Compile Data Set for Download or QSAR

Found 48 hits Enz. Inhib. hit(s) with all data for entry = 2437   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20557 (AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20557 (AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20579 (N-{4-[(6-{4-[(1S)-1-[4-(trifluoromethyl)phenyl]eth...) Show SMILES CC(N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C26H25F3N6O2S/c1-16(18-6-8-19(9-7-18)26(27,28)29)34-10-12-35(13-11-34)22-14-23(31-15-30-22)37-20-4-3-5-21-24(20)33-25(38-21)32-17(2)36/h3-9,14-16H,10-13H2,1-2H3,(H,32,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20581 (N-{4-[(6-{4-[(1R)-1-(4-fluorophenyl)ethyl]piperazi...) Show SMILES C[C@@H](N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C25H25FN6O2S/c1-16(18-6-8-19(26)9-7-18)31-10-12-32(13-11-31)22-14-23(28-15-27-22)34-20-4-3-5-21-24(20)30-25(35-21)29-17(2)33/h3-9,14-16H,10-13H2,1-2H3,(H,29,30,33)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20561 (N-[4-({6-[4-(trifluoromethyl)cyclohex-1-en-1-yl]py...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)C3=CCC(CC3)C(F)(F)F)cccc2s1 |t:16| Show InChI InChI=1S/C20H17F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-5,9-10,13H,6-8H2,1H3,(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20577 (N-{4-[(6-{4-[(1S)-1-(2-fluorophenyl)ethyl]piperazi...) Show SMILES CC(N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)c1ccccc1F Show InChI InChI=1S/C25H25FN6O2S/c1-16(18-6-3-4-7-19(18)26)31-10-12-32(13-11-31)22-14-23(28-15-27-22)34-20-8-5-9-21-24(20)30-25(35-21)29-17(2)33/h3-9,14-16H,10-13H2,1-2H3,(H,29,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20577 (N-{4-[(6-{4-[(1S)-1-(2-fluorophenyl)ethyl]piperazi...) Show SMILES CC(N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)c1ccccc1F Show InChI InChI=1S/C25H25FN6O2S/c1-16(18-6-3-4-7-19(18)26)31-10-12-32(13-11-31)22-14-23(28-15-27-22)34-20-8-5-9-21-24(20)30-25(35-21)29-17(2)33/h3-9,14-16H,10-13H2,1-2H3,(H,29,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20568 (N-[4-({6-[4-(2,2-dimethylpropyl)piperazin-1-yl]pyr...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCN(CC(C)(C)C)CC3)cccc2s1 Show InChI InChI=1S/C22H28N6O2S/c1-15(29)25-21-26-20-16(6-5-7-17(20)31-21)30-19-12-18(23-14-24-19)28-10-8-27(9-11-28)13-22(2,3)4/h5-7,12,14H,8-11,13H2,1-4H3,(H,25,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20583 (N-{4-[(6-{4-[1-(4-fluorophenyl)ethyl]piperazin-1-y...) Show SMILES CC(N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)c1ccc(F)cc1 Show InChI InChI=1S/C25H25FN6O2S/c1-16(18-6-8-19(26)9-7-18)31-10-12-32(13-11-31)22-14-23(28-15-27-22)34-20-4-3-5-21-24(20)30-25(35-21)29-17(2)33/h3-9,14-16H,10-13H2,1-2H3,(H,29,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20581 (N-{4-[(6-{4-[(1R)-1-(4-fluorophenyl)ethyl]piperazi...) Show SMILES C[C@@H](N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C25H25FN6O2S/c1-16(18-6-8-19(26)9-7-18)31-10-12-32(13-11-31)22-14-23(28-15-27-22)34-20-4-3-5-21-24(20)30-25(35-21)29-17(2)33/h3-9,14-16H,10-13H2,1-2H3,(H,29,30,33)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20573 (N-{4-[(6-{4-[(1S)-1-phenylethyl]piperazin-1-yl}pyr...) Show SMILES CC(N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)c1ccccc1 Show InChI InChI=1S/C25H26N6O2S/c1-17(19-7-4-3-5-8-19)30-11-13-31(14-12-30)22-15-23(27-16-26-22)33-20-9-6-10-21-24(20)29-25(34-21)28-18(2)32/h3-10,15-17H,11-14H2,1-2H3,(H,28,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20583 (N-{4-[(6-{4-[1-(4-fluorophenyl)ethyl]piperazin-1-y...) Show SMILES CC(N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)c1ccc(F)cc1 Show InChI InChI=1S/C25H25FN6O2S/c1-16(18-6-8-19(26)9-7-18)31-10-12-32(13-11-31)22-14-23(28-15-27-22)34-20-4-3-5-21-24(20)30-25(35-21)29-17(2)33/h3-9,14-16H,10-13H2,1-2H3,(H,29,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.90	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20568 (N-[4-({6-[4-(2,2-dimethylpropyl)piperazin-1-yl]pyr...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCN(CC(C)(C)C)CC3)cccc2s1 Show InChI InChI=1S/C22H28N6O2S/c1-15(29)25-21-26-20-16(6-5-7-17(20)31-21)30-19-12-18(23-14-24-19)28-10-8-27(9-11-28)13-22(2,3)4/h5-7,12,14H,8-11,13H2,1-4H3,(H,25,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20579 (N-{4-[(6-{4-[(1S)-1-[4-(trifluoromethyl)phenyl]eth...) Show SMILES CC(N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C26H25F3N6O2S/c1-16(18-6-8-19(9-7-18)26(27,28)29)34-10-12-35(13-11-34)22-14-23(31-15-30-22)37-20-4-3-5-21-24(20)33-25(38-21)32-17(2)36/h3-9,14-16H,10-13H2,1-2H3,(H,32,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20582 (N-{4-[(6-{4-[(1S)-1-(4-fluorophenyl)ethyl]piperazi...) Show SMILES C[C@H](N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C25H25FN6O2S/c1-16(18-6-8-19(26)9-7-18)31-10-12-32(13-11-31)22-14-23(28-15-27-22)34-20-4-3-5-21-24(20)30-25(35-21)29-17(2)33/h3-9,14-16H,10-13H2,1-2H3,(H,29,30,33)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20573 (N-{4-[(6-{4-[(1S)-1-phenylethyl]piperazin-1-yl}pyr...) Show SMILES CC(N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)c1ccccc1 Show InChI InChI=1S/C25H26N6O2S/c1-17(19-7-4-3-5-8-19)30-11-13-31(14-12-30)22-15-23(27-16-26-22)33-20-9-6-10-21-24(20)29-25(34-21)28-18(2)32/h3-10,15-17H,11-14H2,1-2H3,(H,28,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20582 (N-{4-[(6-{4-[(1S)-1-(4-fluorophenyl)ethyl]piperazi...) Show SMILES C[C@H](N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C25H25FN6O2S/c1-16(18-6-8-19(26)9-7-18)31-10-12-32(13-11-31)22-14-23(28-15-27-22)34-20-4-3-5-21-24(20)30-25(35-21)29-17(2)33/h3-9,14-16H,10-13H2,1-2H3,(H,29,30,33)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20578 (N-{4-[(6-{4-[(1S)-1-(3-fluorophenyl)ethyl]piperazi...) Show SMILES CC(N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)c1cccc(F)c1 Show InChI InChI=1S/C25H25FN6O2S/c1-16(18-5-3-6-19(26)13-18)31-9-11-32(12-10-31)22-14-23(28-15-27-22)34-20-7-4-8-21-24(20)30-25(35-21)29-17(2)33/h3-8,13-16H,9-12H2,1-2H3,(H,29,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20570 (N-(4-{[6-(4-phenylpiperazin-1-yl)pyrimidin-4-yl]ox...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCN(CC3)c3ccccc3)cccc2s1 Show InChI InChI=1S/C23H22N6O2S/c1-16(30)26-23-27-22-18(8-5-9-19(22)32-23)31-21-14-20(24-15-25-21)29-12-10-28(11-13-29)17-6-3-2-4-7-17/h2-9,14-15H,10-13H2,1H3,(H,26,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20562 (N-[4-({6-[4-(trifluoromethyl)cyclohexyl]pyrimidin-...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)C3CCC(CC3)C(F)(F)F)cccc2s1 |(15.15,-10.72,;16.44,-11.49,;16.44,-13.04,;17.8,-10.72,;19.09,-11.49,;19.28,-12.98,;20.77,-13.37,;21.61,-14.66,;20.83,-16.01,;19.28,-16.01,;18.57,-17.37,;17.02,-17.5,;16.25,-16.08,;16.96,-14.79,;18.51,-14.72,;16.31,-18.79,;17.15,-20.08,;16.31,-21.44,;14.83,-21.5,;13.99,-20.14,;14.83,-18.79,;14.12,-22.86,;12.76,-23.63,;15.47,-23.57,;12.76,-22.08,;23.09,-14.66,;23.87,-13.3,;23.16,-12.01,;21.61,-12.01,;20.51,-10.91,)| Show InChI InChI=1S/C20H19F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-4,9-10,12-13H,5-8H2,1H3,(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20578 (N-{4-[(6-{4-[(1S)-1-(3-fluorophenyl)ethyl]piperazi...) Show SMILES CC(N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)c1cccc(F)c1 Show InChI InChI=1S/C25H25FN6O2S/c1-16(18-5-3-6-19(26)13-18)31-9-11-32(12-10-31)22-14-23(28-15-27-22)34-20-7-4-8-21-24(20)30-25(35-21)29-17(2)33/h3-8,13-16H,9-12H2,1-2H3,(H,29,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20563 (N-[4-({6-[4-(trifluoromethyl)piperidin-1-yl]pyrimi...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCC(CC3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C19H18F3N5O2S/c1-11(28)25-18-26-17-13(3-2-4-14(17)30-18)29-16-9-15(23-10-24-16)27-7-5-12(6-8-27)19(20,21)22/h2-4,9-10,12H,5-8H2,1H3,(H,25,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20574 (N-{4-[(6-{4-[(1S)-1-phenylpropyl]piperazin-1-yl}py...) Show SMILES CCC(N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)c1ccccc1 Show InChI InChI=1S/C26H28N6O2S/c1-3-20(19-8-5-4-6-9-19)31-12-14-32(15-13-31)23-16-24(28-17-27-23)34-21-10-7-11-22-25(21)30-26(35-22)29-18(2)33/h4-11,16-17,20H,3,12-15H2,1-2H3,(H,29,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20575 (N-[4-({6-[4-(diphenylmethyl)piperazin-1-yl]pyrimid...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCN(CC3)C(c3ccccc3)c3ccccc3)cccc2s1 Show InChI InChI=1S/C30H28N6O2S/c1-21(37)33-30-34-28-24(13-8-14-25(28)39-30)38-27-19-26(31-20-32-27)35-15-17-36(18-16-35)29(22-9-4-2-5-10-22)23-11-6-3-7-12-23/h2-14,19-20,29H,15-18H2,1H3,(H,33,34,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20580 (N-{4-[(6-{4-[(1S)-1-(4-methoxyphenyl)ethyl]piperaz...) Show SMILES COc1ccc(cc1)C(C)N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1 Show InChI InChI=1S/C26H28N6O3S/c1-17(19-7-9-20(34-3)10-8-19)31-11-13-32(14-12-31)23-15-24(28-16-27-23)35-21-5-4-6-22-25(21)30-26(36-22)29-18(2)33/h4-10,15-17H,11-14H2,1-3H3,(H,29,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20561 (N-[4-({6-[4-(trifluoromethyl)cyclohex-1-en-1-yl]py...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)C3=CCC(CC3)C(F)(F)F)cccc2s1 |t:16| Show InChI InChI=1S/C20H17F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-5,9-10,13H,6-8H2,1H3,(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20576 (N-[4-({6-[4-(2-phenylpropan-2-yl)piperazin-1-yl]py...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCN(CC3)C(C)(C)c3ccccc3)cccc2s1 Show InChI InChI=1S/C26H28N6O2S/c1-18(33)29-25-30-24-20(10-7-11-21(24)35-25)34-23-16-22(27-17-28-23)31-12-14-32(15-13-31)26(2,3)19-8-5-4-6-9-19/h4-11,16-17H,12-15H2,1-3H3,(H,29,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20574 (N-{4-[(6-{4-[(1S)-1-phenylpropyl]piperazin-1-yl}py...) Show SMILES CCC(N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)c1ccccc1 Show InChI InChI=1S/C26H28N6O2S/c1-3-20(19-8-5-4-6-9-19)31-12-14-32(15-13-31)23-16-24(28-17-27-23)34-21-10-7-11-22-25(21)30-26(35-22)29-18(2)33/h4-11,16-17,20H,3,12-15H2,1-2H3,(H,29,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20571 (N-(4-{[6-(4-benzylpiperazin-1-yl)pyrimidin-4-yl]ox...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCN(Cc4ccccc4)CC3)cccc2s1 Show InChI InChI=1S/C24H24N6O2S/c1-17(31)27-24-28-23-19(8-5-9-20(23)33-24)32-22-14-21(25-16-26-22)30-12-10-29(11-13-30)15-18-6-3-2-4-7-18/h2-9,14,16H,10-13,15H2,1H3,(H,27,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20580 (N-{4-[(6-{4-[(1S)-1-(4-methoxyphenyl)ethyl]piperaz...) Show SMILES COc1ccc(cc1)C(C)N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1 Show InChI InChI=1S/C26H28N6O3S/c1-17(19-7-9-20(34-3)10-8-19)31-11-13-32(14-12-31)23-15-24(28-16-27-23)35-21-5-4-6-22-25(21)30-26(36-22)29-18(2)33/h4-10,15-17H,11-14H2,1-3H3,(H,29,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20570 (N-(4-{[6-(4-phenylpiperazin-1-yl)pyrimidin-4-yl]ox...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCN(CC3)c3ccccc3)cccc2s1 Show InChI InChI=1S/C23H22N6O2S/c1-16(30)26-23-27-22-18(8-5-9-19(22)32-23)31-21-14-20(24-15-25-21)29-12-10-28(11-13-29)17-6-3-2-4-7-17/h2-9,14-15H,10-13H2,1H3,(H,26,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20576 (N-[4-({6-[4-(2-phenylpropan-2-yl)piperazin-1-yl]py...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCN(CC3)C(C)(C)c3ccccc3)cccc2s1 Show InChI InChI=1S/C26H28N6O2S/c1-18(33)29-25-30-24-20(10-7-11-21(24)35-25)34-23-16-22(27-17-28-23)31-12-14-32(15-13-31)26(2,3)19-8-5-4-6-9-19/h4-11,16-17H,12-15H2,1-3H3,(H,29,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20571 (N-(4-{[6-(4-benzylpiperazin-1-yl)pyrimidin-4-yl]ox...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCN(Cc4ccccc4)CC3)cccc2s1 Show InChI InChI=1S/C24H24N6O2S/c1-17(31)27-24-28-23-19(8-5-9-20(23)33-24)32-22-14-21(25-16-26-22)30-12-10-29(11-13-30)15-18-6-3-2-4-7-18/h2-9,14,16H,10-13,15H2,1H3,(H,27,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20569 (N-[4-({6-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]p...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCN(CC(F)(F)F)CC3)cccc2s1 Show InChI InChI=1S/C19H19F3N6O2S/c1-12(29)25-18-26-17-13(3-2-4-14(17)31-18)30-16-9-15(23-11-24-16)28-7-5-27(6-8-28)10-19(20,21)22/h2-4,9,11H,5-8,10H2,1H3,(H,25,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20563 (N-[4-({6-[4-(trifluoromethyl)piperidin-1-yl]pyrimi...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCC(CC3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C19H18F3N5O2S/c1-11(28)25-18-26-17-13(3-2-4-14(17)30-18)29-16-9-15(23-10-24-16)27-7-5-12(6-8-27)19(20,21)22/h2-4,9-10,12H,5-8H2,1H3,(H,25,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20562 (N-[4-({6-[4-(trifluoromethyl)cyclohexyl]pyrimidin-...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)C3CCC(CC3)C(F)(F)F)cccc2s1 |(15.15,-10.72,;16.44,-11.49,;16.44,-13.04,;17.8,-10.72,;19.09,-11.49,;19.28,-12.98,;20.77,-13.37,;21.61,-14.66,;20.83,-16.01,;19.28,-16.01,;18.57,-17.37,;17.02,-17.5,;16.25,-16.08,;16.96,-14.79,;18.51,-14.72,;16.31,-18.79,;17.15,-20.08,;16.31,-21.44,;14.83,-21.5,;13.99,-20.14,;14.83,-18.79,;14.12,-22.86,;12.76,-23.63,;15.47,-23.57,;12.76,-22.08,;23.09,-14.66,;23.87,-13.3,;23.16,-12.01,;21.61,-12.01,;20.51,-10.91,)| Show InChI InChI=1S/C20H19F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-4,9-10,12-13H,5-8H2,1H3,(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20569 (N-[4-({6-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]p...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCN(CC(F)(F)F)CC3)cccc2s1 Show InChI InChI=1S/C19H19F3N6O2S/c1-12(29)25-18-26-17-13(3-2-4-14(17)31-18)30-16-9-15(23-11-24-16)28-7-5-27(6-8-28)10-19(20,21)22/h2-4,9,11H,5-8,10H2,1H3,(H,25,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20566 (N-[4-({6-[4-(propan-2-yl)piperazin-1-yl]pyrimidin-...) Show SMILES CC(C)N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1 Show InChI InChI=1S/C20H24N6O2S/c1-13(2)25-7-9-26(10-8-25)17-11-18(22-12-21-17)28-15-5-4-6-16-19(15)24-20(29-16)23-14(3)27/h4-6,11-13H,7-10H2,1-3H3,(H,23,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20575 (N-[4-({6-[4-(diphenylmethyl)piperazin-1-yl]pyrimid...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCN(CC3)C(c3ccccc3)c3ccccc3)cccc2s1 Show InChI InChI=1S/C30H28N6O2S/c1-21(37)33-30-34-28-24(13-8-14-25(28)39-30)38-27-19-26(31-20-32-27)35-15-17-36(18-16-35)29(22-9-4-2-5-10-22)23-11-6-3-7-12-23/h2-14,19-20,29H,15-18H2,1H3,(H,33,34,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20567 (N-(4-{[6-(4-tert-butylpiperazin-1-yl)pyrimidin-4-y...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCN(CC3)C(C)(C)C)cccc2s1 Show InChI InChI=1S/C21H26N6O2S/c1-14(28)24-20-25-19-15(6-5-7-16(19)30-20)29-18-12-17(22-13-23-18)26-8-10-27(11-9-26)21(2,3)4/h5-7,12-13H,8-11H2,1-4H3,(H,24,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20572 (N-[4-({6-[4-(2-phenylethyl)piperazin-1-yl]pyrimidi...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCN(CCc4ccccc4)CC3)cccc2s1 Show InChI InChI=1S/C25H26N6O2S/c1-18(32)28-25-29-24-20(8-5-9-21(24)34-25)33-23-16-22(26-17-27-23)31-14-12-30(13-15-31)11-10-19-6-3-2-4-7-19/h2-9,16-17H,10-15H2,1H3,(H,28,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20564 (N-(4-{[6-(morpholin-4-yl)pyrimidin-4-yl]oxy}-1,3-b...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCOCC3)cccc2s1 Show InChI InChI=1S/C17H17N5O3S/c1-11(23)20-17-21-16-12(3-2-4-13(16)26-17)25-15-9-14(18-10-19-15)22-5-7-24-8-6-22/h2-4,9-10H,5-8H2,1H3,(H,20,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20567 (N-(4-{[6-(4-tert-butylpiperazin-1-yl)pyrimidin-4-y...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCN(CC3)C(C)(C)C)cccc2s1 Show InChI InChI=1S/C21H26N6O2S/c1-14(28)24-20-25-19-15(6-5-7-16(19)30-20)29-18-12-17(22-13-23-18)26-8-10-27(11-9-26)21(2,3)4/h5-7,12-13H,8-11H2,1-4H3,(H,24,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20564 (N-(4-{[6-(morpholin-4-yl)pyrimidin-4-yl]oxy}-1,3-b...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCOCC3)cccc2s1 Show InChI InChI=1S/C17H17N5O3S/c1-11(23)20-17-21-16-12(3-2-4-13(16)26-17)25-15-9-14(18-10-19-15)22-5-7-24-8-6-22/h2-4,9-10H,5-8H2,1H3,(H,20,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20565 (N-(4-{[6-(piperazin-1-yl)pyrimidin-4-yl]oxy}-1,3-b...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCNCC3)cccc2s1 Show InChI InChI=1S/C17H18N6O2S/c1-11(24)21-17-22-16-12(3-2-4-13(16)26-17)25-15-9-14(19-10-20-15)23-7-5-18-6-8-23/h2-4,9-10,18H,5-8H2,1H3,(H,21,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20565 (N-(4-{[6-(piperazin-1-yl)pyrimidin-4-yl]oxy}-1,3-b...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCNCC3)cccc2s1 Show InChI InChI=1S/C17H18N6O2S/c1-11(24)21-17-22-16-12(3-2-4-13(16)26-17)25-15-9-14(19-10-20-15)23-7-5-18-6-8-23/h2-4,9-10,18H,5-8H2,1H3,(H,21,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20572 (N-[4-({6-[4-(2-phenylethyl)piperazin-1-yl]pyrimidi...) Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)N3CCN(CCc4ccccc4)CC3)cccc2s1 Show InChI InChI=1S/C25H26N6O2S/c1-18(32)28-25-29-24-20(8-5-9-21(24)34-25)33-23-16-22(26-17-27-23)31-14-12-30(13-15-31)11-10-19-6-3-2-4-7-19/h2-9,16-17H,10-15H2,1H3,(H,28,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20566 (N-[4-({6-[4-(propan-2-yl)piperazin-1-yl]pyrimidin-...) Show SMILES CC(C)N1CCN(CC1)c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1 Show InChI InChI=1S/C20H24N6O2S/c1-13(2)25-7-9-26(10-8-25)17-11-18(22-12-21-17)28-15-5-4-6-16-19(15)24-20(29-16)23-14(3)27/h4-6,11-13H,7-10H2,1-3H3,(H,23,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3528-39 (2007) Article DOI: 10.1021/jm070191h BindingDB Entry DOI: 10.7270/Q2MW2FF4
					More data for this Ligand-Target Pair