Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM92862 (US9284315, BEZ-235 | mTOR Inhibitor, BEZ235) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 1.70 | -50.1 | 3.90 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description The LanthaScreen TR-FRET mTOR assay was performed using Costar low-binding 284-well plates at room temperature according to the instructions of the m... | Biochemistry 49: 8488-98 (2010) Article DOI: 10.1021/bi100673c BindingDB Entry DOI: 10.7270/Q26M35FQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM92862 (US9284315, BEZ-235 | mTOR Inhibitor, BEZ235) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 2.5 | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The mTOR activity was determined by measuring the amount of [gamma-33 P] phosphae from ATP incorporated in the substrate protein. | Biochemistry 49: 8488-98 (2010) Article DOI: 10.1021/bi100673c BindingDB Entry DOI: 10.7270/Q26M35FQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM25045 (3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 19 | -44.1 | 38 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description The LanthaScreen TR-FRET mTOR assay was performed using Costar low-binding 284-well plates at room temperature according to the instructions of the m... | Biochemistry 49: 8488-98 (2010) Article DOI: 10.1021/bi100673c BindingDB Entry DOI: 10.7270/Q26M35FQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM25045 (3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 20 | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The mTOR activity was determined by measuring the amount of [gamma-33 P] phosphae from ATP incorporated in the substrate protein. | Biochemistry 49: 8488-98 (2010) Article DOI: 10.1021/bi100673c BindingDB Entry DOI: 10.7270/Q26M35FQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM92863 (US9505773, Rapamycin | mTOR Inhibitor, Rapamycin) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description The mTOR activity was determined by measuring the amount of [gamma-33 P] phosphae from ATP incorporated in the substrate protein. | Biochemistry 49: 8488-98 (2010) Article DOI: 10.1021/bi100673c BindingDB Entry DOI: 10.7270/Q26M35FQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM92863 (US9505773, Rapamycin | mTOR Inhibitor, Rapamycin) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description The LanthaScreen TR-FRET mTOR assay was performed using Costar low-binding 284-well plates at room temperature according to the instructions of the m... | Biochemistry 49: 8488-98 (2010) Article DOI: 10.1021/bi100673c BindingDB Entry DOI: 10.7270/Q26M35FQ | |||||||||||
More data for this Ligand-Target Pair |