Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM152274 (US8993556, 5-[2,4-Dihydroxy-6-(4-nitrophenoxy)phen...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | n/a | 0.800 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM152287 (US8993556, N-(1-Cyclohexylpiperidin-4-yl)-5-{2-[4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 0.0900 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM152276 (US8993556, 5-[2,4-Dihydroxy-6-(4-nitrophenoxy)phen...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 3.20 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM152277 (US8993556, N-(1-Cyclohexylpiperidin-4-yl)-5-[2,4-d...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM50442759 (CHEMBL2443138) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 0.120 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM152278 (US8993556, N-[1-(4,4-Difluorocyclohexyl)piperidin-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 0.800 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM50442760 (CHEMBL2443044) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | n/a | 0.350 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM50442757 (CHEMBL2443026) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 0.0570 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM152279 (US8993556, 3-{2-[4-(Dimethylamino)phenoxy]-4,6-dih...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 0.0430 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM152280 (US8993556, 3-{2-[4-(Dimethylamino)phenoxy]-4,6-dih...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 0.0660 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM50442758 (CHEMBL2443139) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 0.218 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM152281 (US8993556, 5-{2-[4-(Dimethylamino)phenoxy]-4,6-dih...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 0.0800 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM152282 (US8993556, 5-{2-[4-(Dimethylamino)phenoxy]-4,6-dih...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 0.423 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM152283 (US8993556, 5-{2-[4-(Dimethylamino)phenoxy]-4,6-dih...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 0.0790 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM152284 (US8993556, N-[1-(Cyclohexylmethyl)piperidin-4-yl]-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 0.188 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM152285 (US8993556, N-[1-(4,4-Difluorocyclohexyl)piperidin-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 0.0570 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM152286 (US8993556, 3-[2,4-Dihydroxy-6-(4-nitrophenoxy)phen...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 0.240 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-alpha (Homo sapiens (Human)) | BDBM152275 (US8993556, 5-[2-(4-Chlorophenoxy)-4,6-dihydroxyphe...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 9.20 | n/a | n/a | n/a | 7.6 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ... | US Patent US8993556 (2015) BindingDB Entry DOI: 10.7270/Q2Q81BSQ | |||||||||||
More data for this Ligand-Target Pair |