Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dihydrofolate reductase (Mycobacterium avium) | BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | 7.0 | 30 |
Oklahoma State University at Stillwater | Assay Description Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba... | Antimicrob Agents Chemother 48: 4643-9 (2004) Article DOI: 10.1128/AAC.48.12.4643-4649.2004 BindingDB Entry DOI: 10.7270/Q2JQ0Z9F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Bacillus anthracis) | BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 15.1 | n/a | n/a | n/a | n/a | 7.0 | 30 |
Oklahoma State University at Stillwater | Assay Description Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba... | Antimicrob Agents Chemother 48: 4643-9 (2004) Article DOI: 10.1128/AAC.48.12.4643-4649.2004 BindingDB Entry DOI: 10.7270/Q2JQ0Z9F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | 24.3 | n/a | n/a | n/a | n/a | 7.0 | 30 |
Oklahoma State University at Stillwater | Assay Description Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba... | Antimicrob Agents Chemother 48: 4643-9 (2004) Article DOI: 10.1128/AAC.48.12.4643-4649.2004 BindingDB Entry DOI: 10.7270/Q2JQ0Z9F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dihydrofolate reductase (Mycobacterium avium) | BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 5.75E+3 | n/a | n/a | n/a | n/a | 7.0 | 30 |
Oklahoma State University at Stillwater | Assay Description Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba... | Antimicrob Agents Chemother 48: 4643-9 (2004) Article DOI: 10.1128/AAC.48.12.4643-4649.2004 BindingDB Entry DOI: 10.7270/Q2JQ0Z9F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dihydrofolate reductase (Bacillus anthracis) | BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 7.73E+4 | n/a | n/a | n/a | n/a | 7.0 | 30 |
Oklahoma State University at Stillwater | Assay Description Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba... | Antimicrob Agents Chemother 48: 4643-9 (2004) Article DOI: 10.1128/AAC.48.12.4643-4649.2004 BindingDB Entry DOI: 10.7270/Q2JQ0Z9F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 1.62E+6 | n/a | n/a | n/a | n/a | 7.0 | 30 |
Oklahoma State University at Stillwater | Assay Description Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba... | Antimicrob Agents Chemother 48: 4643-9 (2004) Article DOI: 10.1128/AAC.48.12.4643-4649.2004 BindingDB Entry DOI: 10.7270/Q2JQ0Z9F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |