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Compile Data Set for Download or QSAR

Found 131 hits Enz. Inhib. hit(s) with all data for entry = 8471   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251420
PNG
(US9452990, 102)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NCC1(C)COC1)c1ccc(cc1)C#N |r|
Show InChI InChI=1/C29H34FN7O4/c1-29(16-41-17-29)15-33-21(19-6-4-18(14-31)5-7-19)13-23(38)36-8-10-37(11-9-36)28-34-25-20(27(32)35-28)12-22(39-2)26(40-3)24(25)30/h4-7,12,21,33H,8-11,13,15-17H2,1-3H3,(H2,32,34,35)/t21-/s2
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n/an/a 1n/an/an/an/a7.425



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251408
PNG
(US9452990, 90)
Show SMILES CCN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccc(cc1)C#N |r|
Show InChI InChI=1/C26H30FN7O3/c1-4-30-19(17-7-5-16(15-28)6-8-17)14-21(35)33-9-11-34(12-10-33)26-31-23-18(25(29)32-26)13-20(36-2)24(37-3)22(23)27/h5-8,13,19,30H,4,9-12,14H2,1-3H3,(H2,29,31,32)/t19-/s2
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n/an/a 1n/an/an/an/a7.425



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251449
PNG
(US9452990, 131)
Show SMILES CCNC(=O)[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccc(F)cc1 |r|
Show InChI InChI=1/C26H30F2N6O4/c1-4-30-25(36)17(15-5-7-16(27)8-6-15)14-20(35)33-9-11-34(12-10-33)26-31-22-18(24(29)32-26)13-19(37-2)23(38-3)21(22)28/h5-8,13,17H,4,9-12,14H2,1-3H3,(H,30,36)(H2,29,31,32)/t17-/s2
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n/an/a 3n/an/an/an/a7.425



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251413
PNG
(US9452990, 95)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NC(C)C)c1ccc(cc1)C#N |r|
Show InChI InChI=1/C27H32FN7O3/c1-16(2)31-20(18-7-5-17(15-29)6-8-18)14-22(36)34-9-11-35(12-10-34)27-32-24-19(26(30)33-27)13-21(37-3)25(38-4)23(24)28/h5-8,13,16,20,31H,9-12,14H2,1-4H3,(H2,30,32,33)/t20-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251397
PNG
(US9452990, 77)
Show SMILES CN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccc(cc1)C#N |r|
Show InChI InChI=1/C25H28FN7O3/c1-29-18(16-6-4-15(14-27)5-7-16)13-20(34)32-8-10-33(11-9-32)25-30-22-17(24(28)31-25)12-19(35-2)23(36-3)21(22)26/h4-7,12,18,29H,8-11,13H2,1-3H3,(H2,28,30,31)/t18-/s2
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n/an/a 4n/an/an/an/a7.425



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251411
PNG
(US9452990, 93)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NCC1CC1)c1ccsc1 |r|
Show InChI InChI=1/C25H31FN6O3S/c1-34-19-11-17-22(21(26)23(19)35-2)29-25(30-24(17)27)32-8-6-31(7-9-32)20(33)12-18(16-5-10-36-14-16)28-13-15-3-4-15/h5,10-11,14-15,18,28H,3-4,6-9,12-13H2,1-2H3,(H2,27,29,30)/t18-/s2
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n/an/a 4n/an/an/an/a7.425



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251348
PNG
(US9452990, 28)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1c1ccccc1)C(=O)c1cc2cc(ccc2[nH]1)C#N |r|
Show InChI InChI=1/C30H26FN7O3/c1-40-24-14-20-26(25(31)27(24)41-2)35-30(36-28(20)33)38-11-10-37(16-23(38)18-6-4-3-5-7-18)29(39)22-13-19-12-17(15-32)8-9-21(19)34-22/h3-9,12-14,23,34H,10-11,16H2,1-2H3,(H2,33,35,36)/t23-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251451
PNG
(US9452990, 80)
Show SMILES CN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccc(F)cc1 |r|
Show InChI InChI=1/C24H28F2N6O3/c1-28-17(14-4-6-15(25)7-5-14)13-19(33)31-8-10-32(11-9-31)24-29-21-16(23(27)30-24)12-18(34-2)22(35-3)20(21)26/h4-7,12,17,28H,8-11,13H2,1-3H3,(H2,27,29,30)/t17-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251345
PNG
(US9452990, 25)
Show SMILES CC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)c1cc2cc(ccc2[nH]1)C#N |r|
Show InChI InChI=1/C26H26FN7O3/c1-4-16-13-33(25(35)19-10-15-9-14(12-28)5-6-18(15)30-19)7-8-34(16)26-31-22-17(24(29)32-26)11-20(36-2)23(37-3)21(22)27/h5-6,9-11,16,30H,4,7-8,13H2,1-3H3,(H2,29,31,32)/t16-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251412
PNG
(US9452990, 94)
Show SMILES COCCCN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccc(F)cc1 |r|
Show InChI InChI=1/C27H34F2N6O4/c1-37-14-4-9-31-20(17-5-7-18(28)8-6-17)16-22(36)34-10-12-35(13-11-34)27-32-24-19(26(30)33-27)15-21(38-2)25(39-3)23(24)29/h5-8,15,20,31H,4,9-14,16H2,1-3H3,(H2,30,32,33)/t20-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251417
PNG
(US9452990, 99)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N1CCCCC1)c1ccc(F)cc1 |r|
Show InChI InChI=1/C28H34F2N6O3/c1-38-22-16-20-25(24(30)26(22)39-2)32-28(33-27(20)31)36-14-12-35(13-15-36)23(37)17-21(34-10-4-3-5-11-34)18-6-8-19(29)9-7-18/h6-9,16,21H,3-5,10-15,17H2,1-2H3,(H2,31,32,33)/t21-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251416
PNG
(US9452990, 98)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NCCF)c1ccc(F)cc1 |r|
Show InChI InChI=1/C25H29F3N6O3/c1-36-19-13-17-22(21(28)23(19)37-2)31-25(32-24(17)29)34-11-9-33(10-12-34)20(35)14-18(30-8-7-26)15-3-5-16(27)6-4-15/h3-6,13,18,30H,7-12,14H2,1-2H3,(H2,29,31,32)/t18-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251402
PNG
(US9452990, 84)
Show SMILES CCN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccc(F)cc1 |r|
Show InChI InChI=1/C25H30F2N6O3/c1-4-29-18(15-5-7-16(26)8-6-15)14-20(34)32-9-11-33(12-10-32)25-30-22-17(24(28)31-25)13-19(35-2)23(36-3)21(22)27/h5-8,13,18,29H,4,9-12,14H2,1-3H3,(H2,28,30,31)/t18-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251330
PNG
(US9452990, 10)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1c1ccccc1)C(=O)\C=C\c1ccc(cc1)C#N |r|
Show InChI InChI=1/C30H27FN6O3/c1-39-24-16-22-27(26(31)28(24)40-2)34-30(35-29(22)33)37-15-14-36(18-23(37)21-6-4-3-5-7-21)25(38)13-12-19-8-10-20(17-32)11-9-19/h3-13,16,23H,14-15,18H2,1-2H3,(H2,33,34,35)/b13-12+/t23-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251389
PNG
(US9452990, 69)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1c1ccccc1)C(=O)C[C@@H](N)c1ccc(F)cc1 |r|
Show InChI InChI=1/C29H30F2N6O3/c1-39-23-14-20-26(25(31)27(23)40-2)34-29(35-28(20)33)37-13-12-36(16-22(37)18-6-4-3-5-7-18)24(38)15-21(32)17-8-10-19(30)11-9-17/h3-11,14,21-22H,12-13,15-16,32H2,1-2H3,(H2,33,34,35)/t21-,22-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251384
PNG
(US9452990, 64)
Show SMILES CC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)C[C@@H](N)c1ccc(cc1)C#N |r|
Show InChI InChI=1/C26H30FN7O3/c1-4-17-14-33(21(35)12-19(29)16-7-5-15(13-28)6-8-16)9-10-34(17)26-31-23-18(25(30)32-26)11-20(36-2)24(37-3)22(23)27/h5-8,11,17,19H,4,9-10,12,14,29H2,1-3H3,(H2,30,31,32)/t17-,19+/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251410
PNG
(US9452990, 92)
Show SMILES CCCN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccc(Cl)s1 |r|
Show InChI InChI=1/C24H30ClFN6O3S/c1-4-7-28-15(17-5-6-18(25)36-17)13-19(33)31-8-10-32(11-9-31)24-29-21-14(23(27)30-24)12-16(34-2)22(35-3)20(21)26/h5-6,12,15,28H,4,7-11,13H2,1-3H3,(H2,27,29,30)/t15-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251378
PNG
(US9452990, 58)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)C[C@@H](N)c1ccc(cc1)C#N |r|
Show InChI InChI=1/C25H28FN7O3/c1-14-13-32(20(34)11-18(28)16-6-4-15(12-27)5-7-16)8-9-33(14)25-30-22-17(24(29)31-25)10-19(35-2)23(36-3)21(22)26/h4-7,10,14,18H,8-9,11,13,28H2,1-3H3,(H2,29,30,31)/t14-,18+/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251387
PNG
(US9452990, 67)
Show SMILES CCC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)C[C@@H](N)c1ccc(cc1)C#N |r|
Show InChI InChI=1/C27H32FN7O3/c1-4-5-18-15-34(22(36)13-20(30)17-8-6-16(14-29)7-9-17)10-11-35(18)27-32-24-19(26(31)33-27)12-21(37-2)25(38-3)23(24)28/h6-9,12,18,20H,4-5,10-11,13,15,30H2,1-3H3,(H2,31,32,33)/t18-,20+/s2
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n/an/a 10n/an/an/an/a7.425



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251364
PNG
(US9452990, 44)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(cc1)C#N |r|
Show InChI InChI=1/C24H26FN7O3/c1-34-18-11-16-21(20(25)22(18)35-2)29-24(30-23(16)28)32-9-7-31(8-10-32)19(33)12-17(27)15-5-3-14(13-26)4-6-15/h3-6,11,17H,7-10,12,27H2,1-2H3,(H2,28,29,30)/t17-/s2
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n/an/a 10n/an/an/an/a7.425



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251448
PNG
(US9452990, 130)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](C(N)=O)c1ccc(F)cc1 |r|
Show InChI InChI=1/C24H26F2N6O4/c1-35-17-11-16-20(19(26)21(17)36-2)29-24(30-22(16)27)32-9-7-31(8-10-32)18(33)12-15(23(28)34)13-3-5-14(25)6-4-13/h3-6,11,15H,7-10,12H2,1-2H3,(H2,28,34)(H2,27,29,30)/t15-/s2
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n/an/a 10n/an/an/an/a7.425



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251414
PNG
(US9452990, 96)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N1CCC1)c1ccc(F)cc1 |r|
Show InChI InChI=1/C26H30F2N6O3/c1-36-20-14-18-23(22(28)24(20)37-2)30-26(31-25(18)29)34-12-10-33(11-13-34)21(35)15-19(32-8-3-9-32)16-4-6-17(27)7-5-16/h4-7,14,19H,3,8-13,15H2,1-2H3,(H2,29,30,31)/t19-/s2
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n/an/a 10n/an/an/an/a7.425



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251346
PNG
(US9452990, 26)
Show SMILES CCC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)c1cc2cc(ccc2[nH]1)C#N |r|
Show InChI InChI=1/C27H28FN7O3/c1-4-5-17-14-34(26(36)20-11-16-10-15(13-29)6-7-19(16)31-20)8-9-35(17)27-32-23-18(25(30)33-27)12-21(37-2)24(38-3)22(23)28/h6-7,10-12,17,31H,4-5,8-9,14H2,1-3H3,(H2,30,32,33)/t17-/s2
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n/an/a 11n/an/an/an/a7.425



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251328
PNG
(US9452990, 8)
Show SMILES CC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)\C=C\c1ccc(cc1)C#N |r|
Show InChI InChI=1/C26H27FN6O3/c1-4-18-15-32(21(34)10-9-16-5-7-17(14-28)8-6-16)11-12-33(18)26-30-23-19(25(29)31-26)13-20(35-2)24(36-3)22(23)27/h5-10,13,18H,4,11-12,15H2,1-3H3,(H2,29,30,31)/b10-9+/t18-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251415
PNG
(US9452990, 97)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1[C@@H](C)CN(C[C@H]1C)C(=O)C[C@@H](NC(C)C)c1ccc(cc1)C#N |r|
Show InChI InChI=1/C29H36FN7O3/c1-16(2)33-22(20-9-7-19(13-31)8-10-20)12-24(38)36-14-17(3)37(18(4)15-36)29-34-26-21(28(32)35-29)11-23(39-5)27(40-6)25(26)30/h7-11,16-18,22,33H,12,14-15H2,1-6H3,(H2,32,34,35)/t17-,18+,22-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251409
PNG
(US9452990, 91)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NC(C)C)c1ccc(F)c(c1)C#N |r|
Show InChI InChI=1/C27H31F2N7O3/c1-15(2)32-20(16-5-6-19(28)17(11-16)14-30)13-22(37)35-7-9-36(10-8-35)27-33-24-18(26(31)34-27)12-21(38-3)25(39-4)23(24)29/h5-6,11-12,15,20,32H,7-10,13H2,1-4H3,(H2,31,33,34)/t20-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251419
PNG
(US9452990, 101)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NC(C)C)c1ccc(F)cn1 |r|
Show InChI InChI=1/C25H31F2N7O3/c1-14(2)30-18(17-6-5-15(26)13-29-17)12-20(35)33-7-9-34(10-8-33)25-31-22-16(24(28)32-25)11-19(36-3)23(37-4)21(22)27/h5-6,11,13-14,18,30H,7-10,12H2,1-4H3,(H2,28,31,32)/t18-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251349
PNG
(US9452990, 29)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1c1ccccc1)C(=O)c1cc2cc(F)ccc2[nH]1 |r|
Show InChI InChI=1/C29H26F2N6O3/c1-39-23-14-19-25(24(31)26(23)40-2)34-29(35-27(19)32)37-11-10-36(15-22(37)16-6-4-3-5-7-16)28(38)21-13-17-12-18(30)8-9-20(17)33-21/h3-9,12-14,22,33H,10-11,15H2,1-2H3,(H2,32,34,35)/t22-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251343
PNG
(US9452990, 23)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)c1cc2cc(ccc2[nH]1)C#N |r|
Show InChI InChI=1/C25H24FN7O3/c1-13-12-32(24(34)18-9-15-8-14(11-27)4-5-17(15)29-18)6-7-33(13)25-30-21-16(23(28)31-25)10-19(35-2)22(36-3)20(21)26/h4-5,8-10,13,29H,6-7,12H2,1-3H3,(H2,28,30,31)/t13-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251421
PNG
(US9452990, 103)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N1CCCC1)c1ccc(F)cc1 |r|
Show InChI InChI=1/C27H32F2N6O3/c1-37-21-15-19-24(23(29)25(21)38-2)31-27(32-26(19)30)35-13-11-34(12-14-35)22(36)16-20(33-9-3-4-10-33)17-5-7-18(28)8-6-17/h5-8,15,20H,3-4,9-14,16H2,1-2H3,(H2,30,31,32)/t20-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251322
PNG
(US9452990, 2)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)\C=C\c1ccc(cc1)C#N
Show InChI InChI=1S/C24H23FN6O3/c1-33-18-13-17-21(20(25)22(18)34-2)28-24(29-23(17)27)31-11-9-30(10-12-31)19(32)8-7-15-3-5-16(14-26)6-4-15/h3-8,13H,9-12H2,1-2H3,(H2,27,28,29)/b8-7+
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251342
PNG
(US9452990, 22)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)c1cc2cc(F)cc(F)c2[nH]1
Show InChI InChI=1S/C23H21F3N6O3/c1-34-16-10-13-19(17(26)20(16)35-2)29-23(30-21(13)27)32-5-3-31(4-6-32)22(33)15-8-11-7-12(24)9-14(25)18(11)28-15/h7-10,28H,3-6H2,1-2H3,(H2,27,29,30)
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251418
PNG
(US9452990, 100)
Show SMILES COCCN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccc(F)cc1 |r|
Show InChI InChI=1/C26H32F2N6O4/c1-36-13-8-30-19(16-4-6-17(27)7-5-16)15-21(35)33-9-11-34(12-10-33)26-31-23-18(25(29)32-26)14-20(37-2)24(38-3)22(23)28/h4-7,14,19,30H,8-13,15H2,1-3H3,(H2,29,31,32)/t19-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251327
PNG
(US9452990, 7)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)\C=C\c1ccc(cc1)C#N |r|
Show InChI InChI=1/C25H25FN6O3/c1-15-14-31(20(33)9-8-16-4-6-17(13-27)7-5-16)10-11-32(15)25-29-22-18(24(28)30-25)12-19(34-2)23(35-3)21(22)26/h4-9,12,15H,10-11,14H2,1-3H3,(H2,28,29,30)/b9-8+/t15-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251380
PNG
(US9452990, 60)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)C[C@@H](N)c1ccc(F)cc1 |r|
Show InChI InChI=1/C24H28F2N6O3/c1-13-12-31(19(33)11-17(27)14-4-6-15(25)7-5-14)8-9-32(13)24-29-21-16(23(28)30-24)10-18(34-2)22(35-3)20(21)26/h4-7,10,13,17H,8-9,11-12,27H2,1-3H3,(H2,28,29,30)/t13-,17+/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251439
PNG
(US9452990, 121)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1c1ccccc1)C(=O)C[C@@H]1CCCCN1 |r|
Show InChI InChI=1/C27H33FN6O3/c1-36-21-15-19-24(23(28)25(21)37-2)31-27(32-26(19)29)34-13-12-33(16-20(34)17-8-4-3-5-9-17)22(35)14-18-10-6-7-11-30-18/h3-5,8-9,15,18,20,30H,6-7,10-14,16H2,1-2H3,(H2,29,31,32)/t18-,20+/s2
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US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251329
PNG
(US9452990, 9)
Show SMILES CCC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)\C=C\c1ccc(cc1)C#N |r|
Show InChI InChI=1/C27H29FN6O3/c1-4-5-19-16-33(22(35)11-10-17-6-8-18(15-29)9-7-17)12-13-34(19)27-31-24-20(26(30)32-27)14-21(36-2)25(37-3)23(24)28/h6-11,14,19H,4-5,12-13,16H2,1-3H3,(H2,30,31,32)/b11-10+/t19-/s2
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251338
PNG
(US9452990, 18)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)c1cc2cc(ccc2[nH]1)C#N
Show InChI InChI=1S/C24H22FN7O3/c1-34-18-11-15-20(19(25)21(18)35-2)29-24(30-22(15)27)32-7-5-31(6-8-32)23(33)17-10-14-9-13(12-26)3-4-16(14)28-17/h3-4,9-11,28H,5-8H2,1-2H3,(H2,27,29,30)
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251385
PNG
(US9452990, 65)
Show SMILES CC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)C[C@@H](N)c1ccc(F)cc1 |r|
Show InChI InChI=1/C25H30F2N6O3/c1-4-16-13-32(20(34)12-18(28)14-5-7-15(26)8-6-14)9-10-33(16)25-30-22-17(24(29)31-25)11-19(35-2)23(36-3)21(22)27/h5-8,11,16,18H,4,9-10,12-13,28H2,1-3H3,(H2,29,30,31)/t16-,18+/s2
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251401
PNG
(US9452990, 83)
Show SMILES COc1cc2nc(nc(N)c2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(F)cc1 |r|
Show InChI InChI=1/C23H26F2N6O3/c1-33-17-12-16-19(20(25)21(17)34-2)22(27)29-23(28-16)31-9-7-30(8-10-31)18(32)11-15(26)13-3-5-14(24)6-4-13/h3-6,12,15H,7-11,26H2,1-2H3,(H2,27,28,29)/t15-/s2
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251406
PNG
(US9452990, 88)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NCC(F)(F)F)c1ccc(F)cc1 |r|
Show InChI InChI=1/C25H27F5N6O3/c1-38-18-11-16-21(20(27)22(18)39-2)33-24(34-23(16)31)36-9-7-35(8-10-36)19(37)12-17(32-13-25(28,29)30)14-3-5-15(26)6-4-14/h3-6,11,17,32H,7-10,12-13H2,1-2H3,(H2,31,33,34)/t17-/s2
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251407
PNG
(US9452990, 89)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NC(C)C)c1ccc(F)cc1 |r|
Show InChI InChI=1/C26H32F2N6O3/c1-15(2)30-19(16-5-7-17(27)8-6-16)14-21(35)33-9-11-34(12-10-33)26-31-23-18(25(29)32-26)13-20(36-3)24(37-4)22(23)28/h5-8,13,15,19,30H,9-12,14H2,1-4H3,(H2,29,31,32)/t19-/s2
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251405
PNG
(US9452990, 87)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NC(CF)CF)c1ccc(F)cc1 |r|
Show InChI InChI=1/C26H30F4N6O3/c1-38-20-11-18-23(22(30)24(20)39-2)33-26(34-25(18)31)36-9-7-35(8-10-36)21(37)12-19(32-17(13-27)14-28)15-3-5-16(29)6-4-15/h3-6,11,17,19,32H,7-10,12-14H2,1-2H3,(H2,31,33,34)/t19-/s2
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251404
PNG
(US9452990, 86)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N(C)C)c1ccc(F)cc1 |r|
Show InChI InChI=1/C25H30F2N6O3/c1-31(2)18(15-5-7-16(26)8-6-15)14-20(34)32-9-11-33(12-10-32)25-29-22-17(24(28)30-25)13-19(35-3)23(36-4)21(22)27/h5-8,13,18H,9-12,14H2,1-4H3,(H2,28,29,30)/t18-/s2
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251381
PNG
(US9452990, 61)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)C[C@@H](N)c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1/C25H28F4N6O3/c1-13-12-34(19(36)11-17(30)14-4-6-15(7-5-14)25(27,28)29)8-9-35(13)24-32-21-16(23(31)33-24)10-18(37-2)22(38-3)20(21)26/h4-7,10,13,17H,8-9,11-12,30H2,1-3H3,(H2,31,32,33)/t13-,17+/s2
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251366
PNG
(US9452990, 46)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(F)cc1 |r|
Show InChI InChI=1/C23H26F2N6O3/c1-33-17-11-15-20(19(25)21(17)34-2)28-23(29-22(15)27)31-9-7-30(8-10-31)18(32)12-16(26)13-3-5-14(24)6-4-13/h3-6,11,16H,7-10,12,26H2,1-2H3,(H2,27,28,29)/t16-/s2
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251363
PNG
(US9452990, 43)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1cccc(c1)C#N |r|
Show InChI InChI=1/C24H26FN7O3/c1-34-18-11-16-21(20(25)22(18)35-2)29-24(30-23(16)28)32-8-6-31(7-9-32)19(33)12-17(27)15-5-3-4-14(10-15)13-26/h3-5,10-11,17H,6-9,12,27H2,1-2H3,(H2,28,29,30)/t17-/s2
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251357
PNG
(US9452990, 37)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccsc1 |r|
Show InChI InChI=1/C21H25FN6O3S/c1-30-15-9-13-18(17(22)19(15)31-2)25-21(26-20(13)24)28-6-4-27(5-7-28)16(29)10-14(23)12-3-8-32-11-12/h3,8-9,11,14H,4-7,10,23H2,1-2H3,(H2,24,25,26)/t14-/s2
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251373
PNG
(US9452990, 53)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(cc1)C(F)F |r|
Show InChI InChI=1/C24H27F3N6O3/c1-35-17-11-15-20(19(25)21(17)36-2)30-24(31-23(15)29)33-9-7-32(8-10-33)18(34)12-16(28)13-3-5-14(6-4-13)22(26)27/h3-6,11,16,22H,7-10,12,28H2,1-2H3,(H2,29,30,31)/t16-/s2
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251392
PNG
(US9452990, 72 | US9452990, 79)
Show SMILES CN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccccc1 |r|
Show InChI InChI=1/C24H29FN6O3/c1-27-17(15-7-5-4-6-8-15)14-19(32)30-9-11-31(12-10-30)24-28-21-16(23(26)29-24)13-18(33-2)22(34-3)20(21)25/h4-8,13,17,27H,9-12,14H2,1-3H3,(H2,26,28,29)/t17-/s2
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair
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