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Compile Data Set for Download or QSAR

Found 47 hits Enz. Inhib. hit(s) with all data for entry = 6313   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122451
PNG
(US8729074, 8)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1cccnc1
Show InChI InChI=1S/C23H15ClFN5O2S/c24-23-20(29-33(31,32)19-6-4-18(25)5-7-19)10-17(12-28-23)21-13-27-22-8-3-16(14-30(21)22)15-2-1-9-26-11-15/h1-14,29H
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1n/a 4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122459
PNG
(US8729074, 19)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1ccnc(c1)C(F)(F)F
Show InChI InChI=1S/C20H16ClF3N6O2S/c1-29(2)33(31,32)28-15-7-14(9-27-19(15)21)16-10-26-18-4-3-13(11-30(16)18)12-5-6-25-17(8-12)20(22,23)24/h3-11,28H,1-2H3
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1n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122468
PNG
(US8729074, 18)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1ccncc1
Show InChI InChI=1S/C19H17ClN6O2S/c1-25(2)29(27,28)24-16-9-15(10-23-19(16)20)17-11-22-18-4-3-14(12-26(17)18)13-5-7-21-8-6-13/h3-12,24H,1-2H3
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1n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122450
PNG
(US8729074, 7)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1ccncc1
Show InChI InChI=1S/C23H15ClFN5O2S/c24-23-20(29-33(31,32)19-4-2-18(25)3-5-19)11-17(12-28-23)21-13-27-22-6-1-16(14-30(21)22)15-7-9-26-10-8-15/h1-14,29H
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2n/a 5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122452
PNG
(US8729074, 9)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)N1CCOCC1
Show InChI InChI=1S/C22H19ClFN5O3S/c23-22-19(27-33(30,31)18-4-1-16(24)2-5-18)11-15(12-26-22)20-13-25-21-6-3-17(14-29(20)21)28-7-9-32-10-8-28/h1-6,11-14,27H,7-10H2
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4n/a 6n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122469
PNG
(US8729074, 23)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(C)c(cn12)-c1ccncc1
Show InChI InChI=1S/C20H19ClN6O2S/c1-13-8-19-23-11-18(27(19)12-16(13)14-4-6-22-7-5-14)15-9-17(20(21)24-10-15)25-30(28,29)26(2)3/h4-12,25H,1-3H3
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4n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122460
PNG
(US8729074, 20)
Show SMILES CS(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(ccn12)-c1cccnc1
Show InChI InChI=1S/C18H14ClN5O2S/c1-27(25,26)23-15-7-14(10-22-18(15)19)16-11-21-17-8-12(4-6-24(16)17)13-3-2-5-20-9-13/h2-11,23H,1H3
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5n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122449
PNG
(US8729074, 6)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(Br)cn12
Show InChI InChI=1S/C18H11BrClFN4O2S/c19-12-1-6-17-22-9-16(25(17)10-12)11-7-15(18(20)23-8-11)24-28(26,27)14-4-2-13(21)3-5-14/h1-10,24H
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6n/a 14n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122461
PNG
(US8729074, 21)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(ccn12)-c1ccncc1
Show InChI InChI=1S/C19H17ClN6O2S/c1-25(2)29(27,28)24-16-9-15(11-23-19(16)20)17-12-22-18-10-14(5-8-26(17)18)13-3-6-21-7-4-13/h3-12,24H,1-2H3
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15n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122465
PNG
(US8729074, 4)
Show SMILES Cc1ccn2c(cnc2c1)-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2)c1
Show InChI InChI=1S/C19H14ClFN4O2S/c1-12-6-7-25-17(11-22-18(25)8-12)13-9-16(19(20)23-10-13)24-28(26,27)15-4-2-14(21)3-5-15/h2-11,24H,1H3
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19n/a 13n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122448
PNG
(US8729074, 5)
Show SMILES Cc1nc2ccc(Br)cn2c1-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2)c1
Show InChI InChI=1S/C19H13BrClFN4O2S/c1-11-18(26-10-13(20)2-7-17(26)24-11)12-8-16(19(21)23-9-12)25-29(27,28)15-5-3-14(22)4-6-15/h2-10,25H,1H3
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20n/a 16n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122462
PNG
(US8729074, 22)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(ccn12)-c1cccnc1
Show InChI InChI=1S/C19H17ClN6O2S/c1-25(2)29(27,28)24-16-8-15(11-23-19(16)20)17-12-22-18-9-13(5-7-26(17)18)14-4-3-6-21-10-14/h3-12,24H,1-2H3
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21n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122463
PNG
(US8729074, 25)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(Cl)nn12
Show InChI InChI=1S/C17H10Cl2FN5O2S/c18-15-5-6-16-21-9-14(25(16)23-15)10-7-13(17(19)22-8-10)24-28(26,27)12-3-1-11(20)2-4-12/h1-9,24H
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22n/a 47n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122464
PNG
(US8729074, 3)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccccn12
Show InChI InChI=1S/C18H12ClFN4O2S/c19-18-15(23-27(25,26)14-6-4-13(20)5-7-14)9-12(10-22-18)16-11-21-17-3-1-2-8-24(16)17/h1-11,23H
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28n/a 30n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122446
PNG
(US8729074, 1)
Show SMILES Cc1nc2ccccn2c1-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2)c1
Show InChI InChI=1S/C19H14ClFN4O2S/c1-12-18(25-9-3-2-4-17(25)23-12)13-10-16(19(20)22-11-13)24-28(26,27)15-7-5-14(21)6-8-15/h2-11,24H,1H3
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126n/a 76n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122456
PNG
(US8729074, 14)
Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1[C@H](Cc2ccccc2)COC1=O |r|
Show InChI InChI=1S/C24H22N4O4/c1-30-21-11-17(12-26-23(21)31-2)20-13-25-22-9-8-18(14-27(20)22)28-19(15-32-24(28)29)10-16-6-4-3-5-7-16/h3-9,11-14,19H,10,15H2,1-2H3/t19-/m1/s1
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268n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122457
PNG
(US8729074, 15)
Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1[C@@H](Cc2ccccc2)COC1=O |r|
Show InChI InChI=1S/C24H22N4O4/c1-30-21-11-17(12-26-23(21)31-2)20-13-25-22-9-8-18(14-27(20)22)28-19(15-32-24(28)29)10-16-6-4-3-5-7-16/h3-9,11-14,19H,10,15H2,1-2H3/t19-/m0/s1
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286n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122470
PNG
(US8729074, 24)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ncccn12
Show InChI InChI=1S/C17H11ClFN5O2S/c18-16-14(23-27(25,26)13-4-2-12(19)3-5-13)8-11(9-21-16)15-10-22-17-20-6-1-7-24(15)17/h1-10,23H
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378n/a 781n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122467
PNG
(US8729074, 17)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccn(Cc3ccccc3)c(=O)n12
Show InChI InChI=1S/C24H17ClFN5O3S/c25-23-20(29-35(33,34)19-8-6-18(26)7-9-19)12-17(13-28-23)21-14-27-22-10-11-30(24(32)31(21)22)15-16-4-2-1-3-5-16/h1-14,29H,15H2
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465n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122454
PNG
(US8729074, 12)
Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)-c1ccncc1
Show InChI InChI=1S/C19H16N4O2/c1-24-17-9-15(10-22-19(17)25-2)16-11-21-18-4-3-14(12-23(16)18)13-5-7-20-8-6-13/h3-12H,1-2H3
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626n/a 861n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122453
PNG
(US8729074, 11)
Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(Br)cn12
Show InChI InChI=1S/C14H12BrN3O2/c1-19-12-5-9(6-17-14(12)20-2)11-7-16-13-4-3-10(15)8-18(11)13/h3-8H,1-2H3
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779n/a 1.50E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122458
PNG
(US8729074, 16)
Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1CCOCC1
Show InChI InChI=1S/C18H20N4O3/c1-23-16-9-13(10-20-18(16)24-2)15-11-19-17-4-3-14(12-22(15)17)21-5-7-25-8-6-21/h3-4,9-12H,5-8H2,1-2H3
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1.08E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122447
PNG
(US8729074, 2)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cncc(c1)-c1cnc2ccccn12
Show InChI InChI=1S/C18H13FN4O2S/c19-14-4-6-16(7-5-14)26(24,25)22-15-9-13(10-20-11-15)17-12-21-18-3-1-2-8-23(17)18/h1-12,22H
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1.29E+3n/a 931n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122455
PNG
(US8729074, 13)
Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1CCOC1=O
Show InChI InChI=1S/C17H16N4O4/c1-23-14-7-11(8-19-16(14)24-2)13-9-18-15-4-3-12(10-21(13)15)20-5-6-25-17(20)22/h3-4,7-10H,5-6H2,1-2H3
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>1.50E+3n/a 4.67E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM122466
PNG
(US8729074, 10)
Show SMILES COc1cc(cnc1OC)-c1cnc2ccccn12
Show InChI InChI=1S/C14H13N3O2/c1-18-12-7-10(8-16-14(12)19-2)11-9-15-13-5-3-4-6-17(11)13/h3-9H,1-2H3
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>1.50E+3n/a 1.57E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122459
PNG
(US8729074, 19)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1ccnc(c1)C(F)(F)F
Show InChI InChI=1S/C20H16ClF3N6O2S/c1-29(2)33(31,32)28-15-7-14(9-27-19(15)21)16-10-26-18-4-3-13(11-30(16)18)12-5-6-25-17(8-12)20(22,23)24/h3-11,28H,1-2H3
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n/an/a 15n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122468
PNG
(US8729074, 18)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1ccncc1
Show InChI InChI=1S/C19H17ClN6O2S/c1-25(2)29(27,28)24-16-9-15(10-23-19(16)20)17-11-22-18-4-3-14(12-26(17)18)13-5-7-21-8-6-13/h3-12,24H,1-2H3
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n/an/a 15n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122469
PNG
(US8729074, 23)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(C)c(cn12)-c1ccncc1
Show InChI InChI=1S/C20H19ClN6O2S/c1-13-8-19-23-11-18(27(19)12-16(13)14-4-6-22-7-5-14)15-9-17(20(21)24-10-15)25-30(28,29)26(2)3/h4-12,25H,1-3H3
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n/an/a 18n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122451
PNG
(US8729074, 8)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1cccnc1
Show InChI InChI=1S/C23H15ClFN5O2S/c24-23-20(29-33(31,32)19-6-4-18(25)5-7-19)10-17(12-28-23)21-13-27-22-8-3-16(14-30(21)22)15-2-1-9-26-11-15/h1-14,29H
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n/an/a 32n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122460
PNG
(US8729074, 20)
Show SMILES CS(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(ccn12)-c1cccnc1
Show InChI InChI=1S/C18H14ClN5O2S/c1-27(25,26)23-15-7-14(10-22-18(15)19)16-11-21-17-8-12(4-6-24(16)17)13-3-2-5-20-9-13/h2-11,23H,1H3
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n/an/a 32n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122450
PNG
(US8729074, 7)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1ccncc1
Show InChI InChI=1S/C23H15ClFN5O2S/c24-23-20(29-33(31,32)19-4-2-18(25)3-5-19)11-17(12-28-23)21-13-27-22-6-1-16(14-30(21)22)15-7-9-26-10-8-15/h1-14,29H
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n/an/a 36n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122449
PNG
(US8729074, 6)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(Br)cn12
Show InChI InChI=1S/C18H11BrClFN4O2S/c19-12-1-6-17-22-9-16(25(17)10-12)11-7-15(18(20)23-8-11)24-28(26,27)14-4-2-13(21)3-5-14/h1-10,24H
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n/an/a 39n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122463
PNG
(US8729074, 25)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(Cl)nn12
Show InChI InChI=1S/C17H10Cl2FN5O2S/c18-15-5-6-16-21-9-14(25(16)23-15)10-7-13(17(19)22-8-10)24-28(26,27)12-3-1-11(20)2-4-12/h1-9,24H
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n/an/a 102n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122464
PNG
(US8729074, 3)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccccn12
Show InChI InChI=1S/C18H12ClFN4O2S/c19-18-15(23-27(25,26)14-6-4-13(20)5-7-14)9-12(10-22-18)16-11-21-17-3-1-2-8-24(16)17/h1-11,23H
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n/an/a 155n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122462
PNG
(US8729074, 22)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(ccn12)-c1cccnc1
Show InChI InChI=1S/C19H17ClN6O2S/c1-25(2)29(27,28)24-16-8-15(11-23-19(16)20)17-12-22-18-9-13(5-7-26(17)18)14-4-3-6-21-10-14/h3-12,24H,1-2H3
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n/an/a 157n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122467
PNG
(US8729074, 17)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccn(Cc3ccccc3)c(=O)n12
Show InChI InChI=1S/C24H17ClFN5O3S/c25-23-20(29-35(33,34)19-8-6-18(26)7-9-19)12-17(13-28-23)21-14-27-22-10-11-30(24(32)31(21)22)15-16-4-2-1-3-5-16/h1-14,29H,15H2
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n/an/a 180n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122461
PNG
(US8729074, 21)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(ccn12)-c1ccncc1
Show InChI InChI=1S/C19H17ClN6O2S/c1-25(2)29(27,28)24-16-9-15(11-23-19(16)20)17-12-22-18-10-14(5-8-26(17)18)13-3-6-21-7-4-13/h3-12,24H,1-2H3
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n/an/a 258n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122452
PNG
(US8729074, 9)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)N1CCOCC1
Show InChI InChI=1S/C22H19ClFN5O3S/c23-22-19(27-33(30,31)18-4-1-16(24)2-5-18)11-15(12-26-22)20-13-25-21-6-3-17(14-29(20)21)28-7-9-32-10-8-28/h1-6,11-14,27H,7-10H2
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n/an/a 364n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122448
PNG
(US8729074, 5)
Show SMILES Cc1nc2ccc(Br)cn2c1-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2)c1
Show InChI InChI=1S/C19H13BrClFN4O2S/c1-11-18(26-10-13(20)2-7-17(26)24-11)12-8-16(19(21)23-9-12)25-29(27,28)15-5-3-14(22)4-6-15/h2-10,25H,1H3
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n/an/a 848n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122457
PNG
(US8729074, 15)
Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1[C@@H](Cc2ccccc2)COC1=O |r|
Show InChI InChI=1S/C24H22N4O4/c1-30-21-11-17(12-26-23(21)31-2)20-13-25-22-9-8-18(14-27(20)22)28-19(15-32-24(28)29)10-16-6-4-3-5-7-16/h3-9,11-14,19H,10,15H2,1-2H3/t19-/m0/s1
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n/an/a 2.04E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122453
PNG
(US8729074, 11)
Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(Br)cn12
Show InChI InChI=1S/C14H12BrN3O2/c1-19-12-5-9(6-17-14(12)20-2)11-7-16-13-4-3-10(15)8-18(11)13/h3-8H,1-2H3
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n/an/a 2.17E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122454
PNG
(US8729074, 12)
Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)-c1ccncc1
Show InChI InChI=1S/C19H16N4O2/c1-24-17-9-15(10-22-19(17)25-2)16-11-21-18-4-3-14(12-23(16)18)13-5-7-20-8-6-13/h3-12H,1-2H3
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n/an/a 3.75E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122458
PNG
(US8729074, 16)
Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1CCOCC1
Show InChI InChI=1S/C18H20N4O3/c1-23-16-9-13(10-20-18(16)24-2)15-11-19-17-4-3-14(12-22(15)17)21-5-7-25-8-6-21/h3-4,9-12H,5-8H2,1-2H3
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n/an/a 4.52E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122456
PNG
(US8729074, 14)
Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1[C@H](Cc2ccccc2)COC1=O |r|
Show InChI InChI=1S/C24H22N4O4/c1-30-21-11-17(12-26-23(21)31-2)20-13-25-22-9-8-18(14-27(20)22)28-19(15-32-24(28)29)10-16-6-4-3-5-7-16/h3-9,11-14,19H,10,15H2,1-2H3/t19-/m1/s1
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n/an/a 5.10E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122455
PNG
(US8729074, 13)
Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1CCOC1=O
Show InChI InChI=1S/C17H16N4O4/c1-23-14-7-11(8-19-16(14)24-2)13-9-18-15-4-3-12(10-21(13)15)20-5-6-25-17(20)22/h3-4,7-10H,5-6H2,1-2H3
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n/an/a 9.66E+3n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122466
PNG
(US8729074, 10)
Show SMILES COc1cc(cnc1OC)-c1cnc2ccccn12
Show InChI InChI=1S/C14H13N3O2/c1-18-12-7-10(8-16-14(12)19-2)11-9-15-13-5-3-4-6-17(11)13/h3-9H,1-2H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM122470
PNG
(US8729074, 24)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ncccn12
Show InChI InChI=1S/C17H11ClFN5O2S/c18-16-14(23-27(25,26)13-4-2-12(19)3-5-13)8-11(9-21-16)15-10-22-17-20-6-1-7-24(15)17/h1-10,23H
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Amgen Inc.

US Patent


Assay Description
The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...


US Patent US8729074 (2014)


BindingDB Entry DOI: 10.7270/Q2RJ4H4G
More data for this
Ligand-Target Pair