BindingDB PrimarySearch

Found 9 hits Enz. Inhib. hit(s) with all data for entry = 2035
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM16270 ((2R,4S,5S)-N-[(1S)-1-(benzylcarbamoyl)-2-methylpro...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	14.2	-46.6	n/a	n/a	n/a	n/a	n/a	4.5	37
University of Illinois at Chicago					Assay Description Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...				Bioorg Med Chem Lett 15: 15-20 (2005) Article DOI: 10.1016/j.bmcl.2004.10.084 BindingDB Entry DOI: 10.7270/Q2ZC814B
University of Illinois at Chicago					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM16271 ((2R,4S,5S)-N-[(1S)-1-(benzylcarbamoyl)-2-methylpro...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	25.1	-45.1	n/a	n/a	n/a	n/a	n/a	4.5	37
University of Illinois at Chicago					Assay Description Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...				Bioorg Med Chem Lett 15: 15-20 (2005) Article DOI: 10.1016/j.bmcl.2004.10.084 BindingDB Entry DOI: 10.7270/Q2ZC814B
University of Illinois at Chicago					More data for this Ligand-Target Pair				3D Structure (crystal)
Beta-secretase 1 (Homo sapiens (Human))	BDBM16263 (amide-urethane derived inhibitor 12a \| prop-2-en-1...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	26.6	-45.0	n/a	n/a	n/a	n/a	n/a	4.5	37
University of Illinois at Chicago					Assay Description Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...				Bioorg Med Chem Lett 15: 15-20 (2005) Article DOI: 10.1016/j.bmcl.2004.10.084 BindingDB Entry DOI: 10.7270/Q2ZC814B
University of Illinois at Chicago					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM16267 ((2R,4S,5S)-N-[(1S)-1-(benzylcarbamoyl)-2-methylpro...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	28.4	-44.8	n/a	n/a	n/a	n/a	n/a	4.5	37
University of Illinois at Chicago					Assay Description Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...				Bioorg Med Chem Lett 15: 15-20 (2005) Article DOI: 10.1016/j.bmcl.2004.10.084 BindingDB Entry DOI: 10.7270/Q2ZC814B
University of Illinois at Chicago					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM16266 (amide-urethane derived inhibitor 12b \| but-3-en-1-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	61.4	-42.8	n/a	n/a	n/a	n/a	n/a	4.5	37
University of Illinois at Chicago					Assay Description Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...				Bioorg Med Chem Lett 15: 15-20 (2005) Article DOI: 10.1016/j.bmcl.2004.10.084 BindingDB Entry DOI: 10.7270/Q2ZC814B
University of Illinois at Chicago					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM16264 ((2R,4S,5S)-N-[(1S)-1-(benzylcarbamoyl)-2-methylpro...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	87.2	-41.9	n/a	n/a	n/a	n/a	n/a	4.5	37
University of Illinois at Chicago					Assay Description Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...				Bioorg Med Chem Lett 15: 15-20 (2005) Article DOI: 10.1016/j.bmcl.2004.10.084 BindingDB Entry DOI: 10.7270/Q2ZC814B
University of Illinois at Chicago					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM16268 ((2R,4S,5S)-N-[(1S)-1-(benzylcarbamoyl)-2-methylpro...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	108	-41.4	n/a	n/a	n/a	n/a	n/a	4.5	37
University of Illinois at Chicago					Assay Description Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...				Bioorg Med Chem Lett 15: 15-20 (2005) Article DOI: 10.1016/j.bmcl.2004.10.084 BindingDB Entry DOI: 10.7270/Q2ZC814B
University of Illinois at Chicago					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM16269 (amide-urethane derived inhibitor 12c \| pent-4-en-1...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	112	-41.3	n/a	n/a	n/a	n/a	n/a	4.5	37
University of Illinois at Chicago					Assay Description Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...				Bioorg Med Chem Lett 15: 15-20 (2005) Article DOI: 10.1016/j.bmcl.2004.10.084 BindingDB Entry DOI: 10.7270/Q2ZC814B
University of Illinois at Chicago					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM16265 ((2R,4S,5S)-N-[(1S)-1-(benzylcarbamoyl)-2-methylpro...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	218	-39.6	n/a	n/a	n/a	n/a	n/a	4.5	37
University of Illinois at Chicago					Assay Description Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...				Bioorg Med Chem Lett 15: 15-20 (2005) Article DOI: 10.1016/j.bmcl.2004.10.084 BindingDB Entry DOI: 10.7270/Q2ZC814B
University of Illinois at Chicago					More data for this Ligand-Target Pair