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Compile Data Set for Download or QSAR

Found 73 hits Enz. Inhib. hit(s) with all data for entry = 2061   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15131
PNG
(5-indazolyl pyridine 3 | 5-{5-[(2S)-2-amino-3-(1H-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1 |r|
Show InChI InChI=1S/C24H23N5O/c1-15-22-10-16(6-7-24(22)29-28-15)17-9-20(13-26-11-17)30-14-19(25)8-18-12-27-23-5-3-2-4-21(18)23/h2-7,9-13,19,27H,8,14,25H2,1H3,(H,28,29)/t19-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16531
PNG
((3Z)-5-(5-{[(2S)-2-amino-3-(1H-indol-3-yl)propyl]o...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc2NC(=O)\C(=C/c3ccco3)c2c1)Cc1c[nH]c2ccccc12 |r|
Show InChI InChI=1S/C29H24N4O3/c30-21(10-20-15-32-27-6-2-1-5-24(20)27)17-36-23-11-19(14-31-16-23)18-7-8-28-25(12-18)26(29(34)33-28)13-22-4-3-9-35-22/h1-9,11-16,21,32H,10,17,30H2,(H,33,34)/b26-13-/t21-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16532
PNG
((2S)-1-(1H-indol-3-yl)-3-{[5-(3-methyl-1H-pyrazolo...)
Show SMILES Cc1n[nH]c2cnc(cc12)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1 |r|
Show InChI InChI=1S/C23H22N6O/c1-14-20-8-22(27-12-23(20)29-28-14)16-7-18(11-25-9-16)30-13-17(24)6-15-10-26-21-5-3-2-4-19(15)21/h2-5,7-12,17,26H,6,13,24H2,1H3,(H,28,29)/t17-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16587
PNG
((2S)-1-{[5-(3-methyl-1H-pyrazolo[3,4-c]pyridin-5-y...)
Show SMILES Cc1n[nH]c2cnc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(c2)C(F)(F)F)c1 |r|
Show InChI InChI=1S/C22H20F3N5O/c1-13-19-8-20(28-11-21(19)30-29-13)15-7-18(10-27-9-15)31-12-17(26)6-14-3-2-4-16(5-14)22(23,24)25/h2-5,7-11,17H,6,12,26H2,1H3,(H,29,30)/t17-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16548
PNG
((2S)-1-(3-iodophenyl)-3-{[5-(3-methyl-1H-indazol-5...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(I)c2)c1 |r|
Show InChI InChI=1S/C22H21IN4O/c1-14-21-10-16(5-6-22(21)27-26-14)17-9-20(12-25-11-17)28-13-19(24)8-15-3-2-4-18(23)7-15/h2-7,9-12,19H,8,13,24H2,1H3,(H,26,27)/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16564
PNG
((2S)-1-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(c2)C(F)(F)F)c1 |r|
Show InChI InChI=1S/C23H21F3N4O/c1-14-21-10-16(5-6-22(21)30-29-14)17-9-20(12-28-11-17)31-13-19(27)8-15-3-2-4-18(7-15)23(24,25)26/h2-7,9-12,19H,8,13,27H2,1H3,(H,29,30)/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16569
PNG
((2S)-1-[6-fluoro-3-(trifluoromethyl)phenyl]-3-{[5-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cc(ccc2F)C(F)(F)F)c1 |r|
Show InChI InChI=1S/C23H20F4N4O/c1-13-20-9-14(2-5-22(20)31-30-13)16-8-19(11-29-10-16)32-12-18(28)7-15-6-17(23(25,26)27)3-4-21(15)24/h2-6,8-11,18H,7,12,28H2,1H3,(H,30,31)/t18-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16555
PNG
((2S)-1-(4-bromo-3-fluorophenyl)-3-{[5-(3-methyl-1H...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(Br)c(F)c2)c1 |r|
Show InChI InChI=1S/C22H20BrFN4O/c1-13-19-9-15(3-5-22(19)28-27-13)16-8-18(11-26-10-16)29-12-17(25)6-14-2-4-20(23)21(24)7-14/h2-5,7-11,17H,6,12,25H2,1H3,(H,27,28)/t17-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16535
PNG
((3E)-5-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc2NC(=O)\C(=C\c3ccco3)c2c1)Cc1ccccc1 |r|
Show InChI InChI=1S/C27H23N3O3/c28-21(11-18-5-2-1-3-6-18)17-33-23-12-20(15-29-16-23)19-8-9-26-24(13-19)25(27(31)30-26)14-22-7-4-10-32-22/h1-10,12-16,21H,11,17,28H2,(H,30,31)/b25-14+/t21-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16567
PNG
((2S)-1-[4-fluoro-3-(trifluoromethyl)phenyl]-3-{[5-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(F)c(c2)C(F)(F)F)c1 |r|
Show InChI InChI=1S/C23H20F4N4O/c1-13-19-9-15(3-5-22(19)31-30-13)16-8-18(11-29-10-16)32-12-17(28)6-14-2-4-21(24)20(7-14)23(25,26)27/h2-5,7-11,17H,6,12,28H2,1H3,(H,30,31)/t17-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16552
PNG
((2S)-1-(3,4-dichlorophenyl)-3-{[5-(3-methyl-1H-ind...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(Cl)c(Cl)c2)c1 |r|
Show InChI InChI=1S/C22H20Cl2N4O/c1-13-19-9-15(3-5-22(19)28-27-13)16-8-18(11-26-10-16)29-12-17(25)6-14-2-4-20(23)21(24)7-14/h2-5,7-11,17H,6,12,25H2,1H3,(H,27,28)/t17-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15067
PNG
((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12 |r|
Show InChI InChI=1S/C25H22N4O/c26-22(10-21-14-29-25-4-2-1-3-24(21)25)16-30-23-11-20(13-28-15-23)17-5-6-19-12-27-8-7-18(19)9-17/h1-9,11-15,22,29H,10,16,26H2/t22-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16546
PNG
((2S)-1-(3-bromophenyl)-3-{[5-(3-methyl-1H-indazol-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(Br)c2)c1 |r|
Show InChI InChI=1S/C22H21BrN4O/c1-14-21-10-16(5-6-22(21)27-26-14)17-9-20(12-25-11-17)28-13-19(24)8-15-3-2-4-18(23)7-15/h2-7,9-12,19H,8,13,24H2,1H3,(H,26,27)/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16561
PNG
((2S)-1-(3-fluoro-4-methylphenyl)-3-{[5-(3-methyl-1...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(C)c(F)c2)c1 |r|
Show InChI InChI=1S/C23H23FN4O/c1-14-3-4-16(8-22(14)24)7-19(25)13-29-20-9-18(11-26-12-20)17-5-6-23-21(10-17)15(2)27-28-23/h3-6,8-12,19H,7,13,25H2,1-2H3,(H,27,28)/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16558
PNG
((2S)-1-(3-methyl-4-bromophenyl)-3-{[5-(3-methyl-1H...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(Br)c(C)c2)c1 |r|
Show InChI InChI=1S/C23H23BrN4O/c1-14-7-16(3-5-22(14)24)8-19(25)13-29-20-9-18(11-26-12-20)17-4-6-23-21(10-17)15(2)27-28-23/h3-7,9-12,19H,8,13,25H2,1-2H3,(H,27,28)/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16586
PNG
((2S)-1-{[5-(3-chloro-1H-pyrazolo[3,4-c]pyridin-5-y...)
Show SMILES N[C@H](COc1cncc(c1)-c1cc2c(Cl)n[nH]c2cn1)Cc1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C21H17ClF3N5O/c22-20-17-7-18(28-10-19(17)29-30-20)13-6-16(9-27-8-13)31-11-15(26)5-12-2-1-3-14(4-12)21(23,24)25/h1-4,6-10,15H,5,11,26H2,(H,29,30)/t15-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16549
PNG
((2S)-1-(3-chloro-4-fluorophenyl)-3-{[5-(3-methyl-1...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(F)c(Cl)c2)c1 |r|
Show InChI InChI=1S/C22H20ClFN4O/c1-13-19-9-15(3-5-22(19)28-27-13)16-8-18(11-26-10-16)29-12-17(25)6-14-2-4-21(24)20(23)7-14/h2-5,7-11,17H,6,12,25H2,1H3,(H,27,28)/t17-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16570
PNG
((2S)-1-[3-fluoro-4-(trifluoromethyl)phenyl]-3-{[5-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(c(F)c2)C(F)(F)F)c1 |r|
Show InChI InChI=1S/C23H20F4N4O/c1-13-19-9-15(3-5-22(19)31-30-13)16-8-18(11-29-10-16)32-12-17(28)6-14-2-4-20(21(24)7-14)23(25,26)27/h2-5,7-11,17H,6,12,28H2,1H3,(H,30,31)/t17-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16573
PNG
((2S)-1-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(OC(F)(F)F)c2)c1 |r|
Show InChI InChI=1S/C23H21F3N4O2/c1-14-21-10-16(5-6-22(21)30-29-14)17-9-20(12-28-11-17)31-13-18(27)7-15-3-2-4-19(8-15)32-23(24,25)26/h2-6,8-12,18H,7,13,27H2,1H3,(H,29,30)/t18-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16550
PNG
((2S)-1-(3-fluoro-4-chlorophenyl)-3-{[5-(3-methyl-1...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(Cl)c(F)c2)c1 |r|
Show InChI InChI=1S/C22H20ClFN4O/c1-13-19-9-15(3-5-22(19)28-27-13)16-8-18(11-26-10-16)29-12-17(25)6-14-2-4-20(23)21(24)7-14/h2-5,7-11,17H,6,12,25H2,1H3,(H,27,28)/t17-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16557
PNG
((2S)-1-(5-fluoro-2-methylphenyl)-3-{[5-(3-methyl-1...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cc(F)ccc2C)c1 |r|
Show InChI InChI=1S/C23H23FN4O/c1-14-3-5-19(24)7-17(14)8-20(25)13-29-21-9-18(11-26-12-21)16-4-6-23-22(10-16)15(2)27-28-23/h3-7,9-12,20H,8,13,25H2,1-2H3,(H,27,28)/t20-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM16564
PNG
((2S)-1-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(c2)C(F)(F)F)c1 |r|
Show InChI InChI=1S/C23H21F3N4O/c1-14-21-10-16(5-6-22(21)30-29-14)17-9-20(12-28-11-17)31-13-19(27)8-15-3-2-4-18(7-15)23(24,25)26/h2-7,9-12,19H,8,13,27H2,1H3,(H,29,30)/t19-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16588
PNG
((2S)-1-(2,3-difluorophenyl)-3-{[5-(3-methyl-1H-pyr...)
Show SMILES Cc1n[nH]c2cnc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(F)c2F)c1 |r|
Show InChI InChI=1S/C21H19F2N5O/c1-12-17-7-19(26-10-20(17)28-27-12)14-6-16(9-25-8-14)29-11-15(24)5-13-3-2-4-18(22)21(13)23/h2-4,6-10,15H,5,11,24H2,1H3,(H,27,28)/t15-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16547
PNG
((2S)-1-(4-bromophenyl)-3-{[5-(3-methyl-1H-indazol-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(Br)cc2)c1 |r|
Show InChI InChI=1S/C22H21BrN4O/c1-14-21-10-16(4-7-22(21)27-26-14)17-9-20(12-25-11-17)28-13-19(24)8-15-2-5-18(23)6-3-15/h2-7,9-12,19H,8,13,24H2,1H3,(H,26,27)/t19-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16551
PNG
((2S)-1-(2,3-dichlorophenyl)-3-{[5-(3-methyl-1H-ind...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(Cl)c2Cl)c1 |r|
Show InChI InChI=1S/C22H20Cl2N4O/c1-13-19-9-14(5-6-21(19)28-27-13)16-8-18(11-26-10-16)29-12-17(25)7-15-3-2-4-20(23)22(15)24/h2-6,8-11,17H,7,12,25H2,1H3,(H,27,28)/t17-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16543
PNG
((2S)-1-(3-chlorophenyl)-3-{[5-(3-methyl-1H-indazol...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(Cl)c2)c1 |r|
Show InChI InChI=1S/C22H21ClN4O/c1-14-21-10-16(5-6-22(21)27-26-14)17-9-20(12-25-11-17)28-13-19(24)8-15-3-2-4-18(23)7-15/h2-7,9-12,19H,8,13,24H2,1H3,(H,26,27)/t19-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16560
PNG
((2S)-1-(2-methyl-4-fluorophenyl)-3-{[5-(3-methyl-1...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(F)cc2C)c1 |r|
Show InChI InChI=1S/C23H23FN4O/c1-14-7-19(24)5-3-16(14)8-20(25)13-29-21-9-18(11-26-12-21)17-4-6-23-22(10-17)15(2)27-28-23/h3-7,9-12,20H,8,13,25H2,1-2H3,(H,27,28)/t20-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM15131
PNG
(5-indazolyl pyridine 3 | 5-{5-[(2S)-2-amino-3-(1H-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1 |r|
Show InChI InChI=1S/C24H23N5O/c1-15-22-10-16(6-7-24(22)29-28-15)17-9-20(13-26-11-17)30-14-19(25)8-18-12-27-23-5-3-2-4-21(18)23/h2-7,9-13,19,27H,8,14,25H2,1H3,(H,28,29)/t19-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16581
PNG
(5-{5-[(2S)-2-amino-3-[3-(piperidin-4-ylmethoxy)phe...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(OCC3CCNCC3)c2)c1 |r|
Show InChI InChI=1S/C28H33N5O2/c1-19-27-14-22(5-6-28(27)33-32-19)23-13-26(16-31-15-23)35-18-24(29)11-21-3-2-4-25(12-21)34-17-20-7-9-30-10-8-20/h2-6,12-16,20,24,30H,7-11,17-18,29H2,1H3,(H,32,33)/t24-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM16588
PNG
((2S)-1-(2,3-difluorophenyl)-3-{[5-(3-methyl-1H-pyr...)
Show SMILES Cc1n[nH]c2cnc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(F)c2F)c1 |r|
Show InChI InChI=1S/C21H19F2N5O/c1-12-17-7-19(26-10-20(17)28-27-12)14-6-16(9-25-8-14)29-11-15(24)5-13-3-2-4-18(22)21(13)23/h2-4,6-10,15H,5,11,24H2,1H3,(H,27,28)/t15-/m0/s1
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Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16585
PNG
((2S)-1-{[5-(1H-pyrazolo[3,4-c]pyridin-5-yl)pyridin...)
Show SMILES N[C@H](COc1cncc(c1)-c1cc2cn[nH]c2cn1)Cc1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)16-3-1-2-13(4-16)5-17(25)12-30-18-6-14(8-26-10-18)19-7-15-9-28-29-20(15)11-27-19/h1-4,6-11,17H,5,12,25H2,(H,28,29)/t17-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16563
PNG
((2S)-1-(5-fluoro-2-methoxyphenyl)-3-{[5-(3-methyl-...)
Show SMILES COc1ccc(F)cc1C[C@H](N)COc1cncc(c1)-c1ccc2[nH]nc(C)c2c1 |r|
Show InChI InChI=1S/C23H23FN4O2/c1-14-21-10-15(3-5-22(21)28-27-14)17-9-20(12-26-11-17)30-13-19(25)8-16-7-18(24)4-6-23(16)29-2/h3-7,9-12,19H,8,13,25H2,1-2H3,(H,27,28)/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16536
PNG
((2S)-1-(3-fluorophenyl)-3-{[5-(3-methyl-1H-indazol...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(F)c2)c1 |r|
Show InChI InChI=1S/C22H21FN4O/c1-14-21-10-16(5-6-22(21)27-26-14)17-9-20(12-25-11-17)28-13-19(24)8-15-3-2-4-18(23)7-15/h2-7,9-12,19H,8,13,24H2,1H3,(H,26,27)/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16537
PNG
((2S)-1-(2,3-difluorophenyl)-3-{[5-(3-methyl-1H-ind...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(F)c2F)c1 |r|
Show InChI InChI=1S/C22H20F2N4O/c1-13-19-9-14(5-6-21(19)28-27-13)16-8-18(11-26-10-16)29-12-17(25)7-15-3-2-4-20(23)22(15)24/h2-6,8-11,17H,7,12,25H2,1H3,(H,27,28)/t17-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM16537
PNG
((2S)-1-(2,3-difluorophenyl)-3-{[5-(3-methyl-1H-ind...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(F)c2F)c1 |r|
Show InChI InChI=1S/C22H20F2N4O/c1-13-19-9-14(5-6-21(19)28-27-13)16-8-18(11-26-10-16)29-12-17(25)7-15-3-2-4-20(23)22(15)24/h2-6,8-11,17H,7,12,25H2,1H3,(H,27,28)/t17-/m0/s1
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Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16554
PNG
((2S)-1-(4-bromo-2-fluorophenyl)-3-{[5-(3-methyl-1H...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(Br)cc2F)c1 |r|
Show InChI InChI=1S/C22H20BrFN4O/c1-13-20-8-14(3-5-22(20)28-27-13)16-7-19(11-26-10-16)29-12-18(25)6-15-2-4-17(23)9-21(15)24/h2-5,7-11,18H,6,12,25H2,1H3,(H,27,28)/t18-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16559
PNG
((2S)-1-(3-methyl-4-fluorophenyl)-3-{[5-(3-methyl-1...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(F)c(C)c2)c1 |r|
Show InChI InChI=1S/C23H23FN4O/c1-14-7-16(3-5-22(14)24)8-19(25)13-29-20-9-18(11-26-12-20)17-4-6-23-21(10-17)15(2)27-28-23/h3-7,9-12,19H,8,13,25H2,1-2H3,(H,27,28)/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16544
PNG
((2S)-1-(4-chlorophenyl)-3-{[5-(3-methyl-1H-indazol...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(Cl)cc2)c1 |r|
Show InChI InChI=1S/C22H21ClN4O/c1-14-21-10-16(4-7-22(21)27-26-14)17-9-20(12-25-11-17)28-13-19(24)8-15-2-5-18(23)6-3-15/h2-7,9-12,19H,8,13,24H2,1H3,(H,26,27)/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16540
PNG
((2S)-1-(2,3,4-trifluorophenyl)-3-{[5-(3-methyl-1H-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(F)c(F)c2F)c1 |r|
Show InChI InChI=1S/C22H19F3N4O/c1-12-18-8-13(3-5-20(18)29-28-12)15-7-17(10-27-9-15)30-11-16(26)6-14-2-4-19(23)22(25)21(14)24/h2-5,7-10,16H,6,11,26H2,1H3,(H,28,29)/t16-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16571
PNG
((2S)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-{[5-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(cc2F)C(F)(F)F)c1 |r|
Show InChI InChI=1S/C23H20F4N4O/c1-13-20-8-14(3-5-22(20)31-30-13)16-7-19(11-29-10-16)32-12-18(28)6-15-2-4-17(9-21(15)24)23(25,26)27/h2-5,7-11,18H,6,12,28H2,1H3,(H,30,31)/t18-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM16587
PNG
((2S)-1-{[5-(3-methyl-1H-pyrazolo[3,4-c]pyridin-5-y...)
Show SMILES Cc1n[nH]c2cnc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc(c2)C(F)(F)F)c1 |r|
Show InChI InChI=1S/C22H20F3N5O/c1-13-19-8-20(28-11-21(19)30-29-13)15-7-18(10-27-9-15)31-12-17(26)6-14-3-2-4-16(5-14)22(23,24)25/h2-5,7-11,17H,6,12,26H2,1H3,(H,29,30)/t17-/m0/s1
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Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16578
PNG
((2S)-1-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc3OC(F)(F)C(F)(F)Oc3c2)c1 |r|
Show InChI InChI=1S/C24H20F4N4O3/c1-13-19-9-15(3-4-20(19)32-31-13)16-8-18(11-30-10-16)33-12-17(29)6-14-2-5-21-22(7-14)35-24(27,28)23(25,26)34-21/h2-5,7-11,17H,6,12,29H2,1H3,(H,31,32)/t17-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16568
PNG
((2S)-1-[5-fluoro-3-(trifluoromethyl)phenyl]-3-{[5-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cc(F)cc(c2)C(F)(F)F)c1 |r|
Show InChI InChI=1S/C23H20F4N4O/c1-13-21-8-15(2-3-22(21)31-30-13)16-7-20(11-29-10-16)32-12-19(28)6-14-4-17(23(25,26)27)9-18(24)5-14/h2-5,7-11,19H,6,12,28H2,1H3,(H,30,31)/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15138
PNG
(5-indazolyl pyridine 11g | 5-{5-[(2S)-2-amino-3-ph...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1 |r|
Show InChI InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15022
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12 |r|
Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16577
PNG
((2S)-1-(2,2-difluoro-1,3-benzodioxol-4-yl)-3-{[5-(...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cccc3OC(F)(F)Oc23)c1 |r|
Show InChI InChI=1S/C23H20F2N4O3/c1-13-19-9-14(5-6-20(19)29-28-13)16-8-18(11-27-10-16)30-12-17(26)7-15-3-2-4-21-22(15)32-23(24,25)31-21/h2-6,8-11,17H,7,12,26H2,1H3,(H,28,29)/t17-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM16547
PNG
((2S)-1-(4-bromophenyl)-3-{[5-(3-methyl-1H-indazol-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(Br)cc2)c1 |r|
Show InChI InChI=1S/C22H21BrN4O/c1-14-21-10-16(4-7-22(21)27-26-14)17-9-20(12-25-11-17)28-13-19(24)8-15-2-5-18(23)6-3-15/h2-7,9-12,19H,8,13,24H2,1H3,(H,26,27)/t19-/m0/s1
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Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM16586
PNG
((2S)-1-{[5-(3-chloro-1H-pyrazolo[3,4-c]pyridin-5-y...)
Show SMILES N[C@H](COc1cncc(c1)-c1cc2c(Cl)n[nH]c2cn1)Cc1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C21H17ClF3N5O/c22-20-17-7-18(28-10-19(17)29-30-20)13-6-16(9-27-8-13)31-11-15(26)5-12-2-1-3-14(4-12)21(23,24)25/h1-4,6-10,15H,5,11,26H2,(H,29,30)/t15-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM16572
PNG
((2S)-1-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2OC(F)(F)F)c1 |r|
Show InChI InChI=1S/C23H21F3N4O2/c1-14-20-10-15(6-7-21(20)30-29-14)17-9-19(12-28-11-17)31-13-18(27)8-16-4-2-3-5-22(16)32-23(24,25)26/h2-7,9-12,18H,8,13,27H2,1H3,(H,29,30)/t18-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM15138
PNG
(5-indazolyl pyridine 11g | 5-{5-[(2S)-2-amino-3-ph...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1 |r|
Show InChI InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1
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Abbott Laboratories



Assay Description
The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...


J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
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