Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.89 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM120816 ((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit [1-973] (Homo sapiens (Human)) | BDBM120816 ((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM120818 ((E)-5-(((3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.75 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage-stimulating protein receptor (Homo sapiens (Human)) | BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.52 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage-stimulating protein receptor (Homo sapiens (Human)) | BDBM120816 ((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.24 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 4.86 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM120815 ((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.04 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 5.61 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM120817 ((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-(piperidin-1-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.63 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit [1-973] (Homo sapiens (Human)) | BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 6.72 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor alpha [1-973] (Homo sapiens (Human)) | BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) | PDB UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 6.78 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human)) | BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 6.89 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM120816 ((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.38 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human)) | BDBM120816 ((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.56 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM120819 ((E)-5-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.78 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor alpha [1-973] (Homo sapiens (Human)) | BDBM120816 ((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...) | PDB UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 32.2 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM120816 ((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 326 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.99E+3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-973] (Homo sapiens (Human)) | BDBM120816 ((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Shenyang Pharmaceutical University, Ministry of Education | Assay Description The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w... | Bioorg Chem 57: 30-42 (2014) Article DOI: 10.1016/j.bioorg.2014.07.011 BindingDB Entry DOI: 10.7270/Q2BG2MPQ | |||||||||||
More data for this Ligand-Target Pair |