Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Carbonic anhydrase 9 (Homo sapiens (Human)) | BDBM50022180 (5,7-Dihydroxy-4-methyl-2H-chromen-2-one (2) | 5,7-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 190 | -35.7 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 9 (Homo sapiens (Human)) | BDBM248070 (4-Methyl-2H-benzo[g]chromen-2-one (5)) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 200 | -35.5 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 9 (Homo sapiens (Human)) | BDBM248069 (4-Methyl-2H-benzo[h]chromen-2-one (4)) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 230 | -35.2 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 9 (Homo sapiens (Human)) | BDBM50022184 (7,8-Dihydroxy-4-methyl-2H-chromen-2-one (3) | 7,8-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 270 | -34.9 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 9 (Homo sapiens (Human)) | BDBM50022178 (4-Methyl-7-hydroxycoumarin | 4-methylumbelliferone...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 450 | -33.7 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 12 (Homo sapiens (Human)) | BDBM248070 (4-Methyl-2H-benzo[g]chromen-2-one (5)) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 3.30E+3 | -29.1 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 12 (Homo sapiens (Human)) | BDBM50022178 (4-Methyl-7-hydroxycoumarin | 4-methylumbelliferone...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 4.30E+3 | -28.5 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM50022178 (4-Methyl-7-hydroxycoumarin | 4-methylumbelliferone...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 4.80E+3 | -28.2 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 12 (Homo sapiens (Human)) | BDBM248069 (4-Methyl-2H-benzo[h]chromen-2-one (4)) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 5.50E+3 | -27.9 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 12 (Homo sapiens (Human)) | BDBM50022180 (5,7-Dihydroxy-4-methyl-2H-chromen-2-one (2) | 5,7-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 6.40E+3 | -27.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 12 (Homo sapiens (Human)) | BDBM50022184 (7,8-Dihydroxy-4-methyl-2H-chromen-2-one (3) | 7,8-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 6.60E+3 | -27.5 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM248070 (4-Methyl-2H-benzo[g]chromen-2-one (5)) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 8.20E+3 | -27.0 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM50022180 (5,7-Dihydroxy-4-methyl-2H-chromen-2-one (2) | 5,7-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 8.40E+3 | -26.9 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM50022184 (7,8-Dihydroxy-4-methyl-2H-chromen-2-one (3) | 7,8-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 8.70E+3 | -26.8 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM248069 (4-Methyl-2H-benzo[h]chromen-2-one (4)) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 9.00E+3 | -26.8 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM248069 (4-Methyl-2H-benzo[h]chromen-2-one (4)) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | >2.00E+5 | >-19.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM50022184 (7,8-Dihydroxy-4-methyl-2H-chromen-2-one (3) | 7,8-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | >2.00E+5 | >-19.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM50022180 (5,7-Dihydroxy-4-methyl-2H-chromen-2-one (2) | 5,7-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | >2.00E+5 | >-19.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM50022178 (4-Methyl-7-hydroxycoumarin | 4-methylumbelliferone...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | >2.00E+5 | >-19.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM248070 (4-Methyl-2H-benzo[g]chromen-2-one (5)) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | >2.00E+5 | >-19.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
S.G.S.I.T.S | Assay Description An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of... | J Enzyme Inhib Med Chem 29: 292-6 (2014) Article DOI: 10.3109/14756366.2013.777334 BindingDB Entry DOI: 10.7270/Q2J38RFK | |||||||||||
More data for this Ligand-Target Pair |