrenergic receptor in brain prefrontal cortex membrane assessed as inhibition of UK14304-induced [35S]-GTPgamma...				J Med Chem 58: 963-77 (2015) Article DOI: 10.1021/jm501635e BindingDB Entry DOI: 10.7270/Q280549P
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50070100 (CHEMBL3408018) Show SMILES Cl.C1CN=C(Nc2cnc3CCCCc3c2)N1 \|t:2\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4.23E+3	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Antagonist activity at human alpha-2 adrenergic receptor in brain prefrontal cortex membrane assessed as inhibition of UK14304-induced [35S]-GTPgamma...				J Med Chem 58: 963-77 (2015) Article DOI: 10.1021/jm501635e BindingDB Entry DOI: 10.7270/Q280549P
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50476630 (CHEMBL242102) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.38E+3	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Antagonist activity at human brain adrenergic alpha-2 receptor assessed as UK-14304-stimulated [35S]GTPgammaS binding at 10 uM				J Med Chem 50: 4516-27 (2007) Article DOI: 10.1021/jm070229q BindingDB Entry DOI: 10.7270/Q2571FSN
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50019059 ((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...) Show SMILES CNCC(O)c1ccc(O)c(O)c1F Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Agonistic potency at alpha 2-Adrenergic receptor for inhibition of 10 uM forskolin-elicited stimulation of adenylate cyclase in human platelet membra...				J Med Chem 31: 1972-7 (1988) BindingDB Entry DOI: 10.7270/Q2V69K54
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50270854 (CHEMBL4127933) Show SMILES Cl.NC(=N)Nc1sc2CCCCc2c1C#N Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Activity at alpha2 adrenergic receptor in human brain prefrontal cortex membranes assessed as effect on UK14304-induced [35S]GTPgammaS binding by mea...				Eur J Med Chem 138: 38-50 (2017) Article DOI: 10.1016/j.ejmech.2017.06.008 BindingDB Entry DOI: 10.7270/Q2BV7K3C
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50070099 (CHEMBL3408019) Show SMILES Cl.CCNc1ccc(NC2=NCCN2)cn1 \|t:8\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.71E+3	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Antagonist activity at human alpha-2 adrenergic receptor in brain prefrontal cortex membrane assessed as inhibition of UK14304-induced [35S]-GTPgamma...				J Med Chem 58: 963-77 (2015) Article DOI: 10.1021/jm501635e BindingDB Entry DOI: 10.7270/Q280549P
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50270851 (CHEMBL4127137) Show SMILES Cl.NC(=N)Nc1cc2CCCCCc2s1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.07E+4	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Activity at alpha2 adrenergic receptor in human brain prefrontal cortex membranes assessed as effect on UK14304-induced [35S]GTPgammaS binding by mea...				Eur J Med Chem 138: 38-50 (2017) Article DOI: 10.1016/j.ejmech.2017.06.008 BindingDB Entry DOI: 10.7270/Q2BV7K3C
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM34572 (BRIMONIDINE \| CHEMBL844 \| MLS000069370 \| SMR000058...) Show SMILES Brc1c(NC2=NCCN2)ccc2nccnc12 \|t:4\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	1.14E+4	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Agonist activity at human brain adrenergic alpha2 receptor by [35S]GTPgammaS binding assay				J Med Chem 50: 4516-27 (2007) Article DOI: 10.1021/jm070229q BindingDB Entry DOI: 10.7270/Q2571FSN
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50270780 (CHEMBL4125903) Show SMILES Cl.NC(=N)Nc1nc2CCCCc2s1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.14E+4	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Activity at alpha2 adrenergic receptor in human brain prefrontal cortex membranes assessed as effect on UK14304-induced [35S]GTPgammaS binding by mea...				Eur J Med Chem 138: 38-50 (2017) Article DOI: 10.1016/j.ejmech.2017.06.008 BindingDB Entry DOI: 10.7270/Q2BV7K3C
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM34572 (BRIMONIDINE \| CHEMBL844 \| MLS000069370 \| SMR000058...) Show SMILES Brc1c(NC2=NCCN2)ccc2nccnc12 \|t:4\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	1.14E+4	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Agonist activity at alpha2 adrenoceptor in human cortical membrane after 2 hrs by [35S]GTPgammaS binding assay				J Med Chem 52: 601-9 (2009) Article DOI: 10.1021/jm800838r BindingDB Entry DOI: 10.7270/Q26M39MM
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50476636 (4-Guanidinoaniline Dihydrochloride Salt \| CHEMBL12...) Show SMILES Cl.Cl.CN(C)c1ccc(NC(N)=N)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Antagonist activity at human brain adrenergic alpha-2 receptor assessed as UK-14304-stimulated [35S]GTPgammaS binding at 10 uM				J Med Chem 50: 4516-27 (2007) Article DOI: 10.1021/jm070229q BindingDB Entry DOI: 10.7270/Q2571FSN
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50479674 (CHEMBL482359) Show SMILES CCN(C)c1ccc(NC(N)=N)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.62E+4	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Agonist activity at alpha2 adrenoceptor in human cortical membrane after 2 hrs by [35S]GTPgammaS binding assay				J Med Chem 52: 601-9 (2009) Article DOI: 10.1021/jm800838r BindingDB Entry DOI: 10.7270/Q26M39MM
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50476635 (CHEMBL230644) Show SMILES COc1ccc(NC2=NCCN2)cc1 \|t:7\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.04E+4	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Agonist activity at human brain adrenergic alpha2 receptor by [35S]GTPgammaS binding assay				J Med Chem 50: 4516-27 (2007) Article DOI: 10.1021/jm070229q BindingDB Entry DOI: 10.7270/Q2571FSN
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50070098 (CHEMBL3408028) Show SMILES Cl.N=C(NCc1ccco1)Nc1ccc2CCCCc2n1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Antagonist activity at human alpha-2 adrenergic receptor in brain prefrontal cortex membrane assessed as inhibition of UK14304-induced [35S]-GTPgamma...				J Med Chem 58: 963-77 (2015) Article DOI: 10.1021/jm501635e BindingDB Entry DOI: 10.7270/Q280549P
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50479677 (CHEMBL482200) Show SMILES CCC(CC)c1ccc(NC(N)=N)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.87E+4	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Agonist activity at alpha2 adrenoceptor in human cortical membrane after 2 hrs by [35S]GTPgammaS binding assay				J Med Chem 52: 601-9 (2009) Article DOI: 10.1021/jm800838r BindingDB Entry DOI: 10.7270/Q26M39MM
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50476646 (CHEMBL242839) Show SMILES NC(=N)Nc1ccc2OCCOc2c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.22E+4	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Agonist activity at human brain adrenergic alpha2 receptor by [35S]GTPgammaS binding assay				J Med Chem 50: 4516-27 (2007) Article DOI: 10.1021/jm070229q BindingDB Entry DOI: 10.7270/Q2571FSN
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50223870 (CHEMBL9441) Show SMILES CSc1ccc(NC2=NCCN2)cc1 \|t:7\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.53E+4	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Agonist activity at human brain adrenergic alpha2 receptor by [35S]GTPgammaS binding assay				J Med Chem 50: 4516-27 (2007) Article DOI: 10.1021/jm070229q BindingDB Entry DOI: 10.7270/Q2571FSN
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50213214 (CHEMBL42139) Show SMILES C1CN=C(Nc2ccc3OCCOc3c2)N1 \|t:2\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.64E+4	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Agonist activity at human brain adrenergic alpha2 receptor by [35S]GTPgammaS binding assay				J Med Chem 50: 4516-27 (2007) Article DOI: 10.1021/jm070229q BindingDB Entry DOI: 10.7270/Q2571FSN
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50479679 (CHEMBL506313) Show SMILES CCNc1ccc(NC2=NCCN2)cc1 \|t:8\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.93E+4	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Agonist activity at alpha2 adrenoceptor in human cortical membrane after 2 hrs by [35S]GTPgammaS binding assay				J Med Chem 52: 601-9 (2009) Article DOI: 10.1021/jm800838r BindingDB Entry DOI: 10.7270/Q26M39MM
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50070081 (CHEMBL3408032) Show SMILES Cl.OCCNC1=NCc2ccccc2N1 \|t:4\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.03E+4	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Antagonist activity at human alpha-2 adrenergic receptor in brain prefrontal cortex membrane assessed as inhibition of UK14304-induced [35S]-GTPgamma...				J Med Chem 58: 963-77 (2015) Article DOI: 10.1021/jm501635e BindingDB Entry DOI: 10.7270/Q280549P
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50479673 (CHEMBL467525) Show SMILES CNc1ccc(NC2=NCCN2)cc1 \|t:7\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.14E+4	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Agonist activity at alpha2 adrenoceptor in human cortical membrane after 2 hrs by [35S]GTPgammaS binding assay				J Med Chem 52: 601-9 (2009) Article DOI: 10.1021/jm800838r BindingDB Entry DOI: 10.7270/Q26M39MM
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50479676 (CHEMBL509581) Show SMILES CNc1ccc(NC(N)=N)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	8.23E+4	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Agonist activity at alpha2 adrenoceptor in human cortical membrane after 2 hrs by [35S]GTPgammaS binding assay				J Med Chem 52: 601-9 (2009) Article DOI: 10.1021/jm800838r BindingDB Entry DOI: 10.7270/Q26M39MM
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50476629 (4,4''-Di(2-Imidazolidinylimino)Diphenyl Ether \| CH...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Agonist activity at human brain adrenergic alpha2 receptor by [35S]GTPgammaS binding assay				J Med Chem 50: 4516-27 (2007) Article DOI: 10.1021/jm070229q BindingDB Entry DOI: 10.7270/Q2571FSN
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50476639 (CHEMBL243061) Show SMILES C1CN=C(Nc2ccc3OCOc3c2)N1 \|t:2\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.41E+5	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Antagonist activity at human brain adrenergic alpha-2 receptor assessed as UK-14304-stimulated [35S]GTPgammaS binding at 10 uM				J Med Chem 50: 4516-27 (2007) Article DOI: 10.1021/jm070229q BindingDB Entry DOI: 10.7270/Q2571FSN
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50476634 (4,4''-Di(2-Imidazolidinylimino)Diphenyl Sulfide \| ...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.32E+5	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Agonist activity at human brain adrenergic alpha2 receptor by [35S]GTPgammaS binding assay				J Med Chem 50: 4516-27 (2007) Article DOI: 10.1021/jm070229q BindingDB Entry DOI: 10.7270/Q2571FSN
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50476632 (CHEMBL390246) Show SMILES CN(C)c1ccc(NC2=NCCN2)cc1 \|t:8\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.55E+5	n/a	n/a	n/a	n/a
University of Dublin Curated by ChEMBL					Assay Description Antagonist activity at human brain adrenergic alpha-2 receptor assessed as UK-14304-stimulated [35S]GTPgammaS binding at 10 uM				J Med Chem 50: 4516-27 (2007) Article DOI: 10.1021/jm070229q BindingDB Entry DOI: 10.7270/Q2571FSN
University of Dublin Curated by ChEMBL					More data for this Ligand-Target Pair