Compile Data Set for Download or QSAR

Found 30 hits Enz. Inhib. hit(s) with all data for entry = 1834   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14423 (4-{[3-(3-ethoxyphenyl)-1-methyl-2-oxo-2,3-dihydro-...) Show SMILES CCOc1cccc(c1)-n1c2cc(ccc2n(C)c1=O)C(O)(c1cncn1C)c1ccc(cc1)C#N Show InChI InChI=1S/C28H25N5O3/c1-4-36-23-7-5-6-22(15-23)33-25-14-21(12-13-24(25)32(3)27(33)34)28(35,26-17-30-18-31(26)2)20-10-8-19(16-29)9-11-20/h5-15,17-18,35H,4H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14434 (6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl...) Show SMILES Cn1cncc1C(N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.650	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14419 (4-{[3-(3-chlorophenyl)-1-methyl-2-oxo-2,3-dihydro-...) Show SMILES Cn1cncc1C(O)(c1ccc(cc1)C#N)c1ccc2n(C)c(=O)n(-c3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C26H20ClN5O2/c1-30-16-29-15-24(30)26(34,18-8-6-17(14-28)7-9-18)19-10-11-22-23(12-19)32(25(33)31(22)2)21-5-3-4-20(27)13-21/h3-13,15-16,34H,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14421 (4-{hydroxy[3-(3-methoxyphenyl)-1-methyl-2-oxo-2,3-...) Show SMILES COc1cccc(c1)-n1c2cc(ccc2n(C)c1=O)C(O)(c1cncn1C)c1ccc(cc1)C#N Show InChI InChI=1S/C27H23N5O3/c1-30-17-29-16-25(30)27(34,19-9-7-18(15-28)8-10-19)20-11-12-23-24(13-20)32(26(33)31(23)2)21-5-4-6-22(14-21)35-3/h4-14,16-17,34H,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14429 (4-({3-[(3-chlorophenyl)methyl]-1-methyl-2-oxo-2,3-...) Show SMILES Cn1cncc1C(O)(c1ccc(cc1)C#N)c1ccc2n(C)c(=O)n(Cc3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C27H22ClN5O2/c1-31-17-30-15-25(31)27(35,20-8-6-18(14-29)7-9-20)21-10-11-23-24(13-21)33(26(34)32(23)2)16-19-4-3-5-22(28)12-19/h3-13,15,17,35H,16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14422 (5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...) Show SMILES CCOc1cccc(c1)-n1c2cc(ccc2n(C)c1=O)C(O)(c1cncn1C)c1ccc(Cl)cc1 Show InChI InChI=1S/C27H25ClN4O3/c1-4-35-22-7-5-6-21(15-22)32-24-14-19(10-13-23(24)31(3)26(32)33)27(34,25-16-29-17-30(25)2)18-8-11-20(28)12-9-18/h5-17,34H,4H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14420 (5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...) Show SMILES COc1cccc(c1)-n1c2cc(ccc2n(C)c1=O)C(O)(c1cncn1C)c1ccc(Cl)cc1 Show InChI InChI=1S/C26H23ClN4O3/c1-29-16-28-15-24(29)26(33,17-7-10-19(27)11-8-17)18-9-12-22-23(13-18)31(25(32)30(22)2)20-5-4-6-21(14-20)34-3/h4-16,33H,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.70	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14425 (4-{[3-(2H-1,3-benzodioxol-5-yl)-1-methyl-2-oxo-2,3...) Show SMILES Cn1cncc1C(O)(c1ccc(cc1)C#N)c1ccc2n(C)c(=O)n(-c3ccc4OCOc4c3)c2c1 Show InChI InChI=1S/C27H21N5O4/c1-30-15-29-14-25(30)27(34,18-5-3-17(13-28)4-6-18)19-7-9-21-22(11-19)32(26(33)31(21)2)20-8-10-23-24(12-20)36-16-35-23/h3-12,14-15,34H,16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14433 (4-[2-(4-{6,15-dibromo-13-chloro-4-azatricyclo[9.4....) Show SMILES NC(=O)N1CCC(CC(=O)N2CCC(CC2)C2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 Show InChI InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	8.30	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14417 (3-(3-chlorophenyl)-5-[(4-chlorophenyl)(hydroxy)(1-...) Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)n(-c3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C25H20Cl2N4O2/c1-29-15-28-14-23(29)25(33,16-6-9-18(26)10-7-16)17-8-11-21-22(12-17)31(24(32)30(21)2)20-5-3-4-19(27)13-20/h3-15,33H,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14426 (5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...) Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)n(-c3ccc4ccccc4c3)c2c1 Show InChI InChI=1S/C29H23ClN4O2/c1-32-18-31-17-27(32)29(36,21-8-11-23(30)12-9-21)22-10-14-25-26(16-22)34(28(35)33(25)2)24-13-7-19-5-3-4-6-20(19)15-24/h3-18,36H,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14418 (3-(3-chlorophenyl)-5-[hydroxy(4-iodophenyl)(1-meth...) Show SMILES Cn1cncc1C(O)(c1ccc(I)cc1)c1ccc2n(C)c(=O)n(-c3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C25H20ClIN4O2/c1-29-15-28-14-23(29)25(33,16-6-9-19(27)10-7-16)17-8-11-21-22(12-17)31(24(32)30(21)2)20-5-3-4-18(26)13-20/h3-15,33H,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14430 ((4-chlorophenyl)[1-(3-chlorophenyl)-1H-indol-6-yl]...) Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2ccn(-c3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C25H19Cl2N3O/c1-29-16-28-15-24(29)25(31,18-7-9-20(26)10-8-18)19-6-5-17-11-12-30(23(17)13-19)22-4-2-3-21(27)14-22/h2-16,31H,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14428 (3-[(3-chlorophenyl)methyl]-5-[hydroxy(4-iodophenyl...) Show SMILES Cn1cncc1C(O)(c1ccc(I)cc1)c1ccc2n(C)c(=O)n(Cc3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C26H22ClIN4O2/c1-30-16-29-14-24(30)26(34,18-6-9-21(28)10-7-18)19-8-11-22-23(13-19)32(25(33)31(22)2)15-17-4-3-5-20(27)12-17/h3-14,16,34H,15H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14424 (3-(2H-1,3-benzodioxol-5-yl)-5-[(4-chlorophenyl)(hy...) Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)n(-c3ccc4OCOc4c3)c2c1 Show InChI InChI=1S/C26H21ClN4O4/c1-29-14-28-13-24(29)26(33,16-3-6-18(27)7-4-16)17-5-9-20-21(11-17)31(25(32)30(20)2)19-8-10-22-23(12-19)35-15-34-22/h3-14,33H,15H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14427 (5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...) Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)n(Cc3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C26H22Cl2N4O2/c1-30-16-29-14-24(30)26(34,18-6-9-20(27)10-7-18)19-8-11-22-23(13-19)32(25(33)31(22)2)15-17-4-3-5-21(28)12-17/h3-14,16,34H,15H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14431 ((4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)[1-(nap...) Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2ccn(-c3cccc4ccccc34)c2c1 Show InChI InChI=1S/C29H22ClN3O/c1-32-19-31-18-28(32)29(34,22-11-13-24(30)14-12-22)23-10-9-21-15-16-33(27(21)17-23)26-8-4-6-20-5-2-3-7-25(20)26/h2-19,34H,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14434 (6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl...) Show SMILES Cn1cncc1C(N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14432 (1-(3-chlorophenyl)-5-[(4-chlorophenyl)(hydroxy)(1-...) Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2n(-c3cccc(Cl)c3)c(=O)n(C)c2c1 Show InChI InChI=1S/C25H20Cl2N4O2/c1-29-15-28-14-23(29)25(33,16-6-9-18(26)10-7-16)17-8-11-21-22(12-17)30(2)24(32)31(21)20-5-3-4-19(27)13-20/h3-15,33H,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14418 (3-(3-chlorophenyl)-5-[hydroxy(4-iodophenyl)(1-meth...) Show SMILES Cn1cncc1C(O)(c1ccc(I)cc1)c1ccc2n(C)c(=O)n(-c3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C25H20ClIN4O2/c1-29-15-28-14-23(29)25(33,16-6-9-19(27)10-7-16)17-8-11-21-22(12-17)31(24(32)30(21)2)20-5-3-4-18(26)13-20/h3-15,33H,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14419 (4-{[3-(3-chlorophenyl)-1-methyl-2-oxo-2,3-dihydro-...) Show SMILES Cn1cncc1C(O)(c1ccc(cc1)C#N)c1ccc2n(C)c(=O)n(-c3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C26H20ClN5O2/c1-30-16-29-15-24(30)26(34,18-8-6-17(14-28)7-9-18)19-10-11-22-23(12-19)32(25(33)31(22)2)21-5-3-4-20(27)13-21/h3-13,15-16,34H,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14426 (5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...) Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)n(-c3ccc4ccccc4c3)c2c1 Show InChI InChI=1S/C29H23ClN4O2/c1-32-18-31-17-27(32)29(36,21-8-11-23(30)12-9-21)22-10-14-25-26(16-22)34(28(35)33(25)2)24-13-7-19-5-3-4-6-20(19)15-24/h3-18,36H,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14429 (4-({3-[(3-chlorophenyl)methyl]-1-methyl-2-oxo-2,3-...) Show SMILES Cn1cncc1C(O)(c1ccc(cc1)C#N)c1ccc2n(C)c(=O)n(Cc3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C27H22ClN5O2/c1-31-17-30-15-25(31)27(35,20-8-6-18(14-29)7-9-20)21-10-11-23-24(13-21)33(26(34)32(23)2)16-19-4-3-5-22(28)12-19/h3-13,15,17,35H,16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14422 (5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...) Show SMILES CCOc1cccc(c1)-n1c2cc(ccc2n(C)c1=O)C(O)(c1cncn1C)c1ccc(Cl)cc1 Show InChI InChI=1S/C27H25ClN4O3/c1-4-35-22-7-5-6-21(15-22)32-24-14-19(10-13-23(24)31(3)26(32)33)27(34,25-16-29-17-30(25)2)18-8-11-20(28)12-9-18/h5-17,34H,4H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14425 (4-{[3-(2H-1,3-benzodioxol-5-yl)-1-methyl-2-oxo-2,3...) Show SMILES Cn1cncc1C(O)(c1ccc(cc1)C#N)c1ccc2n(C)c(=O)n(-c3ccc4OCOc4c3)c2c1 Show InChI InChI=1S/C27H21N5O4/c1-30-15-29-14-25(30)27(34,18-5-3-17(13-28)4-6-18)19-7-9-21-22(11-19)32(26(33)31(21)2)20-8-10-23-24(12-20)36-16-35-23/h3-12,14-15,34H,16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14421 (4-{hydroxy[3-(3-methoxyphenyl)-1-methyl-2-oxo-2,3-...) Show SMILES COc1cccc(c1)-n1c2cc(ccc2n(C)c1=O)C(O)(c1cncn1C)c1ccc(cc1)C#N Show InChI InChI=1S/C27H23N5O3/c1-30-17-29-16-25(30)27(34,19-9-7-18(15-28)8-10-19)20-11-12-23-24(13-20)32(26(33)31(23)2)21-5-4-6-22(14-21)35-3/h4-14,16-17,34H,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14423 (4-{[3-(3-ethoxyphenyl)-1-methyl-2-oxo-2,3-dihydro-...) Show SMILES CCOc1cccc(c1)-n1c2cc(ccc2n(C)c1=O)C(O)(c1cncn1C)c1ccc(cc1)C#N Show InChI InChI=1S/C28H25N5O3/c1-4-36-23-7-5-6-22(15-23)33-25-14-21(12-13-24(25)32(3)27(33)34)28(35,26-17-30-18-31(26)2)20-10-8-19(16-29)9-11-20/h5-15,17-18,35H,4H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14420 (5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...) Show SMILES COc1cccc(c1)-n1c2cc(ccc2n(C)c1=O)C(O)(c1cncn1C)c1ccc(Cl)cc1 Show InChI InChI=1S/C26H23ClN4O3/c1-29-16-28-15-24(29)26(33,17-7-10-19(27)11-8-17)18-9-12-22-23(13-18)31(25(32)30(22)2)20-5-4-6-21(14-20)34-3/h4-16,33H,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14433 (4-[2-(4-{6,15-dibromo-13-chloro-4-azatricyclo[9.4....) Show SMILES NC(=O)N1CCC(CC(=O)N2CCC(CC2)C2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 Show InChI InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair				3D Structure (crystal)
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14417 (3-(3-chlorophenyl)-5-[(4-chlorophenyl)(hydroxy)(1-...) Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)n(-c3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C25H20Cl2N4O2/c1-29-15-28-14-23(29)25(33,16-6-9-18(26)10-7-16)17-8-11-21-22(12-17)31(24(32)30(21)2)20-5-3-4-19(27)13-20/h3-15,33H,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
					More data for this Ligand-Target Pair